Department of Health and Human ServicesNational Institutes of HealthNational Heart Lung and Blood Institute
Urinary Exosome Protein Database
NHLBI Division of Intramural ResearchLaboratory of Kidney and Electrolyte Metabolism
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Mechanism of exosome formation and excretionUrinary Exosome Protein Database This database of urinary exosome proteins is based on published and unpublished protein mass spectrometry data from the NHLBI Laboratory of Kidney and Electrolyte Metabolism. All data are from urinary exosomes isolated from healthy human volunteers. The figure on the right illustrates the mechanism of exosome formation and excretion.

In the first step of the process, apical membrane proteins undergo endocytosis. In the second step, the endosome is targeted to the multivesicular body (MVB). The signal that marks plasma membrane proteins for incorporation into MVB is mono-ubiquitination. In the third step, the endosome fuses with the MVB. Consequently, the apical plasma membrane proteins are segregated in the MVB outer membranes and internalized by membrane invagination. Finally, the outer membrane of the MVB fuses with the apical plasma membrane releasing its internal vesicles, called 'exosomes', in the urinary space. Exosomes contain both membrane and cytosolic proteins.

This current database contains protein identification of human urinary exosomes using two different mass spectrometer analyzers. The LCQ mass analyzer was used for technique # 1 and the LTQ mass analyzer was used for technique # 2.

References:

  1. Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73.
  2. Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA. Large-scale Proteomics and Phosphoproteomics of Human Urinary Exosomes. J Am Soc Nephrol. in press

Current Database Size: 1160 proteins (Download Data).

The Urinary Exosome Protein Database was created by Patricia A. Gonzales, Guozhong Ma, Trairak Pisitkun, Brian Ruttenberg and Mark A. Knepper.

Contact us with questions or comments.

Protein NameGene NamePeptide #Acc NoGO ComponentGO ProcessGO FunctionTech
alpha 1B- glycoprotein A1BG1NP_570602extracellular regionnot classifiednot classified2
alpha- 2- macroglobulin- like 1 A2ML11NP_653271not classifiednot classifiedendopeptidase inhibitor activity2
aminoadipate- semialdehyde dehydrogenase- phosphopantetheinyl transferaseAASDHPPT1NP_056238not classifiedfatty acid biosynthesismagnesium ion binding phosphopantetheinyltransferase activity transferase activity2
ATP- binding cassette sub- family B member 1 ABCB123NP_000918cell surface integral to membrane membrane membrane fractionresponse to drug transportATP binding ATPase activity hydrolase activity nucleotide binding transporter activity xenobiotic- transporting ATPase activity1, 2
ATP- binding cassette, sub- family B (MDR/TAP), member 11 ABCB111NP_003733integral to plasma membrane membrane membrane fractiontransportATP binding ATPase activity bile acid- exporting ATPase activity nucleotide binding sodium- exporting ATPase activity, phosphorylative mechanism transporter activity2
ATP- binding cassette, sub- family B, member 6 ABCB61NP_005680ATP- binding cassette (ABC) transporter complex integral to membrane membrane mitochondrial envelope mitochondrioniron ion homeostasis transportATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding2
ATP- binding cassette, sub- family C, member 11 isoform a ABCC111NP_149163integral to membrane membranetransportATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding2
ATP- binding cassette, sub- family C, member 9 isoform SUR2A- delta- 14 ABCC91NP_064694integral to membrane membranepotassium ion transport transportATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding receptor activity sulfonylurea receptor activity transporter activity2
abhydrolase domain containing 14B ABHD14B6NP_116139nucleusnot classifiednot classified1, 2
abl- interactor 1 isoform d ABI12NP_001012770cytoskeleton cytosol endoplasmic reticulum nucleus soluble fractionnegative regulation of cell proliferation transmembrane receptor protein tyrosine kinase signaling pathwaycytoskeletal protein binding2
acetyl- Coenzyme A acetyltransferase 1 precursor ACAT11NP_000010mitochondrionnot classifiedacetyl- CoA C- acetyltransferase activity acyltransferase activity transferase activity2
angiotensin I converting enzyme isoform 1 precursor ACE23NP_000780integral to membrane membrane membrane fraction plasma membrane soluble fractionblood pressure regulation metabolism proteolysiscarboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding1, 2
angiotensin I converting enzyme isoform 2 precursor ACE12NP_690043integral to membrane membrane membrane fraction plasma membrane soluble fractionblood pressure regulation metabolism proteolysiscarboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding2
angiotensin I converting enzyme 2 precursor ACE28NP_068576extracellular region integral to membrane membraneentry of virus into host cell proteolysiscarboxypeptidase activity chloride ion binding metal ion binding peptidyl- dipeptidase A activity protein binding viral receptor activity zinc ion binding2
ATP citrate lyase isoform 2 ACLY1NP_942127citrate lyase complexATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolismATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity2
ATP citrate lyase isoform 1 ACLY1NP_001087citrate lyase complexATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolismATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity1
aconitase 1 ACO16NP_002188cytoplasmmetabolism tricarboxylic acid cycle4 iron, 4 sulfur cluster binding aconitate hydratase activity iron ion binding lyase activity metal ion binding RNA binding2
thioesterase, adipose associated isoform BFIT2 ACOT111NP_671517cytoplasmfatty acid metabolism intracellular signaling cascade response to temperature stimulusacyl- CoA thioesterase activity hydrolase activity serine esterase activity2
acyl- CoA thioesterase 7 isoform hBACHd ACOT71NP_863656cytoplasm mitochondrionlipid metabolismacyl- CoA binding hydrolase activity palmitoyl- CoA hydrolase activity serine esterase activity2
acid phosphatase 1 isoform b ACP11NP_009030cytoplasm soluble fractionprotein amino acid dephosphorylationacid phosphatase activity hydrolase activity non- membrane spanning protein tyrosine phosphatase activity protein tyrosine phosphatase activity2
lysosomal acid phosphatase 2 precursor ACP27NP_001601integral to membrane lysosomal membrane lysosomenot classifiedacid phosphatase activity hydrolase activity1, 2
prostatic acid phosphatase precursor ACPP8NP_001090extracellular regionregulation of progression through cell cycleacid phosphatase activity hydrolase activity protein tyrosine phosphatase activity1, 2
acyl- CoA synthetase long- chain family member 4 isoform 2 ACSL41NP_075266integral to membrane membrane peroxisomefatty acid metabolism learning and/or memory lipid metabolism metabolismligase activity long- chain- fatty- acid- CoA ligase activity magnesium ion binding2
acyl- CoA synthetase medium- chain family member 1 ACSM11NP_443188mitochondrial matrixbenzoate metabolism butyrate metabolism energy derivation by oxidation of organic compounds fatty acid oxidation metabolismacyl- CoA ligase activity butyrate- CoA ligase activity catalytic activity2
actinin, alpha 1 ACTN11NP_001093cytoskeleton focal adhesion pseudopodiumfocal adhesion formation negative regulation of cell motility regulation of apoptosisactin binding calcium ion binding integrin binding protein binding vinculin binding2
ARP1 actin- related protein 1 homolog A, centractin alpha ACTR1A1NP_005727actin filament cytoplasm cytoskeletonnot classifiedATP binding nucleotide binding protein binding structural constituent of cytoskeleton2
actin- related protein 2 isoform a ACTR21NP_001005386cytoskeletonnot classifiedprotein binding structural molecule activity2
ARP3 actin- related protein 3 homolog ACTR36NP_005712Arp2/3 protein complexcell motilityATP binding nucleotide binding protein binding structural molecule activity2
aminoacylase 1 ACY115NP_000657cytoplasm cytosolamino acid metabolism proteolysisaminoacylase activity hydrolase activity metallopeptidase activity protein dimerization activity zinc ion binding1, 2
aspartoacylase (aminocyclase) 3 ACY31NP_542389not classifiedmetabolismaspartoacylase activity hydrolase activity, acting on ester bonds2
brain adenylate cyclase 1 ADCY11NP_066939integral to membrane membranecAMP biosynthesis intracellular signaling cascadecalcium- and calmodulin- responsive adenylate cyclase activity calmodulin binding magnesium ion binding 2
class III alcohol dehydrogenase 5 chi subunit ADH51NP_000662not classifiedethanol oxidationalcohol dehydrogenase activity electron carrier activity fatty acid binding formaldehyde dehydrogenase (glutathione) activity metal ion binding S- (hydroxymethyl)glutathione dehydrogenase activity zinc ion binding2
class V alcohol dehydrogenase 6 ADH61NP_000663not classifiedethanol oxidationalcohol dehydrogenase activity electron carrier activity metal ion binding oxidoreductase activity zinc ion binding2
transcription factor ELYS AHCTF11NP_056261nucleusdevelopment transcriptionDNA binding2
S- adenosylhomocysteine hydrolase AHCY10NP_000678cytoplasmone- carbon compound metabolismadenosylhomocysteinase activity hydrolase activity2
AHNAK nucleoprotein isoform 1AHNAK1NP_001611nucleusnervous system developmentprotein binding2
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 AHSA11NP_036243cytoplasm endoplasmic reticulumprotein folding response to stressATPase stimulator activity chaperone activator activity chaperone binding2
alpha- 2- HS- glycoprotein (Fetuin- A)AHSG1NP_001613extracellular region extracellular spaceacute- phase response negative regulation of bone mineralization negative regulation of insulin receptor signaling pathway pinocytosis positive regulation of phagocytosis regulation of inflammatory response skeletal developmentcysteine protease inhibitor activity kinase inhibitor activity2
adenylate kinase 1 AK14NP_000467cytoplasm cytosolATP metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolismadenylate kinase activity ATP binding kinase activity nucleotide binding transferase activity2
aldo- keto reductase family 1, member A1 AKR1A17NP_006057not classifiedaldehyde metabolism glucose metabolismalcohol dehydrogenase (NADP+) activity aldehyde reductase activity electron carrier activity oxidoreductase activity protein binding2
aldo- keto reductase family 1, member B1 AKR1B13NP_001619extracellular spacecarbohydrate metabolismaldehyde reductase activity electron carrier activity oxidoreductase activity1, 2
aldo- keto reductase family 7, member A2 AKR7A22NP_003680not classifiedaldehyde metabolism carbohydrate metabolismaldehyde reductase activity electron carrier activity2
aldo- keto reductase family 7, member A3 AKR7A32NP_036199cytosolaldehyde metabolismaldo- keto reductase activity electron carrier activity2
delta- aminolevulinic acid dehydratase isoform a ALAD1NP_001003945not classifiedheme biosynthesislyase activity metal ion binding porphobilinogen synthase activity zinc ion binding2
albumin precursor ALB36NP_000468extracellular region extracellular space protein complexbody fluid osmoregulation cellular response to starvation hemolysis of host red blood cells maintenance of mitochondrion localization negative regulation of apoptosis negative regulation of non- apoptotic programmed cell death transport water homeostasisantioxidant activity carrier activity copper ion binding DNA binding drug binding fatty acid binding metal ion binding oxygen binding protein binding pyridoxal phosphate binding toxin binding water binding1, 2
activated leukocyte cell adhesion molecule ALCAM1NP_001618integral to plasma membrane membrane membrane fractionantimicrobial humoral response (sensu Vertebrata) cell adhesion signal transduction receptor binding2
aldehyde dehydrogenase 1A1 ALDH1A110NP_000680cytoplasmaldehyde metabolism metabolismaldehyde dehydrogenase (NAD) activity androgen binding oxidoreductase activity Ras GTPase activator activity retinal dehydrogenase activity2
aldehyde dehydrogenase 1 family, member L1 ALDH1L19NP_036322cytoplasm10- formyltetrahydrofolate catabolism biosynthesis one- carbon compound metabolism protein biosynthesiscofactor binding formyltetrahydrofolate dehydrogenase activity hydroxymethyl- , formyl- and related transferase activity methyltransferase activity oxidoreductase activity2
mitochondrial aldehyde dehydrogenase 2 precursorALDH21NP_000681mitochondrionalcohol metabolism carbohydrate metabolism metabolismaldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity electron carrier activity2
aldehyde dehydrogenase 3B1 isoform aALDH3B11NP_000685not classifiedalcohol metabolism aldehyde metabolism lipid metabolism metabolism3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity2
aldehyde dehydrogenase 3B1 isoform b ALDH3B11NP_001025181not classifiedalcohol metabolism aldehyde metabolism lipid metabolism metabolism3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity2
aldehyde dehydrogenase 8A1 isoform 1 ALDH8A11NP_072090intracellularcell surface extracellular matrix (sensu Metazoa) membraneoxidoreductase activity retinal dehydrogenase activity2
aldehyde dehydrogenase 9A1 ALDH9A15NP_000687cytoplasmaldehyde metabolism electron transport hormone metabolism metabolism neurotransmitter biosynthesis4- trimethylammoniobutyraldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity aminobutyraldehyde dehydrogenase activity oxidoreductase activity2
aldolase A ALDOA7NP_908930not classifiedfructose metabolism glycolysis metabolism striated muscle contractionfructose- bisphosphate aldolase activity lyase activity2
fructose- bisphosphate aldolase C ALDOC1NP_005156not classifiedfructose metabolism glycolsis metabolismfructose- bisphosphate aldolase activity lyase activity2
anaplastic lymphoma kinase Ki- 1 ALK1NP_004295integral to plasma membrane membranebrain development nervous system development protein amino acid N- linked glycosylation protein amino acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathwayATP binding nucleotide binding receptor activity receptor signaling protein tyrosine kinase activity transferase activity transmembrane receptor protein tyrosine kinase activity2
arachidonate 12- lipoxygenase ALOX121NP_000688cytosol sarcolemmaanti- apoptosis arachidonic acid metabolism cell motility electron transport fatty acid oxidation leukotriene biosynthesis negative regulation of cell volume oxygen and reactive oxygen species metabolism positive regulation of cell adhesion positive regulaarachidonate 12- lipoxygenase activity hepoxilin- epoxide hydrolase activity iron ion binding lipoxygenase activity metal ion binding oxidoreductase activity potassium channel inhibitor activity2
tissue non- specific alkaline phosphatase precursor ALPL3NP_000469integral to membrane membranemetabolism ossificationalkaline phosphatase activity GPI anchor binding hydrolase activity magnesium ion binding zinc ion binding2
alpha- 1- microglobulin/bikunin precursor AMBP4NP_001624extracellular region plasma membraneanti- inflammatory response cell adhesion heme catabolism negative regulation of immune response negative regulation of JNK cascade pregnancy protein- chromophore linkage transportcalcium channel inhibitor activity calcium oxalate binding heme binding IgA binding plasmin inhibitor activity protein homodimerization activity transporter activity trypsin inhibitor activity1, 2
amnionless protein precursor AMN1NP_112205integral to membrane membranedevelopmentnot classified2
angiopoietin- like 2 precursor ANGPTL21NP_036230extracellular spacedevelopmentreceptor binding2
ankyrin repeat and FYVE domain containing 1 isoform 1 ANKFY12NP_057460endosome membrane membraneendocytosismetal ion binding protein binding zinc ion binding2
ankyrin repeat and FYVE domain containing 1 isoform 2 ANKFY12NP_065791endosome membrane membraneendocytosismetal ion binding protein binding zinc ion binding2
membrane alanine aminopeptidase precursor ANPEP69NP_001141ER- Golgi intermediate compartment integral to plasma membraneangiogenesis cell differentiation proteolysisaminopeptidase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity receptor activity zinc ion binding1, 2
annexin I ANXA119NP_000691cornified envelope cytoplasmanti- apoptosis cell motility cell surface receptor linked signal transduction inflammatory response keratinocyte differentiation lipid metabolism peptide cross- linkingcalcium ion binding calcium- dependent phospholipid binding phospholipase A2 inhibitor activity phospholipase inhibitor activity protein binding, bridging receptor binding structural molecule activity2
annexin A11 ANXA1131NP_665875cytoplasm nuclear envelope nucleoplasm nucleusimmune responsecalcium ion binding calcium- dependent phospholipid binding protein binding2
annexin A13 isoform b ANXA131NP_001003954plasma membranecell differentiationcalcium ion binding calcium- dependent phospholipid binding2
annexin A2 isoform 2 ANXA229NP_001002857plasma membrane soluble fractionskeletal developmentcalcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity2
annexin A2 isoform 1 ANXA220NP_001002858plasma membrane soluble fractionskeletal developmentcalcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity2
annexin A3 ANXA38NP_005130cytoplasmsignal transductioncalcium ion binding calcium- dependent phospholipid binding diphosphoinositol- polyphosphate diphosphatase activity phospholipase A2 inhibitor activity1, 2
annexin IV ANXA424NP_001144cytoplasmanti- apoptosis negative regulation of coagulation signal transductioncalcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity1, 2
annexin 5 ANXA524NP_001145cytoplasm intracellularanti- apoptosis blood coagulation negative regulation of coagulation signal transductioncalcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity protein binding1, 2
annexin VI isoform 1 ANXA627NP_001146not classifiednot classifiedcalcium ion binding calcium- dependent phospholipid binding protein binding1, 2
annexin VI isoform 2 ANXA620NP_004024not classifiednot classifiedcalcium ion binding calcium- dependent phospholipid binding protein binding2
annexin VII isoform 2 ANXA713NP_004025not classifiednot classifiedcalcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity2
annexin VII isoform 1 ANXA72NP_001147not classifiednot classifiedcalcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity1
aldehyde oxidase 1 AOX11NP_001150not classifiedelectron transport inflammatory response oxygen and reactive oxygen species metabolism2 iron, 2 sulfur cluster binding aldehyde oxidase activity electron carrier activity iron ion binding metal ion binding molybdenum ion binding oxidoreductase activity xanthine dehydrogenase activity2
adaptor- related protein complex 1, mu 1 subunit AP1M11NP_115882clathrin vesicle coat coated pitintracellular protein transportprotein binding2
adaptor- related protein complex 2, mu 1 subunit isoform a AP2M11NP_004059clathrin vesicle coat coated pitintracellular protein transport transportlipid binding protein binding transporter activity2
adaptor- related protein complex 4, mu 1 subunit AP4M11NP_004713clathrin vesicle coat coated pit coated vesicle membrane Golgi trans cisterna membrane coat adaptor complexintracellular protein transport transport vesicle- mediated transporttransporter activity2
apoptotic peptidase activating factor 1 isoform b APAF11NP_001151cytosol intracellularcaspase activation via cytochrome c nervous system development regulation of apoptosisATP binding caspase activator activity nucleotide binding protein binding2
serum amyloid P component precursor APCS5NP_001630extracellular region extracellular spaceacute- phase response chaperone- mediated protein complex assembly protein foldingcalcium ion binding sugar binding unfolded protein binding1, 2
apolipoprotein A- I preproprotein APOA16NP_000030extracellular region extracellular spacecholesterol metabolism cholesterol transport circulation lipid metabolism lipid transport lipoprotein metabolism steroid metabolismhigh- density lipoprotein binding lipid binding lipid transporter activity protein binding2
apolipoprotein A- II preproprotein APOA21NP_001634extracellular regionglucose metabolism lipid transport negative regulation of lipid catabolism negative regulation of lipoprotein metabolism neutrophil activation positive regulation of interleukin- 8 biosynthesis regulation of cytokine production response to glucose stimuluslipid binding lipid transporter activity protein heterodimerization activity protein homodimerization activity2
apolipoprotein A- IV precursor APOA42NP_000473chylomicron extracellular regioncirculation lipid metabolism lipid transport lipoprotein metabolismlipid binding lipid transporter activity2
apolipoprotein D precursor APOD7NP_001638extracellular region extracellular spacelipid metabolism transporthigh- density lipoprotein binding lipid binding lipid transporter activity protein binding1, 2
apolipoprotein E precursor APOE6NP_000032chylomicron cytoplasm extracellular regioncholesterol homeostasis circulation cytoskeleton organization and biogenesis induction of apoptosis intracellular transport learning and/or memory lipid transport lipoprotein metabolism protein tetramerization regulation of axon extension regulation of neantioxidant activity apolipoprotein E receptor binding beta- amyloid binding heparin binding lipid transporter activity phospholipid binding tau protein binding2
adaptor protein containing pH domain, PTB domain and leucine zipper motif APPL1NP_036228cytoplasm endosome membrane membrane nucleus NuRD complexcell cycle cell proliferation signal transductionprotein binding2
adenine phosphoribosyltransferase isoform a APRT3NP_000476cytoplasmadenine salvage nucleoside metabolism purine ribonucleoside salvageadenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups1, 2
adenine phosphoribosyltransferase isoform b APRT3NP_001025189cytoplasmadenine salvage nucleoside metabolism purine ribonucleoside salvageadenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups2
aquaporin 1 AQP13NP_932766integral to membrane integral to plasma membrane membrane outer membraneexcretion transport water transportporin activity transporter activity water transporter activity1, 2
aquaporin 2 AQP27NP_000477apical plasma membrane integral to membrane plasma membraneexcretion transport water transporttransporter activity water channel activity1, 2
ADP- ribosylation factor 1 ARF16NP_001649intracellular plasma membraneER to Golgi vesicle- mediated transport transport rRNA processing small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding protein binding receptor signaling protein activity1
ADP- ribosylation factor interacting protein 1 isoform 2 ARFIP11NP_055262cytosol Golgi membraneintracellular protein transport regulation of protein secretionnot classified1
Rho GTPase activating protein 1 ARHGAP11NP_004299intracellularcytoskeleton organization and biogenesis Rho protein signal transduction signal transductionGTP binding protein binding Rho GTPase activator activity SH3/SH2 adaptor activity2
Rho GDP dissociation inhibitor (GDI) alpha ARHGDIA1NP_004300cytoplasm cytoskeletonanti- apoptosis cell motility negative regulation of cell adhesion Rho protein signal transductionGTPase activator activity protein binding Rho GDP- dissociation inhibitor activity2
Rho GDP dissociation inhibitor (GDI) beta ARHGDIB1NP_001166cytoplasm cytoplasmic membrane- bound vesicle cytoskeletonactin cytoskeleton organization and biogenesis cell motility development immune response negative regulation of cell adhesion Rho protein signal transductionGTPase activator activity Rho GDP- dissociation inhibitor activity2
Rho guanine nucleotide exchange factor (GEF) 12 ARHGEF121NP_056128intracellularregulation of Rho protein signal transductionGTPase activator activity protein binding Rho guanyl- nucleotide exchange factor activity2
ADP- ribosylation factor related protein 2 ARL151NP_061960not classifiednot classifiedGTP binding2
ADP- ribosylation factor- like 3 ARL32NP_004302intracellularG- protein coupled receptor protein signaling pathway rRNA processing small GTPase mediated signal transductionGTP binding nucleotide binding signal transducer activity1, 2
ADP- ribosylation factor- like 6 ARL63NP_115522cytoplasm intracellular membranerRNA processing small GTPase mediated signal transductionGTP binding nucleotide binding protein binding2
ADP- ribosylation factor- like 10B ARL8A1NP_620150cytoplasm intracellular membrane midbody spindle midzonechromosome segregation rRNA processing small GTPase mediated signal transductionalpha- tubulin binding beta- tubulin binding GTP binding GTPase activity nucleotide binding2
ADP- ribosylation factor- like 10C ARL8B1NP_060654cytoplasm intracellular membrane midbody spindle midzonechromosome segregation rRNA processing small GTPase mediated signal transductionalpha- tubulin binding beta- tubulin binding GDP binding GTP binding GTPase activity nucleotide binding2
armadillo repeat containing 3 ARMC31NP_775104not classifiednot classifiedbinding2
armadillo repeat containing 9 ARMC91NP_079415not classifiednot classifiedbinding2
actin related protein 2/3 complex subunit 1A ARPC1A1NP_006400not classifiednot classifiednot classified2
actin related protein 2/3 complex subunit 2 ARPC25NP_005722Arp2/3 protein complex cytoskeletoncell motility regulation of actin filament polymerizationstructural constituent of cytoskeleton2
actin related protein 2/3 complex subunit 3 ARPC32NP_005710Arp2/3 protein complexcell motility regulation of actin filament polymerizationstructural constituent of cytoskeleton2
actin related protein 2/3 complex subunit 4 isoform a ARPC42NP_005709Arp2/3 protein complex cytoskeletonactin filament polymerization actin nucleationactin filament binding protein binding, bridging structural constituent of cytoskeleton1, 2
actin related protein 2/3 complex subunit 4 isoform b ARPC42NP_001020130Arp2/3 protein complex cytoskeletonactin filament polymerization actin nucleationactin filament binding protein binding, bridging structural constituent of cytoskeleton2
actin related protein 2/3 complex subunit 5 ARPC51NP_005708Arp2/3 protein complex cytoplasm cytoskeletonactin cytoskeleton organization and biogenesis cell motility regulation of actin filament polymerizationstructural constituent of cytoskeleton2
actin related protein 2/3 complex, subunit 5- like ARPC5L1NP_112240cytoskeletonregulation of actin filament polymerizationnot classified2
arrestin domain containing 1 ARRDC15NP_689498not classifiednot classifiednot classified1, 2
arylsulfatase E precursor ARSE1NP_000038not classifiedmetabolism skeletal developmentarylsulfatase activity calcium ion binding hydrolase activity2
arylsulfatase F precursor ARSF12NP_004033not classifiedmetabolismarylsulfatase activity calcium ion binding hydrolase activity2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 preproprotein isoform a ASAH17NP_808592lysosomecarboxylic acid metabolism ceramide metabolism fatty acid metabolismceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer1, 2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 isoform b ASAH19NP_004306lysosomecarboxylic acid metabolism ceramide metabolism fatty acid metabolismceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer2
argininosuccinate lyase isoform 3 ASL1NP_001020117cytoplasmamino acid biosynthesis arginine biosynthesis arginine catabolism urea cycleargininosuccinate lyase activity catalytic activity lyase activity2
arsA arsenite transporter, ATP- binding, homolog 1 ASNA11NP_004308cytoplasm membrane nucleolus soluble fractionanion transport response to arsenic transportarsenite transporter activity arsenite- transporting ATPase activity ATP binding hydrolase activity nucleotide binding transporter activity2
argininosuccinate synthetase 1 ASS120NP_000041cytoplasmamino acid biosynthesis arginine biosynthesis urea cycleargininosuccinate synthase activity ATP binding ligase activity nucleotide binding protein binding1, 2
two AAA domain containing protein ATAD21NP_054828not classifiednot classifiedATP binding nucleoside- triphosphatase activity nucleotide binding2
5- aminoimidazole- 4- carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ATIC1NP_004035not classifiednucleobase, nucleoside, nucleotide and nucleic acid metabolismhydrolase activity IMP cyclohydrolase activity phosphoribosylaminoimidazolecarboxamide formyltransferase activity transferase activity2
Na+/K+ - ATPase beta 1 subunit isoform b ATP1B11NP_001001787integral to membrane membrane sodium:potassium- exchanging ATPase complexion transport potassium ion transport sodium ion transportpotassium ion binding sodium ion binding sodium:potassium- exchanging ATPase activity2
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precursor ATP5A13NP_001001937membrane fraction mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting two- sector ATPase complexATP synthesis coupled proton transport ion transport proton transportATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement ofsubstances meta2
ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit precursor ATP5B4NP_001677mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting ATP synthase, catalytic core (sensu Eukaryota)ATP synthesis coupled proton transport generation of precursor metabolites and energy ion transport proton transportATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleoside- triphos2
ATPase, H+ transporting, lysosomal accessory protein 1 precursor ATP6AP11NP_001174membrane proton- transportin two- sector ATPase complex vacuoleATP synthesis coupled proton transport ion transport proton transportATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding transporter activity2
ATPase, H+ transporting, lysosomal accessory protein 2 ATP6AP21NP_005756integral to membrane membranenot classifiedreceptor activity2
ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 ATP6V0A11NP_005168integral to membrane membraneion transport proton transporthydrogen ion transporter activity2
ATPase, H+ transporting, lysosomal V0 subunit a4 ATP6V0A41NP_065683hydrogen- translocating V- type ATPase complex integral to membrane membraneion transport proton transport regulation of pHhydrogen ion transporter activity2
ATPase, H+ transporting, lysosomal, V0 subunit c ATP6V0C1NP_001685membrane proton- transporting two- sector ATPase complex vacuoleATP synthesis coupled proton transport ion transport proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotation mechanism hydrolase activity metal ion binding2
ATPase, H+ transporting, lysosomal, V0 subunit d1 ATP6V0D11NP_004682hydrogen- translocating V- type ATPase complex proton- transporting two- sector ATPase complexATP synthesis coupled proton transport ion transport proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D2 ATP6V0D22NP_689778proton- transporting two- sector ATPase complexATP synthesis coupled proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotation mechanism2
ATPase, H+ transporting, lysosomal 70kD, V1 subunit A, isoform 1 ATP6V1A22NP_001681integral to plasma membrane proton- transporting two- sector ATPase complexATP synthesis coupled proton transport ion transport proton transportATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 ATP6V1B18NP_001683cytoplasm plasma membrane proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting two- sector ATPase complexATP synthesis coupled proton transport energy coupled proton transport, against electrochemical gradient excretion ion transport regulation of pH sensory perception of soundATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding2
vacuolar H+ATPase B2 ATP6V1B212NP_001684cytoplasm proton- transporting two- sector ATPase complexATP synthesis coupled proton transport energy coupled proton transport, against electrochemical gradient ion transportATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding2
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 isoform A ATP6V1C11NP_001686proton- transporting two- sector ATPase complexATP synthesis coupled proton transport ion transport proton transportATP binding hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances metal ion binding transporter activity2
vacuolar H+ ATPase C2 isoform a ATP6V1C21NP_001034451proton- transporting two- sector ATPase complexATP synthesis coupled proton transportATP binding hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances2
H(+)- transporting two- sector ATPase ATP6V1D2NP_057078proton- transporting two- sector ATPase complexATP synthesis coupled proton transport ion transport proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding2
vacuolar H+ ATPase E1 isoform a ATP6V1E12NP_001687plasma membrane proton- transporting two- sector ATPase complexATP synthesis coupled proton transport ion transport proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding2
vacuolar H+ ATPase E1 isoform c ATP6V1E11NP_001034456plasma membrane proton- transporting two- sector ATPase complex plasma membraneATP synthesis coupled proton transport ion transport proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transportin ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding2
vacuolar H+ ATPase E1 isoform b ATP6V1E11NP_001034455plasma membrane proton- transporting two- sector ATPase complex plasma membraneATP synthesis coupled proton transport ion transport proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transportin ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding2
ATPase, H+ transporting, lysosomal 14kD, V1 subunit F ATP6V1F1NP_004222membrane fraction proton- transporting two- sector ATPase complexATP synthesis coupled proton transport ion transport proton transporthydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding2
vacuolar H+ ATPase G1 ATP6V1G11NP_004879not classifiedATP biosynthesis ion transport proton transporthydrogen ion transporter activity hydrolase activity metal ion binding2
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 1 ATP6V1H8NP_998784hydrogen- transporting ATPase V1 domain peripheral to membrane of membrane fractionATP hydrolysis coupled proton transport ATP synthesis coupled proton transport endocytosis ion transport proton transport vacuolar acidificationATP binding ATPase activity ATPase stimulator activity enzyme regulator activity hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding protein bin2
attractin isoform 1 ATRN1NP_647537extracellular space integral to plasma membrane plasma membranedevelopment inflammatory responsereceptor activity sugar binding2
attractin isoform 2 ATRN1NP_647538extracellular space integral to plasma membrane plasma membranedevelopment inflammatory responsereceptor activity sugar binding2
azurocidin 1 preproprotein AZU11NP_001691azurophil granule extracellular regionanti- apoptosis cellular extravasation chemotaxis defense response to Gram- negative bacterium glial cell migration induction of positive chemotaxis macrophage chemotaxis microglial cell activation monocyte activation positive regulation of cell adhesion poheparin binding serine- type endopeptidase activity toxin binding2
beta- 2- microglobulin precursor B2M1NP_004039extracellular regionantigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I immune responseMHC class I receptor activity2
UDP- Gal:betaGlcNAc beta 1, 4- galactosyltransferase 1, membrane- bound form B4GALT11NP_001488Golgi apparatus integral to membrane membranecarbohydrate metabolism oligosaccharide biosynthesisbeta- N- acetylglucosaminylglycopeptide beta- 1, 4- galactosyltransferase activity galactosyltransferase activity lactose synthase activity manganese ion binding metal ion binding N- acetyllactosamine synthase activity transferase activity, transferring glycosy2
BAI1- associated protein 2 isoform 1 BAIAP29NP_059344not classifiednot classifiedprotein binding1, 2
BAI1- associated protein 2 isoform 2 BAIAP26NP_059345not classifiednot classifiedprotein binding2
BAI1- associated protein 2- like 1 BAIAP2L14NP_061330not classifiednot classifiednot classified1, 2
brain abundant, membrane attached signal protein 1 BASP16NP_006308cytoskeleton plasma membranenot classifiednot classified2
HLA- B associated transcript- 2 isoform a BAT21NP_542417nucleusnot classifiedprotein binding2
bromodomain adjacent to zinc finger domain, 1B BAZ1B1NP_075381nucleusregulation of transcription, DNA- dependent transcriptionmetal ion binding protein binding transcription factor activity zinc ion binding2
gamma- butyrobetaine dioxygenase BBOX16NP_003977not classifiedcarnitine biosynthesis electron transportgamma- butyrobetaine dioxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen1, 2
basal cell adhesion molecule isoform 1 precursor BCAM1NP_005572cell surface integral to plasma membrane plasma membranecell adhesion signal transductiontransmembrane receptor activity2
basal cell adhesion molecule isoform 2 precursor BCAM2NP_001013275cell surface integral to plasma membrane plasma membranecell adhesion signal transductiontransmembrane receptor activity2
BCL2- like 12 isoform 2 BCL2L121NP_443074not classifiedapoptosisnot classified2
breakpoint cluster region isoform 1 BCR2NP_004318intracellularintracellular signaling cascade protein amino acid phosphorylation regulation of Rho protein signal transduction signal transductionGTPase activator activity kinase activity protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity2
breakpoint cluster region isoform 2 BCR2NP_067585intracellularintracellular signaling cascade protein amino acid phosphorylation regulation of Rho protein signal transduction signal transductionGTPase activator activity kinase activity protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity2
3- hydroxybutyrate dehydrogenase, type 2 BDH25NP_064524cytoplasm mitochondrionfatty acid beta- oxidation metabolism3- hydroxybutyrate dehydrogenase activity NAD binding oxidoreductase activity2
biglycan preproprotein BGN1NP_001702extracellular matrix (sensu Metazoa) transport vesiclenot classifiedextracellular matrix structural constituent transferase activity2
basic helix- loop- helix domain containing, class B, 9 BHLHB91NP_085142not classifiednot classifiedbinding2
betaine- homocysteine methyltransferase 2 BHMT21NP_060084not classifiednot classifiedhomocysteine S- methyltransferase activity methyltransferase activity transferase activity2
bleomycin hydrolase BLMH1NP_000377cytoplasm nucleusproteolysisaminopeptidase activity bleomycin hydrolase activity carboxypeptidase activity2
biliverdin reductase ABLVRA1NP_000703not classifiedelectron transport heme catabolism metabolismbiliverdin reductase activity metal ion binding oxidoreductase activity zinc ion binding2
biliverdin reductase B (flavin reductase (NADPH)) BLVRB4NP_000704not classifiedcellular metabolismbiliverdin reductase activity coenzyme binding flavin reductase activity oxidoreductase activity2
bactericidal/permeability- increasing protein precursor BPI4NP_001716integral to plasma membrane membranedefense response to bacterium immune responseGram- negative bacterial binding lipid binding2
bone marrow stromal cell antigen 2 BST21NP_004326integral to plasma membrane membranecell proliferation cell- cell signaling development humoral immune response positive regulation of I- kappaB kinase/NF- kappaB cascade defense response to bacteriumsignal transducer activity1, 2
B- cell translocation gene 2 BTG21NP_006754not classifiedDNA repair negative regulation of cell proliferation regulation of transcription, DNA- dependent transcriptiontranscription factor activity2
adipose specific 2 C10orf1162NP_006820not classifiednot classifiednot classified2
PREDICTED: similar to retinoblastoma- associated protein 140 isoform 1 C10orf181XP_374765not classifiednot classifiednot classified2
hypothetical protein LOC222389 C10orf301NP_689964not classifiednot classifiednot classified2
hypothetical protein LOC283294 C11orf471NP_775860not classifiednot classifiednot classified2
hypothetical protein LOC91894 C11orf521NP_542390not classifiednot classifiednot classified2
hypothetical protein LOC28970 C11orf541NP_054758nucleusnot classifiedhydrolase activity metal ion binding zinc ion binding2
hypothetical protein LOC55004 C11orf593NP_060377not classifiednot classifiednot classified1, 2
hypothetical protein LOC283450 C12orf511NP_776174not classifiednot classifiednot classified2
hypothetical protein LOC120939 C12orf591NP_694567not classifiednot classifiednot classified2
transcription factor IIB C16orf801NP_037374not classifieddevelopmentnot classified2
hypothetical protein LOC254863 C17orf612NP_689979not classifiednot classifiednot classified2
lung cancer- related protein 8 C17orf801NP_060411not classifiednot classifiednot classified2
hypothetical protein LOC147685 C19orf181NP_689687integral to membrane membranenot classifiednot classified2
specifically androgen- regulated protein C1orf1164NP_076427not classifiednot classifiednot classified2
hypothetical protein LOC338094 C1orf1794NP_788954not classifiednot classifiednot classified2
hypothetical protein LOC54680 C1orf1811NP_060423not classifiednot classifiednot classified2
keratinocyte expressed, proline- rich proteinC1orf451NP_001020402not classifiednot classifiednot classified2
hypothetical protein LOC148362 C1orf5817NP_653296not classifiednot classifiednot classified1, 2
hypothetical protein LOC127281 C1orf931NP_689584not classifiednot classifiednot classified2
hypothetical protein LOC200232 C20orf1061NP_001012989not classifiednot classifiednot classified2
LPLUNC1 protein precursor C20orf11410NP_149974not classifiednot classifiedlipid binding2
hypothetical protein LOC140710 isoform 1 C20orf1171NP_542194not classifiednot classifiedcatalytic activity2
hypothetical protein LOC84226 C2orf161NP_115642not classifiednot classifiednot classified2
hypothetical protein LOC54978 C2orf182NP_060347integral to membrane membranenot classifiednot classified2
complement component 5 C51NP_001726extracellular region extracellular space membrane attack complexactivation of MAPK activity chemotaxis complement activation, alternative pathway complement activation, classical pathway cytolysis G- protein coupled receptor protein signaling pathway inflammatory response innate immune response response to stresschemokine activity endopeptidase inhibitor activity receptor binding2
putative nuclear protein ORF1- FL49 C5orf322NP_115788nucleusnot classifiednot classified1, 2
putative c- Myc- responsive isoform 2 C6orf1081NP_954653nucleuscell proliferationnot classified2
hypothetical protein LOC51534 C6orf55 (VTA1)6NP_057569not classifiednot classifiednot classified1, 2
hypothetical protein LOC352999 C6orf581NP_001010905not classifiednot classifiednot classified2
hypothetical protein LOC79017 C7orf241NP_076956not classifiednot classifiednot classified2
complement component 9 C91NP_001728integral to plasma membrane membrane membrane attack complexcomplement activation, alternative pathway complement activation, classical pathway cytolysis hemolysis of host red blood cells innate immune responsenot classified2
chromosome 9 open reading frame 19 C9orf192NP_071738extracellular region membranenot classifiednot classified1, 2
hypothetical protein LOC54875 C9orf391NP_060208membranesignal transductiontwo- component sensor activity2
ionized calcium binding adapter molecule 2 isoform 1 C9orf582NP_113614actin cytoskeleton focal adhesionnot classifiedcalcium ion binding2
hypothetical protein LOC64855 isoform 2 C9orf882NP_001030611not classifiednot classifiednot classified2
carbonic anhydrase II CA29NP_000058cytoplasmone- carbon compound metabolismcarbonate dehydratase activity lyase activity metal ion binding zinc ion binding1, 2
carbonic anhydrase IV precursor CA42NP_000708membrane membrane fractionone- carbon compound metabolism response to stimulus visual perceptioncarbonate dehydratase activity GPI anchor binding lyase activity metal ion binding zinc ion binding1, 2
calcium binding protein 39 CAB399NP_057373not classifiednot classifiedprotein binding1, 2
calcium binding protein 39- like CAB39L1NP_001026894not classifiednot classifiedbinding2
calcium channel, voltage- dependent, alpha 2/delta subunit 1 CACNA2D11NP_000713integral to membrane membrane membrane fraction voltage- gated calcium channel complexcalcium ion transport ion transportcalcium channel activity calcium ion binding dihydropyridine- sensitive calcium channel activity receptor activity voltage- gated ion channel activity2
calbindin 1 CALB12NP_004920not classifiednot classifiedcalcium ion binding protein binding vitamin D binding1, 2
calmodulin- like 3 CALML31NP_005176not classifiednot classifiedcalcium ion binding2
calreticulin precursor CALR1NP_004334cytosol endoplasmic reticulum endoplasmic reticulum lumencalcium ion homeostasis protein export from nucleus protein folding regulation of apoptosis regulation of transcription, DNA- dependentcalcium ion binding DNA binding sugar binding unfolded protein binding zinc ion binding1
calcium/calmodulin- dependent protein kinase IV CAMK41NP_001735nucleusprotein amino acid phosphorylation signal transductionATP binding calcium ion binding calcium- and calmodulin- dependent protein kinase activity calmodulin binding nucleotide binding protein serine/threonine kinase activity transferase activity2
cathelicidin antimicrobial peptide CAMP1NP_004336extracellular regiondefense response to bacteriumnot classified2
TIP120 protein CAND11NP_060918nucleus ubiquitin ligase complexnegative regulation of enzyme activity protein ubiquitination regulation of transcription, DNA- dependent transcriptionprotein binding2
adenylyl cyclase- associated protein CAP11NP_006358membraneadenylate cyclase activation establishment and/or maintenance of cell polarity signal transductionactin binding2
gelsolin- like capping protein CAPG8NP_001738F- actin capping protein complex nucleusbarbed- end actin filament capping protein complex assemblyactin binding2
calpain 1, large subunit CAPN115NP_005177intracellularpositive regulation of cell proliferation proteolysiscalcium ion binding calpain activity2
calpain 2, large subunit CAPN21NP_001739intracellularproteolysiscalcium ion binding calpain activity2
calpain 5 CAPN510NP_004046intracellularproteolysis signal transductioncalpain activity2
calpain 7 CAPN730NP_055111intracellular nucleusproteolysisbinding calpain activity cysteine- type peptidase activity1, 2
F- actin capping protein alpha- 1 subunit CAPZA12NP_006126F- actin capping protein complexactin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility protein complex assemblyactin binding2
capping protein (actin filament) muscle Z- line, alpha 2 CAPZA21NP_006127F- actin capping protein complexactin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility protein complex assemblyactin binding2
F- actin capping protein beta subunit CAPZB2NP_004921F- actin capping protein complexactin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motilityactin binding2
carbonyl reductase 1 CBR15NP_001748cytosolmetabolism15- hydroxyprostaglandin dehydrogenase (NADP+) activity carbonyl reductase (NADPH) activity oxidoreductase activity prostaglandin- E2 9- reductase activity2
coiled- coil and C2 domain containing 1A CC2D1A6NP_060191nucleuspositive regulation of I- kappaB kinase/NF- kappaB cascade regulation of transcription, DNA- dependent transcriptionDNA binding signal transducer activity2
coiled- coil domain containing 105 CCDC1052NP_775753not classifiednot classifiednot classified2
chaperonin containing TCP1, subunit 2 CCT21NP_006422cytosolprotein folding regulation of progression through cell cycleATP binding nucleotide binding unfolded protein binding2
chaperonin containing TCP1, subunit 3 isoform c CCT31NP_001008800cytoskeletonprotein foldingATP binding nucleotide binding unfolded protein binding2
chaperonin containing TCP1, subunit 3 isoform a CCT33NP_005989cytoskeletonprotein foldingATP binding nucleotide binding unfolded protein binding2
chaperonin containing TCP1, subunit 5 (epsilon) CCT53NP_036205not classifiedprotein foldingATP binding nucleotide binding unfolded protein binding2
chaperonin containing TCP1, subunit 6A isoform b CCT6A2NP_001009186cytoplasmprotein foldingATP binding nucleotide binding unfolded protein binding2
chaperonin containing TCP1, subunit 6A isoform a CCT6A1NP_001753cytoplasmprotein foldingATP binding nucleotide binding unfolded protein binding2
chaperonin containing TCP1, subunit 8 (theta) CCT84NP_006576cytosolprotein foldingATP binding ATPase activity, coupled nucleotide binding unfolded protein binding2
CD14 antigen precursor CD147NP_000582extrinsic to membrane plasma membraneapoptosis cell surface receptor linked signal transduction inflammatory response phagocytosisGPI anchor binding peptidoglycan receptor activity transferase activity2
CD2- associated protein CD2AP14NP_036252actin cytoskeleton cytoplasm filamentous actin ruffleprotein complex assembly signal transduction substrate- bound cell migration, cell extensionprotein binding SH3 domain binding structural constituent of cytoskeleton2
CD59 antigen p18- 20 CD594NP_976074membrane fraction plasma membraneblood coagulation cell surface receptor linked signal transduction immune responseGPI anchor binding protein binding2
CD63 antigen isoform A CD631NP_001771endosome membrane integral to membrane integral to plasma membrane lysosomal membrane plasma membranenot classifiednot classified1, 2
CD63 antigen isoform B CD632NP_001035123endosome membrane integral to membrane integral to plasma membrane lysosomal membrane plasma membranenot classifiednot classified2
CD81 antigen CD814NP_004347integral to plasma membrane membraneactivation of MAPK activity entry of virus into host cell phosphatidylinositol biosynthesis phosphoinositide metabolism positive regulation of 1- phosphatidylinositol 4- kinase activity positive regulation of B cell proliferation positive regulation of celprotein binding1, 2
CD9 antigen CD97NP_001760integral to membrane integral to plasma membrane plasma membranecell adhesion cell motility fusion of sperm to egg plasma membrane paranodal junction assembly platelet activationprotein binding1, 2
cell division cycle 2 protein isoform 2 CDC21NP_203698midbody nucleus spindle microtubuleanti- apoptosis cell cycle cell division mitosis protein amino acid phosphorylation regulation of progression through cell cycle traversing start control point of mitotic cell cycleATP binding cyclin- dependent protein kinase activity nucleotide binding protein binding transferase activity2
cell division cycle 42 isoform 2 CDC427NP_426359cytoplasm filopodium intracellular plasma membraneactin cytoskeleton organization and biogenesis cell cycle cell division establishment and/or maintenance of cell polarity G1 phase macrophage differentiation negative regulation of protein complex assembly positive regulation of pseudopodium formation regGTP binding GTPase activity nucleotide binding protein binding2
CDC42- binding protein kinase alpha isoform A CDC42BPA2NP_055641intercellular junction leading edgeactin cytoskeleton reorganization intracellular signaling cascade protein amino acid phosphorylation regulation of small GTPase mediated signal transductionATP binding diacylglycerol binding identical protein binding kinase activity magnesium ion binding metal ion binding nucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity zinc ion binding2
CDC42- binding protein kinase beta CDC42BPB3NP_006026cytoskeleton intercellular junction leading edgeactin cytoskeleton reorganization cytoskeleton organization and biogenesis establishment and/or maintenance of cell polarity intracellular signaling cascade protein amino acid phosphorylation regulation of small GTPase mediated signal transductionATP binding diacylglycerol binding identical protein binding magnesium ion binding nucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity zinc ion binding2
CDK5 regulatory subunit associated protein 2 isoform bCDK5RAP21NP_001011649centrosome cytoskeletonbrain development regulation of neuron differentiationmicrotubule binding neuronal Cdc2- like kinase binding2
carcinoembryonic antigen- related cell adhesion molecule 5 preproprotein CEACAM51NP_004354integral to membrane integral to plasma membrane membranenot classifiedGPI anchor binding2
centrosomal protein 2 isoform 1 CEP2501NP_009117centrosomemitotic cell cycle regulation of centriole- centriole cohesionprotein kinase binding2
cholesteryl ester transfer protein, plasma precursor CETP7NP_000069not classifiedcholesterol metabolism lipid metabolism lipid transport steroid metabolismcatalytic activitylipid binding2
complement factor D preproprotein CFD2NP_001919not classifiedcomplement activation, alternative pathway innate immune response proteolysiscomplement factor D activity peptidase activity2
complement factor H isoform b precursor CFH1NP_001014975extracellular spacecomplement activation, alternative pathway innate immune responsenot classified2
complement factor I CFI1NP_000195extracellular region membranecomplement activation, classical pathway innate immune response proteolysiscomplement factor I activity peptidase activity scavenger receptor activity2
coiled- coil- helix- coiled- coil- helix domain containing 3 CHCHD31NP_060282mitochondrionnot classifiedprotein binding2
chromatin modifying protein 1A isoform 2 CHMP1A1NP_002759condensed nuclear chromosome early endosome endomembrane system microtubule organizing center nuclear matrix nucleuscell cycle gene silencing mitotic chromosome condensation negative regulation of S phase of mitotic cell cycle negative regulation of transcription by glucose negative regulation of transcription, DNA- dependent protein transport transcription vesicle- mediprotein binding2
chromatin modifying protein 1B CHMP1B6NP_065145not classifiedprotein transportnot classified1, 2
chromatin modifying protein 2A CHMP2A11NP_055268not classifiedprotein transportnot classified1, 2
chromatin modifying protein 2B CHMP2B4NP_054762intracellularprotein transportnot classified1, 2
chromatin modifying protein 4B CHMP4B2NP_789782not classifiedprotein transportnot classified1, 2
chromatin modifying protein 5 CHMP52NP_057494not classifiedprotein transportnot classified1, 2
chromatin modifying protein 6 CHMP62NP_078867membraneprotein transportnot classified2
calcium binding protein P22 CHP1NP_009167not classifiedpotassium ion transport small GTPase mediated signal transductioncalcium ion binding potassium channel regulator activity2
calcium and integrin binding 1 (calmyrin) CIB12NP_006375cytoplasm endoplasmic reticulum membrane nucleoplasmapoptosis cell adhesion double- strand break repair response to DNA damage stimuluscalcium ion binding protein binding2
cytoskeleton- associated protein 4 CKAP41NP_006816integral to membrane membrane fractionnot classifiednot classified2
brain creatine kinase CKB8NP_001814cytoplasmnot classifiedcreatine kinase activity2
chloride intracellular channel 1 CLIC17NP_001279brush border cytoplasm membrane membrane fraction nuclear envelope nucleus soluble fractionchloride transport ion transport signal transductionchloride ion binding protein binding voltage- gated chloride channel activity1, 2
chloride intracellular channel 3 CLIC32NP_004660cytoplasm membrane nucleuschloride transport ion transport signal transductionchloride ion binding protein binding voltage- gated chloride channel activity2
chloride intracellular channel 4 CLIC45NP_039234actin cytoskeleton cytoplasm intracellular membrane microvillus soluble fractioncell differentiation chloride transport ion transport negative regulation of cell migrationchloride ion binding protein binding voltage- gated chloride channel activity1, 2
chloride intracellular channel 5 CLIC51NP_058625actin cytoskeleton insoluble fraction membrane microvilluschloride transport ion transport pregnancychloride ion binding protein binding voltage- gated chloride channel activity2
chloride intracellular channel 6 CLIC62NP_444507membranechloride transport ion transportchloride ion binding voltage- gated chloride channel activity2
clathrin heavy chain 1 CLTC12NP_004850clathrin coat of coated pit clathrin vesicle coatintracellular protein transportprotein binding structural molecule activity2
clusterin isoform 1 CLU6NP_001822extracellular spaceapoptosis cell death complement activation, classical pathway innate immune response lipid metabolismnot classified1, 2
clusterin isoform 2 CLU5NP_976084extracellular spaceapoptosis cell death complement activiation, classical pathway innate immune response lipid metabolismnot classified2
carboxymethylenebutenolidase- like (Pseudomonas) CMBL6NP_620164not classifiednot classifiedhydrolase activity2
cytidylate kinase CMPK3NP_057392cytoplasm nucleusnucleobase, nucleoside, nucleotide and nucleic acid metabolism pyrimidine ribonucleotide biosynthesisATP binding cytidylate kinase activity kinase activity nucleotide binding phosphotransferase activity, phosphate group as acceptor transferase activity uridine kinase activity2
CNDP dipeptidase 2 (metallopeptidase M20 family) CNDP215NP_060705not classifiedproteolysiscarboxypeptidase activity hydrolase activity metallopeptidase activity protein dimerization activity2
connector enhancer of kinase suppressor of Ras 2 CNKSR22NP_055742cytoplasm membraneregulation of signal transductionprotein binding2
2', 3'- cyclic nucleotide 3' phosphodiesterase CNP13NP_149124membranecyclic nucleotide catabolism synaptic transmission2', 3'- cyclic- nucleotide 3'- phosphodiesterase activity hydrolase activity1, 2
coenzyme A synthase isoform a COASY1NP_079509not classifiedbiosynthesis coenzyme A biosynthesisATP binding dephospho- CoA kinase activity nucleotide binding nucleotidyltransferase activity pantetheine- phosphate adenylyltransferase activity transferase activity2
COBL- like 1 COBLL11NP_055715not classifiednot classifiednot classified2
alpha 1 type XV collagen precursor COL15A11NP_001846collagen type XV cytoplasm extracellular matrix (sensu Metazoa)Protein binding Structural Molecule ActivityAngiogenesis Cell Adhesion Cell Differentiation Phosphate Transport2
alpha 1 type XVIII collagen isoform 1 precursor COL18A11NP_085059collagen cytoplasm extracellular matrix extracellular matrix (sensu Metazoa)cell adhesion negative regulation of cell proliferation organ morphogenesis phosphate transport visual perceptionextracellular matrix structural constituent metal ion binding protein binding structural molecule activity zinc ion binding2
collagen, type VI, alpha 1 precursor COL6A16NP_001839collagen collagen type VI cytoplasmcell adhesion phosphate transportextracellular matrix structural constituent protein binding1, 2
alpha 3 type VI collagen isoform 5 precursor COL6A31NP_476508collagen type VI cytoplasm extracellular matrix (sensu Metazoa)cell adhesion muscle development phosphate transportprotein binding serine- type endopeptidase inhibitor activity structural molecule activity2
catechol- O- methyltransferase isoform MB- COMT COMT1NP_000745integral to membrane membrane microsome soluble fractioncatecholamine metabolism neurotransmitter catabolismcatechol O- methyltransferase activity magnesium ion binding protein binding transferase activity2
catechol- O- methyltransferase isoform S- COMT COMT1NP_009294integral to membrane membrane microsome soluble fractioncatecholamine metabolism neurotransmitter catabolismcatechol O- methyltransferase activity magnesium ion binding protein binding transferase activity2
COP9 signalosome subunit 8 isoform 2 COPS81NP_937832nucleus signalosome complexmetabolismracemase and epimerase activity, acting on amino acids and derivatives2
coactosin- like 1 COTL11NP_066972cytoskeleton intracellularnot classifiedactin binding enzyme binding2
ceruloplasmin precursor CP6NP_000087extracellular region extracellular spacecopper ion homeostasis copper ion transport ion transport iron ion homeostasiscopper ion binding copper ion transporter activity ferroxidase activity metal ion binding oxidoreductase activity2
PREDICTED: similar to Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit) CPN22XP_947165not classifiednot classifiednot classified2
copine III CPNE314NP_003900cytoplasm cytosollipid metabolism vesicle- mediated transportcalcium- dependent phospholipid binding kinase activity protein serine/threonine kinase activity transferase activity transporter activity1, 2
copine V CPNE53NP_065990not classifiednot classifiednot classified1, 2
serine carboxypeptidase vitellogenic- like CPVL6NP_112601not classifiedproteolysispeptidase activity serine carboxypeptidase activity2
complement receptor 1 isoform F precursor CR117NP_000564integral to plasma membrane membranecomplement activation, classical pathway innate immune responsecomplement component C3b receptor activity receptor activity1, 2
cellular retinoic acid binding protein 2 CRABP21NP_001869not classifiedepidermis development regulation of transcription, DNA- dependent signal transduction transportlipid binding retinal binding2
crumbs homolog 2 CRB21NP_775960integral to membrane membraneresponse to stimulus visual perceptioncalcium ion binding2
crumbs 3 isoform a precursor CRB31NP_631900integral to membrane membrane tight junctionnot classifiednot classified2
cAMP responsive element binding protein 5 isoform alpha CREB52NP_878901intracellular nucleuspositive regulation of transcription, DNA- dependent transcription transcription from RNA polymerase II promotermetal ion binding protein dimerization activity sequence- specific DNA binding transcription factor activity zinc ion binding2
v- crk sarcoma virus CT10 oncogene homolog isoform a CRK1NP_058431cytoplasm nucleusactin cytoskeleton organization and biogenesis cell motility intracellular signaling cascade regulation of transcription from RNA polymerase II promoterprotein binding SH2 domain binding SH3/SH2 adaptor activity2
cornulin CRNN3NP_057274cytoplasm membranecell- cell adhesion metabolism response to heat response to unfolded proteincalcium ion binding2
ciliary rootlet coiled- coil, rootletin CROCC1NP_055490centriole ciliary rootletcell cycle centrosome organization and biogenesiskinesin binding structural molecule activity2
transducer of regulated cAMP response element- binding protein (CREB) 2 CRTC21NP_859066not classifiednot classifiednot classified2
crystallin, alpha B CRYAB7NP_001876cytoplasm nucleusmuscle contraction protein folding transmembrane receptor protein tyrosine kinase signaling pathway visual perceptionstructural constituent of eye lens unfolded protein binding2
lambda- crystallin CRYL17NP_057058not classifiedfatty acid metabolismoxidoreductase activity2
crystallin, mu isoform 1 CRYM1NP_001879not classifiedvisual perceptionornithine cyclodeaminase activity2
crystallin, mu isoform 2 CRYM1NP_001014444not classifiedvisual perceptionornithine cyclodeaminase activity2
crystallin, zeta CRYZ4NP_001880not classifiedvisual perceptionNADPH:quinone reductase activity oxidoreductase activity zinc ion binding2
CSE1 chromosome segregation 1- like protein CSE1L1NP_001307cytoplasm nuclear pore nucleusapoptosis cell proliferation protein import into nucleus, docking protein transportbinding importin- alpha export receptor activity protein transporter activity2
c- src tyrosine kinase CSK1NP_004374cytoplasm plasma membraneintracellular signaling cascade protein amino acid phosphorylation regulation of progression through cell cycleATP binding nucleotide binding protein C- terminus binding protein- tyrosine kinase activity transferase activity2
cysteine and glycine- rich protein 1 CSRP12NP_004069nucleusnot classifiedmetal ion binding zinc ion binding2
cystatin C precursor CST31NP_000090not classifiednot classifiedcysteine protease inhibitor activity protein homodimerization activity2
cystatin B CSTB2NP_000091intracellular nucleusnot classifiedcysteine protease inhibitor activity2
small CTD phosphatase 3 isoform 2 CTDSPL1NP_005799nucleusnot classifiedphosphoric monoester hydrolase activity2
small CTD phosphatase 3 isoform 1 CTDSPL1NP_001008393nucleusnot classifiedphosphoric monoester hydrolase activity2
cystathionase isoform 2 CTH1NP_714964not classifiedamino acid biosynthesis cysteine biosynthesiscystathionine gamma- lyase activity lyase activity2
cystinosis, nephropathic isoform 1 CTNS1NP_001026851integral to membrane lysosomal membrane membraneamino acid metabolism L- cystine transport transport immune response proteolysisL- cystine transporter activity2
cathepsin A precursor CTSA3NP_000299endoplasmic reticulum lysosomeintracellular protein transport proteolysiscarboxypeptidase C activity enzyme activator activity intracellular transporter activity peptidase activity serine carboxypeptidase activity1, 2
cathepsin C isoform a preproprotein CTSC1NP_001805lysosomeimmune response proteolysischloride ion binding cysteine- type endopeptidase activity dipeptidyl- peptidase I activity2
cathepsin C isoform b precursor CTSC1NP_680475lysosomeimmune response proteolysischloride ion binding cysteine- type endopeptidase activity dipeptidyl- peptidase I activity2
cathepsin D preproprotein CTSD1NP_001900extracellular region lysosome proteolysiscathepsin D activity pepsin A activity peptidase activity2
cathepsin G preproprotein CTSG9NP_001902insoluble fractionimmune response proteolysiscathepsin G activity peptidase activity2
cubilin CUBN104NP_001072brush border membrane extrinsic to external side of plasma membrane membranecholesterol metabolism cobalamin transport lipid metabolism physiological process protein transport receptor mediated endocytosis steroid metabolism tissue homeostasiscalcium ion binding cobalamin binding cobalt ion binding protein homodimerization activity receptor activity transporter activity1, 2
cullin 3 CUL31NP_003581nucleuscell cycle cell cycle arrest G 1/S transition of mitotic cell cycle induction of apoptosis by intracellular signals positive regulation of cell proliferation ubiquitin cycleprotein binding2
cullin 4B CUL4B1NP_003579not classifiedcell cycle ubiquitin cycleprotein binding2
cutA divalent cation tolerance homolog isoform 1 CUTA1NP_001014433membraneprotein localizationenzyme binding2
cutA divalent cation tolerance homolog isoform 3 CUTA1NP_001014840membraneprotein localizationenzyme binding2
cut- like 2 CUTL22NP_056082nucleusregulation of transcription, DNA- dependentsequence- specific DNA binding transcription factor activity2
cytochrome b reductase 1 CYBRD12NP_079119integral to membraneelectron transportferric- chelate reductase activity2
cytoplasmic FMR1 interacting protein 2 CYFIP21NP_055191cytoplasm synaptosomenot classifiednot classified2
dihydroxyacetone kinase 2 DAK15NP_056348not classifiedglycerol metabolismATP binding glycerone kinase activity lyase activity nucleotide binding transferase activity2
drebrin- like isoform b DBNL1NP_001014436cell cortex cytoplasm cytoskeleton intracellular lamellipodiumactivation of JNK activity endocytosis immune response Rac protein signal transductionactin binding enzyme activator activity protein binding2
dermcidin preproprotein DCD1NP_444513extracellular regiondefense response to bacterium defense response to fungus xenobiotic metabolismmanganese ion binding2
dynactin 2 DCTN21NP_006391centrosome cytoskeleton dynactin complex dynein complex kinetochore membrane microtubulecell proliferation microtubule- based process mitosismotor activity2
dicarbonyl/L- xylulose reductase DCXR2NP_057370membranecarbohydrate metabolism D- xylose metabolism glucose metabolism metabolismL- xylulose reductase activity oxidoreductase activity1, 2
dimethylarginine dimethylaminohydrolase 1 DDAH11NP_036269not classifiedarginine catabolism nitric oxide mediated signal transductiondimethylargininase activity hydrolase activity metal ion binding zinc ion binding1, 2
dimethylarginine dimethylaminohydrolase 2 DDAH21NP_039268not classifiedanti- apoptosis arginine catabolism nitric oxide biosynthesis nitric oxide mediated signal transductiondimethylargininase activity hydrolase activity2
damage- specific DNA binding protein 1 DDB11NP_001914nucleusnucleotide- excision repair ubiquitin cycledamaged DNA binding2
dopa decarboxylase (aromatic L- amino acid decarboxylase) DDC11NP_000781not classifiedamino acid and derivative metabolism carboxylic acid metabolism catecholamine biosynthesisaromatic- L- amino- acid decarboxylase activity carboxy- lyase activity lyase activity2
D- dopachrome tautomerase DDT1NP_001346not classifiedmelanin biosynthesis from tyrosinedopachrome isomerase activity lyase activity1, 2
DEAD (Asp- Glu- Ala- As) box polypeptide 19 isoform 2 DDX19B1NP_001014451cytoplasm nuclear pore nucleusmRNA export from nucleusATP binding ATP- dependent helicase activity hydrolase activity nucleic acid binding nucleotide binding RNA binding2
DEAD/H (Asp- Glu- Ala- Asp/His) box polypeptide 3 DDX3X2NP_001347cytoplasm nucleusnot classifiedATP binding ATP- dependent RNA helicase activity DNA binding hydrolase activity nucleotide binding RNA binding2
DEAD (Asp- Glu- Ala- Asp) box polypeptide 5 DDX51NP_004387nucleuscell growthATP binding ATP- dependent helicase activity hydrolase activity nucleic acid binding nucleotide binding RNA binding RNA helicase activity2
defensin, alpha 1 preproprotein DEFA11NP_004075extracellular regiondefense response to bacterium defense response to fungus response to virus xenobiotic metabolismnot classified1
DEAH (Asp- Glu- Ala- His) box polypeptide 34 isoform 2 DHX341NP_919409not classifiedelectron transportATP binding ATP- dependent helicase activity electron transporter activity hydrolase activity metal ion binding nucleic acid binding nucleotide binding RNA binding2
DIP13 beta DIP13B1NP_060641cytoplasm endosome membrane membrane nucleus NuRD complexcell cycle cell proliferation signal transductionprotein binding2
hypothetical protein LOC345651 DKFZp686D09722NP_001017992not classifiednot classifiedprotein binding2
dynein, axonemal, heavy polypeptide 8 DNAH81NP_001362axonemal dynein complex dynein complexciliary or flagellar motility microtubule- based movementATP binding ATPase activity microtubule motor activity nucleotide binding protein binding1, 2
DnaJ (Hsp40) homolog, subfamily A, member 1 DNAJA11NP_001530not classifiedprotein folding response to unfolded proteinheat shock protein binding low- density lipoprotein receptor binding metal ion binding unfolded protein binding zinc ion binding2
DnaJ subfamily A member 2 DNAJA21NP_005871membraneG1 phase of mitotic cell cycle positive regulation of cell proliferation protein folding regulation of progression through cell cycleheat shock protein binding metal ion binding unfolded protein binding zinc ion binding2
DnaJ (Hsp40) homolog, subfamily B, member 1 DNAJB12NP_006136nucleusprotein folding response to unfolded proteinheat shock protein binding unfolded protein binding2
DnaJ (Hsp40) homolog, subfamily C, member 13 DNAJC131NP_056083not classifiedprotein foldingbinding heat shock protein binding2
DnaJ (Hsp40) homolog, subfamily C, member 7 DNAJC71NP_003306not classifiedprotein foldingheat shock protein binding2
dynamin 2 isoform 3 DNM21NP_004936cytoplasm microtubule postsynaptic membraneendocytosis G2/M transition of mitotic cell cycle positive regulation of apoptosis regulation of transcription signal transduction synaptic vesicle transportenzyme binding GTP binding GTPase activity hydrolase activity microtubule binding motor activity nucleotide binding transcriptional activator activity2
dynamin 2 isoform 4 DNM21NP_001005362cytoplasm microtubule postsynaptic membraneendocytosis G2/M transition of mitotic cell cycle positive regulation of apoptosis regulation of transcription signal transduction synaptic vesicle transportenzyme binding GTP binding GTPase activity hydrolase activity microtubule binding motor activity nucleotide binding transcriptional activator activity2
pad- 1- like DOPEY21NP_005119Golgi membranedevelopment endoplasmic reticulum organization and biogenesis Golgi to endosome transportnot classified2
dipeptidase 1 (renal) DPEP131NP_004404endoplasmic reticulum membrane microsomecarbohydrate metabolism proteolysiscation binding dipeptidyl- peptidase activity GPI anchor binding membrane dipeptidase activity metal ion binding metallopeptidase activity zinc ion binding1, 2
dipeptidylpeptidase IV DPP441NP_001926integral to membrane membraneimmune response proteolysisaminopeptidase activity dipeptidyl- peptidase IV activity prolyl oligopeptidase activity1, 2
dihydropyrimidinase DPYS5NP_001376not classifiednucleobase, nucleoside, nucleotide and nucleic acid metabolism response to toxindihydropyrimidinase activity hydrolase activity2
desmocollin 2 isoform Dsc2b preproprotein DSC21NP_004940cytoskeleton integral to membrane intercellular junction membranecell adhesion homophilic cell adhesioncalcium ion binding protein binding2
desmoglein 3 preproprotein DSG31NP_001935cytoskeleton integral to membrane intercellular junction membranecell adhesion homophilic cell adhesioncalcium ion binding protein binding2
desmoplakin isoform II DSP10NP_001008844cell- cell adherens junction cornified envelope intermediate filamentepidermis development keratinocyte differentiation peptide cross- linkingprotein binding, bridging structural constituent of cytoskeleton2
desmoplakin isoform I DSP4NP_004406cell- cell adherens junction cornified envelope intermediate filamentepidermis development keratinocyte differentiation peptide cross- linkingprotein binding, bridging structural constituent of cytoskeleton2
destrin isoform a DSTN1NP_006861intracellularnot classifiedactin binding2
dual specificity phosphatase 26 DUSP261NP_076930not classifiedprotein amino acid dephosphorylationhydrolase activity kinase activity protein tyrosine/serine/threonine phosphatase activity2
dynein, cytoplasmic, heavy polypeptide 1 DYNC1H114NP_001367cytoplasmic dynein complex dynein complex microtubulemicrotubule- based movement mitotic spindle organization and biogenesisATP binding ATPase activity, coupled microtubule motor activity nucleotide binding2
dynein, cytoplasmic, heavy polypeptide 2 DYNC2H12NP_001073932dynein complex Golgi apparatus intracellularGolgi organization and biogenesis microtubule- based movementATP binding ATPase activity ATPase activity, coupled ATPase activity, uncoupled hydrolase activity microtubule motor activity motor activity2
dysferlin DYSF1NP_003485integral to membrane plasma membranemuscle contractionnot classified2
endothelin converting enzyme 1 ECE11NP_001388integral to membrane membrane membrane fractioncell- cell signaling proteolysisendothelin- converting enzyme 1 activity metal ion binding neprilysin activity zinc ion binding2
early endosome antigen 1, 162kD EEA11NP_003557cytoplasm cytosol early endosome extrinsic to plasma membrane intracellular membrane fractionearly endosome to late endosome transport synaptic vesicle to endosome fusion vesicle fusioncalmodulin binding GTP- dependent protein binding metal ion binding nucleic acid binding phosphatidylinositol binding protein homodimerization activity zinc ion binding2
eukaryotic translation elongation factor 1 alpha 1 EEF1A16NP_001393cytoplasmprotein biosynthesis translational elongationGTP binding GTPase activity nucleotide binding protein binding translation elongation factor activity1, 2
eukaryotic translation elongation factor 2 EEF24NP_001952not classifiedprotein biosynthesisGTP binding nucleotide binding translation elongation factor activity2
EGF- containing fibulin- like extracellular matrix protein 1 precursor EFEMP11NP_004096extracellular matrix (sensu Metazoa)visual perceptioncalcium ion binding protein binding2
ephrin- B1 precursor EFNB11NP_004420integral to plasma membrane membrane soluble fraction synapsecell adhesion cell differentiation cell- cell signaling nervous system developmentephrin receptor binding protein binding2
epidermal growth factor (beta- urogastrone) EGF30NP_001954extracellular region integral to membrane nucleus plasma membraneactivation of MAPK activity chromosome organization and biogenesis (sensu Eukaryota) DNA replication epidermal growth factor receptor signaling pathway positive regulation of cell proliferationcalcium ion binding epidermal growth factor receptor activating ligand activity growth factor activity protein binding1, 2
EGF- like- domain, multiple 11 EGFL111NP_938024integral to membrane membranenot classifiedATP binding2
EH- domain containing 1 EHD114NP_006786not classifiednot classifiedATP binding calcium ion binding GTP binding GTPase activity nucleotide binding protein binding1, 2
EH- domain containing 2 EHD21NP_055416nucleusnot classifiedcalcium ion binding GTP binding GTPase activity nucleic acid binding nucleotide binding protein binding2
EH- domain containing 4 EHD417NP_644670endoplasmic reticulum nucleusnot classifiedATP binding calcium ion binding GTP binding GTPase activity nucleic acid binding nucleotide binding1, 2
eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa EIF3H1NP_003747eukaryotic translation initiation factor 3 complexprotein biosynthesis regulation of translational initiationtranslation initiation factor activity not classified2
elastase 2, neutrophil preproprotein ELA21NP_001963cell surface extracellular regionanti- inflammatory response calcium ion homeostasis negative regulation of chemokine biosynthesis negative regulation of chemotaxis negative regulation of inflammatory response negative regulation of interleukin- 8 biosynthesis positive regulation of interlbacterial binding cytokine binding elastase activity peptidase activity serine- type endopeptidase activity2
echinoderm microtubule associated protein like 5 EML51NP_899243not classifiednot classifiedlyase activity2
glutamyl aminopeptidase (aminopeptidase A) ENPEP25NP_001968integral to plasma membrane plasma membranecell migration cell proliferation cell- cell signaling proteolysiscalcium ion binding glutamyl aminopeptidase activity membrane alanyl aminopeptidase activity metallopeptidase activity zinc ion binding1, 2
ectonucleotide pyrophosphatase/phosphodiesterase 3 ENPP32NP_005012integral to plasma membrane membranenucleotide metabolism phosphate metabolismendonuclease activity hydrolase activity nucleic acid binding nucleotide diphosphatase activity phosphodiesterase I activity2
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function) ENPP42NP_055751not classifiednucleotide metabolismnot classified2
ectonucleotide pyrophosphatase/phosphodiesterase 6 ENPP65NP_699174integral to membrane membranelipid catabolism nucleotide metabolismhydrolase activity2
epoxide hydrolase 2, cytoplasmic EPHX21NP_001970cytosol peroxisome soluble fractionaromatic compound catabolism blood pressure regulation calcium ion homeostasis drug metabolism inflammatory response metabolism oxygen and reactive oxygen species metabolism positive regulation of vasodilation response to toxin xenobiotic metabolismepoxide hydrolase activity hydrolase activity magnesium ion binding protein homodimerization activity2
epsin 3 EPN31NP_060427not classifiednot classifiedlipid binding2
epiplakin 1 EPPK14NP_112598cytoskeletonnot classifiedstructural molecule activity2
epidermal growth factor receptor pathway substrate 8 EPS814NP_004438not classifiedcell proliferation epidermal growth factor receptor signaling pathway signal transductionprotein binding SH3/SH2 adaptor activity1, 2
epidermal growth factor receptor pathway substrate 8- like protein 1 isoform a EPS8L16NP_573441not classifiednot classifiednot classified2
epidermal growth factor receptor pathway substrate 8- like protein 1 isoform b EPS8L14NP_060199not classifiednot classifiedhydrolase activity2
epidermal growth factor receptor pathway substrate 8- like protein 2 EPS8L211NP_073609not classifiednot classifiednot classified2
esterase D/formylglutathione hydrolase ESD1NP_001975cytoplasmic membrane- bound vesiclenot classifiedS- formylglutathione hydrolase activity serine esterase activity thiosulfate sulfurtransferase activity2
envoplakin EVPL18NP_001979cornified envelope plasmodesmaepidermis development keratinization keratinocyte differentiation peptide cross- linkingprotein binding, bridging structural molecule activity 2
platelet coagulation factor XI precursor F111NP_000119extracellular region membraneblood coagulation proteolysiscoagulation factor IXa activity coagulation factor XIa activity heparin binding peptidase activity2
fatty acid binding protein 1, liver FABP12NP_001434cytoplasmcell- cell signaling fatty acid metabolism organ morphogenesis transportlipid binding lipid transporter activity2
fatty acid binding protein 3 FABP32NP_004093cytoplasm soluble fractionnegative regulation of cell proliferation transportfatty acid binding lipid transporter activity1, 2
fumarylacetoacetate hydrolase (fumarylacetoacetase) FAH2NP_000128not classifiedaromatic amino acid family metabolism L- phenylalanine catabolism metabolism tyrosine catabolismcalcium ion binding fumarylacetoacetase activity hydrolase activity magnesium ion binding2
hypothetical protein LOC93343 FAM125A2NP_612410nucleusnot classifiednot classified1, 2
hypothetical protein LOC89853 isoform 1 FAM125B1NP_258257not classifiednot classifiednot classified2
family with sequence similarity 20, member C FAM20C1NP_064608not classifiednot classifiednot classified2
hypothetical protein LOC85369 FAM40A1NP_149079not classifiednot classifiednot classified2
hypothetical protein LOC51571 FAM49B1NP_057707not classifiednot classifiednot classified2
hypothetical protein LOC79567 FAM65A2NP_078795not classifiednot classifiedbinding DNA- directed RNA polymerase activity2
fatty acid synthase FASN20NP_004095not classifiedfatty acid biosynthesis3- hydroxypalmitoyl- [acyl- carrier protein] dehydratase activity 3- oxoacyl- [acyl- carrier protein] reductase activity 3- oxoacyl- [acyl- carrier protein] synthase activity catalytic activity cofactor binding enoyl- [acyl- carrier protein] reductase (NADPH, B- spec2
FAT tumor suppressor 1 precursor FAT1NP_005236integral to plasma membrane membranecell adhesion cell- cell signaling homophilic cell adhesion morphogenesiscalcium ion binding protein binding2
fibrillarin FBL1NP_001427nucleus ribonucleoprotein complexrRNA processingRNA binding transferase activity not classified2
fructose- 1, 6- bisphosphatase 1 FBP17NP_000498not classifiedcarbohydrate metabolism fructose metabolism gluconeogenesisfructose- 2, 6- bisphosphate 2- phosphatase activity fructose- bisphosphatase activity hydrolase activity identical protein binding phosphoric ester hydrolase activity zinc ion binding2
fructose- 1, 6- bisphosphatase 2 FBP21NP_003828not classifiedcarbohydrate metabolism fructose metabolism gluconeogenesisfructose- 2, 6- bisphosphate 2- phosphatase activity fructose- bisphosphatase activity hydrolase activity phosphoric ester hydrolase activity2
Fc fragment of IgG binding protein FCGBP14NP_003881not classifiednot classifiednot classified1, 2
ficolin 2 isoform a precursor FCN22NP_004099cytoplasmantimicrobial humoral response (sensu Vertebrata) opsonization phosphate transportantigen binding calcium ion binding sugar binding2
myoferlin isoform a FER1L38NP_038479integral to membrane nuclear envelope plasma membranecirculation muscle contractionnot classified2
myoferlin isoform b FER1L37NP_579899integral to membrane nuclear envelope plasma membranecirculation muscle contractioncalcium ion binding2
fibrinogen, alpha polypeptide isoform alpha- E preproprotein FGA5NP_000499extracellular region fibrinogen complex soluble fractionblood coagulation blood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transductionprotein binding1, 2
fibrinogen, gamma chain isoform gamma- A precursor FGG1NP_000500fibrinogen complexblood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transductioncalcium ion binding2
fibrinogen, gamma chain isoform gamma- B precursor FGG1NP_068656fibrinogen complexblood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transductionFK506 binding2
fibrinogen- like 2 precursor FGL24NP_006673fibrinogen complexnot classifiednot classified2
fidgetin- like 1 FIGNL11NP_071399membranenot classifiedATP binding nucleoside- triphosphatase activity nucleotide binding2
FK506- binding protein 4 FKBP41NP_002005cytoplasm intracellular nucleusprotein foldingisomerase activity peptidyl- prolyl cis- trans isomerase activity protein binding, bridging actin binding2
FK506 binding protein 5 FKBP51NP_004108nucleusprotein foldingFK506 binding isomerase activity peptidyl- prolyl cis- trans isomerase activity protein binding2
coiled- coil domain containing 132 isoform a FLJ200971NP_060137not classifiedtwo- component signal transduction system (phosphorelay)two- component sensor activity2
hypothetical protein LOC148811 FLJ325692NP_689704not classifiedproteolysiscarboxypeptidase activity Gly- X carboxypeptidase activity hydrolase activity metallopeptidase activity protein dimerization activity2
hypothetical protein LOC201931 FLJ384821NP_689894not classifiednot classifiednot classified2
filamin A, alpha isoform 1 FLNA1NP_001447actin cytoskeletonactin cytoskeleton organization and biogenesis cell motility cell surface receptor linked signal transduction nervous system development positive regulation of I- kappaB kinase/NF- kappaB cascadeactin filament binding protein binding signal transduce activity actin binding2
filamin B, beta (actin binding protein 278) FLNB1NP_001448actin cytoskeleton integral to membraneactin cytoskeleton organization and biogenesis cell differentiation cytoskeletal anchoring signal transduction striated muscle developmentprotein binding collagen binding2
flotillin 1 FLOT112NP_005794caveola flotillin complex integral to membrane membranenot classifiedprotein binding1, 2
flotillin 2 FLOT29NP_004466cell surface flotillin complex integral to membrane plasma membranecell adhesion epidermis developmentprotein binding2
fibronectin 1 isoform 1 preproprotein FN11NP_997647ER- Golgi intermediate compartment extracellular matrix (sensu Metazoa) extracellular regionacute- phase response cell adhesion cell migration metabolism response to wounding transmembrane receptor protein tyrosine kinase signaling pathwaycollagen binding extracellular matrix structural constituent heparin binding oxidoreductase activity1, 2
fibronectin 1 isoform 3 preproprotein FN19NP_002017ER- Golgi intermediate compartment extracellular matrix (sensu Metazoa) extracellular regionacute- phase response cell adhesion cell migration metabolism response to wounding transmembrane receptor protein tyrosine kinase signaling pathwaycollagen binding extracellular matrix structural constituent heparin binding oxidoreductase activity2
fyn- related kinase FRK7NP_002022intracellular nucleusintracellular signaling cascade negative regulation of cell proliferation protein amino acid phosphorylation regulation of progression through cell cycleATP binding non- membrane spanning protein tyrosine kinase activity nucleotide binding transferase activity2
formiminotransferase cyclodeaminase FTCD6NP_006648cytoplasmfolic acid and derivative metabolism histidine metabolism metabolismfolic acid binding formimidoyltetrahydrofolate cyclodeaminase activity glutamate formimidoyltransferase activity lyase activity transferase activity2
ferritin, heavy polypeptide 1 FTH11NP_002023ferritin complex plasma membranecell proliferation immune response intracellular sequestering of iron ion iron ion homeostasis iron ion transport negative regulation of cell proliferationbinding ferric iron binding ferroxidase activity kinase binding metal ion binding oxidoreductase activity protein binding2
ferritin, light polypeptide FTL5NP_000137ferritin complexiron ion homeostasis iorn ion transportbinding ferric iron binding identical protein binding metal ion binding1, 2
fucosidase, alpha- L- 1, tissue FUCA11NP_000138cytoplasm lysosomecarbohydrate metabolism glycosaminoglycan catabolism metabolismalpha- L- fucosidase activity hydrolase activity, acting on glycosyl bonds2
fusion (involved in t(12;16) in malignant liposarcoma) isoform a FUS1NP_004951intracellular nucleusnot classifiedDNA binding metal ion binding nucleic acid binding nucleotide binding protein binding RNA binding zinc ion binding1
fuzzy homolog FUZ1NP_079405not classifiednot classifiednot classified2
FXYD domain- containing ion transport regulator 2 isoform 1 FXYD21NP_001671integral to membrane membrane sodium:potassium- exchanging ATPase complexion transport potassium ion transport sodium ion transportion channel activity potassium ion binding sodium ion binding sodium:potassium- exchanging ATPase activity transporter activity1, 2
glucose- 6- phosphate dehydrogenase isoform a G6PD1NP_000393cytoplasmcarbohydrate metabolism glucose 6- phosphate utilization glucose metabolism pentose- phosphate shuntglucose- 6- phosphate 1- dehydrogenase activity oxidoreductase activity2
acid alpha- glucosidase preproprotein GAA4NP_000143lysosomecarbohydrate metabolism generation of precursor metabolites and energy glycogen catabolism metabolismalpha- glucosidase activity hydrolase activity, hydrolyzing O- glycosyl compounds1, 2
acid alpha- glucosidase preproprotein GAA5NP_001073272lysosomecarbohydrate metabolism generation of precursor metabolites and energy glycogen catabolism metabolismhydrolase activity, hydrolyzing O- glycosyl compounds ATP binding2
gamma- aminobutyric acid (GABA) A receptor, beta 2 isoform 1 GABRB21NP_068711integral to plasma membrane postsynaptic membranegamma- aminobutyric acid signaling pathway ion transport synaptic transmissionchloride channel activity chloride ion binding extracellular ligand- gated ion channel activity GABA- A receptor activity ion channel activity neurotransmitter receptor activity2
galactokinase 1 GALK11NP_000145cytoplasm membrane fractioncarbohydrate phosphorylation galactose metabolism metabolismgalactokinase activity galactose binding kinase activity nucleotide binding transferase activity hydrolase activity2
galactose mutarotase (aldose 1- epimerase) GALM2NP_620156not classifiedcarbohydrate metabolism galactose metabolismaldose 1- epimerase activity isomerase activity2
alpha glucosidase II alpha subunit isoform 2 GANAB1NP_938148endoplasmic reticulumcarbohydrate metabolismhydrolase activity hydrolase activity, hydrolyzing O- glycosyl compounds protein binding2
alpha glucosidase II alpha subunit isoform 3 GANAB1NP_938149endoplasmic reticulumcarbohydrate metabolismhydrolase activity, hydrolyzing O- glycosyl compounds protein binding hydrolase activity, acting on glycosyl bonds2
glyceraldehyde- 3- phosphate dehydrogenase GAPDH10NP_002037cytoplasmglucose metabolism glycolysisglyceraldehyde- 3- phosphate dehydrogenase (phosphorylating) activity NAD binding oxidoreductase activity1, 2
glucan (1, 4- alpha- ), branching enzyme 1 GBE11NP_000149not classifiedcarbohydrate metabolism generation of precursor metabolites and energy glycogen biosynthesis1, 4- alpha- glucan branching enzyme activity cation binding hydrolase activity, hydrolyzing O- glycosyl compounds transferase activity, transferrin glycosyl groups2
grancalcin, EF- hand calcium binding protein GCA1NP_036330cytoplasm plasma membranemembrane fusioncalcium ion binding2
mannosyl- oligosaccharide glucosidase GCS11NP_006293endoplasmic reticulum integral to membrane membrane membrane fractionmetabolism oligosaccharide metabolism protein amino acid N- linked glycosylationmannosyl- oligosaccharide glucosidase activity not classified2
growth differentiation factor 2 GDF21NP_057288extracellular region extracellular spacegrowthcytokine activity growth factor activity2
GDP dissociation inhibitor 2 GDI217NP_001485cell surface cytoplasmprotein transport regulation of GTPase activity signal transductionGTPase activator activity Rab GDP- dissociation inhibitor activity2
glycerophosphodiester phosphodiesterase domain containing 3 GDPD31NP_077283not classifiedglycerol metabolismglycerophosphodiester phosphodiesterase activity2
gemin4 GEMIN41NP_056536cytoplasm nucleolus nucleus small nuclear ribonucleoprotein complex spliceosome complexnuclear mRNA splicing, via spliceosome rRNA processingprotein binding2
GDNF family receptor alpha 1 isoform b preproprotein GFRA11NP_665736extrinsic to membrane membranecell surface receptor linked signal transductionglial cell line- derived neurotrophic factor receptor activity GPI anchor binding receptor activity receptor binding2
gamma- glutamyl hydrolase precursor GGH5NP_003869lysosomeglutamine metabolismexopeptidase activity gamma- glutamyl hydrolase activity hydrolase activit2
growth hormone inducible transmembrane protein GHITM1NP_055209integral to membrane membrane mitochondrionnot classifiedprotein binding2
regulator of G- protein signalling 19 interacting protein 1 isoform 1 GIPC11NP_974197cytosol membrane membrane fraction soluble fractionG- protein coupled receptor protein signaling pathwayprotein binding receptor binding2
regulator of G- protein signalling 19 interacting protein 1 isoform 2 GIPC11NP_974196cytosol membrane membrane fraction soluble fractionG- protein coupled receptor protein signaling pathwayreceptor binding ATP binding2
PDZ domain protein GIPC2 GIPC21NP_060125not classifiednot classifiedprotein binding2
glycerol kinase isoform a GK1NP_976325cytoplasm mitrochondrial outer membranecarbohydrate metabolism glycerol- 3- phosphate metabolismglycerol kinase activity nucleotide binding transferase activity ATP binding2
glycerol kinase 2 GK21NP_149991cytoplasm mitrochondrial outer membranecarbohydrate metabolism glycerol- 3- phosphate metabolismglycerol kinase activity nucleotide binding transferase activity GTP binding2
galactosidase, beta 1 isoform a GLB116NP_000395beta- galactosidase complex lysosomecarbohydrate metabolism metabolismbeta- galactosidase activity cation binding hydrolase activity, acting on glycosyl bonds1, 2
golgi apparatus protein 1 GLG12NP_036333Golgi membrane integral to membrane membranenot classifiedfibroblast growth factor binding receptor binding1, 2
glyoxalase I GLO11NP_006699cytoplasmanti- apoptosis carbohydrate metabolismlactoylglutathione lyase activity lyase activity metal ion binding zinc ion binding2
glutamine synthetase GLUL2NP_001028216not classifiedglutamine biosynthesis nitrogen compound metabolism regulation of neurotransmitter levelsglutamate- ammonia ligase activity ligase activity2
GM2 ganglioside activator precursor GM2A2NP_000396lysosomeglycolipid catabolism glycosphingolipid metabolism lipid metabolism sphingolipid catabolismsphingolipid activator protein activity2
guanine nucleotide binding protein (G protein), alpha 11 (Gq class) GNA117NP_002058cytoplasm plasma membraneG- protein coupled receptor protein signaling pathway protein amino acid ADP- ribosylation signal transductionGTP binding GTPase activity nucleotide binding signal transducer activity1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 GNAI18NP_002060plasma membraneG- protein coupled receptor protein signaling pathway signal transduction GTP binding nucleotide binding protein binding signal transducer activity1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 GNAI28NP_002061not classifiedG- protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity response to nutrient signal transductionGTP binding GTPase activity nucleotide binding signal transducer activity1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 GNAI38NP_006487not classifiedG- protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity signal transduction transportGTP binding GTPase activity nucleotide binding signal transducer activity1, 2
guanine nucleotide binding protein (G protein), q polypeptide GNAQ10NP_002063cytoplasm heterotrimeric G- protein complex plasma membraneblood coagulation G- protein coupled receptor protein signaling pathway phospholipase C activation protein amino acid ADP- ribosylation signal transductionGTP binding GTPase activity nucleotide binding signal transducer activity2
guanine nucleotide- binding protein, beta- 1 subunit GNB12NP_002065not classifiedsignal transductionsignal transducer activity1, 2
guanine nucleotide binding protein (G protein), beta polypeptide 2- like 1 GNB2L11NP_006089cytoplasmprotein kinase C activation signal transductionprotein kinase C binding receptor binding2
G- protein gamma- 12 subunit GNG125NP_061329heterotrimeric G- protein complex membraneG- protein coupled receptor protein signaling pathway signal transductionsignal transducer activity1, 2
guanine nucleotide binding protein (G protein), gamma 5 GNG51NP_005265heterotrimeric G- protein complex membraneG- protein coupled receptor protein signaling pathway signal transductionsignal transducer activity2
guanine nucleotide binding protein (G protein), gamma 7 GNG71NP_443079heterotrimeric G- protein complex membraneregulation of G- protein coupled receptor protein signaling pathway signal transductionsignal transducer activity1, 2
glucosamine- 6- phosphate deaminase 1 GNPDA11NP_005462not classifiedcarbohydrate metabolism fertilization (sensu Metazoa) generation of precursor metabolites and energy glucosamine catabolism N- acetylglucosamine metabolismglucosamine- 6- phosphate deaminase activity hydrolase activity2
golgi autoantigen, golgin subfamily a, 7 GOLGA71NP_001002296membranenot classifiednot classified2
aspartate aminotransferase 1 GOT19NP_002070cytosolamino acid metabolism aspartate catabolism biosynthesisaspartate transaminase activity2
glycerol- 3- phosphate dehydrogenase 1 (soluble) GPD111NP_005267cytoplasm glycerol- 3- phosphate dehydrogenase complexcarbohydrate metabolism glycerol- 3- phosphate catabolismglycerol- 3- phosphate dehydrogenase (NAD+) activity NAD binding2
glucose phosphate isomerase GPI9NP_000166extracellular spacecarbohydrate metabolism gluconeogenesis glycolysis hemostasis humoral immune response nervous system developmentcytokine activity glucose- 6- phosphate isomerase activity growth factor activity isomerase activity1, 2
glycoprotein M6A isoform 2 GPM6A1NP_963885cell surface integral to plasma membrane membranenot classifiedglutathione peroxidase activity2
G protein- coupled receptor 155 isoform 10 GPR1551NP_689742integral to membrane membraneintracellular signaling cascadenot classified2
G protein- coupled receptor 98 precursor GPR981NP_115495integral to membrane membranecell- cell adhesion nervous system development neuropeptide signaling pathway response to stimulus sensory perception of sound signal transduction visual perceptioncalcium ion binding G- protein coupled receptor activity receptor activity2
G protein- coupled receptor, family C, group 5, member A GPRC5A1NP_003970integral to plasma membrane membraneG- protein coupled receptor protein signaling pathway signal transductionmetabotropic glutamate, GABA- B- like receptor activity receptor activity1, 2
G protein- coupled receptor, family C, group 5, member B precursor GPRC5B7NP_057319integral to membrane membraneG- protein coupled receptor protein signaling pathway signal transduction visual perceptionmetabotropic glutamate, GABA- B- like receptor activity receptor activity sevenless binding1, 2
G protein- coupled receptor family C, group 5, member C isoform b GPRC5C11NP_061123integral to plasma membrane membraneG- protein coupled receptor protein signaling pathway signal transductionmetabotropic glutamate, GABA- B- like receptor activity protein binding receptor activity2
glutamic- pyruvate transaminase (alanine aminotransferase) GPT1NP_005300cytoplasm soluble fractionbiosynthesis gluconeogenesis nitrogen compound metabolism1- aminocyclopropane- 1- carboxylate synthase activity alanine transaminase activity2
glutathione peroxidase 4 isoform A precursor GPX43NP_002076mitochondriondevelopment electron transport phospholipid metabolism response to oxidative stressglutathione peroxidase activity oxidoreductase activity phospholipid- hydroperoxide glutathione peroxidase activity selenium binding2
glutathione peroxidase 4 isoform C precursor GPX44NP_001034937mitochondriondevelopment electron transport phospholipid metabolism response to oxidative stressoxidoreductase activity phospholipid- hydroperoxide glutathione peroxidase activity selenium binding epidermal growth factor receptor binding2
growth factor receptor- bound protein 2 isoform 1 GRB23NP_002077cytosolcell- cell signaling epidermal growth factor receptor signaling pathway insulin receptor signaling pathway intracellular signaling cascade Ras protein signal transductionepidermal growth factor receptor binding insulin receptor substrate binding SH3/SH2 adaptor activity2
growth factor receptor- bound protein 2 isoform 2 GRB22NP_987102cytosolcell- cell signaling epidermal growth factor receptor signaling pathway insulin receptor signaling pathway intracellular signaling cascade Ras protein signal transductioninsulin receptor substrate binding SH3/SH2 adaptor activity glycerate dehydrogenase activity2
glyoxylate reductase/hydroxypyruvate reductase GRHPR1NP_036335cytoplasmelectron transport excretion L- serine biosynthesis metabolismglyoxylate reductase (NADP) activity hydrohypyruvate reductase activity NAD binding oxidoreductase activity oxidoreductase activity, acting on the CH- OH group of donors, NAD or NADP as acceptor protein binding glutathione transferase activity2
glutamate receptor, ionotropic, delta 1 GRID11NP_060021integral to membrane membrane periplasmic space (sensu Proteobacteria) postsynaptic membraneion transportglutamate- gated ion channel activity ion channel activity ionotropic glutamate receptor activity receptor activity transporter activity2
gelsolin isoform b GSN10NP_937895actin cytoskeleton cytosol extracellular regionactin filament polymerization actin filament severing barbed- end actin filament cappingactin binding calcium ion binding protein binding2
glutathione reductase GSR1NP_000628cytoplasm mitochondrionelectron transport glutathione metabolismdisulfide oxidoreductase activity FAD binding glutathione- disulfide reductase activity2
glutathione synthetase GSS1NP_000169not classifiedamino acid metabolism glutathione biosynthesis nervous system development response to oxidative stressATP binding glutathioone synthase activity ligase activity nucleotide binding2
glutathione S- transferase A1 GSTA11NP_665683cytoplasmglutathione metabolism metabolismglutathione transferase activity transferase activity1, 2
glutathione S- transferase, C- terminal domain containing isoform 1 GSTCD1NP_001026890not classifiednot classifiedmethyltransferase activity transferase activity2
glutathione S- transferase M2 GSTM21NP_000839not classifiedmetabolismglutathione transferase activity transferase activity2
glutathione- S- transferase omega 1 GSTO11NP_004823cytoplasmmetabolismglutathione transferase activity monodehydroascorbate reductase (NADH) activity transferase activity2
glutathione S- transferase omega 2 GSTO21NP_899062cytoplasmmetabolismglutathione transferase activity transferase activity2
glutathione transferase GSTP19NP_000843cytoplasmanti- apoptosis central nervous system development metabolismglutathione transferase activity transferase activity1, 2
GTP- binding protein PTD004 isoform 1 GTPBP92NP_037473cytoplasm intracellularnot classifiedGTP binding nucleotide binding2
glucuronidase, beta GUSB5NP_000172lysosomecarbohydrate metabolism glycosaminoglycan catabolism metabolismbeta- glucuronidase activity cation binding1, 2
oocyte- specific histone H1 H1FOO1NP_722575nucleosome nucleusnucleosome assemblyDNA binding2
beta globin HBB2NP_000509hemoglobin complexnitric oxide transport oxygen transport positive regulation of nitric oxide biosynthesis transportheme binding hemoglobin binding iron ion binding metal ion binding oxygen binding oxygen transporter activity selenium binding2
HBS1- like HBS1L1NP_006611not classifiedprotein biosynthesis signal transductionGTP binding nucleotide binding translation elongation factor activity2
haloacid dehalogenase- like hydrolase domain containing 2 HDHD21NP_115500not classifiedmetabolismmetal ion binding2
heme binding protein 1 HEBP16NP_057071not classifiednot classifiednot classified1, 2
heme binding protein 2 HEBP21NP_055135not classifiednot classifiednot classified2
homogentisate 1, 2- dioxygenase HGD2NP_000178not classifiedL- phenylalanine catabolism tyrosine catabolismhomogentisate 1, 2- dioxygenase activity iron ion binding metal ion binding oxidoreductase activity2
hepatocyte growth factor- regulated tyrosine kinase substrate HGS1NP_004703endosome membraneintracellular protein transport negative regulation of cell proliferation signal transductionzinc ion binding hydrolase activity2
histidine triad nucleotide binding protein 1 HINT11NP_005331cytoskeleton nucleussignal transductionprotein kinase C binding zinc ion binding nucleic acid binding2
histone H2A HIST2H2AB1NP_778235chromosome nucleosome nucleuschromosome organization and biogenesis (sensu Eukaryota) nucleosome assemblyDNA binding2
histone 2, H2bf HIST2H2BF4NP_001019770chromosome nucleosome nucleuschromosome organization and biogenesis (sensu Eukaryota) nucleosome assemblyDNA binding2
histone H4 HIST4H42NP_778224chromosome nucleosome nucleusestablishment and/or maitenance of chromatin architecture nucleosome assembly phosphoinositide- mediated signalingDNA binding1
major histocompatibility complex, class I, B HLA- B1NP_005505integral to membrane integral to plasma membrane membrane membrane fraction MHC class I protein complexantigen processing and presentation antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class IMHC class I receptor activity2
major histocompatibility complex, class II, DR alpha precursor HLA- DRA1NP_061984integral to plasma membrane lysosome membrane plasma membraneantigen processing and presentation of exogenous antigen antigen processing and presentation of exogenous peptide antigen via MHC class II immune responseMHC class II receptor activity2
histamine N- methyltransferase isoform 1 HNMT1NP_008826not classifiedrespiratory gaseous exchangehistamine N- methyltransferase activity methyltransferase activity transferase activity2
heterogeneous nuclear ribonucleoprotein L isoform b HNRNPL1NP_001005335heterogeneous nuclear ribonucleoprotein complex nucleoplasm nucleusmRNA processingnucleotide binding RNA binding ATP binding2
haptoglobin HP2NP_005134extracellular regiondefense response iron ion homeostasis proteolysishemoglobin binding serine- type endopeptidase activity2
4- hydroxyphenylpyruvate dioxygenase HPD1NP_002141not classifiedaromatic amino acid family metabolism L- phenylalanine catabolism tyrosine catabolism4- hydroxyphenylpyruvate dioxygenase activity iron ion binding metal ion binding oxidoreductase activity2
hydroxyprostaglandin dehydrogenase 15- (NAD) HPGD6NP_000851cytosolfatty acid metabolism lipid metabolism lipoxygenase pathway metabolism negative regulation of progression through cell cycle parturition pregnancy prostaglandin metabolism transforming growth factor beta receptor signaling pathway15- hydroxyprostaglandin dehydrogenase (NAD+) activity NAD binding oxidoreductase activity prostaglandin E receptor activity protein homodimerization activity1, 2
hemopexin HPX1NP_000604extracellular region extracellular spaceheme transport iron ion homeostasis transportbinding heme transporter activity iron ion binding metal ion binding2
v- Ha- ras Harvey rat sarcoma viral oncogene homolog isofrom 1 HRAS2NP_005334cytoplasm intracellular membrane plasma membranecell motility cell surface receptor linked signal transduction chemotaxis organ morphogenesis regulation of progression through cell cycle small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding protein C- terminus binding1
histidine- rich glycoprotein precursor HRG2NP_000403extracellular regionnot classifiedcysteine protease inhibitor activity heparin binding2
heat- responsive protein 12 HRSP122NP_005827cytoplasm nucleusregulation of translational terminationendonuclease activity hydrolase activity1, 2
heat shock protein 90Bf HSP90AB6P1NP_001014441not classifiedprotein folding response to unfolded proteinunfolded protein binding2
heat shock 70kDa protein 12A HSPA12A1NP_079291not classifiednot classifiedATP binding nucleotide binding2
heat shock 70kDa protein 1B HSPA1B4NP_005337cytoplasm endoplasmic reticulum mitochondrion nucleusanti- apoptosis mRNA catabolism protein folding response to unfolded proteinATP binding nucleotide binding unfolded protein binding1
heat shock 70kDa protein 2 HSPA216NP_068814cell surfacemale meiosis protein folding response to unfolded protein spermatid developmentATP binding nucleotide binding unfolded protein binding2
heat shock 70kDa protein 5 HSPA51NP_005338caspase complex cell surface endoplasmic reticulum endoplasmic reticulum lumen ER- Golgi intermediate compartment integral to endoplasmic reticulum membrane nucleus perinuclear regionanti- apoptosis negative regulation of caspase activityATP binding calcium ion binding caspase inhibitor activity nucleotide binding protein binding, bridging unfolded protein binding1, 2
heat shock 70kDa protein 8 isoform 1 HSPA819NP_006588cell surface intracellular nucleusprotein folding response to unfolded proteinATP binding ATPase activity, coupled nucleotide binding protein binding1, 2
heat shock 27kDa protein 1 HSPB18NP_001531cell surface cytoplasm cytoskeletonanti- apoptosis cell motility protein folding regulation of translational initiation response to unfolded proteinprotein binding2
chaperonin HSPD11NP_955472cytoplasm mitochondrioncellular protein metabolism protein folding protein import into mitochondrial matrix regulation of apoptosis response to unfolded proteinATP binding chaperone binding nucleotide binding protein binding unfolded protein binding1, 2
heparan sulfate proteoglycan 2 HSPG218NP_005520basement membrane extracellular spacecell adhesionnot classified2
HECT, UBA and WWE domain containing 1 HUWE11NP_113584cytoplasm intracellular nucleushistone ubiquitination mRNA transport protein polyubiquitination ubiquitin cyclebinding DNA binding ligase activity protein binding ubiquitin- protein ligase activity2
intercellular adhesion molecule 1 precursor ICAM11NP_000192integral to plasma membrane plasma membranecell- cell adhesiontransmembrane receptor activity insulin- like growth factor receptor activity2
isocitrate dehydrogenase 1 (NADP+), soluble IDH114NP_005887cytoplasm cytosol peroxisomecarbohydrate metabolism glyoxylate cycle isocitrate metabolism main pathways of carbohydrate metabolism metabolism tricarboxylic acid cycleisocitrate dehydrogenase (NADP+) activity oxidoreductase activity oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor1, 2
insulin- like growth factor 2 receptor precursor IGF2R1NP_000867endosome integral to plasma membrane lysosome membrane trans- Golgi network transport vesiclereceptor mediated endocytosis signal transduction transportreceptor activity transporter activity metal iion binding2
insulin- like growth factor binding protein, acid labile subunit IGFALS6NP_004961extracellular region extracellular space soluble fractioncell adhesion signal transductioninsulin- like growth factor binding protein binding transferase activity2
zinc finger protein, subfamily 1A, 5 IKZF51NP_071911intracellular nucleusnot classifiednucleic acid binding zinc ion binding interleukin- 1 receptor antagonist activity2
interleukin 1 receptor antagonist isoform 1 precursor IL1RN2NP_776214extracellular region extracellular space intracellularinflammatory responseinterleukin- 1 receptor antagonist activity2
interleukin 1 receptor antagonist isoform 4 IL1RN1NP_776215extracellular region extracellular space intracellularinflammatory responsecalcium ion binding2
InaD- like protein INADL7NP_795352membrane tight junctionnot classifiedprotein binding2
IQ motif containing G IQCG1NP_115639not classifiednot classifiednot classified2
IQ motif containing GTPase activating protein 1 IQGAP120NP_003861actin filament intracellular membranenegative regulation of Ras protein signal transduction regulation of small GTPase mediated signal transduction signal transductioncalmodulin binding GTPase inhibitor activity Ras GTPase activator activity2
IQ motif containing GTPase activating protein 2 IQGAP25NP_006624actin cytoskeleton intracellularregulation of small GTPase mediated signal transduction signal transductionactin binding calmodulin binding GTPase inhibitor activity Ras GTPase activator activity2
interferon regulatory factor 6 IRF61NP_006138nucleusregulation of transcription, DNA- dependent transcriptiontranscription factor activity2
integrin, alpha 1 precursor ITGA11NP_852478integral to membrane integrin complex membranecell adhesion cell- matrix adhesion integrin- mediated signaling pathwaycalcium ion binding collagen binding magnesium ion binding receptor activity2
integrin alpha 3 isoform a precursor ITGA31NP_002195integral to membrane integrin complex membranecell adhesion cell- matrix adhesion integrin- mediated signaling pathwaycalcium ion binding protein binding receptor activity2
integrin alpha 3 isoform b, precursor ITGA31NP_005492integral to membrane integrin complex membranecell adhesion cell- matrix adhesion integrin- mediated signaling pahtwyaprotein binding receptor activity protein binding2
integrin alpha- V precursor ITGAV1NP_002201integral to membrane integrin complex membranecell adhesion cell- matrix adhesion integrin- mediated signaling pathwaycalcium ion binding protein binding receptor activity2
integrin beta 1 isoform 1A precursor ITGB11NP_002202endoplasmic reticulum integral to membrane integrin complex membrane rufflecell adhesion cell migration cell- matrix adhesion cellular defense response development homophilic cell adhesion integrin- mediated signaling pathwayidentical protein binding protein binding protein heterodimerization activity receptor activity2
integrin beta 4 binding protein isoform a ITGB4BP1NP_852133nucleusintegrin- mediated signaling pathway mature ribosome assembly protein biosynthesisprotein binding ribosome binding translation initiation factor activity2
integrin, beta 8 precursor ITGB81NP_002205integral to membrane integrin complex membranecell adhesion cell- matrix adhesion integrin- mediated signaling pahtwyareceptor activity not classified2
inter- alpha (globulin) inhibitor H4 ITIH42NP_002209extracellular regionacute- phase response hyaluronan metabolismserine- type endopeptidase inhibitor activity2
intelectin ITLN14NP_060095membranenot classifiedGPI anchor binding sugar binding2
integral membrane protein 2B ITM2B5NP_068839integral to plasma membrane membrane membrane fraction nervous system development sensory perception of soundnot classified1, 2
integral membrane protein 2C isoform 1 ITM2C1NP_112188Golgi apparatus integral to membrane membranenot classifiednot classified2
integral membrane protein 2C isoform 2 ITM2C1NP_001012534Golgi apparatus integral to membrane membranenot classified endocytosis regulation of Rho protein signal transductioncalcium ion binding2
intersectin 2 isoform 1 ITSN21NP_006268intracellularendocytosis regulation of Rho protein signal transductionprotein binding Rho guanyl- nucleotide exchange factor activity SH3/SH2 adaptor activity cytoskeletal protein binding2
junction plakoglobin JUP9NP_068831cytoplasm cytoskeleton membrane fraction soluble fractioncell adhesioncytoskeletal protein binding structural molecule activity2
kalirin, RhoGEF kinase isoform 3 KALRN1NP_008995actin cytoskeleton intracellularintracellular signaling cascade nervous system development protein amino acid phosphorylation regulation of Rho protein signal transduction signal transduction vesicle- mediated transportATP binding nucleotide binding protein binding protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity2
potassium voltage- gated channel, subfamily G, member 2 KCNG21NP_036415integral to membrane membrane voltage- gated potassium channel complexion transport potassium ion transport regulation of heart contractiondelayed rectifier potassium channel activity potassium ion binding protein binding2
ketohexokinase isoform a KHK2NP_000212cytoplasmcarbohydrate metabolismketohexokinase activity kinase activity transferase activity2
ketohexokinase isoform b KHK1NP_006479cytoplasmcarbohydrate metabolismketohexokinase activity kinase activity transferase activity2
putative MAPK activating protein PM28 KIAA017419NP_055576ER- Golgi intermediate compartmentnot classifiedprotein binding1, 2
PREDICTED: similar to Protein KIAA0841 isoform 1 KIAA08411XP_049237not classifiednot classifiednot classified2
hypothetical protein LOC57471 isoform a KIAA11891NP_001009959cytoplasm membranenot classifiednot classified2
hypothetical protein LOC57653 KIAA15291NP_065944not classifiednot classifiednot classified2
PREDICTED: similar to c11.1 CG12132- PA isoform 11 KIAA18332XP_946410not classifiednot classifiedATP binding2
kinesin family member 12 KIF1216NP_612433microtubule microtubule associated complexmicrotubule- based movementATP binding microtubule motor activity nucleotide binding2
kinesin family member 3A KIF3A1NP_008985microtubule microtubule associated complexmicrotubule- based movement organelle organization and biogenesisATP binding microtubule motor activity nucleotide binding2
kinesin family member 3B KIF3B1NP_004789microtubule microtubule associated complex plus- end kinesin complexanterograde axon cargo transport determination of left/right symmetry microtubule- based movementnucleotide binding plus- end- directed microtubule motor activity ATP binding2
kinesin family member 9 isoform 3 KIF91NP_878906microtubule microtubule associated complexmicrotubule- based movementmicrotubule motor activity nucleotide binding ATP binding2
kinesin family member C3 KIFC31NP_005541kinesin complex microtubule microtubule associated complexmicrotubule- based movement visual perceptionmicrotubule motor activity nucleotide binding beta- glucuronidase activity2
klotho KL1NP_004786integral to membrane membraneaging carbohydrate metabolism metabolism positive regulation of bone mineralizationcation binding glucosidase activity hormone activity vitamin D binding IgE binding2
kallikrein 1 preproprotein KLK11NP_002248not classifiedproteolysispeptidase activity tissue kallikrein activity2
kininogen 1 KNG117NP_000884extracellular regionblood coagulation diuresis inflammatory response natriuresis negative regulation of blood coagulation negative regulation of cell adhesion positive regulation of apoptosis smooth muscle contraction vasodilationcysteine protease inhibitor activity heparin binding receptor binding zinc ion binding1, 2
karyopherin beta 1 KPNB12NP_002256cytoplasm nuclear pore nucleusNLS- bearing substrate import into nucleus protein import into nucleus, docking protein import into nucleus, translocation protein transportnuclear localization sequence binding protein binding protein transporter activity zinc ion binding2
laminin alpha 5 LAMA51NP_005551basal lamina extracellular matrix (sensu Metazoa) integral to membrane laminin- 1 membranecell adhesion regulation of cell adhesion regulation of cell migration regulation of embryonic developmentprotein binding receptor binding structural molecule activity2
laminin, gamma 1 precursor LAMC11NP_002284basement membrane laminin- 1cell adhesion endoderm development positive regulation of epithelial cell proliferation protein complex assemblyextracellular matrix structural constituent protein binding2
lysosomal- associated membrane protein 1 LAMP13NP_005552integral to plasma membrane late endosome lysosome membrane membrane fractionnot classifiednot classified1, 2
lysosomal- associated membrane protein 2 precursor LAMP24NP_054701integral to membrane late endosome lysosomal membrane membrane membrane fraction platelet dense granule membranenot classifiednot classified2
leucine aminopeptidase 3 LAP31NP_056991cytoplasm intracellularprotein metabolism proteolysisleucyl aminopeptidase activity magnesium ion binding manganese ion binding peptidase activity prolyl aminopeptidase activity zinc ion binding2
lipopolysaccharide- binding protein precursor LBP2NP_004130extracellular region extracellular space integral to membrane membraneacute- phase response cellular defense response defense response to bacterium lipid transportlipid binding2
lipocalin 2 LCN22NP_005555cytoplasm soluble fractiontransportbinding transporter activity2
L- plastin LCP11NP_002289cytoplasm cytosolnot classifiedactin binding calcium ion binding protein binding2
lactate dehydrogenase A LDHA6NP_005557cytoplasm cytosolanaerobic glycolysis tricarboxylic acid cycle intermediate metabolismL- lactate dehydrogenase activity oxidoreductase activity protein binding1, 2
lactate dehydrogenase B LDHB14NP_002291cytoplasmanaerobic glycolysis tricarboxylic acid cycle intermediate metabolismL- lactate dehydrogenase activity oxidoreductase activity1, 2
leucine proline- enriched proteoglycan (leprecan) 1 LEPRE11NP_071751endoplasmic reticulumprotein metabolismbinding iron ion binding L- ascorbic acid binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, each of oxygen into both donors oxidoreductase activity, actin2
galectin 3 LGALS31NP_002297cytoplasm extracellular region nucleus plasma membranenot classifiedsugar binding not classified2
galectin 3 binding protein LGALS3BP26NP_005558extracellular matrix (sensu Metazoa) extracellular space membranecell adhesion cellular defense response signal transductionprotein binding scavenger receptor activity1, 2
lectin, mannose- binding 2 LMAN210NP_006807endoplasmic reticulum ER- Golgi intermediate compartment integral to membrane membraneprotein transportcalcium ion binding sugar binding1, 2
hypothetical protein LOC124220 LOC1242204NP_660295not classifiednot classifiednot classified2
PREDICTED: similar to peptidylprolyl isomerase A isoform 1 LOC1281921XP_060887not classifiednot classifiednot classified2
PREDICTED: similar to peptidylprolyl isomerase A isoform 1 LOC1316911XP_946711not classifiednot classifiednot classified2
hypothetical protein LOC146909 LOC1469091NP_001073912not classifiednot classifiednot classified2
hypothetical protein LOC283537 LOC2835371NP_861450not classifiednot classifiednot classified2
PREDICTED: hypothetical protein LOC2844221XP_209196not classifiednot classifiednot classified2
similar to F- box only protein 2 LOC3428972NP_001001414not classifiedprotein catabolismprotein binding receptor activity2
PREDICTED: similar to fibrillarin LOC3456302XP_946024not classifiednot classifiednot classified2
PREDICTED: similar to ubiquitin and ribosomal protein S27a precursor LOC3887201XP_371330not classifiednot classifiednot classified2
peptidylprolyl isomerase A LOC3888175NP_001008741not classifiedprotein foldingnot classified2
PREDICTED: hypothetical protein LOC3888491XP_948564not classifiednot classifiednot classified2
PREDICTED: similar to peptidylprolyl isomerase A isoform 1 LOC3902991XP_945177not classifiednot classifiednot classified2
PREDICTED: hypothetical protein isoform 4 LOC4403351XP_950835not classifiednot classifiednot classified2
PREDICTED: hypothetical protein LOC643008 isoform 2 LOC6430081XP_951274not classifiednot classifiednot classified2
hypothetical protein LOC643751 LOC6437511NP_001083064not classifiednot classifiednot classified2
hypothetical protein LOC643752 LOC6437521NP_001083173not classifiednot classifiednot classified2
PREDICTED: similar to cytoplasmic beta- actin LOC6468211XP_942241not classifiednot classifiednot classified2
PREDICTED: similar to actin- related protein 2 LOC6491251XP_943300not classifiednot classifiednot classified2
PREDICTED: similar to immunoglobulin iota chain preproprotein LOC6515361XP_945805not classifiednot classifiedtransferase activity2
PREDICTED: similar to Programmed cell death 6- interacting protein (ALG- 2- interacting protein X) (ALG- 2- interacting protein 1) (E2F1- inducible protein) (Eig2) LOC6542596XP_290660not classifiednot classifiednot classified2
exonuclease NEF- sp LOC816911NP_112203intracellular nucleolusnot classifiedexonuclease activity nucleic acid binding nucleotide binding2
low density lipoprotein- related protein 2 LRP284NP_004516coated pit integral to membrane lysosome membranelipid metabolism protein amino acid glycosylation receptor mediated endocytosiscalcium ion binding protein binding receptor activity1, 2
leucine rich repeat containing 15 LRRC151NP_570843integral to membrane membranenot classifiedtransferase activity2
leucine rich repeat containing 57 LRRC571NP_694992not classifiednot classifiedprotein binding2
leucine- rich repeat kinase 2 LRRK24NP_940980not classifiedprotein amino acid phosphorylation small GTPase mediated signal transductionATP binding binding GTP binding GTPase activator activity nucleotide binding protein serine/threonine kinase activity transferase activity2
leukotriene A4 hydrolase LTA4H6NP_000886not classifiedinflammatory response leukotriene biosynthesis proteolysisepoxide hydrolase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity peptidase activity zinc ion binding2
NADP- dependent leukotriene B4 12- hydroxydehydrogenase LTB4DH5NP_036344cytoplasmleukotriene metabolism15- oxoprostaglandin 13- oxidase activity alcohol dehydrogenase activity oxidoreductase activity zinc ion binding1, 2
lysophospholipase II LYPLA21NP_009191not classifiedfatty acid metabolism lipid metabolismhydrolase activity2
lysozyme precursor LYZ1NP_000230extracellular regioncell wall catabolism cytolysis defense response to bacterium metabolismhydrolase activity, acting on glycosyl bonds lysozyme activity2
membrane- associated guanylate kinase- related 3 isoform 1 MAGI32NP_066016membraneapoptosis intracellular signaling cascadeguanylate kinase activity kinase activity protein binding2
MAL2 proteolipid protein MAL21NP_443118integral to membrane membranenot classifiedferric iron binding2
mannosidase, alpha, class 1A, member 1 MAN1A115NP_005898endoplasmic reticulum ER- Golgi intermediate compartment integral to membrane membrane membrane fractionmetabolism protein amino acid glycosylationcalcium ion binding hydrolase activity, acting on glycosyl bonds mannosidase activity mannosyl- oligosaccharide 1, 2- alpha- mannosidase activity1, 2
mannosidase, alpha, class 2A, member 1 MAN2A11NP_002363Golgi apparatus integral to membrane membrane membrane fractioncell motility carbohydrate metabolism glycoprotein biosynthesis mannose metabolism metabolismalpha- mannosidase activity hydrolase activity, acting on glycosyl bonds mannosyl- oligosaccharide 1, 3- 1, 6- alpha- mannosidase activity2
mitogen- activated protein kinase kinase 1 interacting protein 1 MAP2K1IP11NP_068805membranenot classifiednot classified2
myristoylated alanine- rich protein kinase C substrate MARCKS4NP_002347actin cytoskeleton plasma membranecell motilityactin filament binding calmodulin binding2
mannan- binding lectin serine protease 2 isoform 1 precursor MASP212NP_006601extracellular regionantimicrobial humoral response (sensu Vertebrata) complement activation, classical pathway innate immune response proteolysiscalcium ion binding serine- type endopeptidase activity1, 2
methyl- CpG binding domain protein 5 MBD51NP_060798nucleusnot classifiedDNA binding2
cytosolic malate dehydrogenase MDH15NP_005908cytosolglycolysis malate metabolism tricarboxylic acid cycleL- lactate dehydrogenase activity L- malate dehydrogenase activity malic enzyme activity oxidoreductase activity1, 2
mitochondrial malate dehydrogenase precursor MDH21NP_005909mitochondrial matrix mitochondrionglycolysis malate metabolism tricarboxylic acid cycleL- lactate dehydrogenase activity L- malate dehydrogenase activity oxidoreductase activity2
EGF- like- domain, multiple 4 MEGF82NP_001401integral to membrane membranedevelopmentcalcium ion binding receptor activity structural molecule activity2
milk fat globule- EGF factor 8 protein MFGE82NP_005919lipid particlecell adhesion fertilization (sensu Metazoa)protein binding2
melanoma- associated antigen p97 isoform 1, precursor MFI22NP_005920extracellular region integral to plasma membrane membraneion transport iron ion homeostasis iron ion transportferric iron binding GPI anchor binding metal ion binding zinc ion binding2
melanoma- associated antigen p97 isoform 2, precursor MFI21NP_201573extracellular region integral to plasma membrane membraneion transport iron ion homeostasis iron ion transportGPI anchor binding metal ion binding zinc ion binding cytokine activity2
hypothetical protein LOC146556 MGC454381NP_689672not classifiednot classifiednot classified2
hypothetical protein LOC375791 MGC599371NP_945352not classifiednot classifiednot classified2
mahogunin, ring finger 1 MGRN11NP_056061not classifiedubiquitin cycleligase activity metal ion binding protein binding zinc ion binding2
midline 2 isoform 2 MID21NP_438112intracellular microtubule microtubule associated complexnot classifiedmetal ion binding protein binding zinc ion binding2
macrophage migration inhibitory factor (glycosylation- inhibiting factor) MIF1NP_002406extracellular region extracellular spacecell proliferation cell surface receptor linked signal transduction inflammatory response negative regulation of apoptosis prostaglandin biosynthesis regulation of macrophage activationisomerase activity phenylpyruvate tautomerase activity protein binding ATP binding2
macrophage migration inhibitory factor (glycosylation- inhibiting factor) MIF1NP_002406extracellular region extracellular spacecell proliferation cell surface receptor linked signal transduction inflammatory response negative regulation of apoptosis prostaglanding biosynthesis regulation of macrophase activationcytokine activity isomerase activity phenylpyruvate tautomerase activity protein binding1
misshapen/NIK- related kinase isoform 4 MINK12NP_001020108not classifieddevelopment JNK cascade protein amino acid phosphorylation protein kinase cascade response to stressnucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity metal ion binding2
MIT, microtubule interacting and transport, domain containing 1 MITD19NP_620153not classifiednot classifiednot classified1, 2
myeloid/lymphoid or mixed- lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 MLLT31NP_004520nucleusregulation of transcription, DNA- dependent transcriptionnot classified2
myeloid/lymphoid or mixed- lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 isoform 3 MLLT41NP_005927intercellular junction myosincell adhesion cell- cell signaling signal transductionmotor activity protein binding protein C- terminus binding2
membrane metallo- endopeptidase MME48NP_009219integral to plasma membrane plasma membranecell- cell signaling proteolysismetal ion binding metallopeptidase activity neprilysin activity zinc ion binding1, 2
matrix metalloproteinase 24 preproprotein MMP241NP_006681extracellular matrix (sensu Metazoa) integral to plasma membrane membranepeptidoglycan metabolism proteolysiscalcium ion binding enzyme activator activity metalloendopeptidase activity zinc ion binding2
matrix metalloproteinase 25 preproprotein MMP251NP_073209cell surface extracellular matrix (sensu Metazoa) membraneinflammatory response peptidoglycan metabolism proteolysiscalcium ion binding GPI anchor binding metalloendopeptidase activity zinc ion binding2
multimerin 2 MMRN21NP_079032extracellular matrix (sensu Metazoa)not classifiednot classified1, 2
myeloid cell nuclear differentiation antigen MNDA1NP_002423nucleuscellular defense response regulaion of transcription, DNA- dependent transcription3- mercaptopyruvate sulfurtransferase activity2
Mob4B protein MOBK1B1NP_060691not classifiednot classifiedmetal ion binding zinc ion binding1
myeloperoxidase MPO7NP_000241lysosomeanti- apoptosis defense response hydrogen peroxide catabolism response to oxidative stresscalcium ion binding chromatin binding iron ion binding oxidoreductase activity peroxidase activity2
membrane protein, palmitoylated 5 MPP51NP_071919cytoplasm membrane tight junctionnot classifiedprotein binding2
3- mercaptopyruvate sulfurtransferase MPST3NP_001013454mitochondrial matrixcyanate catabolism response to toxin sulfate transport3- mercaptopyruvate sulfurtransferase activity thiosulfate sulfurtransferase activity transferase activityy2
moesin MSN27NP_002435cytoplasm cytoskeleton plasma membranecell motilitycytoskeletal protein binding receptor binding structural constituent of cytoskeleton1, 2
methionine sulfoxide reductase A MSRA1NP_036463not classifiedmethionine metabolism protein metabolism protein modification response to oxidative stressoxidoreductase activity protein- methionine- S- oxide reductase activity2
5'- methylthioadenosine phosphorylase MTAP1NP_002442not classifiednucleobase, nucleoside, nucleotide and nucleic acid metabolismS- methyl- 5- thioadenosine phosphorylase activity transferase activity, transferring pentosyl groups actin binding2
methylenetetrahydrofolate dehydrogenase 1 MTHFD14NP_005947mitochondrionamino acid biosynthesis folic acid and derivative biosynthesis histidine biosynthesis methionine biosynthesis one- carbon compound metabolism purine nucleotide biosynthesisATP binding formate- tetrahydrofolate ligase activity hydrolase activity ligase activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase (NADP+) activity nucleotide binding oxidoreductase activity2
mucin 1 isoform 3 precursor MUC17NP_001018017cytoskeleton extracellular region integral to membrane integral to plasma membrane membranenot classifiedactin binding hormone activity2
mucin 1 isoform 7 precursor MUC12NP_001037857cytoskeleton extracellular region integral to membrane integral to plasma membrane membranenot classifiedhormone activity extracellular matrix structural constituent2
MUC1 mucin isoform 1 precursor MUC16NP_002447cytoskeleton extracellular region integral to membrane integral to plasma membrane membranenot classifiedactin binding hormone activity1
mu- protocadherin isoform 2 MUCDHL1NP_060187integral to membrane membranecalcium- dependent cell- cell adhesion cell adhesion homophilic cell adhesioncalcium ion binding protein binding2
melanoma associated antigen (mutated) 1- like 1 MUM1L12NP_689636not classifiednot classifiednot classified2
mucin and cadherin- like isoform 3 MUPCDH1NP_112554integral to membrane membranecalcium- dependent cell- cell cell adhesion homophilic cell adhesionprotein binding actin binding2
major vault protein MVP6NP_005106cytoplasm nucleus ribonucleoprotein complexresponse to drugnot classified2
adlican MXRA51NP_056234not classifiedprotein amino acid phosphorylationATP binding transferase activity vascular endothelial growth factor receptor activity2
matrix- remodelling associated 8 MXRA87NP_115724not classifiednot classifiednot classified1, 2
myosin, heavy polypeptide 13, skeletal muscle MYH131NP_003793muscle myosin myosin striated muscle thick filamentstriated muscle contractionactin binding ATP binding calmodulin binding microfilament motor activity nucleotide binding2
myosin, heavy chain 14 isoform 2 MYH148NP_079005myosinregulation of cell shape sensory perception of soundactin binding ATP binding calmodulin binding motor activity nucleotide binding2
myosin, heavy chain 14 isoform 1 MYH141NP_001070654myosinregulation of cell shape sensory perception of soundATP binding calmodulin binding motor activity nucleotide binding ATP binding2
myosin, heavy chain 3, skeletal muscle, embryonic MYH31NP_002461myosin striated muscle thick filamentactin filament- based movement muscle development striated muscle contractionactin binding ATP binding ATPase activity, coupled calmodulin binding microfilament motor activity nucleotide binding2
myosin, heavy polypeptide 9, non- muscle MYH919NP_002464myosinregulation of cell shape sensory perception of soundactin binding ATP binding calmodulin binding motor activity nucleotide binding1, 2
myosin XV MYO15A1NP_057323cytoskeleton myosinsensory perception of soundactin binding ATP binding calmodulin binding motor activity nucleotide binding structural molecule activity2
myosin IB MYO1B2NP_036355myosinnot classifiedactin binding ATP binding calmodulin binding motor activity nucleotide binding2
myosin IC MYO1C33NP_203693myosin unconventional myosinnot classifiedactin binding ATP binding calmodulin binding motor activity nucleotide binding2
myosin ID MYO1D16NP_056009myosinnot classifiedactin binding ATP binding calmodulin binding motor activity nucleotide binding2
Myosin VBMYO5B1NP_001073936myosinnot classifiedactin binding ATP binding calmodulin binding motor activity nucleotide binding2
myosin VI MYO67NP_004990unconventional myosinactin filament- based movement sensory perception of sound striated muscle contractionactin binding ATP binding ATPase activity, coupled calmodulin binding microfilament motor activity motor activity nucleotide binding structural constituent of muscle2
N- Acetylglucosamine kinase NAGK1NP_060037not classifiedN- acetylglucosamine metabolism N- acetylmannosamine metabolismkinase activity N- acetylglucosamine kinase activity nucleotide binding protein binding transferase activity N- acetyltransferase activity 2
alpha- N- acetylglucosaminidase precursor NAGLU21NP_000254lysosomeglycosaminoglycan metabolism metabolism nervous system developmentalpha- N- acetylglucosaminidase activity hydrolase activity, acting on glycosyl bonds1, 2
N- ethylmaleimide- sensitive factor attachment protein, alpha NAPA1NP_003818endoplasmic reticulum Golgi apparatusER to Golgi vesicle- mediated transport intra- Golgi vesicle- mediated transport intracellular protein transport membrane fusionbinding intracellular transporter activity protein binding2
N- acyl- phosphatidylethanolamine- hydrolyzing phospholipase D NAPE- PLD1NP_945341not classifiednot classifiedhydrolase activity2
N- ethylmaleimide- sensitive factor attachment protein, gamma NAPG1NP_003817endoplasmic reticulum Golgi apparatus membrane fraction mitochondrionER to Golgi vesicle- mediated transport intra- Golgi vesicle- mediated transport intracellular protein transport membrane fusion protein complex assembly protein stabilizationintracellular transporter activity protein binding2
nicotinate phosphoribosyltransferase domain containing 1 NAPRT12NP_660202not classifiedpyridine nucleotide biosynthesisnicotinate phosphoribosyltransferase activity transferase activity, transferring glycosyl groups2
napsin A preproprotein NAPSA8NP_004842not classifiedproteolysispepsin A activity peptidase activity1, 2
NMDA receptor regulated 1- like protein isoform 1 NARG1L1NP_078837cytoplasm nucleus transcription factor complexN- terminal protein amino acid acetylation positive regulation of transcription, DNA- dependentacetyltransferase activity protein binding ribosome binding2
asparaginyl- tRNA synthetase NARS1NP_004530cytoplasm soluble fractionasparaginyl- tRNA aminoacylation aspartyl- tRNA aminoacylation DNA replication protein biosynthesisasparagine- tRNA ligase activity aspartate- tRNA ligase activity ATP binding DNA- directed DNA polymerase activity ligase activity nucleic acid binding nucleotide binding protein binding transferase activity2
N- acetyltransferase 13 NAT131NP_079422cytoplasmN- terminal protein amino acid acetylationprotein binding transferase activity protein binding2
NCK- associated protein 1 isoform 1 NCKAP17NP_038464integral to membrane membraneapoptosis central nervous system developmentprotein binding2
NCK- associated protein 1 isoform 2 NCKAP16NP_995314integral to membrane membraneapoptosis central nervous system developmentcalcium ion binding2
nicastrin precursor NCSTN2NP_056146endoplasmic reticulum Golgi apparatus integral to plasma membrane membraneamyloid precursor protein catabolism membrane protein ectodomain proteolysis Notch receptor processing positive regulation of enzyme activity protein processingprotein binding2
N- myc downstream regulated gene 1 NDRG12NP_006087nucleuscell differentiation response to metal ionnot classified2
N- myc downstream- regulated gene 3 isoform b NDRG31NP_071922cytoplasmcell differentiation negative regulation of cell growth spermatogenesisnot classified2
nebulin NEB2NP_004534actin cytoskeleton striated muscle thin filament Z discregulation of actin filament length somatic muscle developmentactin binding protein binding structural constituent of muscle2
nebulette sarcomeric isoform NEBL1NP_006384actin cytoskeletonregulation of actin filament lengthactin binding structural constituent of muscle zinc ion binding2
nidogen 1 precursor NID11NP_002499basement membrane membranecell adhesion cell- matrix adhesionextracellular matrix structural constituent protein binding hedgehog receptor activity2
delangin isoform B NIPBL1NP_056199nucleuscell cyclebinding2
nitrilase family, member 2 NIT21NP_064587not classifiednitrogen compound metabolismhydrolase activity, acting on carbon- nitrogen (but not peptide) bonds2
NK6 transcription factor related, locus 1 NKX6- 11NP_006159nucleusdevelopment organ morphogenesis regulation of transcription, DNA- dependentsequence- specific DNA binding transcription factor activity2
non- POU domain containing, octamer- binding NONO1NP_031389nucleusDNA recombination DNA repair nuclear mRNA splicing, via spliceosome regulation of transcription, DNA- dependent RNA splicing transcriptionDNA binding nucleotide binding protein binding RNA binding1
NADPH oxidase 3 NOX31NP_056533integral to membrane membraneelectron transportFAD binding iron ion binding oxidoreductase activity2
purine nucleoside phosphorylase NP7NP_000261not classifiedDNA modification nucleobase, nucleoside, nucleotide and nucleic acid metabolismpurine- nucleoside phosphorylase activity2
Niemann- Pick disease, type C1 precursor NPC11NP_000262endoplasmic reticulum integral to membrane lysosome membrane nuclear envelope perinuclear regionbile acid metabolism cholesterol homeostasis cholesterol transport lysosomal transportintracellular transporter activity sterol transporter activity sequence- specific DNA binding2
aminopeptidase puromycin sensitive NPEPPS4NP_006301cytosol nucleusproteolysisaminopeptidase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity zinc ion binding2
nephrin NPHS11NP_004637cell adhesion excretioncell adhesion excretionprotein binding2
podocin NPHS26NP_055440integral to plasma membrane membraneexcretionprotein binding1, 2
nucleophosmin 1 isoform 1 NPM11NP_002511centrosome cytoplasm nucleolus nucleusactivation of NF- kappaB transcription factor anti- apoptosis cell aging centrosome cycle intracellular protein transport negative regulation of cell proliferation nucleocytoplasmic transport response to stress ribosome assembly signal transductionNF- kappaB binding protein heterodimerization activity protein homodimeriation activity RNA binding Tat protein binding unfolded protein binding1
NAD(P)H dehydrogenase, quinone 2 NQO21NP_000895not classifiedelectron transportelectron carrier activity metal ion binding NAD(P)H dehydrogenase (quinone) activity NADPH dehydrogenase (quinone) activity zinc ion binding2
nuclear respiratory factor 1 NRF11NP_001035199nucleusgeneration of precursor metabolites and energy regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA- dependent transcriptiontranscription factor activity ADP reductase activity2
5', 3'- nucleotidase, cytosolic NT5C2NP_055410cytoplasm nucleusdephosphorylation nucleotide metabolism pyrimidine deoxyribonucleotide catabolismhydrolase activity magnesium ion binding nucleotidase activity pyrimidine nucleotide binding2
5' nucleotidase, ecto NT5E1NP_002517membrane membrane fractionDNA metabolism nucleotide catabolism5'- nucleotidase activity GPI anchor binding hydrolase activity, acting on ester bonds metal ion binding nucleotide binding zinc ion binding2
nudix- type motif 5 NUDT52NP_054861intracellularD- ribose catabolism nucleotide metabolism ribonucleoside diphosphate catabolismADP- ribose diphosphatase activity ADP- sugar diphosphatase activity hydrolase activity magnesium ion binding protien binding olfactory receptor activity2
nuclear transport factor 2 NUTF21NP_005787intracellularprotein transportprotein binding1
olfactomedin 4 precursor OLFM419NP_006409membranenot classifiedlatrotoxin receptor activity1, 2
olfactory receptor, family 11, subfamily L, member 1 OR11L11NP_001001959integral to membrane membraneG- protein coupled receptor protein signaling pathway response to stimulus sensory perception of smell signal transductionreceptor activity cysteine- type peptidase activity2
oxysterol- binding protein- like 1A isoform A OSBPL1A1NP_060500intracellularcholesterol metabolism lipid transport steroid metabolism vesicle- mediated transportphospholipid binding2
otubain 1 OTUB12NP_060140not classifiedimmune response ubiquitin cycleprotein binding2
oxidative- stress responsive 1 OXSR12NP_005100not classifiedprotein amino acid phosphorylation protein kinase cascade response to oxidative stressATP binding magnesium ion binding nucleotide binding protein binding protein serine/threonine kinase activity transferase activity2
purinergic receptor P2X4 P2RX42NP_002551integral to membrane integral to plasma membrane membraneion transport signal transductionATP binding ATP- gated cation channel activity ion channel activity receptor activity1, 2
prolyl 4- hydroxylase, beta subunit P4HB1NP_000909cell surface endoplasmic reticulum ER- Golgi intermediate compartment extracellular region membranepeptidyl- proline hydroxylation to 4- hydroxy- L- proline protein foldingelectron carrier activity isomerase activity procollagen- proline 4- dioxygenase activity protein disulfide isomerase activity protein disulfide oxidoreductase activity1
protein kinase C and casein kinase substrate in neurons 2 PACSIN24NP_009160cytoplasmactin cytoskeleton organization and biogenesis endocytosis intracellular protein transporttransporter activity2
protein kinase C and casein kinase substrate in neurons 3 PACSIN34NP_057307cytoplasmendocytosis negative regulation of endocytosiscytoskeletal protein binding enzyme binding1, 2
peptidyl arginine deiminase, type II PADI21NP_031391not classifiedprotein modificationcalcium ion binding hydrolase activity protein- arginine deiminase activity2
platelet- activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD)PAFAH1B11NP_000421astral microtubule cell cortex cytoskeleton kinetochore microtubule microtubule associated complex nuclear envelopecell cycle cell differentiation cell division cell motility establishment of mitotic spindle orientation lipid catabolism microtubule- based process mitosis nervous system development signal transduction transportdynein binding2
platelet- activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa PAFAH1B21NP_002563not classifiedlipid catabolism1- alkyl- 2- acetylglycerophosphocholine esterase activity hydrolase activity, acting on ester bonds2
PAR- 6 beta PARD6B1NP_115910plasma membrane tight junctionaxonogenesis cell cycle cell division establishment and/or maintenance of cell polarity intercellular junction assembly regulation of cell migrationnot classified2
DJ- 1 protein PARK71NP_009193cytoplasm nucleusprotein folding Ras protein signal transductioncatalytic activity2
poly (ADP- ribose) polymerase family, member 4 PARP41NP_006428intracellular nucleus ribonucleoprotein complexcell death DNA repair inflammatory response protein amino acid ADP- ribosylation response to drug transportDNA binding enzyme binding NAD+ ADP- ribosyltransferase activity transferase activity, transferring glycosyl groups2
MAWD binding protein isoform a PBLD4NP_071412not classifiedbiosynthesiscatalytic activity isomerase activity2
MAWD binding protein isoform b PBLD1NP_001028255not classifiedbiosynthesisisomerase activity calcium ion binding2
pterin- 4 alpha- carbinolamine dehydratase precursor PCBD11NP_000272not classifiedtetrahydrobiopterin biosynthesis4- alpha- hydroxytetrahydrobiopterin dehydratase activity identical protein binding lyase activity2
poly(rC) binding protein 1 PCBP11NP_006187cytoplasm nucleus ribonucleoprotein complexmRNA metabolismDNA binding protein binding RNA binding single- stranded DNA binding2
cytosolic phosphoenolpyruvate carboxykinase 1 PCK14NP_002582cytosolgluconeogenesisGTP binding lyase activity nucleotide binding phosphoenolpyruvate carboxykinase (GTP) activity2
protocadherin LKC precursor PCLKC1NP_060145integral to membrane membranecell adhesion homophilic cell adhesion negative regulation of cell growthprotein binding not classified2
prenylcysteine oxidase 1 PCYOX14NP_057381lysosomeprenylated protein catabolism prenylcysteine metabolismlyase activity oxidoreductase activity prenylcysteine oxidase activity2
programmed cell death 10 PDCD102NP_009148not classifiedapoptosisnot classified2
programmed cell death 2 isoform 1 PDCD21NP_002589cytoplasm nucleusapoptosisDNA binding metal ion binding protein binding zinc ion binding2
programmed cell death 6 PDCD611NP_037364not classifiedapoptosis induction of apoptosis by extracellular signalscalcium ion binding1, 2
programmed cell death 6 interacting protein PDCD6IP42NP_037506cytosolapoptosis protein transportsignal transducer activity1, 2
Parkinson disease 7 domain containing 1 PDDC11NP_872418not classifiednot classifiednot classified2
phosphodiesterase 8A isoform 2 PDE8A1NP_775656not classifiedcyclic nucleotide metabolism regulation of transcription, DNA- dependent two- component signal transduction system (phosphorelay)hydrolase activity magensium ion binding manganese ion binding two- component response regulator activity 6- phosphofructokinase activity2
pyridoxal kinase PDXK1NP_003672not classifiednot classifiedATP binding metal ion binding nucleotide binding pyridoxal kinase activity transferase activity zinc ion binding2
PDZ domain containing 1 PDZK116NP_002605not classifieddrug transportPDZ domain binding protein C- terminus binding2
PDZK1 interacting protein 1 PDZK1IP14NP_005755extracellular region integral to membrane membranenot classifiednot classified1, 2
prostatic binding protein PEBP18NP_002558not classifiednot classifiedATP binding lipid binding nucleotide binding phosphatidylethanolamine binding serine- type endopeptidase inhibitor activity1, 2
penta- EF hand domain containing 1 PEF15NP_036524membranenot classifiedcalcium ion binding protein binding1, 2
Xaa- Pro dipeptidase PEPD1NP_000276not classifiedamino acid metabolism collagen catabolism proteolysismanganese ion binding metal ion binding metallocarboxypeptidase D activity X- Pro dipeptidase activity2
phosphonoformate immuno- associated protein 5 PFAAP51NP_055702not classifiednot classifiednot classified2
liver phosphofructokinase isoform b PFKL11NP_0026176- phosphofructokinase complex cytoplasmfructose 6- phosphate metabolism glycolysis regulation of glycolysis6- phosphofructokinase activity ATP binding kinase activity magnesium ion binding nucleotide binding transferase activity2
liver phosphofructokinase isoform a PFKL6NP_0010020216- phosphofructokinase complex cytoplasmfructose 6- phosphate metabolism glycolysis regulation of glycolysisATP binding kinase activity magnesium ion binding nucleotide binding trnasferase activity hydrolase activity2
profilin 1 PFN15NP_005013actin cytoskeletonactin cytoskeleton organization and biogenesis cytoskeleton organization and biogenesisactin monomer binding1, 2
profilin 2 isoform a PFN21NP_444252actin cytoskeletonactin cytoskeleton organization and biogenesis cytoskeleton organization and biogenesis regulation of actin polymerization and/or depolymerizationactin binding phosphatidylinositol- 4, 5- bisphosphate binding protein binding1, 2
phosphogluconate dehydrogenase PGD6NP_002622not classifiedelectron transport pentose- phosphate shunt, oxidative branchNADP binding oxidoreductase activity phosphogluconate dehydrogenase (decarboxylating) activity protein binding2
6- phosphogluconolactonase PGLS4NP_036220not classifiedcarbohydrate metabolism pentose- phosphate shunt6- phosphogluconolactonase activity hydrolase activity1, 2
peptidoglycan recognition protein 1 PGLYRP11NP_005082extracellular regiondefense response to Gram- positive bacterium detection of bacterium innate immune response peptidoglycan catabolismbacterial binding N- acetylmuramoyl- L- alanine amidase activity peptidoglycan receptor activity protein binding2
phosphoglucomutase 1 PGM12NP_002624cytoplasmcarbohydrate metabolism gluconeogenesis glucose metabolism glycolysisintramolecular transferase activity, phosphotransferases isomerase activity magnesium ion binding phosphoglucomutase activity2
PHD finger protein 15 PHF151NP_056103not classifiedregulation of transcription, DNA- dependentmetal ion binding protein binding zinc ion binding2
phosphoglycerate dehydrogenase PHGDH2NP_006614extracellular regionamino acid biosynthesis brain development L- serine biosynthesis metabolism transportelectron carrier activity NAD binding oxidoreductase activity oxidoreductase activity, acting on the CH- OH group of donors, NAD or NADP as acceptor phosphoglycerate dehydrogenase activity transporter activity2
phosphohistidine phosphatase 1 PHPT12NP_054891cytoplasm cytosoldephosphorylationphosphohistidine phosphatase activity phosphoprotein phosphatase activity kinase activity2
polymeric immunoglobulin receptor PIGR17NP_002635integral to plasma membrane membraneprotein secretionprotein transporter activity1, 2
phosphoinositide- 3- kinase, class 2, alpha polypeptide PIK3C2A1NP_002636nucleus phosphoinositide 3- kinase complexintracellular signaling cascade phosphatidylinositol biosynthesisinositol or phosphatidylinositol kinase activity phosphatidylinositol 3- kinase activity phosphatidylinositol- 4- phosphate 3- kinase activity phosphoinositide binding protein binding transferase activity2
phosphoinositide- 3- kinase, class 2, beta polypeptide PIK3C2B1NP_002637cytosol microsome nucleus phosphoinositide 3- kinase complex plasma membraneintracellular signaling cascadeinositol or phosphatidylinositol kinase activity kinase activity phosphatidylinositol 3- kinase activity phosphatidylinositol- 4- phosphate 3- kinase activity phosphoinositide binding phosphotransferase activity, alcohol group as acceptor protein binding tran1
prolactin- induced protein PIP2NP_002643extracellular regionnot classifiedactin binding2
phosphatidylinositol- 5- phosphate 4- kinase, type II, gamma PIP4K2C1NP_079055not classifiednot classifiedkinase activity magnesium ion binding2
polycystin 1 isoform 1 precursor PKD11NP_001009944extracellular matrix (sensu Metazoa) integral to membrane integral to plasma membrane membranecalcium- independent cell- matrix adhesion homophilic cell adhesion morphogenesis neuropeptide signaling pathwaysugar binding transferase activity1, 2
polycystin 1- like 3 PKD1L31NP_853514integral to membrane membranecation transport neuropeptide signaling pathwaycalcium ion binding cation channel activity2
polycystin 2 PKD21NP_000288actin cytoskeleton basal body integral to membrane membrane plasma membranecation transport cell- matrix adhesion organ morphogenesiscalcium ion binding cytoskeletal protein binding ion channel activity protein C- terminus binding voltage- gated chloride channel activity voltage- gated sodium channel activity2
polyductin isoform 2 PKHD16NP_733842anchored to external side of plasma membrane apical plasma membrane basal body integral to membrane membranecell- cell adhesion homeostasis negative regulation of cell motilityprotein binding receptor activity2
pyruvate kinase, liver and RBC isoform 1 PKLR1NP_000289not classifiedglycolysismagnesium ion binding pyruvate kinase activity2
pyruvate kinase, liver and RBC isoform 2 PKLR1NP_870986not classifiedglycolysispyruvate kinase activity magnesium ion binding2
pyruvate kinase 3 isoform 2 PKM217NP_872270cytoplasm cytosolglycolysismagnesium ion binding protein binding pyruvate kinase activity transferase activity2
phospholipase C, delta 1 PLCD18NP_006216not classifiedintracellular signaling cascade lipid catabolism lipid metabolism phospholipid metabolismcalcium ion binding hydrolase activity phosphoinositide phospholipase C activity signal transducer activity2
phospholipase D3 isoform 1 PLD31NP_001026866membranemetabolismcatalytic activity2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 PLEKHA11NP_001001974membrane nucleusnot classifiedphospholipid binding2
pleckstrin homology domain containing, family A member 7 PLEKHA71NP_778228not classifiednot classifiednot classified2
lysyl hydroxylase precursor PLOD11NP_000293endoplasmic reticulum membraneelectron transport epidermis development hydroxylysine biosynthesis protein metabolism protein modificationiron ion binding L- ascorbic acid binding metal ion binding oxidoreductase activity procollagen- lysine 5- dioxygenase activity protein homodimerization activity2
procollagen- lysine, 2- oxoglutarate 5- dioxygenase 3 precursor PLOD31NP_001075endoplasmic reticulum membraneprotein metabolism protein modificationiron ion binding L- ascorbic acid binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen procollagen- lysine 5- dioxygenase activity prot2
plastin 1 PLS11NP_002661actin cytoskeleton brush bordernot classifiedactin filament binding calcium ion binding structural constituent of cytoskeleton2
phospholipid scramblase 1 PLSCR12NP_066928integral to membrane plasma membranephospholipid scrambling platelet activation response to viruscalcium ion binding phospholipid scramblase activity protein binding1, 2
phosphomevalonate kinase PMVK1NP_006547cytoplasm peroxisomecholesterol biosynthesis lipid metabolism protein amino acid phosphorylationphosphomevalonate kinase activity transferase activity2
podocalyxin- like precursor isoform 2 PODXL8NP_005388integral to plasma membrane membranenot classifiednot classified2
phosphatidic acid phosphatase type 2A isoform 2 PPAP2A2NP_795714integral to plasma membrane membrane fraction plasma membraneandrogen receptor signaling pathway germ cell migration negative regulation of cell proliferation phospholipid dephosphorylation protein kinase C activation regulation of lipid metabolismhydrolase activity phosphatidate phosphatase activity2
PTPRF interacting protein alpha 2 PPFIA21NP_003616cytoplasmcell- matrix adhesionprotein binding2
peptidylprolyl isomerase A PPIA5NP_066953not classifiedprotein folding regulation of viral genome replicationisomerase activity peptide binding peptidyl- prolyl cis- trans isomerase activity unfolded protein binding virion binding2
peptidylprolyl isomerase B precursor PPIB1NP_000933ndoplasmic reticulum endoplasmic reticulum lumenprotein foldingisomerase activity peptide binding peptidyl- prolyl cis- trans isomerase activity unfolded protein binding2
periplakin PPL18NP_002696cytoskeletonkeratinizationprotein binding structural constituent of cytoskeleton2
protein phosphatase 1, regulatory subunit 7 PPP1R71NP_002703cytoplasm nucleusnot classifiedtransferase activity oxidoreductase activity2
prolylcarboxypeptidase isoform 2 preproprotein PRCP1NP_955450lysosomeproteolysisserine- type peptidase activity serine- type Pro- X carboxypeptidase activity2
peroxiredoxin 5 precursor, isoform a PRDX52NP_036226mitochondrion peroxisomeinflammatory response response to oxidative stressoxidoreductase activity peroxiredoxin activity2
peroxiredoxin 5 precursor, isoform c PRDX52NP_857635mitochondrion perosixomeinflammatory response response to oxidative stressoxidoreductase activity peroxiredoxin activity2
peroxiredoxin 5 precursor, isoform b PRDX51NP_857634mitochondrion peroxisomeregulation of apoptosis response to oxidative stressperoxiredoxin activity ATP binding2
peroxiredoxin 6 PRDX67NP_004896cytosol lysosomelipid catabolism phospholipid catabolism response to oxidative stresshydrolase activity oxidoreductase activity peroxiredoxin activity phospholipase A2 activity1, 2
cAMP- dependent protein kinase, regulatory subunit alpha 2 PRKAR2A1NP_004148cAMP- dependent protein kinase complex cytoplasm membrane fraction plasma membraneintracellular signaling cascade protein amino acid phosphorylation signal transductioncAMP binding cAMP- dependent protein kinase regulator activity kinase activity nucleotide binding2
protein kinase C, alpha PRKCA1NP_002728membrane fractioncell surface receptor linked signal transduction induction of apoptosis by extracellular signals intracellular signaling cascade protein amino acid phosphorylation regulation of progression through cell cycleATP binding calcium ion binding diacylglycerol binding nucleotide binding protein binding protein kinase C activity transferase activity zinc ion binding2
protein kinase C, delta PRKCD1NP_006245cytoplasm membrane nucleusintracellular signaling cascade protein amino acid phosphorylation protein stabilizationATP binding diacylglycerol binding diacylglycerol- activated phospholipid- dependent protein kinase C activity enzyme activator activity enzyme binding metal ion binding nucleotide binding protein C- terminus binding protein serine/threonine kinase activity 2
protein kinase C, eta PRKCH1NP_006246not classifiedintracellular signaling cascade protein amino acid phosphorylationATP binding diacylglycerol binding metal ion binding nucleotide binding protein kinase C activity transferase activity zinc ion binding2
protein kinase C, iota PRKCI1NP_002731cytosol nucleus polarisomecytoskeleton organization and biogenesis establishment and/or maintenance of epithelial cell polarity intercellular junction assembly and maintenance intracellular signaling cascade membrane organization and biogenesis protein amino acid phosphorylation pATP binding atypical protein kinase C activity diacylglycerol binding metal ion binding nucleotide binding phospholipid binding protein binding protein serine/threonine kinase activity transferase activity zinc ion binding2
protein kinase C, zeta isoform 1 PRKCZ1NP_002735cytoplasm membrane fraction plasma membraneanti- apoptosis intracellular signaling cascade protein amino acid phosphorylationATP binding atypical protein kinase C activity diacylglycerol binding metal ion binding nucleotide binding protein binding protein serine/threonine kinase activity transferase activity zinc ion binding2
protein kinase C, zeta isoform 2 PRKCZ1NP_001028754cytoplasm membrane fraction plasma membraneanti- apoptosis intracellular signaling cascade protein amino acid phosphorylationatypical protein kinase C activity diacylglycerol binding metal ion binding nucleotide binding protein binding protien serine/threonine kinase activity transferase activity zinc ion binding copper ion binding2
PRKR interacting protein 1 (IL11 inducible) PRKRIP11NP_078929not classifiednot classifiednot classified2
prion protein preproprotein PRNP1NP_898902cytoplasm endoplasmic reticulum extrinsic to membrane Golgi apparatus lipid raft plasma membranecopper ion homeostasis metabolism response to oxidative stresscopper ion binding GPI anchor binding microtubule binding2
prominin 1 PROM123NP_006008integral to plasma membrane membraneresponse to stimulus visual perceptionnot classified1, 2
prominin 2 PROM218NP_653308integral to membranenot classifiednot classified2
protein Z, vitamin K- dependent plasma glycoprotein PROZ4NP_003882extracellular region extracellular spaceblood coagulation proteolysiscalcium ion binding protein binding serine- type endopeptidase activity2
prostasin preproprotein PRSS84NP_002764extracellular region extracellular space integral to membrane plasma membraneproteolysisserine- type endopeptidase activity2
proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) PRTN31NP_002768not classifiedcollagen catabolism positive regulation of cell proliferation proteolysisprotein binding serine- type endopeptidase activity2
prosaposin isoform a preproprotein PSAP3NP_002769extracellular space integral to membrane lysosomeglycosphingolipid metabolism lipid metabolism lipid transport lysosome organization and biogenesis sphingolipid metabolismalpha- galactosidase activity beta- galactosidase activity cerebroside- sulfatase activity enzyme activator activity galactosylceramidase activity glucosylceramidase activity lipid binding sphingomyelin phosphodiesterase activity1, 2
prosaposin isoform c preproprotein PSAP1NP_001035931extracellular space integral to membrane lysosomeglycosphingolipid metabolism lipid metabolism lipid transport lysosome organization and biogenesis sphingolipid metabolismbeta- galactosidase activity cerebroside- sulfatase activity enzyme activator activity galactosylceramidase activity glucosylceramidase activity lipid binding sphingomyelin phosphodiesterase activity phosphoserine transaminase activity2
phosphoserine aminotransferase isoform 1 PSAT12NP_478059not classifiedamino acid biosynthesis L- serine biosynthesis metabolism pyridoxine biosynthesistransferase activity RNA binding2
prostate stem cell antigen preproprotein PSCA1NP_005663plasma membranenot classifiedGPI anchor binding1, 2
proteasome alpha 1 subunit isoform 1 PSMA12NP_683877cytosol nucleus polysome proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismthreonine endopeptidase activity2
proteasome alpha 2 subunit PSMA22NP_002778cytosol proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismthreonine endopeptidase activity2
proteasome alpha 3 subunit isoform 2 PSMA31NP_687033cytoplasm cytosol nucleus proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismprotein binding threonine endopeptidase activity2
proteasome alpha 4 subunit PSMA41NP_002780cytosol proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismthreonine endopeptidase activity2
proteasome alpha 5 subunit PSMA52NP_002781cytosol proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismhydrolase activity, acting on ester bonds2
proteasome beta 1 subunit PSMB11NP_002784cytosol proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismprotein binding threonine endopeptidase activity2
proteasome beta 2 subunit PSMB21NP_002785cytosol nucleus proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismpeptidase activity threonine endopeptidase activity2
proteasome beta 3 subunit PSMB34NP_002786cytosol nucleus proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismthreonine endopeptidase activity1, 2
proteasome beta 5 subunit PSMB53NP_002788cytosol proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismprotein binding threonine endopeptidase activity2
proteasome beta 6 subunit PSMB61NP_002789cytosol proteasome core complex (sensu Eukaryota)ubiquitin- dependent protein catabolismthreonine endopeptidase activity2
proteasome 26S ATPase subunit 5 PSMC51NP_002796cytoplasm cytosol nucleus proteasome complex (sensu Eukaryota)negative regulation of programmed cell death positive regulation of gene- specific transcription proteasomal ubiquitin- dependent protein catabolism protein catabolismATP binding ATPase activity hydrolase activity nucleotide binding thyrotropin- releasing hormone receptor binding transcription factor binding2
proteasome 26S ATPase subunit 6 PSMC61NP_002797cytoplasm cytosol nucleus proteasome complex (sensu Eukaryota)protein catabolism ubiquitin- dependent protein catabolismATP binding ATPase activity hydrolase activity nucleic acid binding nucleotide binding protein binding, bridging2
proteasome 26S non- ATPase subunit 12 PSMD121NP_002807cytosol proteasome regulatory particle (sensu Eukaryota)not classifiednot classified2
proteasome 26S non- ATPase subunit 3 PSMD31NP_002800cytosol proteasome complex (sensu Eukaryota) protein complexnot classifiedbinding2
proteasome activator subunit 2 PSME21NP_002809cytosol proteasome activator complex proteasome complex (sensu Eukaryota)immune responseproteasome activator activity2
polypyrimidine tract- binding protein 1 isoform a PTBP11NP_002810heterogeneous nuclear ribonucleoprotein complex nucleolus nucleoplasm nucleusnuclear mRNA splicing, via spliceosome RNA splicingnucleic acid binding nucleotide binding poly- pyrimidine tract binding protein binding RNA binding1
phosphotriesterase related PTER2NP_109589not classifiedcatabolismhydrolase activity, acting on ester bonds metal ion binding zinc ion binding2
protein tyrosine phosphatase type IVA, member 2 isoform 2 PTP4A21NP_536317membraneprotein amino acid dephosphorylationprenylated protein tyrosine phosphatase activity hydrolase activity2
protein tyrosine phosphatase, non- receptor type 13 isoform 4 PTPN139NP_542416cytoplasm cytoskeletonprotein amino acid dephosphorylationhydrolase activity non- membrane spanning protein tyrosine phosphatase activity protein binding structural molecule activity2
protein tyrosine phosphatase, non- receptor type 23 PTPN234NP_056281not classifiedprotein amino acid dephosphorylationhydrolase activity protein tyrosine phosphatase activity2
protein tyrosine phosphatase, non- receptor type 6 isoform 3 PTPN61NP_536859cytoskeleton membraneapoptosis G- protein coupled receptor protein signaling pathway intracellular signaling cascade negative regulation of cell proliferation protein amino acid dephosphorylationhydrolase activity protein binding protein tyrosine phosphatase activity2
protein tyrosine phosphatase, receptor type, J precursor PTPRJ1NP_002834integral to plasma membrane membranecell- cell signaling protein amino acid dephosphorylation transmembrane receptor protein tyrosine kinase signaling pathwayhydrolase activity transmembrane receptor protein tyrosine phosphatase activity1, 2
receptor- type protein tyrosine phosphatase O isoform d precursor PTPRO2NP_109595integral to membrane integral to plasma membrane membraneprotein amino acid dephosphorylationhydrolase activity protein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity2
receptor- type protein tyrosine phosphatase O isoform c precursor PTPRO2NP_109596integral to membrane integral to plasma membrane membraneprotein amino acid dephosphorylationprotein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity not classified 2
pituitary tumor- transforming gene 1 protein- interacting protein precursor PTTG1IP1NP_004330cytoplasm integral to membrane membrane nucleusdevelopment protein import into nucleusGTP binding2
quinoid dihydropteridine reductase QDPR1NP_000311cytoplasmamino acid metabolism dihydrobiopterin metabolism L- phenylalanine catabolism metabolism tetrahydrobioprotein biosynthesis6, 7- dihydropteridine reductase activity electron carrier activity2
ras- related GTP- binding protein RAB10 RAB1010NP_057215membraneprotein transport small GTPase mediated signal transductionGTP binding nucleotide binding1, 2
RAB13, member RAS oncogene family RAB132NP_002861intracellular tight junctioncell adhesion protein transport regulation of transcription, DNA- dependent small GTPase mediated signal transduction vesicle- mediated transportATP binding GTP binding GTPase activity nucleotide binding transcription factor binding1, 2
GTPase Rab14 RAB146NP_057406cytosol early endosome Golgi stack intracellular late endosome lysosome membrane fraction nuclear envelope- endoplasmic reticulum network perinuclear region plasma membrane rough endoplasmic reticulum trans- Golgi network transport vesicleGolgi to endosome transport intracellular transport neurotransmitter secretion protein transport small GTPase mediated signal transduction vesicle- mediated transportGTP binding GTPase activity nucleotide binding1, 2
RAB15, member RAS onocogene family RAB151NP_941959membraneprotein transport small GTPase mediated signal transductionnucleotide binding GTP binding2
RAB17, member RAS oncogene family RAB171NP_071894intracellular membraneprotein transport small GTPase mediated signal transductionGTP binding nucleotide binding2
GTP- binding protein RAB19BRAB19B1NP_001008749not classifiedsmall GTPase mediated signal transductionGTP binding nucleotide binding2
RAB2, member RAS oncogene family RAB26NP_002856endoplasmic reticulumER to Golgi vesicle- mediated transport protein transport small GTPase mediated signal transductionGTP binding nucleotide binding1, 2
RAB21, member RAS oncogene family RAB212NP_055814endosomeprotein transport small GTPase mediated signal transductionGTP binding nucleotide binding1, 2
RAS- related protein RAB- 22A RAB22A6NP_065724early endosome plasma membrane endocytosis endosome organization and biogenesis protein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding protein binding2
RAB25 RAB251NP_065120membraneprotein transport small GTPase mediated signal transductionGTP binding nucleotide binding2
Ras- related protein Rab- 27A RAB27A1NP_004571not classifiedprotein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding2
RAB33B, member RAS oncogene family RAB33B1NP_112586Golgi apparatusprotein transport small GTPase mediated signal transductionGTP binding nucleotide binding1
RAB39 RAB341NP_114140membraneprotein transport small GTPase mediated signal transductionnucleotide binding GTP binding2
RAB35, member RAS oncogene family RAB354NP_006852membraneprotein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding1, 2
RAB3B, member RAS oncogene family RAB3B2NP_002858membraneprotein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding1, 2
RAB3D, member RAS oncogene family RAB3D1NP_004274membraneexocytosis hemocyte development (sensu Arthropoda) protein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding protein binding1, 2
RAB3 GTPase- activating protein RAB3GAP11NP_036365soluble fractionregulation of GTPase activityRab GTPase binding GTP binding2
RAB43 protein RAB431NP_940892exosome (RNase complex) membraneintracellular protein transport small GTPase mediated signal transductionGTP binding nucleotide binding2
RAB5B, member RAS oncogene family RAB5B5NP_002859endosome intracellularprotein transport small GTPase mediated signal transductionGTP binding GTP- dependent protein binding nucleotide binding1, 2
RAB5C, member RAS oncogene family isoform a RAB5C5NP_958842not classifiedprotein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding2
RAB7, member RAS oncogene family RAB79NP_004628late endosome lysosomeendocytosis protein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding1, 2
RAB7, member RAS oncogene family- like 1 RAB7L14NP_003920membraneprotein transport small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding protein binding2
mel transforming oncogene RAB8A5NP_005361membraneprotein transport small GTPase mediated signal transductionGTP binding nucleotide binding1, 2
RAB8B, member RAS oncogene family RAB8B2NP_057614intracellular membraneprotein transport regulation of transcription, DNA- dependent small GTPase mediated signal transductionATP binding GTP binding GTPase activity nucleotide binding transcription factor binding1, 2
ras- related C3 botulinum toxin substrate 1 isoform Rac1 RAC16NP_008839intracellularactin filament polymerization lamellipodium biogenesis negative regulation of receptor mediated endocytosis positive regulation of Rho protein signal transduction ruffle organization and biogenesis small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding protein binding1
ras related v- ral simian leukemia viral oncogene homolog A RALA2NP_005393intracellular membranechemotaxis signal transduction small GTPase mediated signal transductionGTP binding nucleotide binding protein binding2
ras- related nuclear protein RAN2NP_006316chromatin cytoplasm exosome (RNase complex) nuclear pore nucleusandrogen receptor signaling pathway DNA metabolism intracellular protein transport mitosis mitotic spindle organization and biogenesis positive regulation of transcription, DNA- dependent protein export from nucleus regulation of progression through cell candrogen receptor binding chromatin binding GTP binding GTPase activity nucleotide binding protein binding transcription coactivator activity2
RAP1B, member of RAS oncogene family RAP1B5NP_056461intracellular membranesmall GTPase mediated signal transductionGTP binding nucleotide binding1
RAP1, GTP- GDP dissociation stimulator 1 RAP1GDS11NP_066982not classifiednot classifiedbinding GTPase activator activity2
RAP2B, member of RAS oncogene family RAP2B1NP_002877intracellular membranesmall GTPase mediated signal transductionGTP binding nucleotide binding2
RAP2C, member of RAS oncogene family RAP2C1NP_067006intracellular membranesmall GTPase mediated signal transductionnucleotide binding intracellular transporter activity2
RAP guanine- nucleotide- exchange factor 3 RAPGEF32NP_006096cAMP- dependent protein kinase complex intracellular membrane fractioncell proliferation protein amino acid phosphorylation regulation of small GTPase mediated signal transductioncAMP binding cAMP- dependent protein kinase regulator activity guanyl- nucleotide exchange factor activity nucleotide binding2
arginyl- tRNA synthetase RARS1NP_002878cytoplasm soluble fractionarginyl- tRNA aminoacylation protein biosynthesisarginine- tRNA ligase activity ATP binding ligase activity nucleotide binding2
retinoblastoma- like 2 (p130) RBL21NP_005602nucleuscell cycle negative regulation of progression through cell cycle regulation of lipid kinase activity regulation of transcription, DNA- dependent transcriptionDNA binding protein binding2
RNA binding motif protein 3 isoform a RBM31NP_006734not classifiedRNA processingnucleic acid binding nucleotide binding RNA binding1
retinol- binding protein 4, plasma precursor RBP42NP_006735extracellular region extracellular spaceresponse to stimulus transport visual perceptionbinding retinal binding retinol binding transporter activity2
retinol binding protein 5, cellular RBP51NP_113679cytoplamstransportintracellular transporter activity lipid binding retinal binding retinol binding1, 2
radixin RDX16NP_002897actin cytoskeleton cytoplasm plasma membranebarbed- end actin filament capping cytoskeletal anchoringactin binding binding structural molecule activity1, 2
renin binding protein RENBP1NP_002901intracellularblood pressure regulation mannose metabolismendopeptidase inhibitor activity isomerase activity mannose- 6- phosphate isomerase activity N- acylglucosamine 2- epimerase activity2
replication factor C large subunit RFC11NP_002904DNA replication factor C complex intracellular nucleusDNA- dependent DNA replication regulation of transcription, DNA- dependent telomere maintenance via telomerase transcriptionDNA binding enzyme activator activity metal ion binding nucleoside- triphosphatase activity nucleotide binding protein binding zinc ion binding methyltransferase activity2
RNA (guanine- 9- ) methyltransferase domain containing 2 RG9MTD21NP_689505not classifiedtRNA processingRNA binding tranferase activity tRNA methyltransferasea activity GTP binding2
Rhesus blood group, C glycoprotein RHCG5NP_057405apical plasma membrane integral to plasma membrane plasma membraneamine transport ammonium transport cell ion homeostasis epithelial cell differentiation homeostasisammonium transporter activity1, 2
Ras homolog enriched in brain RHEB1NP_005605intracellular membranesignal transduction small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding2
ras homolog gene family, member A RHOA4NP_001655cytoskeleton intracellular membraneactin cytoskeleton organization and biogenesis positive regulation of I- kappaB kinase/NF- kappaB cascade positive regulation of NF- kappaB import into nucleus Rho protein signal transduction small GTPase mediated signal transductionGTP binding GTPase activity magnesium ion binding nucleotide binding protein binding signal transducer activity1, 2
ras homolog gene family, member B RHOB1NP_004031endosome membrane intracellular nucleus plasma membraneangiogenesis cell adhesion cell cycle cell differentiation endosome to lysosome transport negative regulation of progression through cell cycle positive regulation of angiogenesis protein transport small GTPase mediated signal transduction transformed celGTP binding nucleotide binding protein binding2
ras homolog gene family, member C precursor RHOC1NP_786886intracellular membranepositive regulation of I- kappaB kinase/NF- kappaB cascade small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding signal transducer activity2
ras homolog gene family, member F RHOF1NP_061907cytoskeleton intracellular membraneactin filament organization small GTPase mediated signal transductionGTP binding GTPase activity nucleotide binding2
ras homolog gene family, member G RHOG5NP_001656intracellular membranepositive regulation of cell proliferation regulation of progression through cell cycle Rho protein signal transductionGTP binding GTPase activity nucleotide binding protein binding1, 2
ribonuclease, RNase A family, 2 (liver, eosinophil- derived neurotoxin) RNASE21NP_002925extracellular regionchemotaxis RNA catabolismendonuclease activity hydrolase activity nucleic acid binding pancreatic ribonuclease activity ribonuclease activity1
ring finger protein 11 RNF111NP_055187ubiquitin ligase complexprotein ubiquitination during ubiquitin- dependent protein catabolismDNA binding metal ion binding protein binding zinc ion binding1, 2
ring finger protein 213 RNF2131NP_065965not classifiednot classifiedprotein binding zinc ion binding protein binding2
ribonuclease/angiogenin inhibitor RNH14NP_976318not classifiedmRNA catabolism regulation of angiogenesisprotein binding ribonuclease inhibitor activity transferase activity2
arginyl aminopeptidase (aminopeptidase B) RNPEP4NP_064601extracellular region Golgi apparatus plasma membraneprotein processing proteolysisaminopeptidase B activity epoxide hydrolase activity membrane alanyl aminopeptidase activity metal ion binding zinc ion binding2
roundabout, axon guidance receptor, homolog 2 ROBO21NP_002933cell surface integral to membrane membranebrain development cell adhesion cell differentiation chemotaxis homophilic cell adhesion positive regulation of axonogenesis ureteric bud developmentaxon guidance receptor activity identical protein binding2
XRP2 protein RP23NP_008846not classifiedbeta- tubulin folding CTP biosynthesis GTP biosynthesis response to stimulus UTP biosynthesis visual perceptionATP binding nucleoside diphosphate kinase activity unfolded protein binding2
ribosomal protein S11 RPS111NP_001006cytosolic small ribosomal subunit (sensu Eukaryota) intracellular ribosomeprotein biosynthesisrRNA binding structural constituent of ribosome2
ribosomal protein S18 RPS182NP_072045cytosolic small ribosomal subunit (sensu Eukaryota) intracellularprotein biosynthesisrRNA binding structural constituent of ribosome2
related RAS viral (r- ras) oncogene homolog RRAS4NP_006261intracellularRas protein signal transductionGTP binding GTPase activity nucleotide binding2
related RAS viral (r- ras) oncogene homolog 2 RRAS24NP_036382intracellular membranesmall GTPase mediated signal transductionGTP binding nucleotide binding protein binding1, 2
ras responsive element binding protein 1 isoform 1 RREB11NP_001003699cytoplasm intracellular nuclear body nucleusdevelopment Ras protein signal transduction regulation of transcription, DNA- dependent transcription transcription from RNA polymerase II promoterDNA binding metal ion binding nucleic acid binding transcriptional activator activity zinc ion binding2
RUN and SH3 domain containing 2 RUSC21NP_055621not classifiednot classifiednot classified2
skeletal muscle ryanodine receptor isoform 1 RYR11NP_000531integral to plasma membrane membrane smooth endoplasmic reticulumcalcium ion homeostasis calcium ion transport ion transport muscle contractioncalcium ion binding calcium- release channel activity ion channel activity receptor activity ryanodine- sensitive calcium- release channel activity2
S100 calcium binding protein A10 S100A101NP_002957not classifiednot classifiedcalcium ion binding2
S100 calcium binding protein A14 S100A142NP_065723not classifiednot classifiedcalcium ion binding2
S100 calcium binding protein A16 S100A161NP_525127not classifiednot classifiedcalcium ion binding1, 2
S100 calcium- binding protein A4 S100A41NP_002952not classifiednot classifiedcalcium ion binding2
S100 calcium- binding protein A6 S100A62NP_055439cytoplasm nuclear envelope nucleus ruffleaxonogenesis cell cycle cell proliferation cell- cell signaling positive regulation of fibroblast proliferation regulation of progression through cell cycle signal transductioncalcium ion binding calcium- dependent protein binding growth factor activity protein homodimerization activity S100 beta binding1, 2
S100 calcium- binding protein A8 S100A86NP_002955extracellular spaceinflammatory responsecalcium ion binding2
S100 calcium- binding protein A9 S100A97NP_002956extracellular spacecell- cell signaling inflammatory responsecalcium ion binding signal transducer activity2
S100 calcium binding protein P S100P1NP_005971cytoplasm nucleusendothelial cell migrationcalcium ion binding calcium- dependent protein binding magnesium ion binding1, 2
sorting and assembly machinery component 50 homolog SAMM501NP_056195integral to membrane membrane mitochondrion outer membranenot classifiednot classified1, 2
spermidine/spermine N1- acetyltransferase 2 SAT21NP_597998not classifiednot classifieddiamine N- acetyltransferase activity N- acetyltransferase activity transferase activity metal ion binding2
scavenger receptor class B, member 2 SCARB29NP_005497integral to plasma membrane lysosomal membrane membrane membrane fractioncell adhesionreceptor activity2
sciellin isoform b SCEL2NP_659001cornified envelope cytoplasmembryonic development epidermis development keratinocyte differentiationprotein binding zinc ion binding sodium ion binding2
scinderin SCIN3NP_149119cell cortex cytoplasm cytoskeletonactin filament severing actin nucleation barbed- end actin filament capping calcium ion- dependent exocytosis negative regulation of cell proliferation positive regulation of apoptosis positive regulation of megakaryocyte differentiation positive regulationactin filament binding calcium ion binding phosphatidylinositol binding phosphatidylinositol- 4, 5- bisphosphate binding phosphatidylserine binding2
sodium channel, voltage- gated, type X, alpha SCN10A1NP_006505membrane membrane fraction voltage- gated sodium channel complexion transport sensory perception sodium ion transport synaptic transmissionsodium ion binding voltage- gated calcium channel activity voltage- gated sodium channel activity2
sodium channel, voltage- gated, type XI, alpha SCN11A1NP_054858membrane membrane fraction voltage- gated sodium channel complexion transport response to drug sodium ion transport synaptic transmissionvoltage- gated sodium channel activity dipeptidase activity2
serine carboxypeptidase 1 precursor protein SCPEP11NP_067639not classifiedproteolysispeptidase activity serine carboxypeptidase activity2
secernin 2 SCRN21NP_612364not classifiedproteolysiscytoskeletal protein binding2
syndecan 1 precursor SDC11NP_002988integral to plasma membrane membranenot classifiedcytoskeletal protein binding2
syntenin isoform 3 SDCBP11NP_001007070adherens junction cytoskeleton endoplasmic reticulum interleukin- 5 receptor complex membrane nucleusactin cytoskeleton organization and biogenesis intracellular signaling cascade metabolism protein targeting to membrane substrate- bound cell migration, cell extension synaptic transmissioncytoskeletal adaptor activity interleukin- 5 receptor binding neurexin binding oxidoreductase activity protein binding protein heterodimerization activity syndecan binding2
syntenin isoform 1 SDCBP16NP_005616adherens junction cytoskeleton endoplasmic reticulum interleukin- 5 receptor complex membrane nucleusactin cytoskeleton organization and biogenesis intracellular signaling cascade metabolism protein targeting to membrane substrate- bound cell migration, cell extension synaptic transmissioninterleukin- 5 receptor binding neurexin binding oxidoreductase activity protein binding protein heterodimerization activity syndecan binding cytoskeletal adaptor activity not classified2
syndecan binding protein 2 isoform a SDCBP21NP_536737cytoplasm plasma membraneintracellular signaling cascade intracellular transport nervous system developmentprotein C- terminus binding protein heterodimerization activity protein homodimerization activity2
SEC13 protein SEC13L11NP_899195not classifiedintracellular protein transportnot classified2
SEC31- like 1 isoform 1 SEC31L11NP_055748COPII vesicle coatER to Golgi vesicle- mediated transportnot classified1
secreted and transmembrane 1 precursor SECTM12NP_002995extracellular space Golgi apparatus integral to membrane membraneimmune response mesoderm developmentcytokine activity signal transducer activity2
selenium binding protein 1 SELENBP15NP_003935not classifiednot classifiedselenium binding2
tumor differentially expressed 2- like SERINC21NP_849196membranephosphatidylserine metabolism positive regulation of transferase activitynot classified2
developmentally regulated protein TPO1 SERINC51NP_840060membranephosphatidylserine metabolism positive regulation of transferase activityprotein binding2
serine (or cysteine) proteinase inhibitor, clade A (alpha- 1 antiproteinase, antitrypsin), member 1 SERPINA14NP_001002236extracellular region extracellular spaceacute- phase responseprotein binding serine- type endopeptidase inhibitor activity2
serpin peptidase inhibitor, clade A, member 3 precursor SERPINA33NP_001076extracellular region intracellularacute- phase response inflammatory response regulation of lipid metabolismchymotrypsin inhibitor activity DNA binding protein binding1, 2
serine (or cysteine) proteinase inhibitor, clade A (alpha- 1 antiproteinase, antitrypsin), member 4 SERPINA42NP_006206not classifiednot classifiedprotein binding serine- type endopeptidase inhibitor activity2
serine (or cysteine) proteinase inhibitor, clade A (alpha- 1 antiproteinase, antitrypsin), member 5 SERPINA512NP_000615extracellular region membrane protein complexfusion of sperm to egg plasma membrane spermatogenesisacrosin binding heparin binding serine- type endopeptidase inhibitor activity1, 2
serine (or cysteine) proteinase inhibitor, clade A, member 7 SERPINA71NP_000345extracellular region extracellular spacenot classifiedbinding serine- type endopeptidase inhibitor activity2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 SERPINB17NP_109591cytoplasmnot classifiedserine- type endopeptidase inhibitor activity2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13 SERPINB131NP_036529not classifiedregulation of proteolysis response to UVserine- type endopeptidase inhibitor activity2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 SERPINB33NP_008850not classifiednot classifiedserine- type endopeptidase inhibitor activity2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 SERPINB62NP_004559cytosolnot classifiedprotein binding serine- type endopeptidase inhibitor activity2
serine (or cysteine) proteinase inhibitor, clade F (alpha- 2 antiplasmin, pigment epithelium derived factor), member 1 SERPINF12NP_002606extracellular regioncell proliferation development negative regulation of angiogenesis positive regulation of neurogenesisserine- type endopeptidase inhibitor activity2
complement component 1 inhibitor precursor SERPING17NP_000053extracellular regionblood coagulation circulation complement activiation, classical pathway innate immune responseserine- type endopeptidase inhibitor activity2
stratifin SFN4NP_006133cytoplasm extracellular spacecell proliferation negative regulation of protein kinase activity regulation of progression through cell cycle signal transductionprotein domain specific binding1, 2
SFT2 domain containing 2 SFT2D21NP_955376integral to membrane membraneprotein transportSH3/SH2 adaptor activity2
SH3 domain binding glutamic acid- rich protein like SH3BGRL1NP_003013nucleusnot classifiedglycine hydroxymethyltransferase activity2
SH3 domain binding glutamic acid- rich protein like 3 SH3BGRL31NP_112576nucleusnot classifiednot classified2
SH3- domain binding protein 4 SH3BP41NP_055336nucleuscell cycle endocytosissignal transducer activity2
serine hydroxymethyltransferase 1 (soluble) isoform 2 SHMT18NP_683718cytosolglycine metabolism L- serine catabolism L- serine metabolism one- carbon compound metabolismglycine hydroxymethyltransferase activity transferase activity2
serine hydroxymethyltransferase 2 (mitochondrial) SHMT21NP_005403mitochondrionglycine metabolism L- serine metabolism one- carbon compound metabolismtransferase activity hydrolase activity2
apical protein of Xenopus- like SHROOM21NP_001640not classifiednot classifiedamiloride- sensitive sodium channel activity protein binding2
cytosolic sialic acid 9- O- acetylesterase homolog SIAE1NP_733746lysosomenot classifiedserine esterase activity sialate O- acetylesterase activity not classified2
signal- regulatory protein alpha precursor SIRPA1NP_001035112integral to membrane plasma membranecell adhesionsodium ion binding2
sodium potassium chloride cotransporter 2 SLC12A125NP_000329integral to membrane membrane membrane fraction plasma membranechloride transport ion transport potassium ion transport sodium ion transportpotassium ion binding sodium ion binding sodium:potassium:chloride symporter activity symporter activity transporter activity1, 2
solute carrier family 12 (sodium/chloride transporters), member 3 SLC12A328NP_000330integral to plasma membrane membrane membrane fractionchloride transport ion transport sodium ion transportsodium ion binding sodium:chloride symporter activity symporter activity transporter activity1, 2
solute carrier family 12 (potassium/chloride transporters), member 9 SLC12A91NP_064631integral to membrane membranetransportcation:chloride symporter activity protein binding2
solute carrier family 13 (sodium- dependent dicarboxylate transporter), member 2 SLC13A25NP_003975integral to plasma membrane membrane membrane fractionion transport sodium ion transportlow affinity sodium:dicarboxylate symporter activity sodium ion binding symporter activity transporter activity2
solute carrier family 13 member 3 isoform a SLC13A32NP_073740integral to membrane membraneion transportsodium ion binding symporter activity transporter activity2
solute carrier family 13 member 3 isoform b SLC13A31NP_001011554integral to membrane membraneion transport sodium ion trasnportsymporter activity tranporter activity oligopeptide transporter activity2
solute carrier family 15 (H+/peptide transporter), member 2 SLC15A21NP_066568integral to plasma membrane membranedrug transport oligopeptide transport protein transportpeptide:hydrogen symporter activity protein binding symporter activity transporter activity organic cation transporter activity2
solute carrier family 1, member 1 SLC1A13NP_004161integral to plasma membrane membrane membrane fractiondicarboxylic acid transport glutamate transport synaptic transmission transportL- glutamate transporter activity sodium:dicarboxylate symporter activity symporter activity1, 2
solute carrier family 22 member 11 SLC22A112NP_060954integral to plasma membrane membraneion transportsodium- independent organic anion transporter activity transporter activity2
urate anion exchanger 1 isoform a SLC22A121NP_653186apical plasma membrane brush border membrane integral to membrane plasma membranecell homeostasis transport urate transportPDZ domain binding protein binding transporter activity urate transporter activity2
organic cation transporter like 3 SLC22A131NP_004247integral to plasma membrane membrane membrane fractiontransporttransporter activity ATP binding2
solute carrier family 22 member 2 isoform a SLC22A22NP_003049integral to membrane integral to plasma membrane membrane membrane fractionfluid secretion ion transport organic cation transport sodium ion transport transportATP binding ion transporter activity nucleotide binding organic cation transporter activity sodium ion binding symporter activity transporter activity2
solute carrier family 22 member 5 SLC22A51NP_003051integral to membrane membranecarnitine transport ion transport sodium ion transport transportcarnitine transporter activity ion transporter activity nucleotide binding sodium ion binding symporter activity transporter activity ATP binding2
solute carrier family 22 member 6 isoform a SLC22A61NP_004781integral to membrane integral to plasma membrane membrane membrane fractionalpha- ketoglutarate transport ion transport organic anion transport sodium ion transportATP binding ion transporter activity nucleotide binding organic anion transporter activity sodium ion binding symporter activity2
solute carrier family 22 member 6 isoform d SLC22A61NP_695010integral to membrane integral to plasma membrane membrane membrane fractionalpha- ketoglutarate transport ion transport organic anion transport sodium ion tranportion transporter activity nucleotide binding organic anion transporter activity sodium ion binding symporter activity nucleobase transporter activity2
solute carrier family 22 member 8 SLC22A81NP_004245integral to membrane integral to plasma membrane membrane membrane fractionion transport organic anion transport sodium ion transport transportnucleotide binding organic anion transporter activity sodium ion binding symporter activity transporter activity2
solute carrier family 23 (nucleobase transporters), member 1 isoform b SLC23A16NP_689898integral to plasma membrane membrane membrane fractionion transport nucleobase transport nucleobase, nucleoside, nucleotide and nucleic acid metabolism sodium ion transportnucleobase transporter activity sodium ion binding symporter activity transporter activity2
solute carrier family 23 (nucleobase transporters), member 1 isoform a SLC23A14NP_005838integral to plasma membrane membrane membrane fractionion transport nucleobase transport nucleobase, nucleoside, nucleotide and nucleic acid metabolism sodium ion transportsodium ion binding symporter activity transporter activity binding2
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 SLC25A11NP_005975integral to membrane membrane mitochondrial inner membrane mitochondrionmitochondrial citrate transport transportcitrate transporter activity transporter activity adenine transporter activity2
solute carrier family 25 member 3 isoform b precursor SLC25A31NP_998776integral to plasma membrane membrane mitochondrial inner membrane mitochondriongeneration of precursor metabolites and energy transportbinding phosphate carrier activity symporter activity2
solute carrier family 26, member 11 SLC26A111NP_775897integral to membranetransporttransporter activity2
pendrin SLC26A42NP_000432integral to membrane membranesensory perception of sound sulfate transport transportchloride ion binding chloride transporter activity iodide transporter activity sulfate porter activity transporter activity2
solute carrier family 27 (fatty acid transporter), member 2 SLC27A21NP_003636endoplasmic reticulum integral to membrane membrane peroxisomal matrix peroxisomelipid metabolism metabolism very- long- chain fatty acid metabolismcatalytic activity ligase activity long- chain- fatty- acid- CoA ligase activity nucleotide binding2
solute carrier family 2 (facilitated glucose/fructose transporter), member 5 SLC2A512NP_003030integral to membrane membrane plasma membranecarbohydrate metabolism carbohydrate transport fructose transport glucose transportfructose transporter activity glucose transporter activity sugar porter activity transporter activity1, 2
solute carrier family 36 (proton/amino acid symporter), member 2 SLC36A27NP_861441not classifiednot classifiednot classified2
solute carrier family 39 (metal ion transporter), member 5 SLC39A51NP_775867integral to membrane membraneion transport metal ion transport zinc ion transportzinc ion binding calcium:sodium antiporter activity2
solute carrier family 3, member 1 SLC3A114NP_000332integral to plasma membrane membrane membrane fractionamino acid metabolism basic amino acid transport carbohydrate metabolism L- cystine transport transportcatalytic activity cation binding L- cystine transporter activity2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform a SLC3A210NP_001012679cell surface integral to membrane membraneamino acid transport calcium ion transport carbohydrate metabolism cell growth tryptophan transportcalcium:sodium antiporter activity catalytic activity cation binding protein binding2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform c SLC3A23NP_002385cell surface integral to membrane membraneamino acid transport calcium ion transport carbohydrate metabolism cell growth tryptophan transportcatalytic activity cation binding protein binding not classified2
CDW92 antigen SLC44A11NP_536856integral to membrane membranetransporttransporter activity2
CTL2 protein SLC44A218NP_065161integral to membrane membranepositive regulation of I- kappaB kinase/NF- kappaB cascade transportsignal transducer activity1, 2
NG22 protein isoform 1 SLC44A46NP_079533integral to membrane membranenot classifiednot classified1, 2
solute carrier family 4, anion exchanger, member 1 SLC4A12NP_000333cortical cytoskeleton integral to plasma membrane membraneanion transport cell ion homeostasisanion transporter activity inorganic anion exchanger activity protein binding2
solute carrier family 4, sodium bicarbonate cotransporter, member 4 SLC4A42NP_003750integral to membrane membraneanion transport sodium ion transportinorganic anion exchanger activity sodium ion binding symporter activity2
solute carrier family 5 (sodium/glucose cotransporter), member 1 SLC5A12NP_000334integral to plasma membrane membrane glucose transport ion transport sodium ion transportglucose:sodium symporter activity sodium ion binding sugar porter activity symporter activity transporter activity2
solute carrier family 5 (sodium/glucose cotransporter), member 10 isoform 1 SLC5A102NP_689564integral to membrane membraneion transport sodium ion transporttransporter activity2
solute carrier family 5 (sodium/glucose cotransporter), member 10 isoform 2 SLC5A101NP_001035915integral to membrane membraneion transport sodium ion trasnporttransporter activity2
solute carrier family 5 (sodium/glucose cotransporter), member 12 isoform 2 SLC5A122NP_848593integral to membrane membraneion transport sodium ion transport transporttransporter activity2
solute carrier family 5 (sodium/glucose cotransporter), member 2 SLC5A24NP_003032integral to membrane membranecarbohydrate metabolism ion transport sodium ion transportlow- affinity glucose:sodium symporter activity sodium ion binding sugar porter activity symporter activity transporter activity2
solute carrier family 5 (iodide transporter), member 8 SLC5A81NP_666018integral to membrane membraneion transport sodium ion transporttransporter activity2
solute carrier family 5 (sodium/glucose cotransporter), member 9 SLC5A91NP_001011547integral to membrane membraneion transport sodium ion trasnportprotein binding2
solute carrier family 6 (neurotransmitter transporter, GABA), member 13 SLC6A131NP_057699integral to plasma membrane membraneneurotransmitter transportgamma- aminobutyric acid:sodium symporter activity neurotransmitter:sodium symporter activity symporter activity2
solute carrier family 6, member 19 SLC6A194NP_001003841integral to plasma membrane membraneamino acid transport neurotransmitter transportamino acid transporter activity neurotransmitter:sodium symporter activity symporter activity2
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 SLC9A32NP_004165integral to membrane membraneion transport regulation of pH sodium ion transportantiporter activity sodium ion binding sodium:hydrogen antiporter activity solute:hydrogen antiporter activity2
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 SLC9A3R14NP_004243actin cytoskeletonprotein complex assembly Wnt receptor signaling pathwaybeta- 2 adrenergic receptor binding protein binding sodium:hydrogen antiporter regulator activity1, 2
solute carrier family 9 isoform 3 regulator 2 SLC9A3R21NP_004776nucleus plasma membraneintracellular signaling cascade protein complex assemblyATP binding2
solute carrier organic anion transporter family, member 4C1 SLCO4C12NP_851322integral to membrane membranetransporttransporter activity2
slit homolog 2 SLIT21NP_004778extracellular region extracellular space integral to membranecell differentiation chemotaxis G- protein coupled receptor protein signaling pathway glial cell migration induction of negative chemotaxis mesoderm migration motor axon guidance nervous system development neuron recognition positive regulation of axonogencalcium ion binding follicle- stimulating hormone receptor activity receptor binding transferase activity2
serine/threonine kinase 2 SLK9NP_055535not classifiedapoptosis nucleotide- excision repair protein amino acid phosphorylationATP binding DNA binding nuclease activity nucleotide binding protein serine/threonine kinase activity transferase activity2
structural maintenance of chromosomes 2- like 1 SMC21NP_001036016chromosome condensin complex cytoplasm nuclear chrosome nucleuscell cycle cell division chromosome organization and biogenesis mitosis mitotic chromosome condensationnucleotide binding protein binding protein heterodimerization activity protein binding2
smoothened SMO1NP_005622integral to membrane membrane membrane fractiondevelopment G- protein coupled receptor protein signaling pathwayG- protein coupled receptor activity non- G- protein coupled 7TM receptor activity protein binding receptor activity2
acid sphingomyelinase- like phosphodiesterase 3B isoform 1 SMPDL3B1NP_055289not classifiedmetabolismhydrolase activity, acting on glycosyl bonds1, 2
Smad ubiquitination regulatory factor 1 isoform 2 SMURF11NP_851994intracellularcell differentiation ectoderm development negative regulation of BMP signaling pathway protein ubiquitination during ubiquitin- dependent protein catabolism ubiquitin cycleligase activity ubiquitin- protein ligase activity2
sorting nexin associated golgi protein 1 SNAG14NP_443102not classifiedintracellular signaling cascade protein transportphosphoinositide binding protein binding1, 2
synaptosomal- associated protein 23 isoform SNAP23B SNAP231NP_570710plasma membrane synapse synaptosomemembrane fusion post- Golgi- vesicle- mediated transport protein transport vesicle targetingt- SNARE activity phosphoionsitide binding2
synuclein, gamma (breast cancer- specific protein 1) SNCG9NP_003078cytoplasmnot classifiednot classified1, 2
EAP30 subunit of ELL complex SNF81NP_009172nucleusprotein transport regulation of transcription, DNA- dependent transcriptionnot classified2
small nuclear ribonucleoprotein D1 polypeptide 16kDa SNRPD11NP_008869nucleus ribonucleoprotein complexnuclear mRNA splicing, via spliceosomeprotein binding1
sorting nexin 12 SNX121NP_037478not classifiedintracellular signaling cascade protein transportprotein binding phosphoinositide binding2
sorting nexin 3 SNX31NP_003786not classifiedendocytosis intracellular signaling cascade protein transportphosphoinositide binding protein binding2
sorting nexin 9 SNX92NP_057308not classifiedintracellular signaling cascade protein localization protein transportprotein binding SH3/SH2 adaptor activity lipid transporter activity2
superoxide dismutase 1, soluble SOD12NP_000445cytoplasmnervous system development response to oxidative stress superoxide metabolismantioxidant activity copper ion binding copper, zinc superoxide dismutase activity metal ion binding oxidoreductase activity zinc ion binding1, 2
sorbitol dehydrogenase SORD3NP_003095not classifiedsorbitol metabolism visual perceptionL- iditol 2- dehydrogenase activity metal ion binding oxidoreductase activity zinc ion binding2
sortilin- related receptor containing LDLR class A repeats preproprotein SORL11NP_003096integral to plasma membrane membranecholesterol metabolism intracellular protein transport lipid metabolism lipid transport receptor mediated endocytosis steroid metabolismprotein transporter activity transmembrane receptor activity not classified2
sperm associated antigen 9 isoform 1 SPAG92NP_003962not classifiednot classifiednot classified2
spastin isoform 2 SPAST3NP_955468nucleusnot classifiedATP binding nucleoside- triphosphatase activity nucleotide binding2
spen homolog, transcriptional regulator SPEN2NP_055816nucleusNotch signaling pathway regulation of transcription, DNA- dependentDNA binding nucleic acid binding nucleotide binding RNA binding2
spondin 2, extracellular matrix protein SPON21NP_036577extracellular matrix (sensu Metazoa) extraellular spaceaxon guidance cell adhesion development immune responseactin binding2
sepiapterin reductase (7, 8- dihydrobiopterin:NADP+ oxidoreductase) SPR1NP_003115not classifiedelectron transport metabolism nitric oxide biosynthesis tetrahydrobiopterin biosynthesisaldo- keto reductase activity NADP binding oxidoreductase activity sepiapterin reductase activity2
small proline- rich protein 3 SPRR35NP_005407cornified envelopeepidermis development keratinization keratinocyte differentiation wound healingprotein binding structural molecule activity2
spectrin, beta, non- erythrocytic 1 isoform 1 SPTBN11NP_003119cytoskeleton membrane spectrinbarbed- end actin filament cappingactin binding calmodulin binding structural constituent of cytoskeleton2
spectrin, beta, non- erythrocytic 1 isoform 2 SPTBN11NP_842565cytoskeleton membrane spectrinbarbed- end actin filament cappingcalmodulin binding structural constituent of cytoskeleton calcium channel regulator activity2
sequestosome 1 SQSTM11NP_003891cytosol nucleusapoptosis cell differentiation endosome transport immune response intracellular signaling cascade positive regulation of transcription from RNA polymerase II promoter protein localization regulation of I- kappaB kinase/NF- kappaB cascade response to stressmetal ion binding protein binding protein kinase binding SH2 domain binding ubiquitin binding zinc ion binding2
proto- oncogene tyrosine- protein kinase SRC SRC1NP_005408integral to membrane membraneprotein amino acid phosphorylation protein kinase cascade signal complex formationATP binding nucleotide binding protein binding protein- tyrosine kinase activity SH2 domain binding SH3/SH2 adaptor activity transferase activity2
sorcin isoform a SRI4NP_003121cytoplasmheart development intracellular sequestering of iron ion muscle development regulation of action potential regulation of heart contraction regulation of striated muscle contraction signal transduction transportcalcium channel regulator activity calcium ion binding receptor binding1, 2
sorcin isoform b SRI3NP_944490cytoplasmheart development intracellular sequestering of iron ion muscle development regulation of action potential regulation of heart contraction regulation of striated muscle contraction signal transduction transportcalcium ion binding receptor binding binding2
heat shock 70kD protein binding protein ST132NP_003923cytoplasmprotein foldingprotein binding, bridging metal ion binding2
STAM binding protein STAMBP2NP_998787membrane nucleusJAK- STAT cascade positive regulation of cell proliferation ubiquitin cyclemetallopeptidase activity protein binding ubiquitin thiolesterase activity zinc ion binding not classified2
serine/threonine protein kinase 11 STK111NP_000446not classifiedprotein amino acid phosphorylationATP binding nucleotide binding protein binding protein serine/threonine kinase activity transferase activity2
serine/threonine kinase 24 (STE20 homolog, yeast) isoform b STK245NP_001027467not classifiedprotein amino acid phosphorylation signal transductionATP binding kinase activity nucleotide binding protein serine/threonine kinase activity protein- tyrosine kinase activity transferase activity2
stomatin isoform a STOM13NP_004090cytoskeleton integral to plasma membrane membranenot classifiednot classified1, 2
syntaxin 3A STX32NP_004168integral to membrane membraneintracellular protein transport neurotransmitter transportprotein transporter activity2
syntaxin binding protein 1 isoform b STXBP11NP_001027392not classifiedprotein transport vesicle docking during exocytosis vesicle- mediated transportcalcium ion binding2
syntaxin binding protein 2 STXBP210NP_008880not classifiedintracellular protein transport vesicle docking during exocytosis vesicle- mediated transportsyntaxin- 2 binding syntaxin- 3 binding2
syntaxin binding protein 4 STXBP41NP_848604not classifiednot classifiedprotein binding ATP binding2
succinate- CoA ligase, ADP- forming, beta subunit SUCLA21NP_003841mitochondrionmetabolism succinyl- CoA metabolism succinyl- CoA pathway tricarboxylic acid cycleligase activity succinate- CoA ligase (ADP- forming) activity G- protein coupled receptor activity, unknown ligand2
succinate receptor 1 SUCNR11NP_149039integral to membrane membraneG- protein coupled receptor protein signaling pathway signal transductionpurinergic nucleotide receptor activity, G- protein coupled receptor activity rhodopsin- like receptor activity not classified2
sushi domain containing 2 SUSD25NP_062547not classifiednot classifiednot classified2
synaptophysin- like 1 isoform b SYPL11NP_874384integral to plasma membrane membrane synaptic vesiclesynaptic transmission transporttransporter activity2
tumor- associated calcium signal transducer 1 precursor TACSTD11NP_002345integral to membrane plasma membranenot classifiedATP binding2
transgelin 2 TAGLN24NP_003555nuclear membrane plasma membranemuscle developmentnot classified2
TAO kinase 1 TAOK11NP_065842not classifiedprotein amino acid phosphorylationATP binding nucleotide binding protein serine/threonine kinase activity transferase activity2
Tax1 (human T- cell leukemia virus type I) binding protein 3 TAX1BP31NP_055419cytoplasm integral to membrane membrane nucleusintracellular signaling cascade ion transport negative regulation of Wnt receptor signaling pathway Rho protein signal transduction Wnt receptor signaling pathwayATP binding ion channel activity protein binding receptor activity2
TBC1 domain family, member 10A TBC1D10A4NP_114143microvillusnot classifiedPDZ domain binding protein binding2
TBC1 domain family, member 21 TBC1D211NP_699187not classifiednot classifiedGTPase activator activity2
T- complex protein 1 isoform a TCP11NP_110379cytosolprotein folding tubulin foldingATP binding nucleotide binding unfolded protein binding2
T- complex protein 1 isoform b TCP12NP_001008897cytosolprotein folding tubulin foldingnucleotide binding unfolded protein binding structural molecule activity2
tectorin alpha precursor TECTA1NP_005413extracellular matrix (sensu Metazoa) extracellular space membranecell- matrix adhesion sensory perception of soundextracellular matrix structural constituent GPI anchor binding2
tektin 3 TEKT31NP_114104microtubulemicrotubule cytoskeleton organization and biogenesisglycosaminoglycan binding2
transferrin TF12NP_001054endocytic vesicle extracellular regionion transport iron ion homeostasis iron ion transportferric iron binding metal ion binding1, 2
transforming growth factor, beta receptor III TGFBR31NP_003234integral to membrane membranedevelopment signal transduction transforming growth factor beta receptor signaling pathwayreceptor activity acyltransferase activity2
transglutaminase 2 isoform b TGM21NP_945189cytosol extracellular matrix (sensu Metazoa) membraneG- protein coupled receptor protein signaling pathway peptide cross- linking positive regulation of cell adhesioncalcium ion binding GTP binding protein- glutamine gamma- glutamyltransferase activity transferase activity nucleotide binding2
transglutaminase 4 (prostate) TGM45NP_003232not classifiedpeptide cross- linking protein amino acid polyaminationacyltransferase activity calcium ion binding protein- glutamine gamma- glutamyltransferase activity transferase activity2
thrombospondin 1 precursor THBS19NP_003237extracellular regionblood coagulation cell adhesion cell motility development nervous system developmentcalcium ion binding endopeptidase inhibitor activity heparin binding protein binding signal transducer activity structural molecule activity1, 2
THO complex 4 THOC41NP_005773nucleus spliceosome complexmRNA export from nucleus nuclear mRNA splicing, via spliceosome protein folding transportprotein binding RNA binding not classified2
Thy- 1 cell surface antigen THY13NP_006279cytosol endoplasmic reticulum external side of plasma membrane growth cone integral to plasma membrane lipid raft plasma membraneangiogenesis cell- cell adhesion cytoskeleton organization and biogenesis focal adhesion formation mast cell activation negative regulation of apoptosis negative regulation of axonogenesis negative regulation of cell migration negative regulation of fibrobGPI anchor binding integrin binding protein binding Rho GTPase activator activity1, 2
T- cell lymphoma invasion and metastasis 2 isoform b TIAM21NP_001010927intracellularintracellular signaling cascade regulation of Rho protein signal transductionprotein binding receptor signaling protein activity Rho guanyl- nucleotide exchange factor activity2
transketolase TKT1NP_001055not classifiednot classifiedcalcium ion binding transferase activity transketolase activity2
talin 1 TLN14NP_006280cytoskeleton cytosol focal adhesion intercellular junction rufflecell motility cytoskeletal anchoring intercellular junction assemblyactin binding binding LIM domain binding protein binding structural constituent of cytoskeleton vinculin binding2
transmembrane 7 superfamily member 3 TM7SF33NP_057635integral to membrane membranenot classifiednot classified1, 2
transmembrane BAX inhibitor motif containing 1 TMBIM11NP_071435integral to membrane membranenot classifiednot classified1, 2
transmembrane protein 12 TMEM121NP_689524integral to membranenot classifiednot classified2
transmembrane protein 16F TMEM16F6NP_001020527integral to membrane membranenot classifiednot classified2
transmembrane protein 2 TMEM21NP_037522integral to membranenot classifiednot classified2
transmembrane protein 27 TMEM272NP_065716integral to membrane membranenot classifiednot classified2
transmembrane protein 38A TMEM38A1NP_076979integral to membranenot classifiedserine- type endopeptidase inhibitor activity2
thymic dendritic cell- derived factor 1 TMEM591NP_004863integral to membranenot classifiedpeptidase activity2
transmembrane protein 63A TMEM63A2NP_055513integral to membrane membranenot classifiednucleotide binding2
transmembrane protease, serine 11D TMPRSS11D1NP_004253extracellular region integral to plasma membrane membraneproteolysis respiratory gaseous exchangeserine- type endopeptidase activity not classified2
transmembrane protease, serine 2 TMPRSS22NP_005647integral to plasma membrane membraneproteolysisscavenger receptor activity serine- type endopeptidase activity1, 2
toll interacting protein TOLLIP1NP_061882cytoplasm interleukin- 1 receptor complex interleukin- 18 receptor complexcell- cell signaling inflammatory response intracellular signaling cascade leukocyte activation phosphorylationprotein binding signal transducer activity Toll binding2
target of myb1 TOM11NP_005479cytosol early endosome endosome intracellular lysosome membraneendocytosis endosome transport intracellular protein transportprotein binding2
target of myb1- like 2 isoform 2 TOM1L21NP_653279intracellularintracellular protein transportnot classified2
target of myb1- like 2 isoform 1 TOM1L21NP_001028723intracellularintracellular protein transportprotein binding2
triosephosphate isomerase 1 TPI17NP_000356not classifiedfatty acid biosynthesis gluconeogenesis glycolysis metabolism pentose- phosphate shuntisomerase activity triose- phosphate isomerase activity1, 2
tripeptidyl- peptidase I preproprotein TPP18NP_000382lysosomelipid metabolism nervous system development proteolysispeptidase activity serine- type endopeptidase activity tripeptidyl- peptidase I activity1, 2
trehalase TREH4NP_009111anchored to plasma membrane plasma membranemetabolism trehalose catabolism trehalose metabolismalpha, alpha- trehalase activity GPI anchor binding hydrolase activity, acting on glycosyl bonds2
thyroid hormone receptor interactor 10 TRIP101NP_004231cytoplasmactin cytoskeleton organization and biogenesis signal transductionalpha- actinin binding2
tumor susceptibility gene 101 TSG10117NP_006283membraneprotein transport regulation of cell growth ubiquitin cycleDNA binding protein binding transcription corepressor activity ubiquitin- protein ligase activity1, 2
tetraspan 1 TSPAN11NP_005718integral to membrane membranecell adhesion cell motility cell proliferationnot classified1, 2
transmembrane 4 superfamily member 8 isoform 2 TSPAN31NP_944492integral to membrane membranecell motility cell proliferationnot classified2
transmembrane 4 superfamily member 6 TSPAN61NP_003261integral to membrane membranecell motility positive regulation of I- kappaB kinase/NF- kappaB cascadesignal transducer activity2
translocator protein (18kDa) isoform PBR TSPO1NP_000705integral to membrane membrane mitochondrial outer membrane mitochondrionprotein targeting to mitochondrion signal transductionbenzodiazepine receptor activity receptor activity2
tissue specific transplantation antigen P35B TSTA31NP_003304cytoplasmde novo' GDP- L- fucose biosynthesis cellular metabolism leukocyte adhesion nucleotide- sugar metabolism protein amino acid glycosylationcoenzyme binding electron carrier activity GDP- 4- dehydro- D- rhamnose reductase activity GDP- L- fucose synthase activity isomerase activity2
tetratricopeptide repeat domain 18 TTC181NP_660153not classifiednot classifiedbinding2
titin isoform novex- 1 TTN4NP_597676condensed nuclear chromosome integral to membrane membrane myofibril nucleus Z disccarbohydrate metabolism mitosis muscle contraction myofibril assembly protein amino acid autophosphorylation protein amino acid phosphorylation response to oxidative stressalpha- actinin binding ATP binding calmodulin binding identical protein binding myosin binding nucleotide binding peroxidase activity protein serine/threonine kinase activity protein- tyrosine kinase activity structural constituent of cell wall transferase 2
titin isoform N2- A TTN1NP_596869condensed nuclear chromosome integral to membrane membrane myofibril nucleus Z disccarbohydrate metabolism mitosis muscle contraction myofibril assembly protein amino acid autophosphorylation protein amino acid phosphorylation response to oxidative stressATP binding calmoduling binding identical protein binding myosin binding nucleotide binding peroxidase activity protein serine/threoninen kinase activity protein- tyrosine kinase activity structural constituent of cell wall transferase activity GTP binding2
tweety 3 TTYH31NP_079526not classifiednot classifiednot classified1, 2
tubulin, alpha 3 TUBA315NP_006000microtubule protein complexmicrotubule- based movement protein polymerizationGTP binding GTPase activity nucleotide binding structural molecule activity2
tubulin, beta 2 TUBB2A7NP_001060cytoplasm cytoskeleton microtubule protein complexmicrotubule- based movement protein polymerizationGTP binding GTPase activity nucleotide binding structural constituent of cytoskeleton1, 2
tubulin, beta 6 TUBB61NP_115914cytoplasm microtubule protein complexmicrotubule- based movement protein polymerizationGTPase activity nucleotide binding structural molecule activity GTP binding2
tubulin, beta 8 TUBB81NP_817124cytoplasm microtubule protein complexmicrotubule- based movement protein polymerizationGTPase activity nucleotide binding structural molecule activity GTP binding not classified2
thioredoxin TXN2NP_003320not classifiedcell motility cell proliferation cell- cell signaling electron transport signal transduction transportelectron carrier activity protein binding protein disulfide oxidoreductase activity thiol- disulfide exchange intermediate activity2
thioredoxin domain containing 8 TXNDC81NP_001003936not classifiedcell differentiation spermatogenesiselectron carrier activity protein disulfide oxidoreductase activity2
thioredoxin- like 5 TXNL52NP_116120not classifiednot classifiedelectron carrier activity protein disulfide oxidoreductase activity2
uveal autoantigen with coiled- coil domains and ankyrin repeats isoform 1 UACA1NP_060473cytoskeleton extracelluar region nucleusviral life cycleATP binding2
ubiquitin- activating enzyme E1 UBA14NP_695012not classifiedDNA replication ubiquitin cyclecatalytic activity ligase activity nucleotide binding protein binding ubiquitin activating enzyme activity ligase activity2
ubiquitin associated domain containing 1 UBADC11NP_057256not classifiednot classifiednot classified2
ubiquitin- activating enzyme E1 UBE12NP_003325not classifiedDNA replication ubiquitin cycleATP binding catalytic activity ligase activity nucleotide binding protein binding ubiquitin activating enzyme activity2
ubiquitin- conjugating enzyme E2G 1 UBE2G11NP_003333not classifiedubiquitin cycleubiquitin- protein ligase activity not classified2
ubiquitin- like 3 UBL32NP_009037intracellular membraneprotein modificationL- lactate dehydrogenase activity2
UBX domain containing 1 UBXD11NP_079517not classifiednot classifiednot classified2
ubiquitin- conjugating enzyme E2- like isoform b UEVLD11NP_060784not classifiedglycolysis protein transport tricarboxylic acid cycle intermediate metabolism ubiquitin cycleL- lactate dehydrogenase activity oxidoreductase activity ubiquitin- protein ligase activity1, 2
ubiquitin- conjugating enzyme E2- like isoform a UEVLD4NP_001035787not classifiedglycolysis protein transport tricarboxylic acid cycle intermediate metabolism ubiquitn cycleoxidoreductase activity ubiquitin- protein ligase activity not classified2
ubiquitin- fold modifier conjugating enzyme 1 UFC11NP_057490not classifiedubiquitin cyclekinase activity2
UDP- glucose pyrophosphorylase 2 isoform a UGP22NP_006750not classifiedmetabolism UDP- glucose metabolismkinase activity nucleotidyltransferase activity transferase activity UTP:glucose- 1- phosphate uridylyltransferase activity2
UDP- glucose pyrophosphorylase 2 isoform b UGP23NP_001001521not classifiedmetabolism UDP- glucose metabolismnucleotidyltransferase activity transferase activity UTP: glucose- 1- phosphate uridylyltransfease activity ATP binding2
unc- 51- like kinase 3 ULK34NP_056333not classifiedprotein amino acid phosphorylationATP binding nucleotide binding protein serine/threonine kinase activity protein- tyrosine kinase activity transferase activity1, 2
uromodulin precursor UMOD35NP_003352extracellular space extrinsic to membrane membranecellular defense response negative regulation of cell proliferationcalcium ion binding GPI anchor binding1, 2
beta- ureidopropionase UPB11NP_057411not classifiednitrogen compound metabolismhydrolase activity, acting on carbon- nitrogen (but not peptide) bonds metal ion binding zinc ion binding protein binding2
uroplakin 1A UPK1A5NP_008931endoplasmic reticulum integral to membrane plasma membraneendocytosis epithelial cell differentiation protein oligomerization signal transductionmonosaccharide binding protein binding protein homodimerization activity1, 2
uroplakin 1B UPK1B1NP_008883integral to membrane membraneepithelial cell differentiation physiological processstructural molecule activity2
uroplakin 2 UPK24NP_006751endoplasmic reticulum integral to endoplasmic reticulum membrane integral to plasma membrane membranedevelopment epithelial cell differentiation membrane organization and biogenesisnot classified1, 2
uroplakin 3A precursor UPK3A1NP_008884endoplasmic reticulum integral to membrane membrane membrane fractionepithelial cell differentiationnot classified2
utrophin UTRN1NP_009055cytoskeleton membrane fraction plasma membranemuscle contraction muscle developmentactin binding calcium ion binding protein binding structural molecule activity zinc ion binding2
vesicle- associated membrane protein 3 (cellubrevin) VAMP31NP_004772integral to membrane membrane synapse synaptosomemembrane fusion protein complex assembly vesicle docking during exocytosisprotein binding1
vesicle- associated membrane protein 7 VAMP71NP_005629endoplasmic reticulum integral to membrane membraneprotein transport vesicle docking during exocytosis vesicle- mediated transportactin binding2
vesicle- associated membrane protein 8 VAMP81NP_003752early endosome integral to membrane membrane membrane fraction synaptic vesicleprotein complex assembly vesicle docking during exocytosis vesicle- mediated transportnot classified2
slit- like 2 VASN1NP_612449integral to membrane membranenot classifiedtransferase activity2
vasodilator- stimulated phosphoprotein VASP1NP_003361actin cytoskeletoncell motilityactin binding2
vesicle amine transport protein 1 VAT17NP_006364integral to membrane nucleus synaptic vesiclecell growthDNA binding oxidoreductase activity zinc ion binding2
vinculin isoform VCL VCL4NP_003364actin cytoskeleton adherens junction cell- matrix junction costamere focal adhesion intercellular junction protein complexapical junction assembly cell adhesion cell motility lamellipodium biogenesis negative regulation of cell migrationactin binding alpha- catenin binding oxidoreductase activity structural molecule activity2
vinculin isoform meta- VCL VCL3NP_054706actin cytoskeleton adherens junction cell- matrix junction constamere focal adhesion intercellular junction protein complexapical junction assembly cell adhesion cell motility lamellipodium biogenesis negative regulation of cell migrationalpha- catenin binding oxidoreductase activity structural molecule activity not classified2
valosin- containing protein VCP2NP_009057cytosol endoplasmic reticulum microsome nucleuscaspase activation double- strand break repair ER- associated protein catabolism establishment of protein localization protein ubiquitination regulation of apoptosis retrograde protein transport, ER to cytosol transport unfolded protein responseATP binding ATPase activity hydrolase activity lipid binding nucleotide binding protein binding2
voltage- dependent anion channel 1 VDAC16NP_003365integral to membrane membrane mitochondrial outer membrane mitochondrion outer membraneanion transport apoptotic programapoptogenic cytochrome c release channel activity voltage- gated anion channel porin activity voltage- gated ion- selective channel activity2
voltage- dependent anion channel 3 VDAC31NP_005653integral to plasma membrane membrane mitochondrial outer membrane mitochondrion outer membraneadenine transport anion transportvoltage- gated anion channel porin activity voltage- gated ion- selective channel activity2
villin 1 VIL12NP_009058cytoskeleton F- actin capping protein complexactin filament bundle formation actin filament severing barbed- end actin filament capping cytoskeleton organization and biogenesis protein complex assemblyactin binding calcium ion binding2
secretory protein LOC284013 VMO14NP_872372not classifiednot classifiednot classified2
vacuolar protein sorting 13C protein isoform 1B VPS13C1NP_060550not classifiedprotein localizationnot classified2
vacuolar protein sorting 13D isoform 1 VPS13D1NP_056193not classifiedprotein localizationnot classified2
vacuolar protein sorting 24 isoform 1 VPS241NP_057163membraneprotein transportnot classified2
vacuolar protein sorting 24 isoform 2 VPS241NP_001005753membraneprotein transportprotein binding2
vacuolar protein sorting 25 VPS256NP_115729nucleusprotein transport regulation of transcription, DNA- dependent transcriptionnot classified2
vacuolar protein sorting 28 isoform 1 VPS287NP_057292cytosol endosomeprotein transportprotein binding1, 2
vacuolar protein sorting 28 isoform 2 VPS282NP_898880cytosol endosomeprotein transportprotease binding2
vacuolar protein sorting 35 VPS353NP_060676cytosol endosome membraneprotein transport retrograde transport, endosome to Golgiprotein binding2
vacuolar protein sorting 36 VPS365NP_057159nucleusprotein transport regulation of transcription, DNA- dependent transcriptionlipid binding2
vacuolar protein sorting 37B VPS37B5NP_078943not classifiednot classifiednot classified2
vacuolar protein sorting 37C VPS37C1NP_060436not classifiednot classifiednot classified2
vacuolar protein sorting 37D VPS37D5NP_001071089not classifiednot classifiednot classified2
vacuolar protein sorting factor 4B VPS4B15NP_004860endosome membrane vacuoleendosome transport membrane fusion peroxisome organization and biogenesis regulation of transcription, DNA- dependentATP binding ATPase activity, coupled nucleotide binding protein binding1, 2
von Willebrand factor preproprotein VWF1NP_000543extracellular matrix (sensu Metazoa) extracellular regioncell adhesion platelet activation response to woundingprotein binding actin binding2
Wiskott- Aldrich syndrome gene- like proteinWASL1NP_003932actin cytoskeleton nucleusactin polymerization and/or depolymerization cell motility protein complex assembly regulation of transcription, DNA- dependent transcriptionactin binding small GTPase regulator activity 2
eukaryotic translation initiation factor 4H isoform 1 WBSCR11NP_071496eukaryotic translation initiation factor 4F complexprotein biosynthesis regulation of translational initiationnucleic acid binding nucleotide binding RNA binding translation initiation factor activity1
WD repeat- containing protein 1 isoform 1 WDR110NP_059830cytoskeletonsensory perception of soundactin binding protein binding2
WD repeat- containing protein 1 isoform 2 WDR14NP_005103cytoskeletonsensory perception of soundprotein binding metal ion binding2
widely- interspaced zinc finger motifs WIZ1NP_067064intracellular nucleusnot classifiednucleic acid binding zinc ion binding metal ion binding2
wingless- type MMTV integration site family, member 5B precursor WNT5B2NP_116031extracellular regiondevelopment frizzled- 2 signaling pathwaysignal transducer activity2
X- prolyl aminopeptidase 2, membrane- bound XPNPEP233NP_003390membraneproteolysisGPI anchor binding manganese ion binding metal ion binding metalloexopeptidase activity X- Pro aminopeptidase activity1, 2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, epsilon polypeptide YWHAE4NP_006752not classifiednot classifiedenzyme binding protein domain specific binding1, 2
tyrosine 3- monooxygenase/tryptophan 5- monooxygenase activation protein, gamma polypeptide YWHAG2NP_036611cytoplasmcytoskeleton organization and biogenesis negative regulation of apoptosis negative regulation of protein kinase activity regulation of mitosis regulation of neuron differentiation regulation of signal transduction regulation of synaptic plasticityactin binding insulin- like growth factor receptor binding protein domain specific binding protein homodimerization activity protein kinase C binding protein kinase C inhibitor activity1, 2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, eta polypeptide YWHAH1NP_003396cytoplasmcytoskeleton organization and biogenesis glucocorticoid catabolism glucocorticoid receptor signaling pathway intracellular protein transport negative regulation of apoptosis negative regulation of dendrite morphogenesis negative regulation of protein kinaactin binding glucocorticoid receptor binding insulin- like growth factor receptor binding protein domain specific binding protein kinase C inhibitor activity transcriptional activator activity2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, theta polypeptide YWHAQ1NP_006817not classifiedexocytosis regulation of progression through cell cycleprotein domain specific binding protein kinase C inhibitor activity1, 2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, zeta polypeptide YWHAZ8NP_003397not classifiednot classifiedprotein domain specific binding transcription factor binding1, 2
zinc finger, CCHC domain containing 11 isoform aZCCHC111NP_001009881not classifiednot classifiedmetal ion binding nucleic acid binding nucleotidyltransferase activity zinc ion binding2
zinc finger, DHHC domain containing 1 ZDHHC11NP_037436integral to membrane membranenot classifiedacyltransferase activity DNA binding metal ion binding protein binding transferase activity zinc ion binding2
zinc metalloproteinase STE24 ZMPSTE241NP_005848endoplasmic reticulum integral to membrane membraneproteolysismetalloendopeptidase activity metalloexopeptidase activity zinc ion binding DNA binding2
zinc finger protein 114 ZNF1141NP_705836intracellular nucleusregulation of transcription, DNA- dependentmetal ion binding nucleic acid binding zinc ion binding2
zinc finger protein 486 ZNF4861NP_443084intracellular nucleusregulation of transcription, DNA- dependent transcriptionmetal ion binding zinc ion binding2