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Enzymes Section
Earl R Stadtman, PhD,
Principal Investigator
Research in the Section on Enzymes in the Laboratory of Biochemistry,
NHLBI, is directed toward elucidation of basic mechanisms involved
in the production of cellular damage during exposure to oxidative
stress and the contributions of such damage to aging and disease.
To this end, our current research involves studies in the following
areas of research: (a) Regulation of apoptosis. (b) Role of apoptosis
in aging. (c) Examination of apoptosis in unicellular organisms.
(d) Effect of bicarbonate-carbon dioxide buffers on iron-catalyzed
oxidation of low density lipoprotein. (e) Cyclic nitration and
denitrification of tyrosine residues of proteins. (f) Biochemical
consequences of RNA oxidation.
For more information, please contact Earl
R Stadtman.
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Reactive oxygen species (ROS)
are involved in the oxidation of proteins, lipids, and nucleic
acids. Read
more. |
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