Urinary Exosome Protein Database. LKEM, DIR, NHLBI, NIH

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Mechanism of exosome formation and excretion Urinary Exosome Protein Database This database of urinary exosome proteins is based on published and unpublished protein mass spectrometry data from the NHLBI Laboratory of Kidney and Electrolyte Metabolism. All data are from urinary exosomes isolated from healthy human volunteers. The figure on the right illustrates the mechanism of exosome formation and excretion.

In the first step of the process, apical membrane proteins undergo endocytosis. In the second step, the endosome is targeted to the multivesicular body (MVB). The signal that marks plasma membrane proteins for incorporation into MVB is mono-ubiquitination. In the third step, the endosome fuses with the MVB. Consequently, the apical plasma membrane proteins are segregated in the MVB outer membranes and internalized by membrane invagination. Finally, the outer membrane of the MVB fuses with the apical plasma membrane releasing its internal vesicles, called 'exosomes', in the urinary space. Exosomes contain both membrane and cytosolic proteins.

This current database contains protein identification of human urinary exosomes using two different mass spectrometer analyzers. The LCQ mass analyzer was used for technique # 1 and the LTQ mass analyzer was used for technique # 2.

References:

Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA. Large-scale Proteomics and Phosphoproteomics of Human Urinary Exosomes. J Am Soc Nephrol. in press

Current Database Size: 1160 proteins (Download Data).

The Urinary Exosome Protein Database was created by Patricia A. Gonzales, Guozhong Ma, Trairak Pisitkun, Brian Ruttenberg and Mark A. Knepper.

Protein Name	Gene Name	Peptide #	Acc No	GO Component	GO Process	GO Function	Tech
alpha 1B- glycoprotein	A1BG	1	NP_570602	extracellular region	not classified	not classified	2
alpha- 2- macroglobulin- like 1	A2ML1	1	NP_653271	not classified	not classified	endopeptidase inhibitor activity	2
aminoadipate- semialdehyde dehydrogenase- phosphopantetheinyl transferase	AASDHPPT	1	NP_056238	not classified	fatty acid biosynthesis	magnesium ion binding phosphopantetheinyltransferase activity transferase activity	2
ATP- binding cassette sub- family B member 1	ABCB1	23	NP_000918	cell surface integral to membrane membrane membrane fraction	response to drug transport	ATP binding ATPase activity hydrolase activity nucleotide binding transporter activity xenobiotic- transporting ATPase activity	1, 2
ATP- binding cassette, sub- family B (MDR/TAP), member 11	ABCB11	1	NP_003733	integral to plasma membrane membrane membrane fraction	transport	ATP binding ATPase activity bile acid- exporting ATPase activity nucleotide binding sodium- exporting ATPase activity, phosphorylative mechanism transporter activity	2
ATP- binding cassette, sub- family B, member 6	ABCB6	1	NP_005680	ATP- binding cassette (ABC) transporter complex integral to membrane membrane mitochondrial envelope mitochondrion	iron ion homeostasis transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding	2
ATP- binding cassette, sub- family C, member 11 isoform a	ABCC11	1	NP_149163	integral to membrane membrane	transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding	2
ATP- binding cassette, sub- family C, member 9 isoform SUR2A- delta- 14	ABCC9	1	NP_064694	integral to membrane membrane	potassium ion transport transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding receptor activity sulfonylurea receptor activity transporter activity	2
abhydrolase domain containing 14B	ABHD14B	6	NP_116139	nucleus	not classified	not classified	1, 2
abl- interactor 1 isoform d	ABI1	2	NP_001012770	cytoskeleton cytosol endoplasmic reticulum nucleus soluble fraction	negative regulation of cell proliferation transmembrane receptor protein tyrosine kinase signaling pathway	cytoskeletal protein binding	2
acetyl- Coenzyme A acetyltransferase 1 precursor	ACAT1	1	NP_000010	mitochondrion	not classified	acetyl- CoA C- acetyltransferase activity acyltransferase activity transferase activity	2
angiotensin I converting enzyme isoform 1 precursor	ACE	23	NP_000780	integral to membrane membrane membrane fraction plasma membrane soluble fraction	blood pressure regulation metabolism proteolysis	carboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding	1, 2
angiotensin I converting enzyme isoform 2 precursor	ACE	12	NP_690043	integral to membrane membrane membrane fraction plasma membrane soluble fraction	blood pressure regulation metabolism proteolysis	carboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding	2
angiotensin I converting enzyme 2 precursor	ACE2	8	NP_068576	extracellular region integral to membrane membrane	entry of virus into host cell proteolysis	carboxypeptidase activity chloride ion binding metal ion binding peptidyl- dipeptidase A activity protein binding viral receptor activity zinc ion binding	2
ATP citrate lyase isoform 2	ACLY	1	NP_942127	citrate lyase complex	ATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolism	ATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity	2
ATP citrate lyase isoform 1	ACLY	1	NP_001087	citrate lyase complex	ATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolism	ATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity	1
aconitase 1	ACO1	6	NP_002188	cytoplasm	metabolism tricarboxylic acid cycle	4 iron, 4 sulfur cluster binding aconitate hydratase activity iron ion binding lyase activity metal ion binding RNA binding	2
thioesterase, adipose associated isoform BFIT2	ACOT11	1	NP_671517	cytoplasm	fatty acid metabolism intracellular signaling cascade response to temperature stimulus	acyl- CoA thioesterase activity hydrolase activity serine esterase activity	2
acyl- CoA thioesterase 7 isoform hBACHd	ACOT7	1	NP_863656	cytoplasm mitochondrion	lipid metabolism	acyl- CoA binding hydrolase activity palmitoyl- CoA hydrolase activity serine esterase activity	2
acid phosphatase 1 isoform b	ACP1	1	NP_009030	cytoplasm soluble fraction	protein amino acid dephosphorylation	acid phosphatase activity hydrolase activity non- membrane spanning protein tyrosine phosphatase activity protein tyrosine phosphatase activity	2
lysosomal acid phosphatase 2 precursor	ACP2	7	NP_001601	integral to membrane lysosomal membrane lysosome	not classified	acid phosphatase activity hydrolase activity	1, 2
prostatic acid phosphatase precursor	ACPP	8	NP_001090	extracellular region	regulation of progression through cell cycle	acid phosphatase activity hydrolase activity protein tyrosine phosphatase activity	1, 2
acyl- CoA synthetase long- chain family member 4 isoform 2	ACSL4	1	NP_075266	integral to membrane membrane peroxisome	fatty acid metabolism learning and/or memory lipid metabolism metabolism	ligase activity long- chain- fatty- acid- CoA ligase activity magnesium ion binding	2
acyl- CoA synthetase medium- chain family member 1	ACSM1	1	NP_443188	mitochondrial matrix	benzoate metabolism butyrate metabolism energy derivation by oxidation of organic compounds fatty acid oxidation metabolism	acyl- CoA ligase activity butyrate- CoA ligase activity catalytic activity	2
actinin, alpha 1	ACTN1	1	NP_001093	cytoskeleton focal adhesion pseudopodium	focal adhesion formation negative regulation of cell motility regulation of apoptosis	actin binding calcium ion binding integrin binding protein binding vinculin binding	2
ARP1 actin- related protein 1 homolog A, centractin alpha	ACTR1A	1	NP_005727	actin filament cytoplasm cytoskeleton	not classified	ATP binding nucleotide binding protein binding structural constituent of cytoskeleton	2
actin- related protein 2 isoform a	ACTR2	1	NP_001005386	cytoskeleton	not classified	protein binding structural molecule activity	2
ARP3 actin- related protein 3 homolog	ACTR3	6	NP_005712	Arp2/3 protein complex	cell motility	ATP binding nucleotide binding protein binding structural molecule activity	2
aminoacylase 1	ACY1	15	NP_000657	cytoplasm cytosol	amino acid metabolism proteolysis	aminoacylase activity hydrolase activity metallopeptidase activity protein dimerization activity zinc ion binding	1, 2
aspartoacylase (aminocyclase) 3	ACY3	1	NP_542389	not classified	metabolism	aspartoacylase activity hydrolase activity, acting on ester bonds	2
brain adenylate cyclase 1	ADCY1	1	NP_066939	integral to membrane membrane	cAMP biosynthesis intracellular signaling cascade	calcium- and calmodulin- responsive adenylate cyclase activity calmodulin binding magnesium ion binding	2
class III alcohol dehydrogenase 5 chi subunit	ADH5	1	NP_000662	not classified	ethanol oxidation	alcohol dehydrogenase activity electron carrier activity fatty acid binding formaldehyde dehydrogenase (glutathione) activity metal ion binding S- (hydroxymethyl)glutathione dehydrogenase activity zinc ion binding	2
class V alcohol dehydrogenase 6	ADH6	1	NP_000663	not classified	ethanol oxidation	alcohol dehydrogenase activity electron carrier activity metal ion binding oxidoreductase activity zinc ion binding	2
transcription factor ELYS	AHCTF1	1	NP_056261	nucleus	development transcription	DNA binding	2
S- adenosylhomocysteine hydrolase	AHCY	10	NP_000678	cytoplasm	one- carbon compound metabolism	adenosylhomocysteinase activity hydrolase activity	2
AHNAK nucleoprotein isoform 1	AHNAK	1	NP_001611	nucleus	nervous system development	protein binding	2
AHA1, activator of heat shock 90kDa protein ATPase homolog 1	AHSA1	1	NP_036243	cytoplasm endoplasmic reticulum	protein folding response to stress	ATPase stimulator activity chaperone activator activity chaperone binding	2
alpha- 2- HS- glycoprotein (Fetuin- A)	AHSG	1	NP_001613	extracellular region extracellular space	acute- phase response negative regulation of bone mineralization negative regulation of insulin receptor signaling pathway pinocytosis positive regulation of phagocytosis regulation of inflammatory response skeletal development	cysteine protease inhibitor activity kinase inhibitor activity	2
adenylate kinase 1	AK1	4	NP_000467	cytoplasm cytosol	ATP metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism	adenylate kinase activity ATP binding kinase activity nucleotide binding transferase activity	2
aldo- keto reductase family 1, member A1	AKR1A1	7	NP_006057	not classified	aldehyde metabolism glucose metabolism	alcohol dehydrogenase (NADP+) activity aldehyde reductase activity electron carrier activity oxidoreductase activity protein binding	2
aldo- keto reductase family 1, member B1	AKR1B1	3	NP_001619	extracellular space	carbohydrate metabolism	aldehyde reductase activity electron carrier activity oxidoreductase activity	1, 2
aldo- keto reductase family 7, member A2	AKR7A2	2	NP_003680	not classified	aldehyde metabolism carbohydrate metabolism	aldehyde reductase activity electron carrier activity	2
aldo- keto reductase family 7, member A3	AKR7A3	2	NP_036199	cytosol	aldehyde metabolism	aldo- keto reductase activity electron carrier activity	2
delta- aminolevulinic acid dehydratase isoform a	ALAD	1	NP_001003945	not classified	heme biosynthesis	lyase activity metal ion binding porphobilinogen synthase activity zinc ion binding	2
albumin precursor	ALB	36	NP_000468	extracellular region extracellular space protein complex	body fluid osmoregulation cellular response to starvation hemolysis of host red blood cells maintenance of mitochondrion localization negative regulation of apoptosis negative regulation of non- apoptotic programmed cell death transport water homeostasis	antioxidant activity carrier activity copper ion binding DNA binding drug binding fatty acid binding metal ion binding oxygen binding protein binding pyridoxal phosphate binding toxin binding water binding	1, 2
activated leukocyte cell adhesion molecule	ALCAM	1	NP_001618	integral to plasma membrane membrane membrane fraction	antimicrobial humoral response (sensu Vertebrata) cell adhesion signal transduction	receptor binding	2
aldehyde dehydrogenase 1A1	ALDH1A1	10	NP_000680	cytoplasm	aldehyde metabolism metabolism	aldehyde dehydrogenase (NAD) activity androgen binding oxidoreductase activity Ras GTPase activator activity retinal dehydrogenase activity	2
aldehyde dehydrogenase 1 family, member L1	ALDH1L1	9	NP_036322	cytoplasm	10- formyltetrahydrofolate catabolism biosynthesis one- carbon compound metabolism protein biosynthesis	cofactor binding formyltetrahydrofolate dehydrogenase activity hydroxymethyl- , formyl- and related transferase activity methyltransferase activity oxidoreductase activity	2
mitochondrial aldehyde dehydrogenase 2 precursor	ALDH2	1	NP_000681	mitochondrion	alcohol metabolism carbohydrate metabolism metabolism	aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity electron carrier activity	2
aldehyde dehydrogenase 3B1 isoform a	ALDH3B1	1	NP_000685	not classified	alcohol metabolism aldehyde metabolism lipid metabolism metabolism	3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity	2
aldehyde dehydrogenase 3B1 isoform b	ALDH3B1	1	NP_001025181	not classified	alcohol metabolism aldehyde metabolism lipid metabolism metabolism	3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity	2
aldehyde dehydrogenase 8A1 isoform 1	ALDH8A1	1	NP_072090	intracellular	cell surface extracellular matrix (sensu Metazoa) membrane	oxidoreductase activity retinal dehydrogenase activity	2
aldehyde dehydrogenase 9A1	ALDH9A1	5	NP_000687	cytoplasm	aldehyde metabolism electron transport hormone metabolism metabolism neurotransmitter biosynthesis	4- trimethylammoniobutyraldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity aminobutyraldehyde dehydrogenase activity oxidoreductase activity	2
aldolase A	ALDOA	7	NP_908930	not classified	fructose metabolism glycolysis metabolism striated muscle contraction	fructose- bisphosphate aldolase activity lyase activity	2
fructose- bisphosphate aldolase C	ALDOC	1	NP_005156	not classified	fructose metabolism glycolsis metabolism	fructose- bisphosphate aldolase activity lyase activity	2
anaplastic lymphoma kinase Ki- 1	ALK	1	NP_004295	integral to plasma membrane membrane	brain development nervous system development protein amino acid N- linked glycosylation protein amino acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway	ATP binding nucleotide binding receptor activity receptor signaling protein tyrosine kinase activity transferase activity transmembrane receptor protein tyrosine kinase activity	2
arachidonate 12- lipoxygenase	ALOX12	1	NP_000688	cytosol sarcolemma	anti- apoptosis arachidonic acid metabolism cell motility electron transport fatty acid oxidation leukotriene biosynthesis negative regulation of cell volume oxygen and reactive oxygen species metabolism positive regulation of cell adhesion positive regula	arachidonate 12- lipoxygenase activity hepoxilin- epoxide hydrolase activity iron ion binding lipoxygenase activity metal ion binding oxidoreductase activity potassium channel inhibitor activity	2
tissue non- specific alkaline phosphatase precursor	ALPL	3	NP_000469	integral to membrane membrane	metabolism ossification	alkaline phosphatase activity GPI anchor binding hydrolase activity magnesium ion binding zinc ion binding	2
alpha- 1- microglobulin/bikunin precursor	AMBP	4	NP_001624	extracellular region plasma membrane	anti- inflammatory response cell adhesion heme catabolism negative regulation of immune response negative regulation of JNK cascade pregnancy protein- chromophore linkage transport	calcium channel inhibitor activity calcium oxalate binding heme binding IgA binding plasmin inhibitor activity protein homodimerization activity transporter activity trypsin inhibitor activity	1, 2
amnionless protein precursor	AMN	1	NP_112205	integral to membrane membrane	development	not classified	2
angiopoietin- like 2 precursor	ANGPTL2	1	NP_036230	extracellular space	development	receptor binding	2
ankyrin repeat and FYVE domain containing 1 isoform 1	ANKFY1	2	NP_057460	endosome membrane membrane	endocytosis	metal ion binding protein binding zinc ion binding	2
ankyrin repeat and FYVE domain containing 1 isoform 2	ANKFY1	2	NP_065791	endosome membrane membrane	endocytosis	metal ion binding protein binding zinc ion binding	2
membrane alanine aminopeptidase precursor	ANPEP	69	NP_001141	ER- Golgi intermediate compartment integral to plasma membrane	angiogenesis cell differentiation proteolysis	aminopeptidase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity receptor activity zinc ion binding	1, 2
annexin I	ANXA1	19	NP_000691	cornified envelope cytoplasm	anti- apoptosis cell motility cell surface receptor linked signal transduction inflammatory response keratinocyte differentiation lipid metabolism peptide cross- linking	calcium ion binding calcium- dependent phospholipid binding phospholipase A2 inhibitor activity phospholipase inhibitor activity protein binding, bridging receptor binding structural molecule activity	2
annexin A11	ANXA11	31	NP_665875	cytoplasm nuclear envelope nucleoplasm nucleus	immune response	calcium ion binding calcium- dependent phospholipid binding protein binding	2
annexin A13 isoform b	ANXA13	1	NP_001003954	plasma membrane	cell differentiation	calcium ion binding calcium- dependent phospholipid binding	2
annexin A2 isoform 2	ANXA2	29	NP_001002857	plasma membrane soluble fraction	skeletal development	calcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity	2
annexin A2 isoform 1	ANXA2	20	NP_001002858	plasma membrane soluble fraction	skeletal development	calcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity	2
annexin A3	ANXA3	8	NP_005130	cytoplasm	signal transduction	calcium ion binding calcium- dependent phospholipid binding diphosphoinositol- polyphosphate diphosphatase activity phospholipase A2 inhibitor activity	1, 2
annexin IV	ANXA4	24	NP_001144	cytoplasm	anti- apoptosis negative regulation of coagulation signal transduction	calcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity	1, 2
annexin 5	ANXA5	24	NP_001145	cytoplasm intracellular	anti- apoptosis blood coagulation negative regulation of coagulation signal transduction	calcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity protein binding	1, 2
annexin VI isoform 1	ANXA6	27	NP_001146	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding protein binding	1, 2
annexin VI isoform 2	ANXA6	20	NP_004024	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding protein binding	2
annexin VII isoform 2	ANXA7	13	NP_004025	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity	2
annexin VII isoform 1	ANXA7	2	NP_001147	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity	1
aldehyde oxidase 1	AOX1	1	NP_001150	not classified	electron transport inflammatory response oxygen and reactive oxygen species metabolism	2 iron, 2 sulfur cluster binding aldehyde oxidase activity electron carrier activity iron ion binding metal ion binding molybdenum ion binding oxidoreductase activity xanthine dehydrogenase activity	2
adaptor- related protein complex 1, mu 1 subunit	AP1M1	1	NP_115882	clathrin vesicle coat coated pit	intracellular protein transport	protein binding	2
adaptor- related protein complex 2, mu 1 subunit isoform a	AP2M1	1	NP_004059	clathrin vesicle coat coated pit	intracellular protein transport transport	lipid binding protein binding transporter activity	2
adaptor- related protein complex 4, mu 1 subunit	AP4M1	1	NP_004713	clathrin vesicle coat coated pit coated vesicle membrane Golgi trans cisterna membrane coat adaptor complex	intracellular protein transport transport vesicle- mediated transport	transporter activity	2
apoptotic peptidase activating factor 1 isoform b	APAF1	1	NP_001151	cytosol intracellular	caspase activation via cytochrome c nervous system development regulation of apoptosis	ATP binding caspase activator activity nucleotide binding protein binding	2
serum amyloid P component precursor	APCS	5	NP_001630	extracellular region extracellular space	acute- phase response chaperone- mediated protein complex assembly protein folding	calcium ion binding sugar binding unfolded protein binding	1, 2
apolipoprotein A- I preproprotein	APOA1	6	NP_000030	extracellular region extracellular space	cholesterol metabolism cholesterol transport circulation lipid metabolism lipid transport lipoprotein metabolism steroid metabolism	high- density lipoprotein binding lipid binding lipid transporter activity protein binding	2
apolipoprotein A- II preproprotein	APOA2	1	NP_001634	extracellular region	glucose metabolism lipid transport negative regulation of lipid catabolism negative regulation of lipoprotein metabolism neutrophil activation positive regulation of interleukin- 8 biosynthesis regulation of cytokine production response to glucose stimulus	lipid binding lipid transporter activity protein heterodimerization activity protein homodimerization activity	2
apolipoprotein A- IV precursor	APOA4	2	NP_000473	chylomicron extracellular region	circulation lipid metabolism lipid transport lipoprotein metabolism	lipid binding lipid transporter activity	2
apolipoprotein D precursor	APOD	7	NP_001638	extracellular region extracellular space	lipid metabolism transport	high- density lipoprotein binding lipid binding lipid transporter activity protein binding	1, 2
apolipoprotein E precursor	APOE	6	NP_000032	chylomicron cytoplasm extracellular region	cholesterol homeostasis circulation cytoskeleton organization and biogenesis induction of apoptosis intracellular transport learning and/or memory lipid transport lipoprotein metabolism protein tetramerization regulation of axon extension regulation of ne	antioxidant activity apolipoprotein E receptor binding beta- amyloid binding heparin binding lipid transporter activity phospholipid binding tau protein binding	2
adaptor protein containing pH domain, PTB domain and leucine zipper motif	APPL	1	NP_036228	cytoplasm endosome membrane membrane nucleus NuRD complex	cell cycle cell proliferation signal transduction	protein binding	2
adenine phosphoribosyltransferase isoform a	APRT	3	NP_000476	cytoplasm	adenine salvage nucleoside metabolism purine ribonucleoside salvage	adenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups	1, 2
adenine phosphoribosyltransferase isoform b	APRT	3	NP_001025189	cytoplasm	adenine salvage nucleoside metabolism purine ribonucleoside salvage	adenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups	2
aquaporin 1	AQP1	3	NP_932766	integral to membrane integral to plasma membrane membrane outer membrane	excretion transport water transport	porin activity transporter activity water transporter activity	1, 2
aquaporin 2	AQP2	7	NP_000477	apical plasma membrane integral to membrane plasma membrane	excretion transport water transport	transporter activity water channel activity	1, 2
ADP- ribosylation factor 1	ARF1	6	NP_001649	intracellular plasma membrane	ER to Golgi vesicle- mediated transport transport rRNA processing small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein binding receptor signaling protein activity	1
ADP- ribosylation factor interacting protein 1 isoform 2	ARFIP1	1	NP_055262	cytosol Golgi membrane	intracellular protein transport regulation of protein secretion	not classified	1
Rho GTPase activating protein 1	ARHGAP1	1	NP_004299	intracellular	cytoskeleton organization and biogenesis Rho protein signal transduction signal transduction	GTP binding protein binding Rho GTPase activator activity SH3/SH2 adaptor activity	2
Rho GDP dissociation inhibitor (GDI) alpha	ARHGDIA	1	NP_004300	cytoplasm cytoskeleton	anti- apoptosis cell motility negative regulation of cell adhesion Rho protein signal transduction	GTPase activator activity protein binding Rho GDP- dissociation inhibitor activity	2
Rho GDP dissociation inhibitor (GDI) beta	ARHGDIB	1	NP_001166	cytoplasm cytoplasmic membrane- bound vesicle cytoskeleton	actin cytoskeleton organization and biogenesis cell motility development immune response negative regulation of cell adhesion Rho protein signal transduction	GTPase activator activity Rho GDP- dissociation inhibitor activity	2
Rho guanine nucleotide exchange factor (GEF) 12	ARHGEF12	1	NP_056128	intracellular	regulation of Rho protein signal transduction	GTPase activator activity protein binding Rho guanyl- nucleotide exchange factor activity	2
ADP- ribosylation factor related protein 2	ARL15	1	NP_061960	not classified	not classified	GTP binding	2
ADP- ribosylation factor- like 3	ARL3	2	NP_004302	intracellular	G- protein coupled receptor protein signaling pathway rRNA processing small GTPase mediated signal transduction	GTP binding nucleotide binding signal transducer activity	1, 2
ADP- ribosylation factor- like 6	ARL6	3	NP_115522	cytoplasm intracellular membrane	rRNA processing small GTPase mediated signal transduction	GTP binding nucleotide binding protein binding	2
ADP- ribosylation factor- like 10B	ARL8A	1	NP_620150	cytoplasm intracellular membrane midbody spindle midzone	chromosome segregation rRNA processing small GTPase mediated signal transduction	alpha- tubulin binding beta- tubulin binding GTP binding GTPase activity nucleotide binding	2
ADP- ribosylation factor- like 10C	ARL8B	1	NP_060654	cytoplasm intracellular membrane midbody spindle midzone	chromosome segregation rRNA processing small GTPase mediated signal transduction	alpha- tubulin binding beta- tubulin binding GDP binding GTP binding GTPase activity nucleotide binding	2
armadillo repeat containing 3	ARMC3	1	NP_775104	not classified	not classified	binding	2
armadillo repeat containing 9	ARMC9	1	NP_079415	not classified	not classified	binding	2
actin related protein 2/3 complex subunit 1A	ARPC1A	1	NP_006400	not classified	not classified	not classified	2
actin related protein 2/3 complex subunit 2	ARPC2	5	NP_005722	Arp2/3 protein complex cytoskeleton	cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 3	ARPC3	2	NP_005710	Arp2/3 protein complex	cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 4 isoform a	ARPC4	2	NP_005709	Arp2/3 protein complex cytoskeleton	actin filament polymerization actin nucleation	actin filament binding protein binding, bridging structural constituent of cytoskeleton	1, 2
actin related protein 2/3 complex subunit 4 isoform b	ARPC4	2	NP_001020130	Arp2/3 protein complex cytoskeleton	actin filament polymerization actin nucleation	actin filament binding protein binding, bridging structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 5	ARPC5	1	NP_005708	Arp2/3 protein complex cytoplasm cytoskeleton	actin cytoskeleton organization and biogenesis cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex, subunit 5- like	ARPC5L	1	NP_112240	cytoskeleton	regulation of actin filament polymerization	not classified	2
arrestin domain containing 1	ARRDC1	5	NP_689498	not classified	not classified	not classified	1, 2
arylsulfatase E precursor	ARSE	1	NP_000038	not classified	metabolism skeletal development	arylsulfatase activity calcium ion binding hydrolase activity	2
arylsulfatase F precursor	ARSF	12	NP_004033	not classified	metabolism	arylsulfatase activity calcium ion binding hydrolase activity	2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 preproprotein isoform a	ASAH1	7	NP_808592	lysosome	carboxylic acid metabolism ceramide metabolism fatty acid metabolism	ceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	1, 2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 isoform b	ASAH1	9	NP_004306	lysosome	carboxylic acid metabolism ceramide metabolism fatty acid metabolism	ceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	2
argininosuccinate lyase isoform 3	ASL	1	NP_001020117	cytoplasm	amino acid biosynthesis arginine biosynthesis arginine catabolism urea cycle	argininosuccinate lyase activity catalytic activity lyase activity	2
arsA arsenite transporter, ATP- binding, homolog 1	ASNA1	1	NP_004308	cytoplasm membrane nucleolus soluble fraction	anion transport response to arsenic transport	arsenite transporter activity arsenite- transporting ATPase activity ATP binding hydrolase activity nucleotide binding transporter activity	2
argininosuccinate synthetase 1	ASS1	20	NP_000041	cytoplasm	amino acid biosynthesis arginine biosynthesis urea cycle	argininosuccinate synthase activity ATP binding ligase activity nucleotide binding protein binding	1, 2
two AAA domain containing protein	ATAD2	1	NP_054828	not classified	not classified	ATP binding nucleoside- triphosphatase activity nucleotide binding	2
5- aminoimidazole- 4- carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	ATIC	1	NP_004035	not classified	nucleobase, nucleoside, nucleotide and nucleic acid metabolism	hydrolase activity IMP cyclohydrolase activity phosphoribosylaminoimidazolecarboxamide formyltransferase activity transferase activity	2
Na+/K+ - ATPase beta 1 subunit isoform b	ATP1B1	1	NP_001001787	integral to membrane membrane sodium:potassium- exchanging ATPase complex	ion transport potassium ion transport sodium ion transport	potassium ion binding sodium ion binding sodium:potassium- exchanging ATPase activity	2
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precursor	ATP5A1	3	NP_001001937	membrane fraction mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement ofsubstances meta	2
ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit precursor	ATP5B	4	NP_001677	mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting ATP synthase, catalytic core (sensu Eukaryota)	ATP synthesis coupled proton transport generation of precursor metabolites and energy ion transport proton transport	ATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleoside- triphos	2
ATPase, H+ transporting, lysosomal accessory protein 1 precursor	ATP6AP1	1	NP_001174	membrane proton- transportin two- sector ATPase complex vacuole	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding transporter activity	2
ATPase, H+ transporting, lysosomal accessory protein 2	ATP6AP2	1	NP_005756	integral to membrane membrane	not classified	receptor activity	2
ATPase, H+ transporting, lysosomal V0 subunit a isoform 1	ATP6V0A1	1	NP_005168	integral to membrane membrane	ion transport proton transport	hydrogen ion transporter activity	2
ATPase, H+ transporting, lysosomal V0 subunit a4	ATP6V0A4	1	NP_065683	hydrogen- translocating V- type ATPase complex integral to membrane membrane	ion transport proton transport regulation of pH	hydrogen ion transporter activity	2
ATPase, H+ transporting, lysosomal, V0 subunit c	ATP6V0C	1	NP_001685	membrane proton- transporting two- sector ATPase complex vacuole	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotation mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal, V0 subunit d1	ATP6V0D1	1	NP_004682	hydrogen- translocating V- type ATPase complex proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D2	ATP6V0D2	2	NP_689778	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotation mechanism	2
ATPase, H+ transporting, lysosomal 70kD, V1 subunit A, isoform 1	ATP6V1A	22	NP_001681	integral to plasma membrane proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding	2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	ATP6V1B1	8	NP_001683	cytoplasm plasma membrane proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport energy coupled proton transport, against electrochemical gradient excretion ion transport regulation of pH sensory perception of sound	ATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding	2
vacuolar H+ATPase B2	ATP6V1B2	12	NP_001684	cytoplasm proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport energy coupled proton transport, against electrochemical gradient ion transport	ATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 isoform A	ATP6V1C1	1	NP_001686	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances metal ion binding transporter activity	2
vacuolar H+ ATPase C2 isoform a	ATP6V1C2	1	NP_001034451	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport	ATP binding hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2
H(+)- transporting two- sector ATPase	ATP6V1D	2	NP_057078	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
vacuolar H+ ATPase E1 isoform a	ATP6V1E1	2	NP_001687	plasma membrane proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding	2
vacuolar H+ ATPase E1 isoform c	ATP6V1E1	1	NP_001034456	plasma membrane proton- transporting two- sector ATPase complex plasma membrane	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transportin ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding	2
vacuolar H+ ATPase E1 isoform b	ATP6V1E1	1	NP_001034455	plasma membrane proton- transporting two- sector ATPase complex plasma membrane	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transportin ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding	2
ATPase, H+ transporting, lysosomal 14kD, V1 subunit F	ATP6V1F	1	NP_004222	membrane fraction proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
vacuolar H+ ATPase G1	ATP6V1G1	1	NP_004879	not classified	ATP biosynthesis ion transport proton transport	hydrogen ion transporter activity hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 1	ATP6V1H	8	NP_998784	hydrogen- transporting ATPase V1 domain peripheral to membrane of membrane fraction	ATP hydrolysis coupled proton transport ATP synthesis coupled proton transport endocytosis ion transport proton transport vacuolar acidification	ATP binding ATPase activity ATPase stimulator activity enzyme regulator activity hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding protein bin	2
attractin isoform 1	ATRN	1	NP_647537	extracellular space integral to plasma membrane plasma membrane	development inflammatory response	receptor activity sugar binding	2
attractin isoform 2	ATRN	1	NP_647538	extracellular space integral to plasma membrane plasma membrane	development inflammatory response	receptor activity sugar binding	2
azurocidin 1 preproprotein	AZU1	1	NP_001691	azurophil granule extracellular region	anti- apoptosis cellular extravasation chemotaxis defense response to Gram- negative bacterium glial cell migration induction of positive chemotaxis macrophage chemotaxis microglial cell activation monocyte activation positive regulation of cell adhesion po	heparin binding serine- type endopeptidase activity toxin binding	2
beta- 2- microglobulin precursor	B2M	1	NP_004039	extracellular region	antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I immune response	MHC class I receptor activity	2
UDP- Gal:betaGlcNAc beta 1, 4- galactosyltransferase 1, membrane- bound form	B4GALT1	1	NP_001488	Golgi apparatus integral to membrane membrane	carbohydrate metabolism oligosaccharide biosynthesis	beta- N- acetylglucosaminylglycopeptide beta- 1, 4- galactosyltransferase activity galactosyltransferase activity lactose synthase activity manganese ion binding metal ion binding N- acetyllactosamine synthase activity transferase activity, transferring glycosy	2
BAI1- associated protein 2 isoform 1	BAIAP2	9	NP_059344	not classified	not classified	protein binding	1, 2
BAI1- associated protein 2 isoform 2	BAIAP2	6	NP_059345	not classified	not classified	protein binding	2
BAI1- associated protein 2- like 1	BAIAP2L1	4	NP_061330	not classified	not classified	not classified	1, 2
brain abundant, membrane attached signal protein 1	BASP1	6	NP_006308	cytoskeleton plasma membrane	not classified	not classified	2
HLA- B associated transcript- 2 isoform a	BAT2	1	NP_542417	nucleus	not classified	protein binding	2
bromodomain adjacent to zinc finger domain, 1B	BAZ1B	1	NP_075381	nucleus	regulation of transcription, DNA- dependent transcription	metal ion binding protein binding transcription factor activity zinc ion binding	2
gamma- butyrobetaine dioxygenase	BBOX1	6	NP_003977	not classified	carnitine biosynthesis electron transport	gamma- butyrobetaine dioxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1, 2
basal cell adhesion molecule isoform 1 precursor	BCAM	1	NP_005572	cell surface integral to plasma membrane plasma membrane	cell adhesion signal transduction	transmembrane receptor activity	2
basal cell adhesion molecule isoform 2 precursor	BCAM	2	NP_001013275	cell surface integral to plasma membrane plasma membrane	cell adhesion signal transduction	transmembrane receptor activity	2
BCL2- like 12 isoform 2	BCL2L12	1	NP_443074	not classified	apoptosis	not classified	2
breakpoint cluster region isoform 1	BCR	2	NP_004318	intracellular	intracellular signaling cascade protein amino acid phosphorylation regulation of Rho protein signal transduction signal transduction	GTPase activator activity kinase activity protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity	2
breakpoint cluster region isoform 2	BCR	2	NP_067585	intracellular	intracellular signaling cascade protein amino acid phosphorylation regulation of Rho protein signal transduction signal transduction	GTPase activator activity kinase activity protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity	2
3- hydroxybutyrate dehydrogenase, type 2	BDH2	5	NP_064524	cytoplasm mitochondrion	fatty acid beta- oxidation metabolism	3- hydroxybutyrate dehydrogenase activity NAD binding oxidoreductase activity	2
biglycan preproprotein	BGN	1	NP_001702	extracellular matrix (sensu Metazoa) transport vesicle	not classified	extracellular matrix structural constituent transferase activity	2
basic helix- loop- helix domain containing, class B, 9	BHLHB9	1	NP_085142	not classified	not classified	binding	2
betaine- homocysteine methyltransferase 2	BHMT2	1	NP_060084	not classified	not classified	homocysteine S- methyltransferase activity methyltransferase activity transferase activity	2
bleomycin hydrolase	BLMH	1	NP_000377	cytoplasm nucleus	proteolysis	aminopeptidase activity bleomycin hydrolase activity carboxypeptidase activity	2
biliverdin reductase A	BLVRA	1	NP_000703	not classified	electron transport heme catabolism metabolism	biliverdin reductase activity metal ion binding oxidoreductase activity zinc ion binding	2
biliverdin reductase B (flavin reductase (NADPH))	BLVRB	4	NP_000704	not classified	cellular metabolism	biliverdin reductase activity coenzyme binding flavin reductase activity oxidoreductase activity	2
bactericidal/permeability- increasing protein precursor	BPI	4	NP_001716	integral to plasma membrane membrane	defense response to bacterium immune response	Gram- negative bacterial binding lipid binding	2
bone marrow stromal cell antigen 2	BST2	1	NP_004326	integral to plasma membrane membrane	cell proliferation cell- cell signaling development humoral immune response positive regulation of I- kappaB kinase/NF- kappaB cascade defense response to bacterium	signal transducer activity	1, 2
B- cell translocation gene 2	BTG2	1	NP_006754	not classified	DNA repair negative regulation of cell proliferation regulation of transcription, DNA- dependent transcription	transcription factor activity	2
adipose specific 2	C10orf116	2	NP_006820	not classified	not classified	not classified	2
PREDICTED: similar to retinoblastoma- associated protein 140 isoform 1	C10orf18	1	XP_374765	not classified	not classified	not classified	2
hypothetical protein LOC222389	C10orf30	1	NP_689964	not classified	not classified	not classified	2
hypothetical protein LOC283294	C11orf47	1	NP_775860	not classified	not classified	not classified	2
hypothetical protein LOC91894	C11orf52	1	NP_542390	not classified	not classified	not classified	2
hypothetical protein LOC28970	C11orf54	1	NP_054758	nucleus	not classified	hydrolase activity metal ion binding zinc ion binding	2
hypothetical protein LOC55004	C11orf59	3	NP_060377	not classified	not classified	not classified	1, 2
hypothetical protein LOC283450	C12orf51	1	NP_776174	not classified	not classified	not classified	2
hypothetical protein LOC120939	C12orf59	1	NP_694567	not classified	not classified	not classified	2
transcription factor IIB	C16orf80	1	NP_037374	not classified	development	not classified	2
hypothetical protein LOC254863	C17orf61	2	NP_689979	not classified	not classified	not classified	2
lung cancer- related protein 8	C17orf80	1	NP_060411	not classified	not classified	not classified	2
hypothetical protein LOC147685	C19orf18	1	NP_689687	integral to membrane membrane	not classified	not classified	2
specifically androgen- regulated protein	C1orf116	4	NP_076427	not classified	not classified	not classified	2
hypothetical protein LOC338094	C1orf179	4	NP_788954	not classified	not classified	not classified	2
hypothetical protein LOC54680	C1orf181	1	NP_060423	not classified	not classified	not classified	2
keratinocyte expressed, proline- rich protein	C1orf45	1	NP_001020402	not classified	not classified	not classified	2
hypothetical protein LOC148362	C1orf58	17	NP_653296	not classified	not classified	not classified	1, 2
hypothetical protein LOC127281	C1orf93	1	NP_689584	not classified	not classified	not classified	2
hypothetical protein LOC200232	C20orf106	1	NP_001012989	not classified	not classified	not classified	2
LPLUNC1 protein precursor	C20orf114	10	NP_149974	not classified	not classified	lipid binding	2
hypothetical protein LOC140710 isoform 1	C20orf117	1	NP_542194	not classified	not classified	catalytic activity	2
hypothetical protein LOC84226	C2orf16	1	NP_115642	not classified	not classified	not classified	2
hypothetical protein LOC54978	C2orf18	2	NP_060347	integral to membrane membrane	not classified	not classified	2
complement component 5	C5	1	NP_001726	extracellular region extracellular space membrane attack complex	activation of MAPK activity chemotaxis complement activation, alternative pathway complement activation, classical pathway cytolysis G- protein coupled receptor protein signaling pathway inflammatory response innate immune response response to stress	chemokine activity endopeptidase inhibitor activity receptor binding	2
putative nuclear protein ORF1- FL49	C5orf32	2	NP_115788	nucleus	not classified	not classified	1, 2
putative c- Myc- responsive isoform 2	C6orf108	1	NP_954653	nucleus	cell proliferation	not classified	2
hypothetical protein LOC51534	C6orf55 (VTA1)	6	NP_057569	not classified	not classified	not classified	1, 2
hypothetical protein LOC352999	C6orf58	1	NP_001010905	not classified	not classified	not classified	2
hypothetical protein LOC79017	C7orf24	1	NP_076956	not classified	not classified	not classified	2
complement component 9	C9	1	NP_001728	integral to plasma membrane membrane membrane attack complex	complement activation, alternative pathway complement activation, classical pathway cytolysis hemolysis of host red blood cells innate immune response	not classified	2
chromosome 9 open reading frame 19	C9orf19	2	NP_071738	extracellular region membrane	not classified	not classified	1, 2
hypothetical protein LOC54875	C9orf39	1	NP_060208	membrane	signal transduction	two- component sensor activity	2
ionized calcium binding adapter molecule 2 isoform 1	C9orf58	2	NP_113614	actin cytoskeleton focal adhesion	not classified	calcium ion binding	2
hypothetical protein LOC64855 isoform 2	C9orf88	2	NP_001030611	not classified	not classified	not classified	2
carbonic anhydrase II	CA2	9	NP_000058	cytoplasm	one- carbon compound metabolism	carbonate dehydratase activity lyase activity metal ion binding zinc ion binding	1, 2
carbonic anhydrase IV precursor	CA4	2	NP_000708	membrane membrane fraction	one- carbon compound metabolism response to stimulus visual perception	carbonate dehydratase activity GPI anchor binding lyase activity metal ion binding zinc ion binding	1, 2
calcium binding protein 39	CAB39	9	NP_057373	not classified	not classified	protein binding	1, 2
calcium binding protein 39- like	CAB39L	1	NP_001026894	not classified	not classified	binding	2
calcium channel, voltage- dependent, alpha 2/delta subunit 1	CACNA2D1	1	NP_000713	integral to membrane membrane membrane fraction voltage- gated calcium channel complex	calcium ion transport ion transport	calcium channel activity calcium ion binding dihydropyridine- sensitive calcium channel activity receptor activity voltage- gated ion channel activity	2
calbindin 1	CALB1	2	NP_004920	not classified	not classified	calcium ion binding protein binding vitamin D binding	1, 2
calmodulin- like 3	CALML3	1	NP_005176	not classified	not classified	calcium ion binding	2
calreticulin precursor	CALR	1	NP_004334	cytosol endoplasmic reticulum endoplasmic reticulum lumen	calcium ion homeostasis protein export from nucleus protein folding regulation of apoptosis regulation of transcription, DNA- dependent	calcium ion binding DNA binding sugar binding unfolded protein binding zinc ion binding	1
calcium/calmodulin- dependent protein kinase IV	CAMK4	1	NP_001735	nucleus	protein amino acid phosphorylation signal transduction	ATP binding calcium ion binding calcium- and calmodulin- dependent protein kinase activity calmodulin binding nucleotide binding protein serine/threonine kinase activity transferase activity	2
cathelicidin antimicrobial peptide	CAMP	1	NP_004336	extracellular region	defense response to bacterium	not classified	2
TIP120 protein	CAND1	1	NP_060918	nucleus ubiquitin ligase complex	negative regulation of enzyme activity protein ubiquitination regulation of transcription, DNA- dependent transcription	protein binding	2
adenylyl cyclase- associated protein	CAP1	1	NP_006358	membrane	adenylate cyclase activation establishment and/or maintenance of cell polarity signal transduction	actin binding	2
gelsolin- like capping protein	CAPG	8	NP_001738	F- actin capping protein complex nucleus	barbed- end actin filament capping protein complex assembly	actin binding	2
calpain 1, large subunit	CAPN1	15	NP_005177	intracellular	positive regulation of cell proliferation proteolysis	calcium ion binding calpain activity	2
calpain 2, large subunit	CAPN2	1	NP_001739	intracellular	proteolysis	calcium ion binding calpain activity	2
calpain 5	CAPN5	10	NP_004046	intracellular	proteolysis signal transduction	calpain activity	2
calpain 7	CAPN7	30	NP_055111	intracellular nucleus	proteolysis	binding calpain activity cysteine- type peptidase activity	1, 2
F- actin capping protein alpha- 1 subunit	CAPZA1	2	NP_006126	F- actin capping protein complex	actin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility protein complex assembly	actin binding	2
capping protein (actin filament) muscle Z- line, alpha 2	CAPZA2	1	NP_006127	F- actin capping protein complex	actin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility protein complex assembly	actin binding	2
F- actin capping protein beta subunit	CAPZB	2	NP_004921	F- actin capping protein complex	actin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility	actin binding	2
carbonyl reductase 1	CBR1	5	NP_001748	cytosol	metabolism	15- hydroxyprostaglandin dehydrogenase (NADP+) activity carbonyl reductase (NADPH) activity oxidoreductase activity prostaglandin- E2 9- reductase activity	2
coiled- coil and C2 domain containing 1A	CC2D1A	6	NP_060191	nucleus	positive regulation of I- kappaB kinase/NF- kappaB cascade regulation of transcription, DNA- dependent transcription	DNA binding signal transducer activity	2
coiled- coil domain containing 105	CCDC105	2	NP_775753	not classified	not classified	not classified	2
chaperonin containing TCP1, subunit 2	CCT2	1	NP_006422	cytosol	protein folding regulation of progression through cell cycle	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 3 isoform c	CCT3	1	NP_001008800	cytoskeleton	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 3 isoform a	CCT3	3	NP_005989	cytoskeleton	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 5 (epsilon)	CCT5	3	NP_036205	not classified	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 6A isoform b	CCT6A	2	NP_001009186	cytoplasm	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 6A isoform a	CCT6A	1	NP_001753	cytoplasm	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 8 (theta)	CCT8	4	NP_006576	cytosol	protein folding	ATP binding ATPase activity, coupled nucleotide binding unfolded protein binding	2
CD14 antigen precursor	CD14	7	NP_000582	extrinsic to membrane plasma membrane	apoptosis cell surface receptor linked signal transduction inflammatory response phagocytosis	GPI anchor binding peptidoglycan receptor activity transferase activity	2
CD2- associated protein	CD2AP	14	NP_036252	actin cytoskeleton cytoplasm filamentous actin ruffle	protein complex assembly signal transduction substrate- bound cell migration, cell extension	protein binding SH3 domain binding structural constituent of cytoskeleton	2
CD59 antigen p18- 20	CD59	4	NP_976074	membrane fraction plasma membrane	blood coagulation cell surface receptor linked signal transduction immune response	GPI anchor binding protein binding	2
CD63 antigen isoform A	CD63	1	NP_001771	endosome membrane integral to membrane integral to plasma membrane lysosomal membrane plasma membrane	not classified	not classified	1, 2
CD63 antigen isoform B	CD63	2	NP_001035123	endosome membrane integral to membrane integral to plasma membrane lysosomal membrane plasma membrane	not classified	not classified	2
CD81 antigen	CD81	4	NP_004347	integral to plasma membrane membrane	activation of MAPK activity entry of virus into host cell phosphatidylinositol biosynthesis phosphoinositide metabolism positive regulation of 1- phosphatidylinositol 4- kinase activity positive regulation of B cell proliferation positive regulation of cel	protein binding	1, 2
CD9 antigen	CD9	7	NP_001760	integral to membrane integral to plasma membrane plasma membrane	cell adhesion cell motility fusion of sperm to egg plasma membrane paranodal junction assembly platelet activation	protein binding	1, 2
cell division cycle 2 protein isoform 2	CDC2	1	NP_203698	midbody nucleus spindle microtubule	anti- apoptosis cell cycle cell division mitosis protein amino acid phosphorylation regulation of progression through cell cycle traversing start control point of mitotic cell cycle	ATP binding cyclin- dependent protein kinase activity nucleotide binding protein binding transferase activity	2
cell division cycle 42 isoform 2	CDC42	7	NP_426359	cytoplasm filopodium intracellular plasma membrane	actin cytoskeleton organization and biogenesis cell cycle cell division establishment and/or maintenance of cell polarity G1 phase macrophage differentiation negative regulation of protein complex assembly positive regulation of pseudopodium formation reg	GTP binding GTPase activity nucleotide binding protein binding	2
CDC42- binding protein kinase alpha isoform A	CDC42BPA	2	NP_055641	intercellular junction leading edge	actin cytoskeleton reorganization intracellular signaling cascade protein amino acid phosphorylation regulation of small GTPase mediated signal transduction	ATP binding diacylglycerol binding identical protein binding kinase activity magnesium ion binding metal ion binding nucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity zinc ion binding	2
CDC42- binding protein kinase beta	CDC42BPB	3	NP_006026	cytoskeleton intercellular junction leading edge	actin cytoskeleton reorganization cytoskeleton organization and biogenesis establishment and/or maintenance of cell polarity intracellular signaling cascade protein amino acid phosphorylation regulation of small GTPase mediated signal transduction	ATP binding diacylglycerol binding identical protein binding magnesium ion binding nucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity zinc ion binding	2
CDK5 regulatory subunit associated protein 2 isoform b	CDK5RAP2	1	NP_001011649	centrosome cytoskeleton	brain development regulation of neuron differentiation	microtubule binding neuronal Cdc2- like kinase binding	2
carcinoembryonic antigen- related cell adhesion molecule 5 preproprotein	CEACAM5	1	NP_004354	integral to membrane integral to plasma membrane membrane	not classified	GPI anchor binding	2
centrosomal protein 2 isoform 1	CEP250	1	NP_009117	centrosome	mitotic cell cycle regulation of centriole- centriole cohesion	protein kinase binding	2
cholesteryl ester transfer protein, plasma precursor	CETP	7	NP_000069	not classified	cholesterol metabolism lipid metabolism lipid transport steroid metabolism	catalytic activitylipid binding	2
complement factor D preproprotein	CFD	2	NP_001919	not classified	complement activation, alternative pathway innate immune response proteolysis	complement factor D activity peptidase activity	2
complement factor H isoform b precursor	CFH	1	NP_001014975	extracellular space	complement activation, alternative pathway innate immune response	not classified	2
complement factor I	CFI	1	NP_000195	extracellular region membrane	complement activation, classical pathway innate immune response proteolysis	complement factor I activity peptidase activity scavenger receptor activity	2
coiled- coil- helix- coiled- coil- helix domain containing 3	CHCHD3	1	NP_060282	mitochondrion	not classified	protein binding	2
chromatin modifying protein 1A isoform 2	CHMP1A	1	NP_002759	condensed nuclear chromosome early endosome endomembrane system microtubule organizing center nuclear matrix nucleus	cell cycle gene silencing mitotic chromosome condensation negative regulation of S phase of mitotic cell cycle negative regulation of transcription by glucose negative regulation of transcription, DNA- dependent protein transport transcription vesicle- medi	protein binding	2
chromatin modifying protein 1B	CHMP1B	6	NP_065145	not classified	protein transport	not classified	1, 2
chromatin modifying protein 2A	CHMP2A	11	NP_055268	not classified	protein transport	not classified	1, 2
chromatin modifying protein 2B	CHMP2B	4	NP_054762	intracellular	protein transport	not classified	1, 2
chromatin modifying protein 4B	CHMP4B	2	NP_789782	not classified	protein transport	not classified	1, 2
chromatin modifying protein 5	CHMP5	2	NP_057494	not classified	protein transport	not classified	1, 2
chromatin modifying protein 6	CHMP6	2	NP_078867	membrane	protein transport	not classified	2
calcium binding protein P22	CHP	1	NP_009167	not classified	potassium ion transport small GTPase mediated signal transduction	calcium ion binding potassium channel regulator activity	2
calcium and integrin binding 1 (calmyrin)	CIB1	2	NP_006375	cytoplasm endoplasmic reticulum membrane nucleoplasm	apoptosis cell adhesion double- strand break repair response to DNA damage stimulus	calcium ion binding protein binding	2
cytoskeleton- associated protein 4	CKAP4	1	NP_006816	integral to membrane membrane fraction	not classified	not classified	2
brain creatine kinase	CKB	8	NP_001814	cytoplasm	not classified	creatine kinase activity	2
chloride intracellular channel 1	CLIC1	7	NP_001279	brush border cytoplasm membrane membrane fraction nuclear envelope nucleus soluble fraction	chloride transport ion transport signal transduction	chloride ion binding protein binding voltage- gated chloride channel activity	1, 2
chloride intracellular channel 3	CLIC3	2	NP_004660	cytoplasm membrane nucleus	chloride transport ion transport signal transduction	chloride ion binding protein binding voltage- gated chloride channel activity	2
chloride intracellular channel 4	CLIC4	5	NP_039234	actin cytoskeleton cytoplasm intracellular membrane microvillus soluble fraction	cell differentiation chloride transport ion transport negative regulation of cell migration	chloride ion binding protein binding voltage- gated chloride channel activity	1, 2
chloride intracellular channel 5	CLIC5	1	NP_058625	actin cytoskeleton insoluble fraction membrane microvillus	chloride transport ion transport pregnancy	chloride ion binding protein binding voltage- gated chloride channel activity	2
chloride intracellular channel 6	CLIC6	2	NP_444507	membrane	chloride transport ion transport	chloride ion binding voltage- gated chloride channel activity	2
clathrin heavy chain 1	CLTC	12	NP_004850	clathrin coat of coated pit clathrin vesicle coat	intracellular protein transport	protein binding structural molecule activity	2
clusterin isoform 1	CLU	6	NP_001822	extracellular space	apoptosis cell death complement activation, classical pathway innate immune response lipid metabolism	not classified	1, 2
clusterin isoform 2	CLU	5	NP_976084	extracellular space	apoptosis cell death complement activiation, classical pathway innate immune response lipid metabolism	not classified	2
carboxymethylenebutenolidase- like (Pseudomonas)	CMBL	6	NP_620164	not classified	not classified	hydrolase activity	2
cytidylate kinase	CMPK	3	NP_057392	cytoplasm nucleus	nucleobase, nucleoside, nucleotide and nucleic acid metabolism pyrimidine ribonucleotide biosynthesis	ATP binding cytidylate kinase activity kinase activity nucleotide binding phosphotransferase activity, phosphate group as acceptor transferase activity uridine kinase activity	2
CNDP dipeptidase 2 (metallopeptidase M20 family)	CNDP2	15	NP_060705	not classified	proteolysis	carboxypeptidase activity hydrolase activity metallopeptidase activity protein dimerization activity	2
connector enhancer of kinase suppressor of Ras 2	CNKSR2	2	NP_055742	cytoplasm membrane	regulation of signal transduction	protein binding	2
2', 3'- cyclic nucleotide 3' phosphodiesterase	CNP	13	NP_149124	membrane	cyclic nucleotide catabolism synaptic transmission	2', 3'- cyclic- nucleotide 3'- phosphodiesterase activity hydrolase activity	1, 2
coenzyme A synthase isoform a	COASY	1	NP_079509	not classified	biosynthesis coenzyme A biosynthesis	ATP binding dephospho- CoA kinase activity nucleotide binding nucleotidyltransferase activity pantetheine- phosphate adenylyltransferase activity transferase activity	2
COBL- like 1	COBLL1	1	NP_055715	not classified	not classified	not classified	2
alpha 1 type XV collagen precursor	COL15A1	1	NP_001846	collagen type XV cytoplasm extracellular matrix (sensu Metazoa)	Protein binding Structural Molecule Activity	Angiogenesis Cell Adhesion Cell Differentiation Phosphate Transport	2
alpha 1 type XVIII collagen isoform 1 precursor	COL18A1	1	NP_085059	collagen cytoplasm extracellular matrix extracellular matrix (sensu Metazoa)	cell adhesion negative regulation of cell proliferation organ morphogenesis phosphate transport visual perception	extracellular matrix structural constituent metal ion binding protein binding structural molecule activity zinc ion binding	2
collagen, type VI, alpha 1 precursor	COL6A1	6	NP_001839	collagen collagen type VI cytoplasm	cell adhesion phosphate transport	extracellular matrix structural constituent protein binding	1, 2
alpha 3 type VI collagen isoform 5 precursor	COL6A3	1	NP_476508	collagen type VI cytoplasm extracellular matrix (sensu Metazoa)	cell adhesion muscle development phosphate transport	protein binding serine- type endopeptidase inhibitor activity structural molecule activity	2
catechol- O- methyltransferase isoform MB- COMT	COMT	1	NP_000745	integral to membrane membrane microsome soluble fraction	catecholamine metabolism neurotransmitter catabolism	catechol O- methyltransferase activity magnesium ion binding protein binding transferase activity	2
catechol- O- methyltransferase isoform S- COMT	COMT	1	NP_009294	integral to membrane membrane microsome soluble fraction	catecholamine metabolism neurotransmitter catabolism	catechol O- methyltransferase activity magnesium ion binding protein binding transferase activity	2
COP9 signalosome subunit 8 isoform 2	COPS8	1	NP_937832	nucleus signalosome complex	metabolism	racemase and epimerase activity, acting on amino acids and derivatives	2
coactosin- like 1	COTL1	1	NP_066972	cytoskeleton intracellular	not classified	actin binding enzyme binding	2
ceruloplasmin precursor	CP	6	NP_000087	extracellular region extracellular space	copper ion homeostasis copper ion transport ion transport iron ion homeostasis	copper ion binding copper ion transporter activity ferroxidase activity metal ion binding oxidoreductase activity	2
PREDICTED: similar to Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit)	CPN2	2	XP_947165	not classified	not classified	not classified	2
copine III	CPNE3	14	NP_003900	cytoplasm cytosol	lipid metabolism vesicle- mediated transport	calcium- dependent phospholipid binding kinase activity protein serine/threonine kinase activity transferase activity transporter activity	1, 2
copine V	CPNE5	3	NP_065990	not classified	not classified	not classified	1, 2
serine carboxypeptidase vitellogenic- like	CPVL	6	NP_112601	not classified	proteolysis	peptidase activity serine carboxypeptidase activity	2
complement receptor 1 isoform F precursor	CR1	17	NP_000564	integral to plasma membrane membrane	complement activation, classical pathway innate immune response	complement component C3b receptor activity receptor activity	1, 2
cellular retinoic acid binding protein 2	CRABP2	1	NP_001869	not classified	epidermis development regulation of transcription, DNA- dependent signal transduction transport	lipid binding retinal binding	2
crumbs homolog 2	CRB2	1	NP_775960	integral to membrane membrane	response to stimulus visual perception	calcium ion binding	2
crumbs 3 isoform a precursor	CRB3	1	NP_631900	integral to membrane membrane tight junction	not classified	not classified	2
cAMP responsive element binding protein 5 isoform alpha	CREB5	2	NP_878901	intracellular nucleus	positive regulation of transcription, DNA- dependent transcription transcription from RNA polymerase II promoter	metal ion binding protein dimerization activity sequence- specific DNA binding transcription factor activity zinc ion binding	2
v- crk sarcoma virus CT10 oncogene homolog isoform a	CRK	1	NP_058431	cytoplasm nucleus	actin cytoskeleton organization and biogenesis cell motility intracellular signaling cascade regulation of transcription from RNA polymerase II promoter	protein binding SH2 domain binding SH3/SH2 adaptor activity	2
cornulin	CRNN	3	NP_057274	cytoplasm membrane	cell- cell adhesion metabolism response to heat response to unfolded protein	calcium ion binding	2
ciliary rootlet coiled- coil, rootletin	CROCC	1	NP_055490	centriole ciliary rootlet	cell cycle centrosome organization and biogenesis	kinesin binding structural molecule activity	2
transducer of regulated cAMP response element- binding protein (CREB) 2	CRTC2	1	NP_859066	not classified	not classified	not classified	2
crystallin, alpha B	CRYAB	7	NP_001876	cytoplasm nucleus	muscle contraction protein folding transmembrane receptor protein tyrosine kinase signaling pathway visual perception	structural constituent of eye lens unfolded protein binding	2
lambda- crystallin	CRYL1	7	NP_057058	not classified	fatty acid metabolism	oxidoreductase activity	2
crystallin, mu isoform 1	CRYM	1	NP_001879	not classified	visual perception	ornithine cyclodeaminase activity	2
crystallin, mu isoform 2	CRYM	1	NP_001014444	not classified	visual perception	ornithine cyclodeaminase activity	2
crystallin, zeta	CRYZ	4	NP_001880	not classified	visual perception	NADPH:quinone reductase activity oxidoreductase activity zinc ion binding	2
CSE1 chromosome segregation 1- like protein	CSE1L	1	NP_001307	cytoplasm nuclear pore nucleus	apoptosis cell proliferation protein import into nucleus, docking protein transport	binding importin- alpha export receptor activity protein transporter activity	2
c- src tyrosine kinase	CSK	1	NP_004374	cytoplasm plasma membrane	intracellular signaling cascade protein amino acid phosphorylation regulation of progression through cell cycle	ATP binding nucleotide binding protein C- terminus binding protein- tyrosine kinase activity transferase activity	2
cysteine and glycine- rich protein 1	CSRP1	2	NP_004069	nucleus	not classified	metal ion binding zinc ion binding	2
cystatin C precursor	CST3	1	NP_000090	not classified	not classified	cysteine protease inhibitor activity protein homodimerization activity	2
cystatin B	CSTB	2	NP_000091	intracellular nucleus	not classified	cysteine protease inhibitor activity	2
small CTD phosphatase 3 isoform 2	CTDSPL	1	NP_005799	nucleus	not classified	phosphoric monoester hydrolase activity	2
small CTD phosphatase 3 isoform 1	CTDSPL	1	NP_001008393	nucleus	not classified	phosphoric monoester hydrolase activity	2
cystathionase isoform 2	CTH	1	NP_714964	not classified	amino acid biosynthesis cysteine biosynthesis	cystathionine gamma- lyase activity lyase activity	2
cystinosis, nephropathic isoform 1	CTNS	1	NP_001026851	integral to membrane lysosomal membrane membrane	amino acid metabolism L- cystine transport transport immune response proteolysis	L- cystine transporter activity	2
cathepsin A precursor	CTSA	3	NP_000299	endoplasmic reticulum lysosome	intracellular protein transport proteolysis	carboxypeptidase C activity enzyme activator activity intracellular transporter activity peptidase activity serine carboxypeptidase activity	1, 2
cathepsin C isoform a preproprotein	CTSC	1	NP_001805	lysosome	immune response proteolysis	chloride ion binding cysteine- type endopeptidase activity dipeptidyl- peptidase I activity	2
cathepsin C isoform b precursor	CTSC	1	NP_680475	lysosome	immune response proteolysis	chloride ion binding cysteine- type endopeptidase activity dipeptidyl- peptidase I activity	2
cathepsin D preproprotein	CTSD	1	NP_001900	extracellular region lysosome	proteolysis	cathepsin D activity pepsin A activity peptidase activity	2
cathepsin G preproprotein	CTSG	9	NP_001902	insoluble fraction	immune response proteolysis	cathepsin G activity peptidase activity	2
cubilin	CUBN	104	NP_001072	brush border membrane extrinsic to external side of plasma membrane membrane	cholesterol metabolism cobalamin transport lipid metabolism physiological process protein transport receptor mediated endocytosis steroid metabolism tissue homeostasis	calcium ion binding cobalamin binding cobalt ion binding protein homodimerization activity receptor activity transporter activity	1, 2
cullin 3	CUL3	1	NP_003581	nucleus	cell cycle cell cycle arrest G 1/S transition of mitotic cell cycle induction of apoptosis by intracellular signals positive regulation of cell proliferation ubiquitin cycle	protein binding	2
cullin 4B	CUL4B	1	NP_003579	not classified	cell cycle ubiquitin cycle	protein binding	2
cutA divalent cation tolerance homolog isoform 1	CUTA	1	NP_001014433	membrane	protein localization	enzyme binding	2
cutA divalent cation tolerance homolog isoform 3	CUTA	1	NP_001014840	membrane	protein localization	enzyme binding	2
cut- like 2	CUTL2	2	NP_056082	nucleus	regulation of transcription, DNA- dependent	sequence- specific DNA binding transcription factor activity	2
cytochrome b reductase 1	CYBRD1	2	NP_079119	integral to membrane	electron transport	ferric- chelate reductase activity	2
cytoplasmic FMR1 interacting protein 2	CYFIP2	1	NP_055191	cytoplasm synaptosome	not classified	not classified	2
dihydroxyacetone kinase 2	DAK	15	NP_056348	not classified	glycerol metabolism	ATP binding glycerone kinase activity lyase activity nucleotide binding transferase activity	2
drebrin- like isoform b	DBNL	1	NP_001014436	cell cortex cytoplasm cytoskeleton intracellular lamellipodium	activation of JNK activity endocytosis immune response Rac protein signal transduction	actin binding enzyme activator activity protein binding	2
dermcidin preproprotein	DCD	1	NP_444513	extracellular region	defense response to bacterium defense response to fungus xenobiotic metabolism	manganese ion binding	2
dynactin 2	DCTN2	1	NP_006391	centrosome cytoskeleton dynactin complex dynein complex kinetochore membrane microtubule	cell proliferation microtubule- based process mitosis	motor activity	2
dicarbonyl/L- xylulose reductase	DCXR	2	NP_057370	membrane	carbohydrate metabolism D- xylose metabolism glucose metabolism metabolism	L- xylulose reductase activity oxidoreductase activity	1, 2
dimethylarginine dimethylaminohydrolase 1	DDAH1	1	NP_036269	not classified	arginine catabolism nitric oxide mediated signal transduction	dimethylargininase activity hydrolase activity metal ion binding zinc ion binding	1, 2
dimethylarginine dimethylaminohydrolase 2	DDAH2	1	NP_039268	not classified	anti- apoptosis arginine catabolism nitric oxide biosynthesis nitric oxide mediated signal transduction	dimethylargininase activity hydrolase activity	2
damage- specific DNA binding protein 1	DDB1	1	NP_001914	nucleus	nucleotide- excision repair ubiquitin cycle	damaged DNA binding	2
dopa decarboxylase (aromatic L- amino acid decarboxylase)	DDC	11	NP_000781	not classified	amino acid and derivative metabolism carboxylic acid metabolism catecholamine biosynthesis	aromatic- L- amino- acid decarboxylase activity carboxy- lyase activity lyase activity	2
D- dopachrome tautomerase	DDT	1	NP_001346	not classified	melanin biosynthesis from tyrosine	dopachrome isomerase activity lyase activity	1, 2
DEAD (Asp- Glu- Ala- As) box polypeptide 19 isoform 2	DDX19B	1	NP_001014451	cytoplasm nuclear pore nucleus	mRNA export from nucleus	ATP binding ATP- dependent helicase activity hydrolase activity nucleic acid binding nucleotide binding RNA binding	2
DEAD/H (Asp- Glu- Ala- Asp/His) box polypeptide 3	DDX3X	2	NP_001347	cytoplasm nucleus	not classified	ATP binding ATP- dependent RNA helicase activity DNA binding hydrolase activity nucleotide binding RNA binding	2
DEAD (Asp- Glu- Ala- Asp) box polypeptide 5	DDX5	1	NP_004387	nucleus	cell growth	ATP binding ATP- dependent helicase activity hydrolase activity nucleic acid binding nucleotide binding RNA binding RNA helicase activity	2
defensin, alpha 1 preproprotein	DEFA1	1	NP_004075	extracellular region	defense response to bacterium defense response to fungus response to virus xenobiotic metabolism	not classified	1
DEAH (Asp- Glu- Ala- His) box polypeptide 34 isoform 2	DHX34	1	NP_919409	not classified	electron transport	ATP binding ATP- dependent helicase activity electron transporter activity hydrolase activity metal ion binding nucleic acid binding nucleotide binding RNA binding	2
DIP13 beta	DIP13B	1	NP_060641	cytoplasm endosome membrane membrane nucleus NuRD complex	cell cycle cell proliferation signal transduction	protein binding	2
hypothetical protein LOC345651	DKFZp686D0972	2	NP_001017992	not classified	not classified	protein binding	2
dynein, axonemal, heavy polypeptide 8	DNAH8	1	NP_001362	axonemal dynein complex dynein complex	ciliary or flagellar motility microtubule- based movement	ATP binding ATPase activity microtubule motor activity nucleotide binding protein binding	1, 2
DnaJ (Hsp40) homolog, subfamily A, member 1	DNAJA1	1	NP_001530	not classified	protein folding response to unfolded protein	heat shock protein binding low- density lipoprotein receptor binding metal ion binding unfolded protein binding zinc ion binding	2
DnaJ subfamily A member 2	DNAJA2	1	NP_005871	membrane	G1 phase of mitotic cell cycle positive regulation of cell proliferation protein folding regulation of progression through cell cycle	heat shock protein binding metal ion binding unfolded protein binding zinc ion binding	2
DnaJ (Hsp40) homolog, subfamily B, member 1	DNAJB1	2	NP_006136	nucleus	protein folding response to unfolded protein	heat shock protein binding unfolded protein binding	2
DnaJ (Hsp40) homolog, subfamily C, member 13	DNAJC13	1	NP_056083	not classified	protein folding	binding heat shock protein binding	2
DnaJ (Hsp40) homolog, subfamily C, member 7	DNAJC7	1	NP_003306	not classified	protein folding	heat shock protein binding	2
dynamin 2 isoform 3	DNM2	1	NP_004936	cytoplasm microtubule postsynaptic membrane	endocytosis G2/M transition of mitotic cell cycle positive regulation of apoptosis regulation of transcription signal transduction synaptic vesicle transport	enzyme binding GTP binding GTPase activity hydrolase activity microtubule binding motor activity nucleotide binding transcriptional activator activity	2
dynamin 2 isoform 4	DNM2	1	NP_001005362	cytoplasm microtubule postsynaptic membrane	endocytosis G2/M transition of mitotic cell cycle positive regulation of apoptosis regulation of transcription signal transduction synaptic vesicle transport	enzyme binding GTP binding GTPase activity hydrolase activity microtubule binding motor activity nucleotide binding transcriptional activator activity	2
pad- 1- like	DOPEY2	1	NP_005119	Golgi membrane	development endoplasmic reticulum organization and biogenesis Golgi to endosome transport	not classified	2
dipeptidase 1 (renal)	DPEP1	31	NP_004404	endoplasmic reticulum membrane microsome	carbohydrate metabolism proteolysis	cation binding dipeptidyl- peptidase activity GPI anchor binding membrane dipeptidase activity metal ion binding metallopeptidase activity zinc ion binding	1, 2
dipeptidylpeptidase IV	DPP4	41	NP_001926	integral to membrane membrane	immune response proteolysis	aminopeptidase activity dipeptidyl- peptidase IV activity prolyl oligopeptidase activity	1, 2
dihydropyrimidinase	DPYS	5	NP_001376	not classified	nucleobase, nucleoside, nucleotide and nucleic acid metabolism response to toxin	dihydropyrimidinase activity hydrolase activity	2
desmocollin 2 isoform Dsc2b preproprotein	DSC2	1	NP_004940	cytoskeleton integral to membrane intercellular junction membrane	cell adhesion homophilic cell adhesion	calcium ion binding protein binding	2
desmoglein 3 preproprotein	DSG3	1	NP_001935	cytoskeleton integral to membrane intercellular junction membrane	cell adhesion homophilic cell adhesion	calcium ion binding protein binding	2
desmoplakin isoform II	DSP	10	NP_001008844	cell- cell adherens junction cornified envelope intermediate filament	epidermis development keratinocyte differentiation peptide cross- linking	protein binding, bridging structural constituent of cytoskeleton	2
desmoplakin isoform I	DSP	4	NP_004406	cell- cell adherens junction cornified envelope intermediate filament	epidermis development keratinocyte differentiation peptide cross- linking	protein binding, bridging structural constituent of cytoskeleton	2
destrin isoform a	DSTN	1	NP_006861	intracellular	not classified	actin binding	2
dual specificity phosphatase 26	DUSP26	1	NP_076930	not classified	protein amino acid dephosphorylation	hydrolase activity kinase activity protein tyrosine/serine/threonine phosphatase activity	2
dynein, cytoplasmic, heavy polypeptide 1	DYNC1H1	14	NP_001367	cytoplasmic dynein complex dynein complex microtubule	microtubule- based movement mitotic spindle organization and biogenesis	ATP binding ATPase activity, coupled microtubule motor activity nucleotide binding	2
dynein, cytoplasmic, heavy polypeptide 2	DYNC2H1	2	NP_001073932	dynein complex Golgi apparatus intracellular	Golgi organization and biogenesis microtubule- based movement	ATP binding ATPase activity ATPase activity, coupled ATPase activity, uncoupled hydrolase activity microtubule motor activity motor activity	2
dysferlin	DYSF	1	NP_003485	integral to membrane plasma membrane	muscle contraction	not classified	2
endothelin converting enzyme 1	ECE1	1	NP_001388	integral to membrane membrane membrane fraction	cell- cell signaling proteolysis	endothelin- converting enzyme 1 activity metal ion binding neprilysin activity zinc ion binding	2
early endosome antigen 1, 162kD	EEA1	1	NP_003557	cytoplasm cytosol early endosome extrinsic to plasma membrane intracellular membrane fraction	early endosome to late endosome transport synaptic vesicle to endosome fusion vesicle fusion	calmodulin binding GTP- dependent protein binding metal ion binding nucleic acid binding phosphatidylinositol binding protein homodimerization activity zinc ion binding	2
eukaryotic translation elongation factor 1 alpha 1	EEF1A1	6	NP_001393	cytoplasm	protein biosynthesis translational elongation	GTP binding GTPase activity nucleotide binding protein binding translation elongation factor activity	1, 2
eukaryotic translation elongation factor 2	EEF2	4	NP_001952	not classified	protein biosynthesis	GTP binding nucleotide binding translation elongation factor activity	2
EGF- containing fibulin- like extracellular matrix protein 1 precursor	EFEMP1	1	NP_004096	extracellular matrix (sensu Metazoa)	visual perception	calcium ion binding protein binding	2
ephrin- B1 precursor	EFNB1	1	NP_004420	integral to plasma membrane membrane soluble fraction synapse	cell adhesion cell differentiation cell- cell signaling nervous system development	ephrin receptor binding protein binding	2
epidermal growth factor (beta- urogastrone)	EGF	30	NP_001954	extracellular region integral to membrane nucleus plasma membrane	activation of MAPK activity chromosome organization and biogenesis (sensu Eukaryota) DNA replication epidermal growth factor receptor signaling pathway positive regulation of cell proliferation	calcium ion binding epidermal growth factor receptor activating ligand activity growth factor activity protein binding	1, 2
EGF- like- domain, multiple 11	EGFL11	1	NP_938024	integral to membrane membrane	not classified	ATP binding	2
EH- domain containing 1	EHD1	14	NP_006786	not classified	not classified	ATP binding calcium ion binding GTP binding GTPase activity nucleotide binding protein binding	1, 2
EH- domain containing 2	EHD2	1	NP_055416	nucleus	not classified	calcium ion binding GTP binding GTPase activity nucleic acid binding nucleotide binding protein binding	2
EH- domain containing 4	EHD4	17	NP_644670	endoplasmic reticulum nucleus	not classified	ATP binding calcium ion binding GTP binding GTPase activity nucleic acid binding nucleotide binding	1, 2
eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa	EIF3H	1	NP_003747	eukaryotic translation initiation factor 3 complex	protein biosynthesis regulation of translational initiation	translation initiation factor activity not classified	2
elastase 2, neutrophil preproprotein	ELA2	1	NP_001963	cell surface extracellular region	anti- inflammatory response calcium ion homeostasis negative regulation of chemokine biosynthesis negative regulation of chemotaxis negative regulation of inflammatory response negative regulation of interleukin- 8 biosynthesis positive regulation of interl	bacterial binding cytokine binding elastase activity peptidase activity serine- type endopeptidase activity	2
echinoderm microtubule associated protein like 5	EML5	1	NP_899243	not classified	not classified	lyase activity	2
glutamyl aminopeptidase (aminopeptidase A)	ENPEP	25	NP_001968	integral to plasma membrane plasma membrane	cell migration cell proliferation cell- cell signaling proteolysis	calcium ion binding glutamyl aminopeptidase activity membrane alanyl aminopeptidase activity metallopeptidase activity zinc ion binding	1, 2
ectonucleotide pyrophosphatase/phosphodiesterase 3	ENPP3	2	NP_005012	integral to plasma membrane membrane	nucleotide metabolism phosphate metabolism	endonuclease activity hydrolase activity nucleic acid binding nucleotide diphosphatase activity phosphodiesterase I activity	2
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)	ENPP4	2	NP_055751	not classified	nucleotide metabolism	not classified	2
ectonucleotide pyrophosphatase/phosphodiesterase 6	ENPP6	5	NP_699174	integral to membrane membrane	lipid catabolism nucleotide metabolism	hydrolase activity	2
epoxide hydrolase 2, cytoplasmic	EPHX2	1	NP_001970	cytosol peroxisome soluble fraction	aromatic compound catabolism blood pressure regulation calcium ion homeostasis drug metabolism inflammatory response metabolism oxygen and reactive oxygen species metabolism positive regulation of vasodilation response to toxin xenobiotic metabolism	epoxide hydrolase activity hydrolase activity magnesium ion binding protein homodimerization activity	2
epsin 3	EPN3	1	NP_060427	not classified	not classified	lipid binding	2
epiplakin 1	EPPK1	4	NP_112598	cytoskeleton	not classified	structural molecule activity	2
epidermal growth factor receptor pathway substrate 8	EPS8	14	NP_004438	not classified	cell proliferation epidermal growth factor receptor signaling pathway signal transduction	protein binding SH3/SH2 adaptor activity	1, 2
epidermal growth factor receptor pathway substrate 8- like protein 1 isoform a	EPS8L1	6	NP_573441	not classified	not classified	not classified	2
epidermal growth factor receptor pathway substrate 8- like protein 1 isoform b	EPS8L1	4	NP_060199	not classified	not classified	hydrolase activity	2
epidermal growth factor receptor pathway substrate 8- like protein 2	EPS8L2	11	NP_073609	not classified	not classified	not classified	2
esterase D/formylglutathione hydrolase	ESD	1	NP_001975	cytoplasmic membrane- bound vesicle	not classified	S- formylglutathione hydrolase activity serine esterase activity thiosulfate sulfurtransferase activity	2
envoplakin	EVPL	18	NP_001979	cornified envelope plasmodesma	epidermis development keratinization keratinocyte differentiation peptide cross- linking	protein binding, bridging structural molecule activity	2
platelet coagulation factor XI precursor	F11	1	NP_000119	extracellular region membrane	blood coagulation proteolysis	coagulation factor IXa activity coagulation factor XIa activity heparin binding peptidase activity	2
fatty acid binding protein 1, liver	FABP1	2	NP_001434	cytoplasm	cell- cell signaling fatty acid metabolism organ morphogenesis transport	lipid binding lipid transporter activity	2
fatty acid binding protein 3	FABP3	2	NP_004093	cytoplasm soluble fraction	negative regulation of cell proliferation transport	fatty acid binding lipid transporter activity	1, 2
fumarylacetoacetate hydrolase (fumarylacetoacetase)	FAH	2	NP_000128	not classified	aromatic amino acid family metabolism L- phenylalanine catabolism metabolism tyrosine catabolism	calcium ion binding fumarylacetoacetase activity hydrolase activity magnesium ion binding	2
hypothetical protein LOC93343	FAM125A	2	NP_612410	nucleus	not classified	not classified	1, 2
hypothetical protein LOC89853 isoform 1	FAM125B	1	NP_258257	not classified	not classified	not classified	2
family with sequence similarity 20, member C	FAM20C	1	NP_064608	not classified	not classified	not classified	2
hypothetical protein LOC85369	FAM40A	1	NP_149079	not classified	not classified	not classified	2
hypothetical protein LOC51571	FAM49B	1	NP_057707	not classified	not classified	not classified	2
hypothetical protein LOC79567	FAM65A	2	NP_078795	not classified	not classified	binding DNA- directed RNA polymerase activity	2
fatty acid synthase	FASN	20	NP_004095	not classified	fatty acid biosynthesis	3- hydroxypalmitoyl- [acyl- carrier protein] dehydratase activity 3- oxoacyl- [acyl- carrier protein] reductase activity 3- oxoacyl- [acyl- carrier protein] synthase activity catalytic activity cofactor binding enoyl- [acyl- carrier protein] reductase (NADPH, B- spec	2
FAT tumor suppressor 1 precursor	FAT	1	NP_005236	integral to plasma membrane membrane	cell adhesion cell- cell signaling homophilic cell adhesion morphogenesis	calcium ion binding protein binding	2
fibrillarin	FBL	1	NP_001427	nucleus ribonucleoprotein complex	rRNA processing	RNA binding transferase activity not classified	2
fructose- 1, 6- bisphosphatase 1	FBP1	7	NP_000498	not classified	carbohydrate metabolism fructose metabolism gluconeogenesis	fructose- 2, 6- bisphosphate 2- phosphatase activity fructose- bisphosphatase activity hydrolase activity identical protein binding phosphoric ester hydrolase activity zinc ion binding	2
fructose- 1, 6- bisphosphatase 2	FBP2	1	NP_003828	not classified	carbohydrate metabolism fructose metabolism gluconeogenesis	fructose- 2, 6- bisphosphate 2- phosphatase activity fructose- bisphosphatase activity hydrolase activity phosphoric ester hydrolase activity	2
Fc fragment of IgG binding protein	FCGBP	14	NP_003881	not classified	not classified	not classified	1, 2
ficolin 2 isoform a precursor	FCN2	2	NP_004099	cytoplasm	antimicrobial humoral response (sensu Vertebrata) opsonization phosphate transport	antigen binding calcium ion binding sugar binding	2
myoferlin isoform a	FER1L3	8	NP_038479	integral to membrane nuclear envelope plasma membrane	circulation muscle contraction	not classified	2
myoferlin isoform b	FER1L3	7	NP_579899	integral to membrane nuclear envelope plasma membrane	circulation muscle contraction	calcium ion binding	2
fibrinogen, alpha polypeptide isoform alpha- E preproprotein	FGA	5	NP_000499	extracellular region fibrinogen complex soluble fraction	blood coagulation blood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transduction	protein binding	1, 2
fibrinogen, gamma chain isoform gamma- A precursor	FGG	1	NP_000500	fibrinogen complex	blood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transduction	calcium ion binding	2
fibrinogen, gamma chain isoform gamma- B precursor	FGG	1	NP_068656	fibrinogen complex	blood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transduction	FK506 binding	2
fibrinogen- like 2 precursor	FGL2	4	NP_006673	fibrinogen complex	not classified	not classified	2
fidgetin- like 1	FIGNL1	1	NP_071399	membrane	not classified	ATP binding nucleoside- triphosphatase activity nucleotide binding	2
FK506- binding protein 4	FKBP4	1	NP_002005	cytoplasm intracellular nucleus	protein folding	isomerase activity peptidyl- prolyl cis- trans isomerase activity protein binding, bridging actin binding	2
FK506 binding protein 5	FKBP5	1	NP_004108	nucleus	protein folding	FK506 binding isomerase activity peptidyl- prolyl cis- trans isomerase activity protein binding	2
coiled- coil domain containing 132 isoform a	FLJ20097	1	NP_060137	not classified	two- component signal transduction system (phosphorelay)	two- component sensor activity	2
hypothetical protein LOC148811	FLJ32569	2	NP_689704	not classified	proteolysis	carboxypeptidase activity Gly- X carboxypeptidase activity hydrolase activity metallopeptidase activity protein dimerization activity	2
hypothetical protein LOC201931	FLJ38482	1	NP_689894	not classified	not classified	not classified	2
filamin A, alpha isoform 1	FLNA	1	NP_001447	actin cytoskeleton	actin cytoskeleton organization and biogenesis cell motility cell surface receptor linked signal transduction nervous system development positive regulation of I- kappaB kinase/NF- kappaB cascade	actin filament binding protein binding signal transduce activity actin binding	2
filamin B, beta (actin binding protein 278)	FLNB	1	NP_001448	actin cytoskeleton integral to membrane	actin cytoskeleton organization and biogenesis cell differentiation cytoskeletal anchoring signal transduction striated muscle development	protein binding collagen binding	2
flotillin 1	FLOT1	12	NP_005794	caveola flotillin complex integral to membrane membrane	not classified	protein binding	1, 2
flotillin 2	FLOT2	9	NP_004466	cell surface flotillin complex integral to membrane plasma membrane	cell adhesion epidermis development	protein binding	2
fibronectin 1 isoform 1 preproprotein	FN1	1	NP_997647	ER- Golgi intermediate compartment extracellular matrix (sensu Metazoa) extracellular region	acute- phase response cell adhesion cell migration metabolism response to wounding transmembrane receptor protein tyrosine kinase signaling pathway	collagen binding extracellular matrix structural constituent heparin binding oxidoreductase activity	1, 2
fibronectin 1 isoform 3 preproprotein	FN1	9	NP_002017	ER- Golgi intermediate compartment extracellular matrix (sensu Metazoa) extracellular region	acute- phase response cell adhesion cell migration metabolism response to wounding transmembrane receptor protein tyrosine kinase signaling pathway	collagen binding extracellular matrix structural constituent heparin binding oxidoreductase activity	2
fyn- related kinase	FRK	7	NP_002022	intracellular nucleus	intracellular signaling cascade negative regulation of cell proliferation protein amino acid phosphorylation regulation of progression through cell cycle	ATP binding non- membrane spanning protein tyrosine kinase activity nucleotide binding transferase activity	2
formiminotransferase cyclodeaminase	FTCD	6	NP_006648	cytoplasm	folic acid and derivative metabolism histidine metabolism metabolism	folic acid binding formimidoyltetrahydrofolate cyclodeaminase activity glutamate formimidoyltransferase activity lyase activity transferase activity	2
ferritin, heavy polypeptide 1	FTH1	1	NP_002023	ferritin complex plasma membrane	cell proliferation immune response intracellular sequestering of iron ion iron ion homeostasis iron ion transport negative regulation of cell proliferation	binding ferric iron binding ferroxidase activity kinase binding metal ion binding oxidoreductase activity protein binding	2
ferritin, light polypeptide	FTL	5	NP_000137	ferritin complex	iron ion homeostasis iorn ion transport	binding ferric iron binding identical protein binding metal ion binding	1, 2
fucosidase, alpha- L- 1, tissue	FUCA1	1	NP_000138	cytoplasm lysosome	carbohydrate metabolism glycosaminoglycan catabolism metabolism	alpha- L- fucosidase activity hydrolase activity, acting on glycosyl bonds	2
fusion (involved in t(12;16) in malignant liposarcoma) isoform a	FUS	1	NP_004951	intracellular nucleus	not classified	DNA binding metal ion binding nucleic acid binding nucleotide binding protein binding RNA binding zinc ion binding	1
fuzzy homolog	FUZ	1	NP_079405	not classified	not classified	not classified	2
FXYD domain- containing ion transport regulator 2 isoform 1	FXYD2	1	NP_001671	integral to membrane membrane sodium:potassium- exchanging ATPase complex	ion transport potassium ion transport sodium ion transport	ion channel activity potassium ion binding sodium ion binding sodium:potassium- exchanging ATPase activity transporter activity	1, 2
glucose- 6- phosphate dehydrogenase isoform a	G6PD	1	NP_000393	cytoplasm	carbohydrate metabolism glucose 6- phosphate utilization glucose metabolism pentose- phosphate shunt	glucose- 6- phosphate 1- dehydrogenase activity oxidoreductase activity	2
acid alpha- glucosidase preproprotein	GAA	4	NP_000143	lysosome	carbohydrate metabolism generation of precursor metabolites and energy glycogen catabolism metabolism	alpha- glucosidase activity hydrolase activity, hydrolyzing O- glycosyl compounds	1, 2
acid alpha- glucosidase preproprotein	GAA	5	NP_001073272	lysosome	carbohydrate metabolism generation of precursor metabolites and energy glycogen catabolism metabolism	hydrolase activity, hydrolyzing O- glycosyl compounds ATP binding	2
gamma- aminobutyric acid (GABA) A receptor, beta 2 isoform 1	GABRB2	1	NP_068711	integral to plasma membrane postsynaptic membrane	gamma- aminobutyric acid signaling pathway ion transport synaptic transmission	chloride channel activity chloride ion binding extracellular ligand- gated ion channel activity GABA- A receptor activity ion channel activity neurotransmitter receptor activity	2
galactokinase 1	GALK1	1	NP_000145	cytoplasm membrane fraction	carbohydrate phosphorylation galactose metabolism metabolism	galactokinase activity galactose binding kinase activity nucleotide binding transferase activity hydrolase activity	2
galactose mutarotase (aldose 1- epimerase)	GALM	2	NP_620156	not classified	carbohydrate metabolism galactose metabolism	aldose 1- epimerase activity isomerase activity	2
alpha glucosidase II alpha subunit isoform 2	GANAB	1	NP_938148	endoplasmic reticulum	carbohydrate metabolism	hydrolase activity hydrolase activity, hydrolyzing O- glycosyl compounds protein binding	2
alpha glucosidase II alpha subunit isoform 3	GANAB	1	NP_938149	endoplasmic reticulum	carbohydrate metabolism	hydrolase activity, hydrolyzing O- glycosyl compounds protein binding hydrolase activity, acting on glycosyl bonds	2
glyceraldehyde- 3- phosphate dehydrogenase	GAPDH	10	NP_002037	cytoplasm	glucose metabolism glycolysis	glyceraldehyde- 3- phosphate dehydrogenase (phosphorylating) activity NAD binding oxidoreductase activity	1, 2
glucan (1, 4- alpha- ), branching enzyme 1	GBE1	1	NP_000149	not classified	carbohydrate metabolism generation of precursor metabolites and energy glycogen biosynthesis	1, 4- alpha- glucan branching enzyme activity cation binding hydrolase activity, hydrolyzing O- glycosyl compounds transferase activity, transferrin glycosyl groups	2
grancalcin, EF- hand calcium binding protein	GCA	1	NP_036330	cytoplasm plasma membrane	membrane fusion	calcium ion binding	2
mannosyl- oligosaccharide glucosidase	GCS1	1	NP_006293	endoplasmic reticulum integral to membrane membrane membrane fraction	metabolism oligosaccharide metabolism protein amino acid N- linked glycosylation	mannosyl- oligosaccharide glucosidase activity not classified	2
growth differentiation factor 2	GDF2	1	NP_057288	extracellular region extracellular space	growth	cytokine activity growth factor activity	2
GDP dissociation inhibitor 2	GDI2	17	NP_001485	cell surface cytoplasm	protein transport regulation of GTPase activity signal transduction	GTPase activator activity Rab GDP- dissociation inhibitor activity	2
glycerophosphodiester phosphodiesterase domain containing 3	GDPD3	1	NP_077283	not classified	glycerol metabolism	glycerophosphodiester phosphodiesterase activity	2
gemin4	GEMIN4	1	NP_056536	cytoplasm nucleolus nucleus small nuclear ribonucleoprotein complex spliceosome complex	nuclear mRNA splicing, via spliceosome rRNA processing	protein binding	2
GDNF family receptor alpha 1 isoform b preproprotein	GFRA1	1	NP_665736	extrinsic to membrane membrane	cell surface receptor linked signal transduction	glial cell line- derived neurotrophic factor receptor activity GPI anchor binding receptor activity receptor binding	2
gamma- glutamyl hydrolase precursor	GGH	5	NP_003869	lysosome	glutamine metabolism	exopeptidase activity gamma- glutamyl hydrolase activity hydrolase activit	2
growth hormone inducible transmembrane protein	GHITM	1	NP_055209	integral to membrane membrane mitochondrion	not classified	protein binding	2
regulator of G- protein signalling 19 interacting protein 1 isoform 1	GIPC1	1	NP_974197	cytosol membrane membrane fraction soluble fraction	G- protein coupled receptor protein signaling pathway	protein binding receptor binding	2
regulator of G- protein signalling 19 interacting protein 1 isoform 2	GIPC1	1	NP_974196	cytosol membrane membrane fraction soluble fraction	G- protein coupled receptor protein signaling pathway	receptor binding ATP binding	2
PDZ domain protein GIPC2	GIPC2	1	NP_060125	not classified	not classified	protein binding	2
glycerol kinase isoform a	GK	1	NP_976325	cytoplasm mitrochondrial outer membrane	carbohydrate metabolism glycerol- 3- phosphate metabolism	glycerol kinase activity nucleotide binding transferase activity ATP binding	2
glycerol kinase 2	GK2	1	NP_149991	cytoplasm mitrochondrial outer membrane	carbohydrate metabolism glycerol- 3- phosphate metabolism	glycerol kinase activity nucleotide binding transferase activity GTP binding	2
galactosidase, beta 1 isoform a	GLB1	16	NP_000395	beta- galactosidase complex lysosome	carbohydrate metabolism metabolism	beta- galactosidase activity cation binding hydrolase activity, acting on glycosyl bonds	1, 2
golgi apparatus protein 1	GLG1	2	NP_036333	Golgi membrane integral to membrane membrane	not classified	fibroblast growth factor binding receptor binding	1, 2
glyoxalase I	GLO1	1	NP_006699	cytoplasm	anti- apoptosis carbohydrate metabolism	lactoylglutathione lyase activity lyase activity metal ion binding zinc ion binding	2
glutamine synthetase	GLUL	2	NP_001028216	not classified	glutamine biosynthesis nitrogen compound metabolism regulation of neurotransmitter levels	glutamate- ammonia ligase activity ligase activity	2
GM2 ganglioside activator precursor	GM2A	2	NP_000396	lysosome	glycolipid catabolism glycosphingolipid metabolism lipid metabolism sphingolipid catabolism	sphingolipid activator protein activity	2
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	GNA11	7	NP_002058	cytoplasm plasma membrane	G- protein coupled receptor protein signaling pathway protein amino acid ADP- ribosylation signal transduction	GTP binding GTPase activity nucleotide binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	GNAI1	8	NP_002060	plasma membrane	G- protein coupled receptor protein signaling pathway signal transduction	GTP binding nucleotide binding protein binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	GNAI2	8	NP_002061	not classified	G- protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity response to nutrient signal transduction	GTP binding GTPase activity nucleotide binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	GNAI3	8	NP_006487	not classified	G- protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity signal transduction transport	GTP binding GTPase activity nucleotide binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), q polypeptide	GNAQ	10	NP_002063	cytoplasm heterotrimeric G- protein complex plasma membrane	blood coagulation G- protein coupled receptor protein signaling pathway phospholipase C activation protein amino acid ADP- ribosylation signal transduction	GTP binding GTPase activity nucleotide binding signal transducer activity	2
guanine nucleotide- binding protein, beta- 1 subunit	GNB1	2	NP_002065	not classified	signal transduction	signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), beta polypeptide 2- like 1	GNB2L1	1	NP_006089	cytoplasm	protein kinase C activation signal transduction	protein kinase C binding receptor binding	2
G- protein gamma- 12 subunit	GNG12	5	NP_061329	heterotrimeric G- protein complex membrane	G- protein coupled receptor protein signaling pathway signal transduction	signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), gamma 5	GNG5	1	NP_005265	heterotrimeric G- protein complex membrane	G- protein coupled receptor protein signaling pathway signal transduction	signal transducer activity	2
guanine nucleotide binding protein (G protein), gamma 7	GNG7	1	NP_443079	heterotrimeric G- protein complex membrane	regulation of G- protein coupled receptor protein signaling pathway signal transduction	signal transducer activity	1, 2
glucosamine- 6- phosphate deaminase 1	GNPDA1	1	NP_005462	not classified	carbohydrate metabolism fertilization (sensu Metazoa) generation of precursor metabolites and energy glucosamine catabolism N- acetylglucosamine metabolism	glucosamine- 6- phosphate deaminase activity hydrolase activity	2
golgi autoantigen, golgin subfamily a, 7	GOLGA7	1	NP_001002296	membrane	not classified	not classified	2
aspartate aminotransferase 1	GOT1	9	NP_002070	cytosol	amino acid metabolism aspartate catabolism biosynthesis	aspartate transaminase activity	2
glycerol- 3- phosphate dehydrogenase 1 (soluble)	GPD1	11	NP_005267	cytoplasm glycerol- 3- phosphate dehydrogenase complex	carbohydrate metabolism glycerol- 3- phosphate catabolism	glycerol- 3- phosphate dehydrogenase (NAD+) activity NAD binding	2
glucose phosphate isomerase	GPI	9	NP_000166	extracellular space	carbohydrate metabolism gluconeogenesis glycolysis hemostasis humoral immune response nervous system development	cytokine activity glucose- 6- phosphate isomerase activity growth factor activity isomerase activity	1, 2
glycoprotein M6A isoform 2	GPM6A	1	NP_963885	cell surface integral to plasma membrane membrane	not classified	glutathione peroxidase activity	2
G protein- coupled receptor 155 isoform 10	GPR155	1	NP_689742	integral to membrane membrane	intracellular signaling cascade	not classified	2
G protein- coupled receptor 98 precursor	GPR98	1	NP_115495	integral to membrane membrane	cell- cell adhesion nervous system development neuropeptide signaling pathway response to stimulus sensory perception of sound signal transduction visual perception	calcium ion binding G- protein coupled receptor activity receptor activity	2
G protein- coupled receptor, family C, group 5, member A	GPRC5A	1	NP_003970	integral to plasma membrane membrane	G- protein coupled receptor protein signaling pathway signal transduction	metabotropic glutamate, GABA- B- like receptor activity receptor activity	1, 2
G protein- coupled receptor, family C, group 5, member B precursor	GPRC5B	7	NP_057319	integral to membrane membrane	G- protein coupled receptor protein signaling pathway signal transduction visual perception	metabotropic glutamate, GABA- B- like receptor activity receptor activity sevenless binding	1, 2
G protein- coupled receptor family C, group 5, member C isoform b	GPRC5C	11	NP_061123	integral to plasma membrane membrane	G- protein coupled receptor protein signaling pathway signal transduction	metabotropic glutamate, GABA- B- like receptor activity protein binding receptor activity	2
glutamic- pyruvate transaminase (alanine aminotransferase)	GPT	1	NP_005300	cytoplasm soluble fraction	biosynthesis gluconeogenesis nitrogen compound metabolism	1- aminocyclopropane- 1- carboxylate synthase activity alanine transaminase activity	2
glutathione peroxidase 4 isoform A precursor	GPX4	3	NP_002076	mitochondrion	development electron transport phospholipid metabolism response to oxidative stress	glutathione peroxidase activity oxidoreductase activity phospholipid- hydroperoxide glutathione peroxidase activity selenium binding	2
glutathione peroxidase 4 isoform C precursor	GPX4	4	NP_001034937	mitochondrion	development electron transport phospholipid metabolism response to oxidative stress	oxidoreductase activity phospholipid- hydroperoxide glutathione peroxidase activity selenium binding epidermal growth factor receptor binding	2
growth factor receptor- bound protein 2 isoform 1	GRB2	3	NP_002077	cytosol	cell- cell signaling epidermal growth factor receptor signaling pathway insulin receptor signaling pathway intracellular signaling cascade Ras protein signal transduction	epidermal growth factor receptor binding insulin receptor substrate binding SH3/SH2 adaptor activity	2
growth factor receptor- bound protein 2 isoform 2	GRB2	2	NP_987102	cytosol	cell- cell signaling epidermal growth factor receptor signaling pathway insulin receptor signaling pathway intracellular signaling cascade Ras protein signal transduction	insulin receptor substrate binding SH3/SH2 adaptor activity glycerate dehydrogenase activity	2
glyoxylate reductase/hydroxypyruvate reductase	GRHPR	1	NP_036335	cytoplasm	electron transport excretion L- serine biosynthesis metabolism	glyoxylate reductase (NADP) activity hydrohypyruvate reductase activity NAD binding oxidoreductase activity oxidoreductase activity, acting on the CH- OH group of donors, NAD or NADP as acceptor protein binding glutathione transferase activity	2
glutamate receptor, ionotropic, delta 1	GRID1	1	NP_060021	integral to membrane membrane periplasmic space (sensu Proteobacteria) postsynaptic membrane	ion transport	glutamate- gated ion channel activity ion channel activity ionotropic glutamate receptor activity receptor activity transporter activity	2
gelsolin isoform b	GSN	10	NP_937895	actin cytoskeleton cytosol extracellular region	actin filament polymerization actin filament severing barbed- end actin filament capping	actin binding calcium ion binding protein binding	2
glutathione reductase	GSR	1	NP_000628	cytoplasm mitochondrion	electron transport glutathione metabolism	disulfide oxidoreductase activity FAD binding glutathione- disulfide reductase activity	2
glutathione synthetase	GSS	1	NP_000169	not classified	amino acid metabolism glutathione biosynthesis nervous system development response to oxidative stress	ATP binding glutathioone synthase activity ligase activity nucleotide binding	2
glutathione S- transferase A1	GSTA1	1	NP_665683	cytoplasm	glutathione metabolism metabolism	glutathione transferase activity transferase activity	1, 2
glutathione S- transferase, C- terminal domain containing isoform 1	GSTCD	1	NP_001026890	not classified	not classified	methyltransferase activity transferase activity	2
glutathione S- transferase M2	GSTM2	1	NP_000839	not classified	metabolism	glutathione transferase activity transferase activity	2
glutathione- S- transferase omega 1	GSTO1	1	NP_004823	cytoplasm	metabolism	glutathione transferase activity monodehydroascorbate reductase (NADH) activity transferase activity	2
glutathione S- transferase omega 2	GSTO2	1	NP_899062	cytoplasm	metabolism	glutathione transferase activity transferase activity	2
glutathione transferase	GSTP1	9	NP_000843	cytoplasm	anti- apoptosis central nervous system development metabolism	glutathione transferase activity transferase activity	1, 2
GTP- binding protein PTD004 isoform 1	GTPBP9	2	NP_037473	cytoplasm intracellular	not classified	GTP binding nucleotide binding	2
glucuronidase, beta	GUSB	5	NP_000172	lysosome	carbohydrate metabolism glycosaminoglycan catabolism metabolism	beta- glucuronidase activity cation binding	1, 2
oocyte- specific histone H1	H1FOO	1	NP_722575	nucleosome nucleus	nucleosome assembly	DNA binding	2
beta globin	HBB	2	NP_000509	hemoglobin complex	nitric oxide transport oxygen transport positive regulation of nitric oxide biosynthesis transport	heme binding hemoglobin binding iron ion binding metal ion binding oxygen binding oxygen transporter activity selenium binding	2
HBS1- like	HBS1L	1	NP_006611	not classified	protein biosynthesis signal transduction	GTP binding nucleotide binding translation elongation factor activity	2
haloacid dehalogenase- like hydrolase domain containing 2	HDHD2	1	NP_115500	not classified	metabolism	metal ion binding	2
heme binding protein 1	HEBP1	6	NP_057071	not classified	not classified	not classified	1, 2
heme binding protein 2	HEBP2	1	NP_055135	not classified	not classified	not classified	2
homogentisate 1, 2- dioxygenase	HGD	2	NP_000178	not classified	L- phenylalanine catabolism tyrosine catabolism	homogentisate 1, 2- dioxygenase activity iron ion binding metal ion binding oxidoreductase activity	2
hepatocyte growth factor- regulated tyrosine kinase substrate	HGS	1	NP_004703	endosome membrane	intracellular protein transport negative regulation of cell proliferation signal transduction	zinc ion binding hydrolase activity	2
histidine triad nucleotide binding protein 1	HINT1	1	NP_005331	cytoskeleton nucleus	signal transduction	protein kinase C binding zinc ion binding nucleic acid binding	2
histone H2A	HIST2H2AB	1	NP_778235	chromosome nucleosome nucleus	chromosome organization and biogenesis (sensu Eukaryota) nucleosome assembly	DNA binding	2
histone 2, H2bf	HIST2H2BF	4	NP_001019770	chromosome nucleosome nucleus	chromosome organization and biogenesis (sensu Eukaryota) nucleosome assembly	DNA binding	2
histone H4	HIST4H4	2	NP_778224	chromosome nucleosome nucleus	establishment and/or maitenance of chromatin architecture nucleosome assembly phosphoinositide- mediated signaling	DNA binding	1
major histocompatibility complex, class I, B	HLA- B	1	NP_005505	integral to membrane integral to plasma membrane membrane membrane fraction MHC class I protein complex	antigen processing and presentation antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I	MHC class I receptor activity	2
major histocompatibility complex, class II, DR alpha precursor	HLA- DRA	1	NP_061984	integral to plasma membrane lysosome membrane plasma membrane	antigen processing and presentation of exogenous antigen antigen processing and presentation of exogenous peptide antigen via MHC class II immune response	MHC class II receptor activity	2
histamine N- methyltransferase isoform 1	HNMT	1	NP_008826	not classified	respiratory gaseous exchange	histamine N- methyltransferase activity methyltransferase activity transferase activity	2
heterogeneous nuclear ribonucleoprotein L isoform b	HNRNPL	1	NP_001005335	heterogeneous nuclear ribonucleoprotein complex nucleoplasm nucleus	mRNA processing	nucleotide binding RNA binding ATP binding	2
haptoglobin	HP	2	NP_005134	extracellular region	defense response iron ion homeostasis proteolysis	hemoglobin binding serine- type endopeptidase activity	2
4- hydroxyphenylpyruvate dioxygenase	HPD	1	NP_002141	not classified	aromatic amino acid family metabolism L- phenylalanine catabolism tyrosine catabolism	4- hydroxyphenylpyruvate dioxygenase activity iron ion binding metal ion binding oxidoreductase activity	2
hydroxyprostaglandin dehydrogenase 15- (NAD)	HPGD	6	NP_000851	cytosol	fatty acid metabolism lipid metabolism lipoxygenase pathway metabolism negative regulation of progression through cell cycle parturition pregnancy prostaglandin metabolism transforming growth factor beta receptor signaling pathway	15- hydroxyprostaglandin dehydrogenase (NAD+) activity NAD binding oxidoreductase activity prostaglandin E receptor activity protein homodimerization activity	1, 2
hemopexin	HPX	1	NP_000604	extracellular region extracellular space	heme transport iron ion homeostasis transport	binding heme transporter activity iron ion binding metal ion binding	2
v- Ha- ras Harvey rat sarcoma viral oncogene homolog isofrom 1	HRAS	2	NP_005334	cytoplasm intracellular membrane plasma membrane	cell motility cell surface receptor linked signal transduction chemotaxis organ morphogenesis regulation of progression through cell cycle small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein C- terminus binding	1
histidine- rich glycoprotein precursor	HRG	2	NP_000403	extracellular region	not classified	cysteine protease inhibitor activity heparin binding	2
heat- responsive protein 12	HRSP12	2	NP_005827	cytoplasm nucleus	regulation of translational termination	endonuclease activity hydrolase activity	1, 2
heat shock protein 90Bf	HSP90AB6P	1	NP_001014441	not classified	protein folding response to unfolded protein	unfolded protein binding	2
heat shock 70kDa protein 12A	HSPA12A	1	NP_079291	not classified	not classified	ATP binding nucleotide binding	2
heat shock 70kDa protein 1B	HSPA1B	4	NP_005337	cytoplasm endoplasmic reticulum mitochondrion nucleus	anti- apoptosis mRNA catabolism protein folding response to unfolded protein	ATP binding nucleotide binding unfolded protein binding	1
heat shock 70kDa protein 2	HSPA2	16	NP_068814	cell surface	male meiosis protein folding response to unfolded protein spermatid development	ATP binding nucleotide binding unfolded protein binding	2
heat shock 70kDa protein 5	HSPA5	1	NP_005338	caspase complex cell surface endoplasmic reticulum endoplasmic reticulum lumen ER- Golgi intermediate compartment integral to endoplasmic reticulum membrane nucleus perinuclear region	anti- apoptosis negative regulation of caspase activity	ATP binding calcium ion binding caspase inhibitor activity nucleotide binding protein binding, bridging unfolded protein binding	1, 2
heat shock 70kDa protein 8 isoform 1	HSPA8	19	NP_006588	cell surface intracellular nucleus	protein folding response to unfolded protein	ATP binding ATPase activity, coupled nucleotide binding protein binding	1, 2
heat shock 27kDa protein 1	HSPB1	8	NP_001531	cell surface cytoplasm cytoskeleton	anti- apoptosis cell motility protein folding regulation of translational initiation response to unfolded protein	protein binding	2
chaperonin	HSPD1	1	NP_955472	cytoplasm mitochondrion	cellular protein metabolism protein folding protein import into mitochondrial matrix regulation of apoptosis response to unfolded protein	ATP binding chaperone binding nucleotide binding protein binding unfolded protein binding	1, 2
heparan sulfate proteoglycan 2	HSPG2	18	NP_005520	basement membrane extracellular space	cell adhesion	not classified	2
HECT, UBA and WWE domain containing 1	HUWE1	1	NP_113584	cytoplasm intracellular nucleus	histone ubiquitination mRNA transport protein polyubiquitination ubiquitin cycle	binding DNA binding ligase activity protein binding ubiquitin- protein ligase activity	2
intercellular adhesion molecule 1 precursor	ICAM1	1	NP_000192	integral to plasma membrane plasma membrane	cell- cell adhesion	transmembrane receptor activity insulin- like growth factor receptor activity	2
isocitrate dehydrogenase 1 (NADP+), soluble	IDH1	14	NP_005887	cytoplasm cytosol peroxisome	carbohydrate metabolism glyoxylate cycle isocitrate metabolism main pathways of carbohydrate metabolism metabolism tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity oxidoreductase activity oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor	1, 2
insulin- like growth factor 2 receptor precursor	IGF2R	1	NP_000867	endosome integral to plasma membrane lysosome membrane trans- Golgi network transport vesicle	receptor mediated endocytosis signal transduction transport	receptor activity transporter activity metal iion binding	2
insulin- like growth factor binding protein, acid labile subunit	IGFALS	6	NP_004961	extracellular region extracellular space soluble fraction	cell adhesion signal transduction	insulin- like growth factor binding protein binding transferase activity	2
zinc finger protein, subfamily 1A, 5	IKZF5	1	NP_071911	intracellular nucleus	not classified	nucleic acid binding zinc ion binding interleukin- 1 receptor antagonist activity	2
interleukin 1 receptor antagonist isoform 1 precursor	IL1RN	2	NP_776214	extracellular region extracellular space intracellular	inflammatory response	interleukin- 1 receptor antagonist activity	2
interleukin 1 receptor antagonist isoform 4	IL1RN	1	NP_776215	extracellular region extracellular space intracellular	inflammatory response	calcium ion binding	2
InaD- like protein	INADL	7	NP_795352	membrane tight junction	not classified	protein binding	2
IQ motif containing G	IQCG	1	NP_115639	not classified	not classified	not classified	2
IQ motif containing GTPase activating protein 1	IQGAP1	20	NP_003861	actin filament intracellular membrane	negative regulation of Ras protein signal transduction regulation of small GTPase mediated signal transduction signal transduction	calmodulin binding GTPase inhibitor activity Ras GTPase activator activity	2
IQ motif containing GTPase activating protein 2	IQGAP2	5	NP_006624	actin cytoskeleton intracellular	regulation of small GTPase mediated signal transduction signal transduction	actin binding calmodulin binding GTPase inhibitor activity Ras GTPase activator activity	2
interferon regulatory factor 6	IRF6	1	NP_006138	nucleus	regulation of transcription, DNA- dependent transcription	transcription factor activity	2
integrin, alpha 1 precursor	ITGA1	1	NP_852478	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pathway	calcium ion binding collagen binding magnesium ion binding receptor activity	2
integrin alpha 3 isoform a precursor	ITGA3	1	NP_002195	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pathway	calcium ion binding protein binding receptor activity	2
integrin alpha 3 isoform b, precursor	ITGA3	1	NP_005492	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pahtwya	protein binding receptor activity protein binding	2
integrin alpha- V precursor	ITGAV	1	NP_002201	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pathway	calcium ion binding protein binding receptor activity	2
integrin beta 1 isoform 1A precursor	ITGB1	1	NP_002202	endoplasmic reticulum integral to membrane integrin complex membrane ruffle	cell adhesion cell migration cell- matrix adhesion cellular defense response development homophilic cell adhesion integrin- mediated signaling pathway	identical protein binding protein binding protein heterodimerization activity receptor activity	2
integrin beta 4 binding protein isoform a	ITGB4BP	1	NP_852133	nucleus	integrin- mediated signaling pathway mature ribosome assembly protein biosynthesis	protein binding ribosome binding translation initiation factor activity	2
integrin, beta 8 precursor	ITGB8	1	NP_002205	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pahtwya	receptor activity not classified	2
inter- alpha (globulin) inhibitor H4	ITIH4	2	NP_002209	extracellular region	acute- phase response hyaluronan metabolism	serine- type endopeptidase inhibitor activity	2
intelectin	ITLN1	4	NP_060095	membrane	not classified	GPI anchor binding sugar binding	2
integral membrane protein 2B	ITM2B	5	NP_068839	integral to plasma membrane membrane membrane fraction	nervous system development sensory perception of sound	not classified	1, 2
integral membrane protein 2C isoform 1	ITM2C	1	NP_112188	Golgi apparatus integral to membrane membrane	not classified	not classified	2
integral membrane protein 2C isoform 2	ITM2C	1	NP_001012534	Golgi apparatus integral to membrane membrane	not classified endocytosis regulation of Rho protein signal transduction	calcium ion binding	2
intersectin 2 isoform 1	ITSN2	1	NP_006268	intracellular	endocytosis regulation of Rho protein signal transduction	protein binding Rho guanyl- nucleotide exchange factor activity SH3/SH2 adaptor activity cytoskeletal protein binding	2
junction plakoglobin	JUP	9	NP_068831	cytoplasm cytoskeleton membrane fraction soluble fraction	cell adhesion	cytoskeletal protein binding structural molecule activity	2
kalirin, RhoGEF kinase isoform 3	KALRN	1	NP_008995	actin cytoskeleton intracellular	intracellular signaling cascade nervous system development protein amino acid phosphorylation regulation of Rho protein signal transduction signal transduction vesicle- mediated transport	ATP binding nucleotide binding protein binding protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity	2
potassium voltage- gated channel, subfamily G, member 2	KCNG2	1	NP_036415	integral to membrane membrane voltage- gated potassium channel complex	ion transport potassium ion transport regulation of heart contraction	delayed rectifier potassium channel activity potassium ion binding protein binding	2
ketohexokinase isoform a	KHK	2	NP_000212	cytoplasm	carbohydrate metabolism	ketohexokinase activity kinase activity transferase activity	2
ketohexokinase isoform b	KHK	1	NP_006479	cytoplasm	carbohydrate metabolism	ketohexokinase activity kinase activity transferase activity	2
putative MAPK activating protein PM28	KIAA0174	19	NP_055576	ER- Golgi intermediate compartment	not classified	protein binding	1, 2
PREDICTED: similar to Protein KIAA0841 isoform 1	KIAA0841	1	XP_049237	not classified	not classified	not classified	2
hypothetical protein LOC57471 isoform a	KIAA1189	1	NP_001009959	cytoplasm membrane	not classified	not classified	2
hypothetical protein LOC57653	KIAA1529	1	NP_065944	not classified	not classified	not classified	2
PREDICTED: similar to c11.1 CG12132- PA isoform 11	KIAA1833	2	XP_946410	not classified	not classified	ATP binding	2
kinesin family member 12	KIF12	16	NP_612433	microtubule microtubule associated complex	microtubule- based movement	ATP binding microtubule motor activity nucleotide binding	2
kinesin family member 3A	KIF3A	1	NP_008985	microtubule microtubule associated complex	microtubule- based movement organelle organization and biogenesis	ATP binding microtubule motor activity nucleotide binding	2
kinesin family member 3B	KIF3B	1	NP_004789	microt