Division of Intramural Research
Pulmonary Critical Care Medicine Branch

Bernadette R. Gochuico
M.D., Boston University 

Pulmonary - Critical Care Medicine Branch 
National Heart, Lung, and Blood Institute 
National Institutes of Health 
10 Center Drive, MSC 1590 
Building 10 / Room 6D03 
Bethesda, MD 20892-1590 
Telephone Number: 301-496-1597 
Fax Number: 301-480-1216 
Email Address: gochuicb@nhlbi.nih.gov 

Research Interest(s):

Molecular and Cellular Biology 
Pulmonary / Respiratory Diseases

Research Description:

Molecular and Cellular Dysregulation in Pulmonary Fibrosis

Clinical and basic research focuses on molecular and cellular dysregulation in defined subpopulations with pulmonary fibrosis (i.e., idiopathic pulmonary fibrosis, familial pulmonary fibrosis, pulmonary fibrosis associated with rheumatoid arthritis). Basic research focuses on gene transcription in alveolar macrophages, pathways within fibroblast subsets contributing to cell proliferation and extracellular matrix protein synthesis, and the alveolar microenvironment in pulmonary fibrosis. Clinical research focuses on defining the natural history of disease. Findings of basic and clinical research will be correlated to identify markers of adverse clinical outcome and, thus, potential therapeutic targets in pulmonary fibrosis.

Selected Publications:

Increased 99mTc-DTPA Lung Clearance in Individuals with Biopsy-confirmed Idiopathic Pulmonary Fibrosis. Gochuico BR, MacDonald SD, Wu HP, Avila NA, Beasley M, Travis WD, Chen CC. Am. J. Respir. Crit. Care Med. 161:A527 (2000).

Potential Pathogenesis and Clinical Aspects of Pulmonary Fibrosis Associated with Rheumatoid Arthritis. Gochuico BR. Am. J. Med. Sci. 321:83-88 (2001). PubMed

Rapid 99mTc-DTPA Lung Clearance in Individuals with UIP is Associated with Lung PMN Accumulation. Gochuico BR, MacDonald SD, Rosas I, Beasley M, Travis WD, Ren P, Wu HP, Chen CC. Am. J. Respir. Crit. Care Med. 163:A708 (2001).

Alteration of Alveolar Macrophage Immune Response Gene Expression in Idiopathic Pulmonary Fibrosis. Ren P, Wu HP, Rosas I, MacDonald SD, Gochuico BR. Am. J. Respir. Crit. Care Med. 163(5):A709 (2001).

Concentration of TNF-a in BAL Fluid is Associated with Polymorphism of TNF-a Promoter in Rheumatoid Arthritis. Parker CY, MacDonald SD, Rosas I, Ren P, Wu HP, Gochuico BR. Am. J. Respir. Crit. Care Med. 165:A534 (2002).

Last updated August 29, 2002

Principal Investigators

• Joel Moss
• Martha Vaughan
• Vincent Manganiello
• Bernadette Gochuico
• Stewart Levine