Laboratory of Environmental Lung Disease

RECENT PUBLICATIONS

[2000] [2001] [2002] [2003] [2004] [2005]

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Cook DN, Whitehead GS, Burch LH, Berman KG, Kapadia Z, Wohlford-Lenane C, Schwartz DA. Spontaneous Mutations in Recombinant Inbred mice: Mutant toll-like receptor 4 (tlr4) in BXD29 mice. Genetics. (2005) [PubMed]

Schwartz DA, Cook DN. Polymorphisms of the Toll-like receptors and human disease. Clin Infect Dis. (2005) 41:S403-7. [PubMed]

Zaas AK, Schwartz DA. Innate immunity and the lung: defense at the interface between host and environment. Trends Cardiovasc Med. (2005) 15:195-202. [PubMed]

Burch LH, Schwartz DA. Finding fibrosis genes: the lung. Methods Mol Med. (2005);117:293-313. [PubMed]

Steele MP, Speer MC, Loyd JE, Brown KK, Herron A, Slifer SH, Burch LH, Wahidi MM, Phillips JA 3rd, Sporn TA, McAdams HP, Schwarz MI, Schwartz DA. Clinical and pathologic features of familial interstitial pneumonia. Am J Respir Crit Care Med. (2005) 172:1146-52. [PubMed]

Zaas D, Schwartz DA. Genetics of environmental asthma. Semin Respir Crit Care Med. (2003) 24:185-96. [PubMed]

Visvesvara GS, Moura H, Leitch GJ, Schwartz DA, Xiao LX. Public health importance of Brachiola algerae (Microsporidia)­an emerging pathogen of humans. Folia Parasitol (Praha). (2005) 52:83-94. [PubMed]

Suliman HB, Welty-Wolf KE, Carraway MS, Schwartz DA, Hollingsworth JW, Piantadosi CA. Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. FASEB J. (2005) 19:1531-3. [PubMed]

Martinez FJ, Safrin S, Weycker D, Starko KM, Bradford WZ, King TE Jr, Flaherty KR, Schwartz DA, Noble PW, Raghu G, Brown KK; IPF Study Group. The clinical course of patients with idiopathic pulmonary fibrosis. Ann Intern Med. (2005) 142:963-7. [PubMed]

Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, Stamler JS. Protection from experimental asthma by an endogenous bronchodilator. Science. (2005) 308:1618-21. [PubMed]

Lynch DA, David Godwin J, Safrin S, Starko KM, Hormel P, Brown KK, Raghu G, King TE Jr, Bradford WZ, Schwartz DA, Richard Webb W, Idiopathic Pulmonary Fibrosis Study Group. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med. (2005) 172:488-93. [PubMed]

Schwartz DA. Scientific vision: setting forth a strategy. Environ Health Perspect. (2005) 113:A292. [PubMed]

Bammler T, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li YJ, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin LX, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin JL, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl H, Members of the Toxicogenomics Research Consortium. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods. (2005) 2:351-6. [PubMed]

Savov JD, Brass DM, Lawson BL, McElvania-Tekippe E, Walker JK, Schwartz DA. Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide. Am J Physiol Lung Cell Mol Physiol. (2005) 289:L329-37. [PubMed]

Kleeberger SR, Schwartz DA. From quantitative trait locus to gene: a work in progress. Am J Respir Crit Care Med. (2005) 171:804-5. [PubMed]

Singh J, Schwartz DA. Endotoxin and the lung: Insight into the host-environment interaction. J Allergy Clin Immunol. (2005) 115:330-3. [PubMed]

King TE Jr, Safrin S, Starko KM, Brown KK, Noble PW, Raghu G, Schwartz DA. Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis. Chest. (2005) 127:171-7. [PubMed]

Palmer SM, Burch LH, Trindade AJ, Davis RD, Herczyk WF, Reinsmoen NL, Schwartz DA. Innate immunity influences long-term outcomes after human lung transplant. Am J Respir Crit Care Med. (2005) 171:780-5. [PubMed]

Zhang X, Gainetdinov RR, Beaulieu JM, Sotnikova TD, Burch LH, Williams RB, Schwartz DA, Krishnan KR, Caron MG. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron. (2005) 45:11-6. [PubMed]

Hollingsworth JW, Chen BJ, Brass DM, Berman K, Gunn MD, Cook DN, Schwartz DA. The Critical Role of Hematopoietic Cells in Lipopolysaccharide-induced Airway Inflammation. Am J Respir Crit Care Med. (2005) 171:806-13. [PubMed]
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Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. (2004) 5:975-9. [PubMed]

Piantadosi CA, Schwartz DA. The acute respiratory distress syndrome. Ann Intern Med. (2004) 141:460-70. [PubMed]

Schwartz DA, Freedman JH, Linney EA. Environmental genomics: a key to understanding biology, pathophysiology and disease. Hum Mol Genet. (2004) Oct 1;13 Spec No 2:R217-24. [PubMed]

Brass DM, Savov JD, Whitehead GS, Maxwell AB, Schwartz DA. LPS binding protein is important in the airway response to inhaled endotoxin. J Allergy Clin Immunol. (2004) 114:586-92. [PubMed]

Garantziotis S, Steele MP, Schwartz DA. Pulmonary fibrosis: thinking outside of the lung. J Clin Invest. (2004) 114:319-21. [PubMed]

Cook DN, Wang S, Wang Y, Howles GP, Whitehead GS, Berman KG, Church TD, Frank BC, Gaspard RM, Yu Y, Quackenbush J, Schwartz DA. Genetic regulation of endotoxin-induced airway disease. Genomics. (2004) 83:961-9. [PubMed]

Hollingsworth JW 2nd, Cook DN, Brass DM, Walker JK, Morgan DL, Foster WM, Schwartz DA. The role of Toll-like receptor 4 in environmental airway injury in mice. Am J Respir Crit Care Med. (2004) 170:126-32. [PubMed]

Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, Foster WM, Schwartz DA. Ozone-induced acute pulmonary injury in inbred mouse strains. Am J Respir Cell Mol Biol. (2004) 31:69-77. [PubMed]

Raghu G, Brown KK, Bradford WZ, Starko K, Noble PW, Schwartz DA, King E Jr, Idiopathic Pulmonary Fibrosis Study Group. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis. N Engl J Med. (2004) 350:125-33. [PubMed]
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Cook DN, Hollingsworth JW Jr, Schwartz DA. Toll-like receptors and the genetics of innate immunity. Curr Opin Allergy Clin Immunol. (2003) 3:523-9. [PubMed]

Hunninghake GW, Lynch DA, Galvin JR, Gross BH, Muller N, Schwartz DA, King TE Jr, Lynch JP 3rd, Hegele R, Waldron J, Colby TV, Hogg JC. Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest. (2003) 124:1215-23. [PubMed]

Walker JK, Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ. Beta-arrestin-2 regulates the development of allergic asthma. J Clin Invest. (2003) 112:566-74. [PubMed]

George CL, White ML, O'Neill ME, Thorne PS, Schwartz DA, Snyder JM. Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol. (2003) 285:L1337-44. [PubMed]

Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA. Fibrinolysis in LPS-induced chronic airway disease. Am J Physiol Lung Cell Mol Physiol. (2003) 285:L940-8. [PubMed]

Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA. Subchronic endotoxin inhalation causes persistent airway disease. Am J Physiol Lung Cell Mol Physiol. (2003) 285:L755-61. [PubMed]

Palmer SM, Burch LH, Davis RD, Herczyk WF, Howell DN, Reinsmoen NL, Schwartz DA. The role of innate immunity in acute allograft rejection after g transplantation. Am J Respir Crit Care Med. (2003) 168:628-32. [PubMed]

Brass DM, Savov JD, Schwartz DA. Intercellular adhesion molecule-1 plays a pivotal role in endotoxin-induced airway disease. Chest. (2003) 123:416S. [PubMed]

Cook DN, Wang S, Howles GP, Speer M, Churchhill G, Quackenbush J, Schwartz DA. The genetics of innate immunity in the lung. Chest. (2003) 123:369S. [PubMed]

Whitehead GS, Walker JK, Berman KG, Foster WM, Schwartz DA. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol. (2003) 285:L32-42. [PubMed]
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Warshamana GS, Pociask DA, Sime P, Schwartz DA, Brody AR. Susceptibility to asbestos-induced and transforming growth factor-beta1-induced fibroproliferative lung disease in two strains of mice. Am J Respir Cell Mol Biol. (2002) 27:705-13. [PubMed]

Lange JL, Schwartz DA, Doebbeling BN, Heller JM, Thorne PS. Exposures to the Kuwait oil fires and their association with asthma and bronchitis among gulf war veterans. Environ Health Perspect. (2002) 110:1141-6. [PubMed]

Savov JD, Gavett SH, Brass DM, Costa DL, Schwartz DA. Neutrophils play a critical role in development of LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol. (2002) 283:L952-62. [PubMed]

Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA. CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. Am J Respir Cell Mol Biol. (2002) 27:474-80. [PubMed]

Lorenz E, Hallman M, Marttila R, Haataja R, Schwartz DA. Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population. Pediatr Res. (2002) 52:373-6. [PubMed]

Lorenz E, Patel DD, Hartung T, Schwartz DA. Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Infect Immun. (2002) 70:4892-6. [PubMed]

Cook DN, Brass DM, Schwartz DA. A matrix for new ideas in pulmonary fibrosis. Am J Respir Cell Mol Biol. (2002) 27:122-4. [PubMed]

Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med. (2002) 347:185-92. [PubMed]

Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L,Chapman HA, Friedman SL, King TE Jr, Leinwand LA, Liotta L, Martin GR, z DA, Schultz GS, Wagner CR, Musson RA. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. (2002) 166:236-46. [PubMed]

Schwartz DA. TLR4 and LPS hyporesponsiveness in humans. Int J Hyg Environ Health. (2002) 205:221-7. [PubMed]

Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med. (2002) 162:1028-32. [PubMed]

Thomas AQ, Lane K, Phillips J 3rd, Prince M, Markin C, Speer M, Schwartz DA, Gaddipati R, Marney A, Johnson J, Roberts R, Haines J, Stahlman M, Loyd JE. Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med. (2002) 165:1322-8. [PubMed]

Schwartz DA. The genetics of innate immunity. Chest. (2002) 121:62S-68S. [PubMed]

Wahidi MM, Speer MC, Steele MP, Brown KK, Schwarz MI, Schwartz DA. Familial pulmonary fibrosis in the United States. Chest. (2002) 121:30S. [PubMed]

Maddox L, Schwartz DA. The pathophysiology of asthma. Annu Rev Med. (2002) 53:477-98. [PubMed]
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Schwartz DA. The role of TLR4 in endotoxin responsiveness in humans. J Endotoxin Res. (2001) 7:389-93. [PubMed]

Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R, Schwartz DA. Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol. (2001) 25:457-65. [PubMed]

Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA. Genes other than TLR4 are involved in the response to inhaled LPS. Am J Physiol Lung Cell Mol Physiol. (2001) 281:L1106-14. [PubMed]

Schwartz DA. Inhaled endotoxin, a risk for airway disease in some people. Respir Physiol. (2001) 128:47-55. [PubMed]

Lorenz E, Schwartz DA, Martin PJ, Gooley T, Lin MT, Chien JW, Hansen JA, Clark JG. Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. (2001) 7:384-7. [PubMed]

Lorenz E, Frees KL, Schwartz DA. Determination of the TLR4 genotype using allele-specific PCR. Biotechniques. (2001) 31:22-4. [PubMed]

Hunninghake GW, Zimmerman MB, Schwartz DA, King TE Jr, Lynch J, Hegele R, Waldron J, Colby T, Muller N, Lynch D, Galvin J, Gross B, Hogg J, Toews G, Helmers R, Cooper JA Jr, Baughman R, Strange C, Millard M. Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. (2001) 164:193-6. [PubMed]

Schromm AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K, Golenbock DT. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med. (2001) 194:79-88. [PubMed]

Schwartz DA, Christ WJ, Kleeberger SR, Wohlford-Lenane CL. Inhibition of LPS-induced airway hyperresponsiveness and airway inflammation by LPS antagonists. Am J Physiol Lung Cell Mol Physiol. (2001) 280:L771-8. [PubMed]

Schwartz DA. Does inhalation of endotoxin cause asthma? Am J Respir Crit Care Med. (2001) 163:305-6. [PubMed]

George CL, Jin H, Wohlford-Lenane CL, O'Neill ME, Phipps JC, O'Shaughnessy P, Kline JN, Thorne PS, Schwartz DA. Endotoxin responsiveness and subchronic grain dust-induced airway disease. Am J Physiol Lung Cell Mol Physiol. (2001) 280:L203-13. [PubMed]

Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA. TNF-alpha and IL-1 beta are not essential to the inflammatory response n LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol. (2001) 280:L173-80. [PubMed]
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Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun. (2000) 68:6398-401. [PubMed]

Kline JN, Jagielo PJ, Watt JL, Schwartz DA. Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. J Appl Physiol. (2000) 89:1172-8. [PubMed]

Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. (2000) 25:187-91. [PubMed]

Black DW, Doebbeling BN, Voelker MD, Clarke WR, Woolson RF, Barrett DH, Schwartz DA. Multiple chemical sensitivity syndrome: symptom prevalence and risk factors in a military population. Arch Intern Med. (2000) 160:1169-76. [PubMed]

Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA. IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. J Appl Physiol. (2000) 88:173-9. [PubMed]
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