Division of Intramural Research
Pulmonary Critical Care Medicine Branch

The Pulmonary - Critical Care Medicine Branch (P-CCMB) conducts research related to basic cell and molecular biology, bench-to-bedside translational research projects, and clinical research on lung disease. Areas of basic research include cytokine biology, signal transduction pathways (e.g., nitric oxide, G proteins, cyclic nucleotide phosphodiesterases), vesicular trafficking, post-translational modification of proteins (e.g., ADP-ribosylation), and mechanisms of bacterial toxin action. P-CCMB translational studies use state-of-the-art techniques (e.g., genomics, proteomics) to define the pathogenesis of lung disease (e.g., asthma, cystic fibrosis, lymphangioleiomyomatosis (LAM), pulmonary fibrosis, and sarcoidosis). Areas of active clinical investigation with on-going protocols include: (1) identification of clinical, pathological, genetic, and physiological criteria for the determination of disease severity and progression in cystic fibrosis, LAM, and pulmonary fibrosis, (2) identification of novel therapeutic approaches for the treatment of lung disease (e.g., asthma and sarcoidosis), (3) development of new technologies for the prevention of nosocomial pneumonia and ventilator-induced injury.

Last updated: August 29, 2002

Principal Investigators

• Joel Moss
• Martha Vaughan
• Vincent Manganiello
• Bernadette Gochuico
• Stewart Levine