Urinary Exosome Protein Database. LKEM, DIR, NHLBI, NIH

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Mechanism of exosome formation and excretion Urinary Exosome Protein Database This database of urinary exosome proteins is based on published and unpublished protein mass spectrometry data from the NHLBI Laboratory of Kidney and Electrolyte Metabolism. All data are from urinary exosomes isolated from healthy human volunteers. The figure on the right illustrates the mechanism of exosome formation and excretion.

In the first step of the process, apical membrane proteins undergo endocytosis. In the second step, the endosome is targeted to the multivesicular body (MVB). The signal that marks plasma membrane proteins for incorporation into MVB is mono-ubiquitination. In the third step, the endosome fuses with the MVB. Consequently, the apical plasma membrane proteins are segregated in the MVB outer membranes and internalized by membrane invagination. Finally, the outer membrane of the MVB fuses with the apical plasma membrane releasing its internal vesicles, called 'exosomes', in the urinary space. Exosomes contain both membrane and cytosolic proteins.

This current database contains protein identification of human urinary exosomes using two different mass spectrometer analyzers. The LCQ mass analyzer was used for technique # 1 and the LTQ mass analyzer was used for technique # 2.

References:

Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA. Large-scale Proteomics and Phosphoproteomics of Human Urinary Exosomes. J Am Soc Nephrol. in press

Current Database Size: 1160 proteins (Download Data).

The Urinary Exosome Protein Database was created by Patricia A. Gonzales, Guozhong Ma, Trairak Pisitkun, Brian Ruttenberg and Mark A. Knepper.

Protein Name	Gene Name	Peptide #	Acc No	GO Component	GO Process	GO Function	Tech
alpha 1B- glycoprotein	A1BG	1	NP_570602	extracellular region	not classified	not classified	2
alpha- 2- macroglobulin- like 1	A2ML1	1	NP_653271	not classified	not classified	endopeptidase inhibitor activity	2
aminoadipate- semialdehyde dehydrogenase- phosphopantetheinyl transferase	AASDHPPT	1	NP_056238	not classified	fatty acid biosynthesis	magnesium ion binding phosphopantetheinyltransferase activity transferase activity	2
ATP- binding cassette sub- family B member 1	ABCB1	23	NP_000918	cell surface integral to membrane membrane membrane fraction	response to drug transport	ATP binding ATPase activity hydrolase activity nucleotide binding transporter activity xenobiotic- transporting ATPase activity	1, 2
ATP- binding cassette, sub- family B (MDR/TAP), member 11	ABCB11	1	NP_003733	integral to plasma membrane membrane membrane fraction	transport	ATP binding ATPase activity bile acid- exporting ATPase activity nucleotide binding sodium- exporting ATPase activity, phosphorylative mechanism transporter activity	2
ATP- binding cassette, sub- family B, member 6	ABCB6	1	NP_005680	ATP- binding cassette (ABC) transporter complex integral to membrane membrane mitochondrial envelope mitochondrion	iron ion homeostasis transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding	2
ATP- binding cassette, sub- family C, member 11 isoform a	ABCC11	1	NP_149163	integral to membrane membrane	transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding	2
ATP- binding cassette, sub- family C, member 9 isoform SUR2A- delta- 14	ABCC9	1	NP_064694	integral to membrane membrane	potassium ion transport transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding receptor activity sulfonylurea receptor activity transporter activity	2
abhydrolase domain containing 14B	ABHD14B	6	NP_116139	nucleus	not classified	not classified	1, 2
abl- interactor 1 isoform d	ABI1	2	NP_001012770	cytoskeleton cytosol endoplasmic reticulum nucleus soluble fraction	negative regulation of cell proliferation transmembrane receptor protein tyrosine kinase signaling pathway	cytoskeletal protein binding	2
acetyl- Coenzyme A acetyltransferase 1 precursor	ACAT1	1	NP_000010	mitochondrion	not classified	acetyl- CoA C- acetyltransferase activity acyltransferase activity transferase activity	2
angiotensin I converting enzyme isoform 1 precursor	ACE	23	NP_000780	integral to membrane membrane membrane fraction plasma membrane soluble fraction	blood pressure regulation metabolism proteolysis	carboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding	1, 2
angiotensin I converting enzyme isoform 2 precursor	ACE	12	NP_690043	integral to membrane membrane membrane fraction plasma membrane soluble fraction	blood pressure regulation metabolism proteolysis	carboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding	2
angiotensin I converting enzyme 2 precursor	ACE2	8	NP_068576	extracellular region integral to membrane membrane	entry of virus into host cell proteolysis	carboxypeptidase activity chloride ion binding metal ion binding peptidyl- dipeptidase A activity protein binding viral receptor activity zinc ion binding	2
ATP citrate lyase isoform 2	ACLY	1	NP_942127	citrate lyase complex	ATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolism	ATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity	2
ATP citrate lyase isoform 1	ACLY	1	NP_001087	citrate lyase complex	ATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolism	ATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity	1
aconitase 1	ACO1	6	NP_002188	cytoplasm	metabolism tricarboxylic acid cycle	4 iron, 4 sulfur cluster binding aconitate hydratase activity iron ion binding lyase activity metal ion binding RNA binding	2
thioesterase, adipose associated isoform BFIT2	ACOT11	1	NP_671517	cytoplasm	fatty acid metabolism intracellular signaling cascade response to temperature stimulus	acyl- CoA thioesterase activity hydrolase activity serine esterase activity	2
acyl- CoA thioesterase 7 isoform hBACHd	ACOT7	1	NP_863656	cytoplasm mitochondrion	lipid metabolism	acyl- CoA binding hydrolase activity palmitoyl- CoA hydrolase activity serine esterase activity	2
acid phosphatase 1 isoform b	ACP1	1	NP_009030	cytoplasm soluble fraction	protein amino acid dephosphorylation	acid phosphatase activity hydrolase activity non- membrane spanning protein tyrosine phosphatase activity protein tyrosine phosphatase activity	2
lysosomal acid phosphatase 2 precursor	ACP2	7	NP_001601	integral to membrane lysosomal membrane lysosome	not classified	acid phosphatase activity hydrolase activity	1, 2
prostatic acid phosphatase precursor	ACPP	8	NP_001090	extracellular region	regulation of progression through cell cycle	acid phosphatase activity hydrolase activity protein tyrosine phosphatase activity	1, 2
acyl- CoA synthetase long- chain family member 4 isoform 2	ACSL4	1	NP_075266	integral to membrane membrane peroxisome	fatty acid metabolism learning and/or memory lipid metabolism metabolism	ligase activity long- chain- fatty- acid- CoA ligase activity magnesium ion binding	2
acyl- CoA synthetase medium- chain family member 1	ACSM1	1	NP_443188	mitochondrial matrix	benzoate metabolism butyrate metabolism energy derivation by oxidation of organic compounds fatty acid oxidation metabolism	acyl- CoA ligase activity butyrate- CoA ligase activity catalytic activity	2
actinin, alpha 1	ACTN1	1	NP_001093	cytoskeleton focal adhesion pseudopodium	focal adhesion formation negative regulation of cell motility regulation of apoptosis	actin binding calcium ion binding integrin binding protein binding vinculin binding	2
ARP1 actin- related protein 1 homolog A, centractin alpha	ACTR1A	1	NP_005727	actin filament cytoplasm cytoskeleton	not classified	ATP binding nucleotide binding protein binding structural constituent of cytoskeleton	2
actin- related protein 2 isoform a	ACTR2	1	NP_001005386	cytoskeleton	not classified	protein binding structural molecule activity	2
ARP3 actin- related protein 3 homolog	ACTR3	6	NP_005712	Arp2/3 protein complex	cell motility	ATP binding nucleotide binding protein binding structural molecule activity	2
aminoacylase 1	ACY1	15	NP_000657	cytoplasm cytosol	amino acid metabolism proteolysis	aminoacylase activity hydrolase activity metallopeptidase activity protein dimerization activity zinc ion binding	1, 2
aspartoacylase (aminocyclase) 3	ACY3	1	NP_542389	not classified	metabolism	aspartoacylase activity hydrolase activity, acting on ester bonds	2
brain adenylate cyclase 1	ADCY1	1	NP_066939	integral to membrane membrane	cAMP biosynthesis intracellular signaling cascade	calcium- and calmodulin- responsive adenylate cyclase activity calmodulin binding magnesium ion binding	2
class III alcohol dehydrogenase 5 chi subunit	ADH5	1	NP_000662	not classified	ethanol oxidation	alcohol dehydrogenase activity electron carrier activity fatty acid binding formaldehyde dehydrogenase (glutathione) activity metal ion binding S- (hydroxymethyl)glutathione dehydrogenase activity zinc ion binding	2
class V alcohol dehydrogenase 6	ADH6	1	NP_000663	not classified	ethanol oxidation	alcohol dehydrogenase activity electron carrier activity metal ion binding oxidoreductase activity zinc ion binding	2
transcription factor ELYS	AHCTF1	1	NP_056261	nucleus	development transcription	DNA binding	2
S- adenosylhomocysteine hydrolase	AHCY	10	NP_000678	cytoplasm	one- carbon compound metabolism	adenosylhomocysteinase activity hydrolase activity	2
AHNAK nucleoprotein isoform 1	AHNAK	1	NP_001611	nucleus	nervous system development	protein binding	2
AHA1, activator of heat shock 90kDa protein ATPase homolog 1	AHSA1	1	NP_036243	cytoplasm endoplasmic reticulum	protein folding response to stress	ATPase stimulator activity chaperone activator activity chaperone binding	2
alpha- 2- HS- glycoprotein (Fetuin- A)	AHSG	1	NP_001613	extracellular region extracellular space	acute- phase response negative regulation of bone mineralization negative regulation of insulin receptor signaling pathway pinocytosis positive regulation of phagocytosis regulation of inflammatory response skeletal development	cysteine protease inhibitor activity kinase inhibitor activity	2
adenylate kinase 1	AK1	4	NP_000467	cytoplasm cytosol	ATP metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism	adenylate kinase activity ATP binding kinase activity nucleotide binding transferase activity	2
aldo- keto reductase family 1, member A1	AKR1A1	7	NP_006057	not classified	aldehyde metabolism glucose metabolism	alcohol dehydrogenase (NADP+) activity aldehyde reductase activity electron carrier activity oxidoreductase activity protein binding	2
aldo- keto reductase family 1, member B1	AKR1B1	3	NP_001619	extracellular space	carbohydrate metabolism	aldehyde reductase activity electron carrier activity oxidoreductase activity	1, 2
aldo- keto reductase family 7, member A2	AKR7A2	2	NP_003680	not classified	aldehyde metabolism carbohydrate metabolism	aldehyde reductase activity electron carrier activity	2
aldo- keto reductase family 7, member A3	AKR7A3	2	NP_036199	cytosol	aldehyde metabolism	aldo- keto reductase activity electron carrier activity	2
delta- aminolevulinic acid dehydratase isoform a	ALAD	1	NP_001003945	not classified	heme biosynthesis	lyase activity metal ion binding porphobilinogen synthase activity zinc ion binding	2
albumin precursor	ALB	36	NP_000468	extracellular region extracellular space protein complex	body fluid osmoregulation cellular response to starvation hemolysis of host red blood cells maintenance of mitochondrion localization negative regulation of apoptosis negative regulation of non- apoptotic programmed cell death transport water homeostasis	antioxidant activity carrier activity copper ion binding DNA binding drug binding fatty acid binding metal ion binding oxygen binding protein binding pyridoxal phosphate binding toxin binding water binding	1, 2
activated leukocyte cell adhesion molecule	ALCAM	1	NP_001618	integral to plasma membrane membrane membrane fraction	antimicrobial humoral response (sensu Vertebrata) cell adhesion signal transduction	receptor binding	2
aldehyde dehydrogenase 1A1	ALDH1A1	10	NP_000680	cytoplasm	aldehyde metabolism metabolism	aldehyde dehydrogenase (NAD) activity androgen binding oxidoreductase activity Ras GTPase activator activity retinal dehydrogenase activity	2
aldehyde dehydrogenase 1 family, member L1	ALDH1L1	9	NP_036322	cytoplasm	10- formyltetrahydrofolate catabolism biosynthesis one- carbon compound metabolism protein biosynthesis	cofactor binding formyltetrahydrofolate dehydrogenase activity hydroxymethyl- , formyl- and related transferase activity methyltransferase activity oxidoreductase activity	2
mitochondrial aldehyde dehydrogenase 2 precursor	ALDH2	1	NP_000681	mitochondrion	alcohol metabolism carbohydrate metabolism metabolism	aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity electron carrier activity	2
aldehyde dehydrogenase 3B1 isoform a	ALDH3B1	1	NP_000685	not classified	alcohol metabolism aldehyde metabolism lipid metabolism metabolism	3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity	2
aldehyde dehydrogenase 3B1 isoform b	ALDH3B1	1	NP_001025181	not classified	alcohol metabolism aldehyde metabolism lipid metabolism metabolism	3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity	2
aldehyde dehydrogenase 8A1 isoform 1	ALDH8A1	1	NP_072090	intracellular	cell surface extracellular matrix (sensu Metazoa) membrane	oxidoreductase activity retinal dehydrogenase activity	2
aldehyde dehydrogenase 9A1	ALDH9A1	5	NP_000687	cytoplasm	aldehyde metabolism electron transport hormone metabolism metabolism neurotransmitter biosynthesis	4- trimethylammoniobutyraldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity aminobutyraldehyde dehydrogenase activity oxidoreductase activity	2
aldolase A	ALDOA	7	NP_908930	not classified	fructose metabolism glycolysis metabolism striated muscle contraction	fructose- bisphosphate aldolase activity lyase activity	2
fructose- bisphosphate aldolase C	ALDOC	1	NP_005156	not classified	fructose metabolism glycolsis metabolism	fructose- bisphosphate aldolase activity lyase activity	2
anaplastic lymphoma kinase Ki- 1	ALK	1	NP_004295	integral to plasma membrane membrane	brain development nervous system development protein amino acid N- linked glycosylation protein amino acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway	ATP binding nucleotide binding receptor activity receptor signaling protein tyrosine kinase activity transferase activity transmembrane receptor protein tyrosine kinase activity	2
arachidonate 12- lipoxygenase	ALOX12	1	NP_000688	cytosol sarcolemma	anti- apoptosis arachidonic acid metabolism cell motility electron transport fatty acid oxidation leukotriene biosynthesis negative regulation of cell volume oxygen and reactive oxygen species metabolism positive regulation of cell adhesion positive regula	arachidonate 12- lipoxygenase activity hepoxilin- epoxide hydrolase activity iron ion binding lipoxygenase activity metal ion binding oxidoreductase activity potassium channel inhibitor activity	2
tissue non- specific alkaline phosphatase precursor	ALPL	3	NP_000469	integral to membrane membrane	metabolism ossification	alkaline phosphatase activity GPI anchor binding hydrolase activity magnesium ion binding zinc ion binding	2
alpha- 1- microglobulin/bikunin precursor	AMBP	4	NP_001624	extracellular region plasma membrane	anti- inflammatory response cell adhesion heme catabolism negative regulation of immune response negative regulation of JNK cascade pregnancy protein- chromophore linkage transport	calcium channel inhibitor activity calcium oxalate binding heme binding IgA binding plasmin inhibitor activity protein homodimerization activity transporter activity trypsin inhibitor activity	1, 2
amnionless protein precursor	AMN	1	NP_112205	integral to membrane membrane	development	not classified	2
angiopoietin- like 2 precursor	ANGPTL2	1	NP_036230	extracellular space	development	receptor binding	2
ankyrin repeat and FYVE domain containing 1 isoform 1	ANKFY1	2	NP_057460	endosome membrane membrane	endocytosis	metal ion binding protein binding zinc ion binding	2
ankyrin repeat and FYVE domain containing 1 isoform 2	ANKFY1	2	NP_065791	endosome membrane membrane	endocytosis	metal ion binding protein binding zinc ion binding	2
membrane alanine aminopeptidase precursor	ANPEP	69	NP_001141	ER- Golgi intermediate compartment integral to plasma membrane	angiogenesis cell differentiation proteolysis	aminopeptidase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity receptor activity zinc ion binding	1, 2
annexin I	ANXA1	19	NP_000691	cornified envelope cytoplasm	anti- apoptosis cell motility cell surface receptor linked signal transduction inflammatory response keratinocyte differentiation lipid metabolism peptide cross- linking	calcium ion binding calcium- dependent phospholipid binding phospholipase A2 inhibitor activity phospholipase inhibitor activity protein binding, bridging receptor binding structural molecule activity	2
annexin A11	ANXA11	31	NP_665875	cytoplasm nuclear envelope nucleoplasm nucleus	immune response	calcium ion binding calcium- dependent phospholipid binding protein binding	2
annexin A13 isoform b	ANXA13	1	NP_001003954	plasma membrane	cell differentiation	calcium ion binding calcium- dependent phospholipid binding	2
annexin A2 isoform 2	ANXA2	29	NP_001002857	plasma membrane soluble fraction	skeletal development	calcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity	2
annexin A2 isoform 1	ANXA2	20	NP_001002858	plasma membrane soluble fraction	skeletal development	calcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity	2
annexin A3	ANXA3	8	NP_005130	cytoplasm	signal transduction	calcium ion binding calcium- dependent phospholipid binding diphosphoinositol- polyphosphate diphosphatase activity phospholipase A2 inhibitor activity	1, 2
annexin IV	ANXA4	24	NP_001144	cytoplasm	anti- apoptosis negative regulation of coagulation signal transduction	calcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity	1, 2
annexin 5	ANXA5	24	NP_001145	cytoplasm intracellular	anti- apoptosis blood coagulation negative regulation of coagulation signal transduction	calcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity protein binding	1, 2
annexin VI isoform 1	ANXA6	27	NP_001146	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding protein binding	1, 2
annexin VI isoform 2	ANXA6	20	NP_004024	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding protein binding	2
annexin VII isoform 2	ANXA7	13	NP_004025	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity	2
annexin VII isoform 1	ANXA7	2	NP_001147	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity	1
aldehyde oxidase 1	AOX1	1	NP_001150	not classified	electron transport inflammatory response oxygen and reactive oxygen species metabolism	2 iron, 2 sulfur cluster binding aldehyde oxidase activity electron carrier activity iron ion binding metal ion binding molybdenum ion binding oxidoreductase activity xanthine dehydrogenase activity	2
adaptor- related protein complex 1, mu 1 subunit	AP1M1	1	NP_115882	clathrin vesicle coat coated pit	intracellular protein transport	protein binding	2
adaptor- related protein complex 2, mu 1 subunit isoform a	AP2M1	1	NP_004059	clathrin vesicle coat coated pit	intracellular protein transport transport	lipid binding protein binding transporter activity	2
adaptor- related protein complex 4, mu 1 subunit	AP4M1	1	NP_004713	clathrin vesicle coat coated pit coated vesicle membrane Golgi trans cisterna membrane coat adaptor complex	intracellular protein transport transport vesicle- mediated transport	transporter activity	2
apoptotic peptidase activating factor 1 isoform b	APAF1	1	NP_001151	cytosol intracellular	caspase activation via cytochrome c nervous system development regulation of apoptosis	ATP binding caspase activator activity nucleotide binding protein binding	2
serum amyloid P component precursor	APCS	5	NP_001630	extracellular region extracellular space	acute- phase response chaperone- mediated protein complex assembly protein folding	calcium ion binding sugar binding unfolded protein binding	1, 2
apolipoprotein A- I preproprotein	APOA1	6	NP_000030	extracellular region extracellular space	cholesterol metabolism cholesterol transport circulation lipid metabolism lipid transport lipoprotein metabolism steroid metabolism	high- density lipoprotein binding lipid binding lipid transporter activity protein binding	2
apolipoprotein A- II preproprotein	APOA2	1	NP_001634	extracellular region	glucose metabolism lipid transport negative regulation of lipid catabolism negative regulation of lipoprotein metabolism neutrophil activation positive regulation of interleukin- 8 biosynthesis regulation of cytokine production response to glucose stimulus	lipid binding lipid transporter activity protein heterodimerization activity protein homodimerization activity	2
apolipoprotein A- IV precursor	APOA4	2	NP_000473	chylomicron extracellular region	circulation lipid metabolism lipid transport lipoprotein metabolism	lipid binding lipid transporter activity	2
apolipoprotein D precursor	APOD	7	NP_001638	extracellular region extracellular space	lipid metabolism transport	high- density lipoprotein binding lipid binding lipid transporter activity protein binding	1, 2
apolipoprotein E precursor	APOE	6	NP_000032	chylomicron cytoplasm extracellular region	cholesterol homeostasis circulation cytoskeleton organization and biogenesis induction of apoptosis intracellular transport learning and/or memory lipid transport lipoprotein metabolism protein tetramerization regulation of axon extension regulation of ne	antioxidant activity apolipoprotein E receptor binding beta- amyloid binding heparin binding lipid transporter activity phospholipid binding tau protein binding	2
adaptor protein containing pH domain, PTB domain and leucine zipper motif	APPL	1	NP_036228	cytoplasm endosome membrane membrane nucleus NuRD complex	cell cycle cell proliferation signal transduction	protein binding	2
adenine phosphoribosyltransferase isoform a	APRT	3	NP_000476	cytoplasm	adenine salvage nucleoside metabolism purine ribonucleoside salvage	adenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups	1, 2
adenine phosphoribosyltransferase isoform b	APRT	3	NP_001025189	cytoplasm	adenine salvage nucleoside metabolism purine ribonucleoside salvage	adenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups	2
aquaporin 1	AQP1	3	NP_932766	integral to membrane integral to plasma membrane membrane outer membrane	excretion transport water transport	porin activity transporter activity water transporter activity	1, 2
aquaporin 2	AQP2	7	NP_000477	apical plasma membrane integral to membrane plasma membrane	excretion transport water transport	transporter activity water channel activity	1, 2
ADP- ribosylation factor 1	ARF1	6	NP_001649	intracellular plasma membrane	ER to Golgi vesicle- mediated transport transport rRNA processing small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein binding receptor signaling protein activity	1
ADP- ribosylation factor interacting protein 1 isoform 2	ARFIP1	1	NP_055262	cytosol Golgi membrane	intracellular protein transport regulation of protein secretion	not classified	1
Rho GTPase activating protein 1	ARHGAP1	1	NP_004299	intracellular	cytoskeleton organization and biogenesis Rho protein signal transduction signal transduction	GTP binding protein binding Rho GTPase activator activity SH3/SH2 adaptor activity	2
Rho GDP dissociation inhibitor (GDI) alpha	ARHGDIA	1	NP_004300	cytoplasm cytoskeleton	anti- apoptosis cell motility negative regulation of cell adhesion Rho protein signal transduction	GTPase activator activity protein binding Rho GDP- dissociation inhibitor activity	2
Rho GDP dissociation inhibitor (GDI) beta	ARHGDIB	1	NP_001166	cytoplasm cytoplasmic membrane- bound vesicle cytoskeleton	actin cytoskeleton organization and biogenesis cell motility development immune response negative regulation of cell adhesion Rho protein signal transduction	GTPase activator activity Rho GDP- dissociation inhibitor activity	2
Rho guanine nucleotide exchange factor (GEF) 12	ARHGEF12	1	NP_056128	intracellular	regulation of Rho protein signal transduction	GTPase activator activity protein binding Rho guanyl- nucleotide exchange factor activity	2
ADP- ribosylation factor related protein 2	ARL15	1	NP_061960	not classified	not classified	GTP binding	2
ADP- ribosylation factor- like 3	ARL3	2	NP_004302	intracellular	G- protein coupled receptor protein signaling pathway rRNA processing small GTPase mediated signal transduction	GTP binding nucleotide binding signal transducer activity	1, 2
ADP- ribosylation factor- like 6	ARL6	3	NP_115522	cytoplasm intracellular membrane	rRNA processing small GTPase mediated signal transduction	GTP binding nucleotide binding protein binding	2
ADP- ribosylation factor- like 10B	ARL8A	1	NP_620150	cytoplasm intracellular membrane midbody spindle midzone	chromosome segregation rRNA processing small GTPase mediated signal transduction	alpha- tubulin binding beta- tubulin binding GTP binding GTPase activity nucleotide binding	2
ADP- ribosylation factor- like 10C	ARL8B	1	NP_060654	cytoplasm intracellular membrane midbody spindle midzone	chromosome segregation rRNA processing small GTPase mediated signal transduction	alpha- tubulin binding beta- tubulin binding GDP binding GTP binding GTPase activity nucleotide binding	2
armadillo repeat containing 3	ARMC3	1	NP_775104	not classified	not classified	binding	2
armadillo repeat containing 9	ARMC9	1	NP_079415	not classified	not classified	binding	2
actin related protein 2/3 complex subunit 1A	ARPC1A	1	NP_006400	not classified	not classified	not classified	2
actin related protein 2/3 complex subunit 2	ARPC2	5	NP_005722	Arp2/3 protein complex cytoskeleton	cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 3	ARPC3	2	NP_005710	Arp2/3 protein complex	cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 4 isoform a	ARPC4	2	NP_005709	Arp2/3 protein complex cytoskeleton	actin filament polymerization actin nucleation	actin filament binding protein binding, bridging structural constituent of cytoskeleton	1, 2
actin related protein 2/3 complex subunit 4 isoform b	ARPC4	2	NP_001020130	Arp2/3 protein complex cytoskeleton	actin filament polymerization actin nucleation	actin filament binding protein binding, bridging structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 5	ARPC5	1	NP_005708	Arp2/3 protein complex cytoplasm cytoskeleton	actin cytoskeleton organization and biogenesis cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex, subunit 5- like	ARPC5L	1	NP_112240	cytoskeleton	regulation of actin filament polymerization	not classified	2
arrestin domain containing 1	ARRDC1	5	NP_689498	not classified	not classified	not classified	1, 2
arylsulfatase E precursor	ARSE	1	NP_000038	not classified	metabolism skeletal development	arylsulfatase activity calcium ion binding hydrolase activity	2
arylsulfatase F precursor	ARSF	12	NP_004033	not classified	metabolism	arylsulfatase activity calcium ion binding hydrolase activity	2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 preproprotein isoform a	ASAH1	7	NP_808592	lysosome	carboxylic acid metabolism ceramide metabolism fatty acid metabolism	ceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	1, 2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 isoform b	ASAH1	9	NP_004306	lysosome	carboxylic acid metabolism ceramide metabolism fatty acid metabolism	ceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	2
argininosuccinate lyase isoform 3	ASL	1	NP_001020117	cytoplasm	amino acid biosynthesis arginine biosynthesis arginine catabolism urea cycle	argininosuccinate lyase activity catalytic activity lyase activity	2
arsA arsenite transporter, ATP- binding, homolog 1	ASNA1	1	NP_004308	cytoplasm membrane nucleolus soluble fraction	anion transport response to arsenic transport	arsenite transporter activity arsenite- transporting ATPase activity ATP binding hydrolase activity nucleotide binding transporter activity	2
argininosuccinate synthetase 1	ASS1	20	NP_000041	cytoplasm	amino acid biosynthesis arginine biosynthesis urea cycle	argininosuccinate synthase activity ATP binding ligase activity nucleotide binding protein binding	1, 2
two AAA domain containing protein	ATAD2	1	NP_054828	not classified	not classified	ATP binding nucleoside- triphosphatase activity nucleotide binding	2
5- aminoimidazole- 4- carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	ATIC	1	NP_004035	not classified	nucleobase, nucleoside, nucleotide and nucleic acid metabolism	hydrolase activity IMP cyclohydrolase activity phosphoribosylaminoimidazolecarboxamide formyltransferase activity transferase activity	2
Na+/K+ - ATPase beta 1 subunit isoform b	ATP1B1	1	NP_001001787	integral to membrane membrane sodium:potassium- exchanging ATPase complex	ion transport potassium ion transport sodium ion transport	potassium ion binding sodium ion binding sodium:potassium- exchanging ATPase activity	2
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precursor	ATP5A1	3	NP_001001937	membrane fraction mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement ofsubstances meta	2
ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit precursor	ATP5B	4	NP_001677	mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting ATP synthase, catalytic core (sensu Eukaryota)	ATP synthesis coupled proton transport generation of precursor metabolites and energy ion transport proton transport	ATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleoside- triphos	2
ATPase, H+ transporting, lysosomal accessory protein 1 precursor	ATP6AP1	1	NP_001174	membrane proton- transportin two- sector ATPase complex vacuole	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding transporter activity	2
ATPase, H+ transporting, lysosomal accessory protein 2	ATP6AP2	1	NP_005756	integral to membrane membrane	not classified	receptor activity	2
ATPase, H+ transporting, lysosomal V0 subunit a isoform 1	ATP6V0A1	1	NP_005168	integral to membrane membrane	ion transport proton transport	hydrogen ion transporter activity	2
ATPase, H+ transporting, lysosomal V0 subunit a4	ATP6V0A4	1	NP_065683	hydrogen- translocating V- type ATPase complex integral to membrane membrane	ion transport proton transport regulation of pH	hydrogen ion transporter activity	2
ATPase, H+ transporting, lysosomal, V0 subunit c	ATP6V0C	1	NP_001685	membrane proton- transporting two- sector ATPase complex vacuole	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotation mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal, V0 subunit d1	ATP6V0D1	1	NP_004682	hydrogen- translocating V- type ATPase complex proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D2	ATP6V0D2	2	NP_689778	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotation mechanism	2
ATPase, H+ transporting, lysosomal 70kD, V1 subunit A, isoform 1	ATP6V1A	22	NP_001681	integral to plasma membrane proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding	2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	ATP6V1B1	8	NP_001683	cytoplasm plasma membrane proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport energy coupled proton transport, against electrochemical gradient excretion ion transport regulation of pH sensory perception of sound	ATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding	2
vacuolar H+ATPase B2	ATP6V1B2	12	NP_001684	cytoplasm proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport energy coupled proton transport, against electrochemical gradient ion transport	ATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 isoform A	ATP6V1C1	1	NP_001686	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances metal ion binding transporter activity	2
vacuolar H+ ATPase C2 isoform a	ATP6V1C2	1	NP_001034451	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport	ATP binding hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2
H(+)- transporting two- sector ATPase	ATP6V1D	2	NP_057078	proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
vacuolar H+ ATPase E1 isoform a	ATP6V1E1	2	NP_001687	plasma membrane proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding	2
vacuolar H+ ATPase E1 isoform c	ATP6V1E1	1	NP_001034456	plasma membrane proton- transporting two- sector ATPase complex plasma membrane	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transportin ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding	2
vacuolar H+ ATPase E1 isoform b	ATP6V1E1	1	NP_001034455	plasma membrane proton- transporting two- sector ATPase complex plasma membrane	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transportin ATPase activity, rotational mechanism hydrolase activity metal ion binding protein binding	2
ATPase, H+ transporting, lysosomal 14kD, V1 subunit F	ATP6V1F	1	NP_004222	membrane fraction proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
vacuolar H+ ATPase G1	ATP6V1G1	1	NP_004879	not classified	ATP biosynthesis ion transport proton transport	hydrogen ion transporter activity hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 1	ATP6V1H	8	NP_998784	hydrogen- transporting ATPase V1 domain peripheral to membrane of membrane fraction	ATP hydrolysis coupled proton transport ATP synthesis coupled proton transport endocytosis ion transport proton transport vacuolar acidification	ATP binding ATPase activity ATPase stimulator activity enzyme regulator activity hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding protein bin	2
attractin isoform 1	ATRN	1	NP_647537	extracellular space integral to plasma membrane plasma membrane	development inflammatory response	receptor activity sugar binding	2
attractin isoform 2	ATRN	1	NP_647538	extracellular space integral to plasma membrane plasma membrane	development inflammatory response	receptor activity sugar binding	2
azurocidin 1 preproprotein	AZU1	1	NP_001691	azurophil granule extracellular region	anti- apoptosis cellular extravasation chemotaxis defense response to Gram- negative bacterium glial cell migration induction of positive chemotaxis macrophage chemotaxis microglial cell activation monocyte activation positive regulation of cell adhesion po	heparin binding serine- type endopeptidase activity toxin binding	2
beta- 2- microglobulin precursor	B2M	1	NP_004039	extracellular region	antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I immune response	MHC class I receptor activity	2
UDP- Gal:betaGlcNAc beta 1, 4- galactosyltransferase 1, membrane- bound form	B4GALT1	1	NP_001488	Golgi apparatus integral to membrane membrane	carbohydrate metabolism oligosaccharide biosynthesis	beta- N- acetylglucosaminylglycopeptide beta- 1, 4- galactosyltransferase activity galactosyltransferase activity lactose synthase activity manganese ion binding metal ion binding N- acetyllactosamine synthase activity transferase activity, transferring glycosy	2
BAI1- associated protein 2 isoform 1	BAIAP2	9	NP_059344	not classified	not classified	protein binding	1, 2
BAI1- associated protein 2 isoform 2	BAIAP2	6	NP_059345	not classified	not classified	protein binding	2
BAI1- associated protein 2- like 1	BAIAP2L1	4	NP_061330	not classified	not classified	not classified	1, 2
brain abundant, membrane attached signal protein 1	BASP1	6	NP_006308	cytoskeleton plasma membrane	not classified	not classified	2
HLA- B associated transcript- 2 isoform a	BAT2	1	NP_542417	nucleus	not classified	protein binding	2
bromodomain adjacent to zinc finger domain, 1B	BAZ1B	1	NP_075381	nucleus	regulation of transcription, DNA- dependent transcription	metal ion binding protein binding transcription factor activity zinc ion binding	2
gamma- butyrobetaine dioxygenase	BBOX1	6	NP_003977	not classified	carnitine biosynthesis electron transport	gamma- butyrobetaine dioxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	1, 2
basal cell adhesion molecule isoform 1 precursor	BCAM	1	NP_005572	cell surface integral to plasma membrane plasma membrane	cell adhesion signal transduction	transmembrane receptor activity	2
basal cell adhesion molecule isoform 2 precursor	BCAM	2	NP_001013275	cell surface integral to plasma membrane plasma membrane	cell adhesion signal transduction	transmembrane receptor activity	2
BCL2- like 12 isoform 2	BCL2L12	1	NP_443074	not classified	apoptosis	not classified	2
breakpoint cluster region isoform 1	BCR	2	NP_004318	intracellular	intracellular signaling cascade protein amino acid phosphorylation regulation of Rho protein signal transduction signal transduction	GTPase activator activity kinase activity protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity	2
breakpoint cluster region isoform 2	BCR	2	NP_067585	intracellular	intracellular signaling cascade protein amino acid phosphorylation regulation of Rho protein signal transduction signal transduction	GTPase activator activity kinase activity protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity	2
3- hydroxybutyrate dehydrogenase, type 2	BDH2	5	NP_064524	cytoplasm mitochondrion	fatty acid beta- oxidation metabolism	3- hydroxybutyrate dehydrogenase activity NAD binding oxidoreductase activity	2
biglycan preproprotein	BGN	1	NP_001702	extracellular matrix (sensu Metazoa) transport vesicle	not classified	extracellular matrix structural constituent transferase activity	2
basic helix- loop- helix domain containing, class B, 9	BHLHB9	1	NP_085142	not classified	not classified	binding	2
betaine- homocysteine methyltransferase 2	BHMT2	1	NP_060084	not classified	not classified	homocysteine S- methyltransferase activity methyltransferase activity transferase activity	2
bleomycin hydrolase	BLMH	1	NP_000377	cytoplasm nucleus	proteolysis	aminopeptidase activity bleomycin hydrolase activity carboxypeptidase activity	2
biliverdin reductase A	BLVRA	1	NP_000703	not classified	electron transport heme catabolism metabolism	biliverdin reductase activity metal ion binding oxidoreductase activity zinc ion binding	2
biliverdin reductase B (flavin reductase (NADPH))	BLVRB	4	NP_000704	not classified	cellular metabolism	biliverdin reductase activity coenzyme binding flavin reductase activity oxidoreductase activity	2
bactericidal/permeability- increasing protein precursor	BPI	4	NP_001716	integral to plasma membrane membrane	defense response to bacterium immune response	Gram- negative bacterial binding lipid binding	2
bone marrow stromal cell antigen 2	BST2	1	NP_004326	integral to plasma membrane membrane	cell proliferation cell- cell signaling development humoral immune response positive regulation of I- kappaB kinase/NF- kappaB cascade defense response to bacterium	signal transducer activity	1, 2
B- cell translocation gene 2	BTG2	1	NP_006754	not classified	DNA repair negative regulation of cell proliferation regulation of transcription, DNA- dependent transcription	transcription factor activity	2
adipose specific 2	C10orf116	2	NP_006820	not classified	not classified	not classified	2
PREDICTED: similar to retinoblastoma- associated protein 140 isoform 1	C10orf18	1	XP_374765	not classified	not classified	not classified	2
hypothetical protein LOC222389	C10orf30	1	NP_689964	not classified	not classified	not classified	2
hypothetical protein LOC283294	C11orf47	1	NP_775860	not classified	not classified	not classified	2
hypothetical protein LOC91894	C11orf52	1	NP_542390	not classified	not classified	not classified	2
hypothetical protein LOC28970	C11orf54	1	NP_054758	nucleus	not classified	hydrolase activity metal ion binding zinc ion binding	2
hypothetical protein LOC55004	C11orf59	3	NP_060377	not classified	not classified	not classified	1, 2
hypothetical protein LOC283450	C12orf51	1	NP_776174	not classified	not classified	not classified	2
hypothetical protein LOC120939	C12orf59	1	NP_694567	not classified	not classified	not classified	2
transcription factor IIB	C16orf80	1	NP_037374	not classified	development	not classified	2
hypothetical protein LOC254863	C17orf61	2	NP_689979	not classified	not classified	not classified	2
lung cancer- related protein 8	C17orf80	1	NP_060411	not classified	not classified	not classified	2
hypothetical protein LOC147685	C19orf18	1	NP_689687	integral to membrane membrane	not classified	not classified	2
specifically androgen- regulated protein	C1orf116	4	NP_076427	not classified	not classified	not classified	2
hypothetical protein LOC338094	C1orf179	4	NP_788954	not classified	not classified	not classified	2
hypothetical protein LOC54680	C1orf181	1	NP_060423	not classified	not classified	not classified	2
keratinocyte expressed, proline- rich protein	C1orf45	1	NP_001020402	not classified	not classified	not classified	2
hypothetical protein LOC148362	C1orf58	17	NP_653296	not classified	not classified	not classified	1, 2
hypothetical protein LOC127281	C1orf93	1	NP_689584	not classified	not classified	not classified	2
hypothetical protein LOC200232	C20orf106	1	NP_001012989	not classified	not classified	not classified	2
LPLUNC1 protein precursor	C20orf114	10	NP_149974	not classified	not classified	lipid binding	2
hypothetical protein LOC140710 isoform 1	C20orf117	1	NP_542194	not classified	not classified	catalytic activity	2
hypothetical protein LOC84226	C2orf16	1	NP_115642	not classified	not classified	not classified	2
hypothetical protein LOC54978	C2orf18	2	NP_060347	integral to membrane membrane	not classified	not classified	2
complement component 5	C5	1	NP_001726	extracellular region extracellular space membrane attack complex	activation of MAPK activity chemotaxis complement activation, alternative pathway complement activation, classical pathway cytolysis G- protein coupled receptor protein signaling pathway inflammatory response innate immune response response to stress	chemokine activity endopeptidase inhibitor activity receptor binding	2
putative nuclear protein ORF1- FL49	C5orf32	2	NP_115788	nucleus	not classified	not classified	1, 2
putative c- Myc- responsive isoform 2	C6orf108	1	NP_954653	nucleus	cell proliferation	not classified	2
hypothetical protein LOC51534	C6orf55 (VTA1)	6	NP_057569	not classified	not classified	not classified	1, 2
hypothetical protein LOC352999	C6orf58	1	NP_001010905	not classified	not classified	not classified	2
hypothetical protein LOC79017	C7orf24	1	NP_076956	not classified	not classified	not classified	2
complement component 9	C9	1	NP_001728	integral to plasma membrane membrane membrane attack complex	complement activation, alternative pathway complement activation, classical pathway cytolysis hemolysis of host red blood cells innate immune response	not classified	2
chromosome 9 open reading frame 19	C9orf19	2	NP_071738	extracellular region membrane	not classified	not classified	1, 2
hypothetical protein LOC54875	C9orf39	1	NP_060208	membrane	signal transduction	two- component sensor activity	2
ionized calcium binding adapter molecule 2 isoform 1	C9orf58	2	NP_113614	actin cytoskeleton focal adhesion	not classified	calcium ion binding	2
hypothetical protein LOC64855 isoform 2	C9orf88	2	NP_001030611	not classified	not classified	not classified	2
carbonic anhydrase II	CA2	9	NP_000058	cytoplasm	one- carbon compound metabolism	carbonate dehydratase activity lyase activity metal ion binding zinc ion binding	1, 2
carbonic anhydrase IV precursor	CA4	2	NP_000708	membrane membrane fraction	one- carbon compound metabolism response to stimulus visual perception	carbonate dehydratase activity GPI anchor binding lyase activity metal ion binding zinc ion binding	1, 2
calcium binding protein 39	CAB39	9	NP_057373	not classified	not classified	protein binding	1, 2
calcium binding protein 39- like	CAB39L	1	NP_001026894	not classified	not classified	binding	2
calcium channel, voltage- dependent, alpha 2/delta subunit 1	CACNA2D1	1	NP_000713	integral to membrane membrane membrane fraction voltage- gated calcium channel complex	calcium ion transport ion transport	calcium channel activity calcium ion binding dihydropyridine- sensitive calcium channel activity receptor activity voltage- gated ion channel activity	2
calbindin 1	CALB1	2	NP_004920	not classified	not classified	calcium ion binding protein binding vitamin D binding	1, 2
calmodulin- like 3	CALML3	1	NP_005176	not classified	not classified	calcium ion binding	2
calreticulin precursor	CALR	1	NP_004334	cytosol endoplasmic reticulum endoplasmic reticulum lumen	calcium ion homeostasis protein export from nucleus protein folding regulation of apoptosis regulation of transcription, DNA- dependent	calcium ion binding DNA binding sugar binding unfolded protein binding zinc ion binding	1
calcium/calmodulin- dependent protein kinase IV	CAMK4	1	NP_001735	nucleus	protein amino acid phosphorylation signal transduction	ATP binding calcium ion binding calcium- and calmodulin- dependent protein kinase activity calmodulin binding nucleotide binding protein serine/threonine kinase activity transferase activity	2
cathelicidin antimicrobial peptide	CAMP	1	NP_004336	extracellular region	defense response to bacterium	not classified	2
TIP120 protein	CAND1	1	NP_060918	nucleus ubiquitin ligase complex	negative regulation of enzyme activity protein ubiquitination regulation of transcription, DNA- dependent transcription	protein binding	2
adenylyl cyclase- associated protein	CAP1	1	NP_006358	membrane	adenylate cyclase activation establishment and/or maintenance of cell polarity signal transduction	actin binding	2
gelsolin- like capping protein	CAPG	8	NP_001738	F- actin capping protein complex nucleus	barbed- end actin filament capping protein complex assembly	actin binding	2
calpain 1, large subunit	CAPN1	15	NP_005177	intracellular	positive regulation of cell proliferation proteolysis	calcium ion binding calpain activity	2
calpain 2, large subunit	CAPN2	1	NP_001739	intracellular	proteolysis	calcium ion binding calpain activity	2
calpain 5	CAPN5	10	NP_004046	intracellular	proteolysis signal transduction	calpain activity	2
calpain 7	CAPN7	30	NP_055111	intracellular nucleus	proteolysis	binding calpain activity cysteine- type peptidase activity	1, 2
F- actin capping protein alpha- 1 subunit	CAPZA1	2	NP_006126	F- actin capping protein complex	actin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility protein complex assembly	actin binding	2
capping protein (actin filament) muscle Z- line, alpha 2	CAPZA2	1	NP_006127	F- actin capping protein complex	actin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility protein complex assembly	actin binding	2
F- actin capping protein beta subunit	CAPZB	2	NP_004921	F- actin capping protein complex	actin cytoskeleton organization and biogenesis barbed- end actin filament capping cell motility	actin binding	2
carbonyl reductase 1	CBR1	5	NP_001748	cytosol	metabolism	15- hydroxyprostaglandin dehydrogenase (NADP+) activity carbonyl reductase (NADPH) activity oxidoreductase activity prostaglandin- E2 9- reductase activity	2
coiled- coil and C2 domain containing 1A	CC2D1A	6	NP_060191	nucleus	positive regulation of I- kappaB kinase/NF- kappaB cascade regulation of transcription, DNA- dependent transcription	DNA binding signal transducer activity	2
coiled- coil domain containing 105	CCDC105	2	NP_775753	not classified	not classified	not classified	2
chaperonin containing TCP1, subunit 2	CCT2	1	NP_006422	cytosol	protein folding regulation of progression through cell cycle	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 3 isoform c	CCT3	1	NP_001008800	cytoskeleton	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 3 isoform a	CCT3	3	NP_005989	cytoskeleton	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 5 (epsilon)	CCT5	3	NP_036205	not classified	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 6A isoform b	CCT6A	2	NP_001009186	cytoplasm	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 6A isoform a	CCT6A	1	NP_001753	cytoplasm	protein folding	ATP binding nucleotide binding unfolded protein binding	2
chaperonin containing TCP1, subunit 8 (theta)	CCT8	4	NP_006576	cytosol	protein folding	ATP binding ATPase activity, coupled nucleotide binding unfolded protein binding	2
CD14 antigen precursor	CD14	7	NP_000582	extrinsic to membrane plasma membrane	apoptosis cell surface receptor linked signal transduction inflammatory response phagocytosis	GPI anchor binding peptidoglycan receptor activity transferase activity	2
CD2- associated protein	CD2AP	14	NP_036252	actin cytoskeleton cytoplasm filamentous actin ruffle	protein complex assembly signal transduction substrate- bound cell migration, cell extension	protein binding SH3 domain binding structural constituent of cytoskeleton	2
CD59 antigen p18- 20	CD59	4	NP_976074	membrane fraction plasma membrane	blood coagulation cell surface receptor linked signal transduction immune response	GPI anchor binding protein binding	2
CD63 antigen isoform A	CD63	1	NP_001771	endosome membrane integral to membrane integral to plasma membrane lysosomal membrane plasma membrane	not classified	not classified	1, 2
CD63 antigen isoform B	CD63	2	NP_001035123	endosome membrane integral to membrane integral to plasma membrane lysosomal membrane plasma membrane	not classified	not classified	2
CD81 antigen	CD81	4	NP_004347	integral to plasma membrane membrane	activation of MAPK activity entry of virus into host cell phosphatidylinositol biosynthesis phosphoinositide metabolism positive regulation of 1- phosphatidylinositol 4- kinase activity positive regulation of B cell proliferation positive regulation of cel	protein binding	1, 2
CD9 antigen	CD9	7	NP_001760	integral to membrane integral to plasma membrane plasma membrane	cell adhesion cell motility fusion of sperm to egg plasma membrane paranodal junction assembly platelet activation	protein binding	1, 2
cell division cycle 2 protein isoform 2	CDC2	1	NP_203698	midbody nucleus spindle microtubule	anti- apoptosis cell cycle cell division mitosis protein amino acid phosphorylation regulation of progression through cell cycle traversing start control point of mitotic cell cycle	ATP binding cyclin- dependent protein kinase activity nucleotide binding protein binding transferase activity	2
cell division cycle 42 isoform 2	CDC42	7	NP_426359	cytoplasm filopodium intracellular plasma membrane	actin cytoskeleton organization and biogenesis cell cycle cell division establishment and/or maintenance of cell polarity G1 phase macrophage differentiation negative regulation of protein complex assembly positive regulation of pseudopodium formation reg	GTP binding GTPase activity nucleotide binding protein binding	2
CDC42- binding protein kinase alpha isoform A	CDC42BPA	2	NP_055641	intercellular junction leading edge	actin cytoskeleton reorganization intracellular signaling cascade protein amino acid phosphorylation regulation of small GTPase mediated signal transduction	ATP binding diacylglycerol binding identical protein binding kinase activity magnesium ion binding metal ion binding nucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity zinc ion binding	2
CDC42- binding protein kinase beta	CDC42BPB	3	NP_006026	cytoskeleton intercellular junction leading edge	actin cytoskeleton reorganization cytoskeleton organization and biogenesis establishment and/or maintenance of cell polarity intracellular signaling cascade protein amino acid phosphorylation regulation of small GTPase mediated signal transduction	ATP binding diacylglycerol binding identical protein binding magnesium ion binding nucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity zinc ion binding	2
CDK5 regulatory subunit associated protein 2 isoform b	CDK5RAP2	1	NP_001011649	centrosome cytoskeleton	brain development regulation of neuron differentiation	microtubule binding neuronal Cdc2- like kinase binding	2
carcinoembryonic antigen- related cell adhesion molecule 5 preproprotein	CEACAM5	1	NP_004354	integral to membrane integral to plasma membrane membrane	not classified	GPI anchor binding	2
centrosomal protein 2 isoform 1	CEP250	1	NP_009117	centrosome	mitotic cell cycle regulation of centriole- centriole cohesion	protein kinase binding	2
cholesteryl ester transfer protein, plasma precursor	CETP	7	NP_000069	not classified	cholesterol metabolism lipid metabolism lipid transport steroid metabolism	catalytic activitylipid binding	2
complement factor D preproprotein	CFD	2	NP_001919	not classified	complement activation, alternative pathway innate immune response proteolysis	complement factor D activity peptidase activity	2
complement factor H isoform b precursor	CFH	1	NP_001014975	extracellular space	complement activation, alternative pathway innate immune response	not classified	2
complement factor I	CFI	1	NP_000195	extracellular region membrane	complement activation, classical pathway innate immune response proteolysis	complement factor I activity peptidase activity scavenger receptor activity	2
coiled- coil- helix- coiled- coil- helix domain containing 3	CHCHD3	1	NP_060282	mitochondrion	not classified	protein binding	2
chromatin modifying protein 1A isoform 2	CHMP1A	1	NP_002759	condensed nuclear chromosome early endosome endomembrane system microtubule organizing center nuclear matrix nucleus	cell cycle gene silencing mitotic chromosome condensation negative regulation of S phase of mitotic cell cycle negative regulation of transcription by glucose negative regulation of transcription, DNA- dependent protein transport transcription vesicle- medi	protein binding	2
chromatin modifying protein 1B	CHMP1B	6	NP_065145	not classified	protein transport	not classified	1, 2
chromatin modifying protein 2A	CHMP2A	11	NP_055268	not classified	protein transport	not classified	1, 2
chromatin modifying protein 2B	CHMP2B	4	NP_054762	intracellular	protein transport	not classified	1, 2
chromatin modifying protein 4B	CHMP4B	2	NP_789782	not classified	protein transport	not classified	1, 2
chromatin modifying protein 5	CHMP5	2	NP_057494	not classified	protein transport	not classified	1, 2
chromatin modifying protein 6	CHMP6	2	NP_078867	membrane	protein transport	not classified	2
calcium binding protein P22	CHP	1	NP_009167	not classified	potassium ion transport small GTPase mediated signal transduction	calcium ion binding potassium channel regulator activity	2
calcium and integrin binding 1 (calmyrin)	CIB1	2	NP_006375	cytoplasm endoplasmic reticulum membrane nucleoplasm	apoptosis cell adhesion double- strand break repair response to DNA damage stimulus	calcium ion binding protein binding	2
cytoskeleton- associated protein 4	CKAP4	1	NP_006816	integral to membrane membrane fraction	not classified	not classified	2
brain creatine kinase	CKB	8	NP_001814	cytoplasm	not classified	creatine kinase activity	2
chloride intracellular channel 1	CLIC1	7	NP_001279	brush border cytoplasm membrane membrane fraction nuclear envelope nucleus soluble fraction	chloride transport ion transport signal transduction	chloride ion binding protein binding voltage- gated chloride channel activity	1, 2
chloride intracellular channel 3	CLIC3	2	NP_004660	cytoplasm membrane nucleus	chloride transport ion transport signal transduction	chloride ion binding protein binding voltage- gated chloride channel activity	2
chloride intracellular channel 4	CLIC4	5	NP_039234	actin cytoskeleton cytoplasm intracellular membrane microvillus soluble fraction	cell differentiation chloride transport ion transport negative regulation of cell migration	chloride ion binding protein binding voltage- gated chloride channel activity	1, 2
chloride intracellular channel 5	CLIC5	1	NP_058625	actin cytoskeleton insoluble fraction membrane microvillus	chloride transport ion transport pregnancy	chloride ion binding protein binding voltage- gated chloride channel activity	2
chloride intracellular channel 6	CLIC6	2	NP_444507	membrane	chloride transport ion transport	chloride ion binding voltage- gated chloride channel activity	2
clathrin heavy chain 1	CLTC	12	NP_004850	clathrin coat of coated pit clathrin vesicle coat	intracellular protein transport	protein binding structural molecule activity	2
clusterin isoform 1	CLU	6	NP_001822	extracellular space	apoptosis cell death complement activation, classical pathway innate immune response lipid metabolism	not classified	1, 2
clusterin isoform 2	CLU	5	NP_976084	extracellular space	apoptosis cell death complement activiation, classical pathway innate immune response lipid metabolism	not classified	2
carboxymethylenebutenolidase- like (Pseudomonas)	CMBL	6	NP_620164	not classified	not classified	hydrolase activity	2
cytidylate kinase	CMPK	3	NP_057392	cytoplasm nucleus	nucleobase, nucleoside, nucleotide and nucleic acid metabolism pyrimidine ribonucleotide biosynthesis	ATP binding cytidylate kinase activity kinase activity nucleotide binding phosphotransferase activity, phosphate group as acceptor transferase activity uridine kinase activity	2
CNDP dipeptidase 2 (metallopeptidase M20 family)	CNDP2	15	NP_060705	not classified	proteolysis	carboxypeptidase activity hydrolase activity metallopeptidase activity protein dimerization activity	2
connector enhancer of kinase suppressor of Ras 2	CNKSR2	2	NP_055742	cytoplasm membrane	regulation of signal transduction	protein binding	2
2', 3'- cyclic nucleotide 3' phosphodiesterase	CNP	13	NP_149124	membrane	cyclic nucleotide catabolism synaptic transmission	2', 3'- cyclic- nucleotide 3'- phosphodiesterase activity hydrolase activity	1, 2
coenzyme A synthase isoform a	COASY	1	NP_079509	not classified	biosynthesis coenzyme A biosynthesis	ATP binding dephospho- CoA kinase activity nucleotide binding nucleotidyltransferase activity pantetheine- phosphate adenylyltransferase activity transferase activity	2
COBL- like 1	COBLL1	1	NP_055715	not classified	not classified	not classified	2
alpha 1 type XV collagen precursor	COL15A1	1	NP_001846	collagen type XV cytoplasm extracellular matrix (sensu Metazoa)	Protein binding Structural Molecule Activity	Angiogenesis Cell Adhesion Cell Differentiation Phosphate Transport	2
alpha 1 type XVIII collagen isoform 1 precursor	COL18A1	1	NP_085059	collagen cytoplasm extracellular matrix extracellular matrix (sensu Metazoa)	cell adhesion negative regulation of cell proliferation organ morphogenesis phosphate transport visual perception	extracellular matrix structural constituent metal ion binding protein binding structural molecule activity zinc ion binding	2
collagen, type VI, alpha 1 precursor	COL6A1	6	NP_001839	collagen collagen type VI cytoplasm	cell adhesion phosphate transport	extracellular matrix structural constituent protein binding	1, 2
alpha 3 type VI collagen isoform 5 precursor	COL6A3	1	NP_476508	collagen type VI cytoplasm extracellular matrix (sensu Metazoa)	cell adhesion muscle development phosphate transport	protein binding serine- type endopeptidase inhibitor activity structural molecule activity	2
catechol- O- methyltransferase isoform MB- COMT	COMT	1	NP_000745	integral to membrane membrane microsome soluble fraction	catecholamine metabolism neurotransmitter catabolism	catechol O- methyltransferase activity magnesium ion binding protein binding transferase activity	2
catechol- O- methyltransferase isoform S- COMT	COMT	1	NP_009294	integral to membrane membrane microsome soluble fraction	catecholamine metabolism neurotransmitter catabolism	catechol O- methyltransferase activity magnesium ion binding protein binding transferase activity	2
COP9 signalosome subunit 8 isoform 2	COPS8	1	NP_937832	nucleus signalosome complex	metabolism	racemase and epimerase activity, acting on amino acids and derivatives	2
coactosin- like 1	COTL1	1	NP_066972	cytoskeleton intracellular	not classified	actin binding enzyme binding	2
ceruloplasmin precursor	CP	6	NP_000087	extracellular region extracellular space	copper ion homeostasis copper ion transport ion transport iron ion homeostasis	copper ion binding copper ion transporter activity ferroxidase activity metal ion binding oxidoreductase activity	2
PREDICTED: similar to Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit)	CPN2	2	XP_947165	not classified	not classified	not classified	2
copine III	CPNE3	14	NP_003900	cytoplasm cytosol	lipid metabolism vesicle- mediated transport	calcium- dependent phospholipid binding kinase activity protein serine/threonine kinase activity transferase activity transporter activity	1, 2
copine V	CPNE5	3	NP_065990	not classified	not classified	not classified	1, 2
serine carboxypeptidase vitellogenic- like	CPVL	6	NP_112601	not classified	proteolysis	peptidase activity serine carboxypeptidase activity	2
complement receptor 1 isoform F precursor	CR1	17	NP_000564	integral to plasma membrane membrane	complement activation, classical pathway innate immune response	complement component C3b receptor activity receptor activity	1, 2
cellular retinoic acid binding protein 2	CRABP2	1	NP_001869	not classified	epidermis development regulation of transcription, DNA- dependent signal transduction transport	lipid binding retinal binding	2
crumbs homolog 2	CRB2	1	NP_775960	integral to membrane membrane	response to stimulus visual perception	calcium ion binding	2
crumbs 3 isoform a precursor	CRB3	1	NP_631900	integral to membrane membrane tight junction	not classified	not classified	2
cAMP responsive element binding protein 5 isoform alpha	CREB5	2	NP_878901	intracellular nucleus	positive regulation of transcription, DNA- dependent transcription transcription from RNA polymerase II promoter	metal ion binding protein dimerization activity sequence- specific DNA binding transcription factor activity zinc ion binding	2
v- crk sarcoma virus CT10 oncogene homolog isoform a	CRK	1	NP_058431	cytoplasm nucleus	actin cytoskeleton organization and biogenesis cell motility intracellular signaling cascade regulation of transcription from RNA polymerase II promoter	protein binding SH2 domain binding SH3/SH2 adaptor activity	2
cornulin	CRNN	3	NP_057274	cytoplasm membrane	cell- cell adhesion metabolism response to heat response to unfolded protein	calcium ion binding	2
ciliary rootlet coiled- coil, rootletin	CROCC	1	NP_055490	centriole ciliary rootlet	cell cycle centrosome organization and biogenesis	kinesin binding structural molecule activity	2
transducer of regulated cAMP response element- binding protein (CREB) 2	CRTC2	1	NP_859066	not classified	not classified	not classified	2
crystallin, alpha B	CRYAB	7	NP_001876	cytoplasm nucleus	muscle contraction protein folding transmembrane receptor protein tyrosine kinase signaling pathway visual perception	structural constituent of eye lens unfolded protein binding	2
lambda- crystallin	CRYL1	7	NP_057058	not classified	fatty acid metabolism	oxidoreductase activity	2
crystallin, mu isoform 1	CRYM	1	NP_001879	not classified	visual perception	ornithine cyclodeaminase activity	2
crystallin, mu isoform 2	CRYM	1	NP_001014444	not classified	visual perception	ornithine cyclodeaminase activity	2
crystallin, zeta	CRYZ	4	NP_001880	not classified	visual perception	NADPH:quinone reductase activity oxidoreductase activity zinc ion binding	2
CSE1 chromosome segregation 1- like protein	CSE1L	1	NP_001307	cytoplasm nuclear pore nucleus	apoptosis cell proliferation protein import into nucleus, docking protein transport	binding importin- alpha export receptor activity protein transporter activity	2
c- src tyrosine kinase	CSK	1	NP_004374	cytoplasm plasma membrane	intracellular signaling cascade protein amino acid phosphorylation regulation of progression through cell cycle	ATP binding nucleotide binding protein C- terminus binding protein- tyrosine kinase activity transferase activity	2
cysteine and glycine- rich protein 1	CSRP1	2	NP_004069	nucleus	not classified	metal ion binding zinc ion binding	2
cystatin C precursor	CST3	1	NP_000090	not classified	not classified	cysteine protease inhibitor activity protein homodimerization activity	2
cystatin B	CSTB	2	NP_000091	intracellular nucleus	not classified	cysteine protease inhibitor activity	2
small CTD phosphatase 3 isoform 2	CTDSPL	1	NP_005799	nucleus	not classified	phosphoric monoester hydrolase activity	2
small CTD phosphatase 3 isoform 1	CTDSPL	1	NP_001008393	nucleus	not classified	phosphoric monoester hydrolase activity	2
cystathionase isoform 2	CTH	1	NP_714964	not classified	amino acid biosynthesis cysteine biosynthesis	cystathionine gamma- lyase activity lyase activity	2
cystinosis, nephropathic isoform 1	CTNS	1	NP_001026851	integral to membrane lysosomal membrane membrane	amino acid metabolism L- cystine transport transport immune response proteolysis	L- cystine transporter activity	2
cathepsin A precursor	CTSA	3	NP_000299	endoplasmic reticulum lysosome	intracellular protein transport proteolysis	carboxypeptidase C activity enzyme activator activity intracellular transporter activity peptidase activity serine carboxypeptidase activity	1, 2
cathepsin C isoform a preproprotein	CTSC	1	NP_001805	lysosome	immune response proteolysis	chloride ion binding cysteine- type endopeptidase activity dipeptidyl- peptidase I activity	2
cathepsin C isoform b precursor	CTSC	1	NP_680475	lysosome	immune response proteolysis	chloride ion binding cysteine- type endopeptidase activity dipeptidyl- peptidase I activity	2
cathepsin D preproprotein	CTSD	1	NP_001900	extracellular region lysosome	proteolysis	cathepsin D activity pepsin A activity peptidase activity	2
cathepsin G preproprotein	CTSG	9	NP_001902	insoluble fraction	immune response proteolysis	cathepsin G activity peptidase activity	2
cubilin	CUBN	104	NP_001072	brush border membrane extrinsic to external side of plasma membrane membrane	cholesterol metabolism cobalamin transport lipid metabolism physiological process protein transport receptor mediated endocytosis steroid metabolism tissue homeostasis	calcium ion binding cobalamin binding cobalt ion binding protein homodimerization activity receptor activity transporter activity	1, 2
cullin 3	CUL3	1	NP_003581	nucleus	cell cycle cell cycle arrest G 1/S transition of mitotic cell cycle induction of apoptosis by intracellular signals positive regulation of cell proliferation ubiquitin cycle	protein binding	2
cullin 4B	CUL4B	1	NP_003579	not classified	cell cycle ubiquitin cycle	protein binding	2
cutA divalent cation tolerance homolog isoform 1	CUTA	1	NP_001014433	membrane	protein localization	enzyme binding	2
cutA divalent cation tolerance homolog isoform 3	CUTA	1	NP_001014840	membrane	protein localization	enzyme binding	2
cut- like 2	CUTL2	2	NP_056082	nucleus	regulation of transcription, DNA- dependent	sequence- specific DNA binding transcription factor activity	2
cytochrome b reductase 1	CYBRD1	2	NP_079119	integral to membrane	electron transport	ferric- chelate reductase activity	2
cytoplasmic FMR1 interacting protein 2	CYFIP2	1	NP_055191	cytoplasm synaptosome	not classified	not classified	2
dihydroxyacetone kinase 2	DAK	15	NP_056348	not classified	glycerol metabolism	ATP binding glycerone kinase activity lyase activity nucleotide binding transferase activity	2
drebrin- like isoform b	DBNL	1	NP_001014436	cell cortex cytoplasm cytoskeleton intracellular lamellipodium	activation of JNK activity endocytosis immune response Rac protein signal transduction	actin binding enzyme activator activity protein binding	2
dermcidin preproprotein	DCD	1	NP_444513	extracellular region	defense response to bacterium defense response to fungus xenobiotic metabolism	manganese ion binding	2
dynactin 2	DCTN2	1	NP_006391	centrosome cytoskeleton dynactin complex dynein complex kinetochore membrane microtubule	cell proliferation microtubule- based process mitosis	motor activity	2
dicarbonyl/L- xylulose reductase	DCXR	2	NP_057370	membrane	carbohydrate metabolism D- xylose metabolism glucose metabolism metabolism	L- xylulose reductase activity oxidoreductase activity	1, 2
dimethylarginine dimethylaminohydrolase 1	DDAH1	1	NP_036269	not classified	arginine catabolism nitric oxide mediated signal transduction	dimethylargininase activity hydrolase activity metal ion binding zinc ion binding	1, 2
dimethylarginine dimethylaminohydrolase 2	DDAH2	1	NP_039268	not classified	anti- apoptosis arginine catabolism nitric oxide biosynthesis nitric oxide mediated signal transduction	dimethylargininase activity hydrolase activity	2
damage- specific DNA binding protein 1	DDB1	1	NP_001914	nucleus	nucleotide- excision repair ubiquitin cycle	damaged DNA binding	2
dopa decarboxylase (aromatic L- amino acid decarboxylase)	DDC	11	NP_000781	not classified	amino acid and derivative metabolism carboxylic acid metabolism catecholamine biosynthesis	aromatic- L- amino- acid decarboxylase activity carboxy- lyase activity lyase activity	2
D- dopachrome tautomerase	DDT	1	NP_001346	not classified	melanin biosynthesis from tyrosine	dopachrome isomerase activity lyase activity	1, 2
DEAD (Asp- Glu- Ala- As) box polypeptide 19 isoform 2	DDX19B	1	NP_001014451	cytoplasm nuclear pore nucleus	mRNA export from nucleus	ATP binding ATP- dependent helicase activity hydrolase activity nucleic acid binding nucleotide binding RNA binding	2
DEAD/H (Asp- Glu- Ala- Asp/His) box polypeptide 3	DDX3X	2	NP_001347	cytoplasm nucleus	not classified	ATP binding ATP- dependent RNA helicase activity DNA binding hydrolase activity nucleotide binding RNA binding	2
DEAD (Asp- Glu- Ala- Asp) box polypeptide 5	DDX5	1	NP_004387	nucleus	cell growth	ATP binding ATP- dependent helicase activity hydrolase activity nucleic acid binding nucleotide binding RNA binding RNA helicase activity	2
defensin, alpha 1 preproprotein	DEFA1	1	NP_004075	extracellular region	defense response to bacterium defense response to fungus response to virus xenobiotic metabolism	not classified	1
DEAH (Asp- Glu- Ala- His) box polypeptide 34 isoform 2	DHX34	1	NP_919409	not classified	electron transport	ATP binding ATP- dependent helicase activity electron transporter activity hydrolase activity metal ion binding nucleic acid binding nucleotide binding RNA binding	2
DIP13 beta	DIP13B	1	NP_060641	cytoplasm endosome membrane membrane nucleus NuRD complex	cell cycle cell proliferation signal transduction	protein binding	2
hypothetical protein LOC345651	DKFZp686D0972	2	NP_001017992	not classified	not classified	protein binding	2
dynein, axonemal, heavy polypeptide 8	DNAH8	1	NP_001362	axonemal dynein complex dynein complex	ciliary or flagellar motility microtubule- based movement	ATP binding ATPase activity microtubule motor activity nucleotide binding protein binding	1, 2
DnaJ (Hsp40) homolog, subfamily A, member 1	DNAJA1	1	NP_001530	not classified	protein folding response to unfolded protein	heat shock protein binding low- density lipoprotein receptor binding metal ion binding unfolded protein binding zinc ion binding	2
DnaJ subfamily A member 2	DNAJA2	1	NP_005871	membrane	G1 phase of mitotic cell cycle positive regulation of cell proliferation protein folding regulation of progression through cell cycle	heat shock protein binding metal ion binding unfolded protein binding zinc ion binding	2
DnaJ (Hsp40) homolog, subfamily B, member 1	DNAJB1	2	NP_006136	nucleus	protein folding response to unfolded protein	heat shock protein binding unfolded protein binding	2
DnaJ (Hsp40) homolog, subfamily C, member 13	DNAJC13	1	NP_056083	not classified	protein folding	binding heat shock protein binding	2
DnaJ (Hsp40) homolog, subfamily C, member 7	DNAJC7	1	NP_003306	not classified	protein folding	heat shock protein binding	2
dynamin 2 isoform 3	DNM2	1	NP_004936	cytoplasm microtubule postsynaptic membrane	endocytosis G2/M transition of mitotic cell cycle positive regulation of apoptosis regulation of transcription signal transduction synaptic vesicle transport	enzyme binding GTP binding GTPase activity hydrolase activity microtubule binding motor activity nucleotide binding transcriptional activator activity	2
dynamin 2 isoform 4	DNM2	1	NP_001005362	cytoplasm microtubule postsynaptic membrane	endocytosis G2/M transition of mitotic cell cycle positive regulation of apoptosis regulation of transcription signal transduction synaptic vesicle transport	enzyme binding GTP binding GTPase activity hydrolase activity microtubule binding motor activity nucleotide binding transcriptional activator activity	2
pad- 1- like	DOPEY2	1	NP_005119	Golgi membrane	development endoplasmic reticulum organization and biogenesis Golgi to endosome transport	not classified	2
dipeptidase 1 (renal)	DPEP1	31	NP_004404	endoplasmic reticulum membrane microsome	carbohydrate metabolism proteolysis	cation binding dipeptidyl- peptidase activity GPI anchor binding membrane dipeptidase activity metal ion binding metallopeptidase activity zinc ion binding	1, 2
dipeptidylpeptidase IV	DPP4	41	NP_001926	integral to membrane membrane	immune response proteolysis	aminopeptidase activity dipeptidyl- peptidase IV activity prolyl oligopeptidase activity	1, 2
dihydropyrimidinase	DPYS	5	NP_001376	not classified	nucleobase, nucleoside, nucleotide and nucleic acid metabolism response to toxin	dihydropyrimidinase activity hydrolase activity	2
desmocollin 2 isoform Dsc2b preproprotein	DSC2	1	NP_004940	cytoskeleton integral to membrane intercellular junction membrane	cell adhesion homophilic cell adhesion	calcium ion binding protein binding	2
desmoglein 3 preproprotein	DSG3	1	NP_001935	cytoskeleton integral to membrane intercellular junction membrane	cell adhesion homophilic cell adhesion	calcium ion binding protein binding	2
desmoplakin isoform II	DSP	10	NP_001008844	cell- cell adherens junction cornified envelope intermediate filament	epidermis development keratinocyte differentiation peptide cross- linking	protein binding, bridging structural constituent of cytoskeleton	2
desmoplakin isoform I	DSP	4	NP_004406	cell- cell adherens junction cornified envelope intermediate filament	epidermis development keratinocyte differentiation peptide cross- linking	protein binding, bridging structural constituent of cytoskeleton	2
destrin isoform a	DSTN	1	NP_006861	intracellular	not classified	actin binding	2
dual specificity phosphatase 26	DUSP26	1	NP_076930	not classified	protein amino acid dephosphorylation	hydrolase activity kinase activity protein tyrosine/serine/threonine phosphatase activity	2
dynein, cytoplasmic, heavy polypeptide 1	DYNC1H1	14	NP_001367	cytoplasmic dynein complex dynein complex microtubule	microtubule- based movement mitotic spindle organization and biogenesis	ATP binding ATPase activity, coupled microtubule motor activity nucleotide binding	2
dynein, cytoplasmic, heavy polypeptide 2	DYNC2H1	2	NP_001073932	dynein complex Golgi apparatus intracellular	Golgi organization and biogenesis microtubule- based movement	ATP binding ATPase activity ATPase activity, coupled ATPase activity, uncoupled hydrolase activity microtubule motor activity motor activity	2
dysferlin	DYSF	1	NP_003485	integral to membrane plasma membrane	muscle contraction	not classified	2
endothelin converting enzyme 1	ECE1	1	NP_001388	integral to membrane membrane membrane fraction	cell- cell signaling proteolysis	endothelin- converting enzyme 1 activity metal ion binding neprilysin activity zinc ion binding	2
early endosome antigen 1, 162kD	EEA1	1	NP_003557	cytoplasm cytosol early endosome extrinsic to plasma membrane intracellular membrane fraction	early endosome to late endosome transport synaptic vesicle to endosome fusion vesicle fusion	calmodulin binding GTP- dependent protein binding metal ion binding nucleic acid binding phosphatidylinositol binding protein homodimerization activity zinc ion binding	2
eukaryotic translation elongation factor 1 alpha 1	EEF1A1	6	NP_001393	cytoplasm	protein biosynthesis translational elongation	GTP binding GTPase activity nucleotide binding protein binding translation elongation factor activity	1, 2
eukaryotic translation elongation factor 2	EEF2	4	NP_001952	not classified	protein biosynthesis	GTP binding nucleotide binding translation elongation factor activity	2
EGF- containing fibulin- like extracellular matrix protein 1 precursor	EFEMP1	1	NP_004096	extracellular matrix (sensu Metazoa)	visual perception	calcium ion binding protein binding	2
ephrin- B1 precursor	EFNB1	1	NP_004420	integral to plasma membrane membrane soluble fraction synapse	cell adhesion cell differentiation cell- cell signaling nervous system development	ephrin receptor binding protein binding	2
epidermal growth factor (beta- urogastrone)	EGF	30	NP_001954	extracellular region integral to membrane nucleus plasma membrane	activation of MAPK activity chromosome organization and biogenesis (sensu Eukaryota) DNA replication epidermal growth factor receptor signaling pathway positive regulation of cell proliferation	calcium ion binding epidermal growth factor receptor activating ligand activity growth factor activity protein binding	1, 2
EGF- like- domain, multiple 11	EGFL11	1	NP_938024	integral to membrane membrane	not classified	ATP binding	2
EH- domain containing 1	EHD1	14	NP_006786	not classified	not classified	ATP binding calcium ion binding GTP binding GTPase activity nucleotide binding protein binding	1, 2
EH- domain containing 2	EHD2	1	NP_055416	nucleus	not classified	calcium ion binding GTP binding GTPase activity nucleic acid binding nucleotide binding protein binding	2
EH- domain containing 4	EHD4	17	NP_644670	endoplasmic reticulum nucleus	not classified	ATP binding calcium ion binding GTP binding GTPase activity nucleic acid binding nucleotide binding	1, 2
eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa	EIF3H	1	NP_003747	eukaryotic translation initiation factor 3 complex	protein biosynthesis regulation of translational initiation	translation initiation factor activity not classified	2
elastase 2, neutrophil preproprotein	ELA2	1	NP_001963	cell surface extracellular region	anti- inflammatory response calcium ion homeostasis negative regulation of chemokine biosynthesis negative regulation of chemotaxis negative regulation of inflammatory response negative regulation of interleukin- 8 biosynthesis positive regulation of interl	bacterial binding cytokine binding elastase activity peptidase activity serine- type endopeptidase activity	2
echinoderm microtubule associated protein like 5	EML5	1	NP_899243	not classified	not classified	lyase activity	2
glutamyl aminopeptidase (aminopeptidase A)	ENPEP	25	NP_001968	integral to plasma membrane plasma membrane	cell migration cell proliferation cell- cell signaling proteolysis	calcium ion binding glutamyl aminopeptidase activity membrane alanyl aminopeptidase activity metallopeptidase activity zinc ion binding	1, 2
ectonucleotide pyrophosphatase/phosphodiesterase 3	ENPP3	2	NP_005012	integral to plasma membrane membrane	nucleotide metabolism phosphate metabolism	endonuclease activity hydrolase activity nucleic acid binding nucleotide diphosphatase activity phosphodiesterase I activity	2
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)	ENPP4	2	NP_055751	not classified	nucleotide metabolism	not classified	2
ectonucleotide pyrophosphatase/phosphodiesterase 6	ENPP6	5	NP_699174	integral to membrane membrane	lipid catabolism nucleotide metabolism	hydrolase activity	2
epoxide hydrolase 2, cytoplasmic	EPHX2	1	NP_001970	cytosol peroxisome soluble fraction	aromatic compound catabolism blood pressure regulation calcium ion homeostasis drug metabolism inflammatory response metabolism oxygen and reactive oxygen species metabolism positive regulation of vasodilation response to toxin xenobiotic metabolism	epoxide hydrolase activity hydrolase activity magnesium ion binding protein homodimerization activity	2
epsin 3	EPN3	1	NP_060427	not classified	not classified	lipid binding	2
epiplakin 1	EPPK1	4	NP_112598	cytoskeleton	not classified	structural molecule activity	2
epidermal growth factor receptor pathway substrate 8	EPS8	14	NP_004438	not classified	cell proliferation epidermal growth factor receptor signaling pathway signal transduction	protein binding SH3/SH2 adaptor activity	1, 2
epidermal growth factor receptor pathway substrate 8- like protein 1 isoform a	EPS8L1	6	NP_573441	not classified	not classified	not classified	2
epidermal growth factor receptor pathway substrate 8- like protein 1 isoform b	EPS8L1	4	NP_060199	not classified	not classified	hydrolase activity	2
epidermal growth factor receptor pathway substrate 8- like protein 2	EPS8L2	11	NP_073609	not classified	not classified	not classified	2
esterase D/formylglutathione hydrolase	ESD	1	NP_001975	cytoplasmic membrane- bound vesicle	not classified	S- formylglutathione hydrolase activity serine esterase activity thiosulfate sulfurtransferase activity	2
envoplakin	EVPL	18	NP_001979	cornified envelope plasmodesma	epidermis development keratinization keratinocyte differentiation peptide cross- linking	protein binding, bridging structural molecule activity	2
platelet coagulation factor XI precursor	F11	1	NP_000119	extracellular region membrane	blood coagulation proteolysis	coagulation factor IXa activity coagulation factor XIa activity heparin binding peptidase activity	2
fatty acid binding protein 1, liver	FABP1	2	NP_001434	cytoplasm	cell- cell signaling fatty acid metabolism organ morphogenesis transport	lipid binding lipid transporter activity	2
fatty acid binding protein 3	FABP3	2	NP_004093	cytoplasm soluble fraction	negative regulation of cell proliferation transport	fatty acid binding lipid transporter activity	1, 2
fumarylacetoacetate hydrolase (fumarylacetoacetase)	FAH	2	NP_000128	not classified	aromatic amino acid family metabolism L- phenylalanine catabolism metabolism tyrosine catabolism	calcium ion binding fumarylacetoacetase activity hydrolase activity magnesium ion binding	2
hypothetical protein LOC93343	FAM125A	2	NP_612410	nucleus	not classified	not classified	1, 2
hypothetical protein LOC89853 isoform 1	FAM125B	1	NP_258257	not classified	not classified	not classified	2
family with sequence similarity 20, member C	FAM20C	1	NP_064608	not classified	not classified	not classified	2
hypothetical protein LOC85369	FAM40A	1	NP_149079	not classified	not classified	not classified	2
hypothetical protein LOC51571	FAM49B	1	NP_057707	not classified	not classified	not classified	2
hypothetical protein LOC79567	FAM65A	2	NP_078795	not classified	not classified	binding DNA- directed RNA polymerase activity	2
fatty acid synthase	FASN	20	NP_004095	not classified	fatty acid biosynthesis	3- hydroxypalmitoyl- [acyl- carrier protein] dehydratase activity 3- oxoacyl- [acyl- carrier protein] reductase activity 3- oxoacyl- [acyl- carrier protein] synthase activity catalytic activity cofactor binding enoyl- [acyl- carrier protein] reductase (NADPH, B- spec	2
FAT tumor suppressor 1 precursor	FAT	1	NP_005236	integral to plasma membrane membrane	cell adhesion cell- cell signaling homophilic cell adhesion morphogenesis	calcium ion binding protein binding	2
fibrillarin	FBL	1	NP_001427	nucleus ribonucleoprotein complex	rRNA processing	RNA binding transferase activity not classified	2
fructose- 1, 6- bisphosphatase 1	FBP1	7	NP_000498	not classified	carbohydrate metabolism fructose metabolism gluconeogenesis	fructose- 2, 6- bisphosphate 2- phosphatase activity fructose- bisphosphatase activity hydrolase activity identical protein binding phosphoric ester hydrolase activity zinc ion binding	2
fructose- 1, 6- bisphosphatase 2	FBP2	1	NP_003828	not classified	carbohydrate metabolism fructose metabolism gluconeogenesis	fructose- 2, 6- bisphosphate 2- phosphatase activity fructose- bisphosphatase activity hydrolase activity phosphoric ester hydrolase activity	2
Fc fragment of IgG binding protein	FCGBP	14	NP_003881	not classified	not classified	not classified	1, 2
ficolin 2 isoform a precursor	FCN2	2	NP_004099	cytoplasm	antimicrobial humoral response (sensu Vertebrata) opsonization phosphate transport	antigen binding calcium ion binding sugar binding	2
myoferlin isoform a	FER1L3	8	NP_038479	integral to membrane nuclear envelope plasma membrane	circulation muscle contraction	not classified	2
myoferlin isoform b	FER1L3	7	NP_579899	integral to membrane nuclear envelope plasma membrane	circulation muscle contraction	calcium ion binding	2
fibrinogen, alpha polypeptide isoform alpha- E preproprotein	FGA	5	NP_000499	extracellular region fibrinogen complex soluble fraction	blood coagulation blood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transduction	protein binding	1, 2
fibrinogen, gamma chain isoform gamma- A precursor	FGG	1	NP_000500	fibrinogen complex	blood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transduction	calcium ion binding	2
fibrinogen, gamma chain isoform gamma- B precursor	FGG	1	NP_068656	fibrinogen complex	blood pressure regulation platelet activation positive regulation of cell proliferation protein polymerization signal transduction	FK506 binding	2
fibrinogen- like 2 precursor	FGL2	4	NP_006673	fibrinogen complex	not classified	not classified	2
fidgetin- like 1	FIGNL1	1	NP_071399	membrane	not classified	ATP binding nucleoside- triphosphatase activity nucleotide binding	2
FK506- binding protein 4	FKBP4	1	NP_002005	cytoplasm intracellular nucleus	protein folding	isomerase activity peptidyl- prolyl cis- trans isomerase activity protein binding, bridging actin binding	2
FK506 binding protein 5	FKBP5	1	NP_004108	nucleus	protein folding	FK506 binding isomerase activity peptidyl- prolyl cis- trans isomerase activity protein binding	2
coiled- coil domain containing 132 isoform a	FLJ20097	1	NP_060137	not classified	two- component signal transduction system (phosphorelay)	two- component sensor activity	2
hypothetical protein LOC148811	FLJ32569	2	NP_689704	not classified	proteolysis	carboxypeptidase activity Gly- X carboxypeptidase activity hydrolase activity metallopeptidase activity protein dimerization activity	2
hypothetical protein LOC201931	FLJ38482	1	NP_689894	not classified	not classified	not classified	2
filamin A, alpha isoform 1	FLNA	1	NP_001447	actin cytoskeleton	actin cytoskeleton organization and biogenesis cell motility cell surface receptor linked signal transduction nervous system development positive regulation of I- kappaB kinase/NF- kappaB cascade	actin filament binding protein binding signal transduce activity actin binding	2
filamin B, beta (actin binding protein 278)	FLNB	1	NP_001448	actin cytoskeleton integral to membrane	actin cytoskeleton organization and biogenesis cell differentiation cytoskeletal anchoring signal transduction striated muscle development	protein binding collagen binding	2
flotillin 1	FLOT1	12	NP_005794	caveola flotillin complex integral to membrane membrane	not classified	protein binding	1, 2
flotillin 2	FLOT2	9	NP_004466	cell surface flotillin complex integral to membrane plasma membrane	cell adhesion epidermis development	protein binding	2
fibronectin 1 isoform 1 preproprotein	FN1	1	NP_997647	ER- Golgi intermediate compartment extracellular matrix (sensu Metazoa) extracellular region	acute- phase response cell adhesion cell migration metabolism response to wounding transmembrane receptor protein tyrosine kinase signaling pathway	collagen binding extracellular matrix structural constituent heparin binding oxidoreductase activity	1, 2
fibronectin 1 isoform 3 preproprotein	FN1	9	NP_002017	ER- Golgi intermediate compartment extracellular matrix (sensu Metazoa) extracellular region	acute- phase response cell adhesion cell migration metabolism response to wounding transmembrane receptor protein tyrosine kinase signaling pathway	collagen binding extracellular matrix structural constituent heparin binding oxidoreductase activity	2
fyn- related kinase	FRK	7	NP_002022	intracellular nucleus	intracellular signaling cascade negative regulation of cell proliferation protein amino acid phosphorylation regulation of progression through cell cycle	ATP binding non- membrane spanning protein tyrosine kinase activity nucleotide binding transferase activity	2
formiminotransferase cyclodeaminase	FTCD	6	NP_006648	cytoplasm	folic acid and derivative metabolism histidine metabolism metabolism	folic acid binding formimidoyltetrahydrofolate cyclodeaminase activity glutamate formimidoyltransferase activity lyase activity transferase activity	2
ferritin, heavy polypeptide 1	FTH1	1	NP_002023	ferritin complex plasma membrane	cell proliferation immune response intracellular sequestering of iron ion iron ion homeostasis iron ion transport negative regulation of cell proliferation	binding ferric iron binding ferroxidase activity kinase binding metal ion binding oxidoreductase activity protein binding	2
ferritin, light polypeptide	FTL	5	NP_000137	ferritin complex	iron ion homeostasis iorn ion transport	binding ferric iron binding identical protein binding metal ion binding	1, 2
fucosidase, alpha- L- 1, tissue	FUCA1	1	NP_000138	cytoplasm lysosome	carbohydrate metabolism glycosaminoglycan catabolism metabolism	alpha- L- fucosidase activity hydrolase activity, acting on glycosyl bonds	2
fusion (involved in t(12;16) in malignant liposarcoma) isoform a	FUS	1	NP_004951	intracellular nucleus	not classified	DNA binding metal ion binding nucleic acid binding nucleotide binding protein binding RNA binding zinc ion binding	1
fuzzy homolog	FUZ	1	NP_079405	not classified	not classified	not classified	2
FXYD domain- containing ion transport regulator 2 isoform 1	FXYD2	1	NP_001671	integral to membrane membrane sodium:potassium- exchanging ATPase complex	ion transport potassium ion transport sodium ion transport	ion channel activity potassium ion binding sodium ion binding sodium:potassium- exchanging ATPase activity transporter activity	1, 2
glucose- 6- phosphate dehydrogenase isoform a	G6PD	1	NP_000393	cytoplasm	carbohydrate metabolism glucose 6- phosphate utilization glucose metabolism pentose- phosphate shunt	glucose- 6- phosphate 1- dehydrogenase activity oxidoreductase activity	2
acid alpha- glucosidase preproprotein	GAA	4	NP_000143	lysosome	carbohydrate metabolism generation of precursor metabolites and energy glycogen catabolism metabolism	alpha- glucosidase activity hydrolase activity, hydrolyzing O- glycosyl compounds	1, 2
acid alpha- glucosidase preproprotein	GAA	5	NP_001073272	lysosome	carbohydrate metabolism generation of precursor metabolites and energy glycogen catabolism metabolism	hydrolase activity, hydrolyzing O- glycosyl compounds ATP binding	2
gamma- aminobutyric acid (GABA) A receptor, beta 2 isoform 1	GABRB2	1	NP_068711	integral to plasma membrane postsynaptic membrane	gamma- aminobutyric acid signaling pathway ion transport synaptic transmission	chloride channel activity chloride ion binding extracellular ligand- gated ion channel activity GABA- A receptor activity ion channel activity neurotransmitter receptor activity	2
galactokinase 1	GALK1	1	NP_000145	cytoplasm membrane fraction	carbohydrate phosphorylation galactose metabolism metabolism	galactokinase activity galactose binding kinase activity nucleotide binding transferase activity hydrolase activity	2
galactose mutarotase (aldose 1- epimerase)	GALM	2	NP_620156	not classified	carbohydrate metabolism galactose metabolism	aldose 1- epimerase activity isomerase activity	2
alpha glucosidase II alpha subunit isoform 2	GANAB	1	NP_938148	endoplasmic reticulum	carbohydrate metabolism	hydrolase activity hydrolase activity, hydrolyzing O- glycosyl compounds protein binding	2
alpha glucosidase II alpha subunit isoform 3	GANAB	1	NP_938149	endoplasmic reticulum	carbohydrate metabolism	hydrolase activity, hydrolyzing O- glycosyl compounds protein binding hydrolase activity, acting on glycosyl bonds	2
glyceraldehyde- 3- phosphate dehydrogenase	GAPDH	10	NP_002037	cytoplasm	glucose metabolism glycolysis	glyceraldehyde- 3- phosphate dehydrogenase (phosphorylating) activity NAD binding oxidoreductase activity	1, 2
glucan (1, 4- alpha- ), branching enzyme 1	GBE1	1	NP_000149	not classified	carbohydrate metabolism generation of precursor metabolites and energy glycogen biosynthesis	1, 4- alpha- glucan branching enzyme activity cation binding hydrolase activity, hydrolyzing O- glycosyl compounds transferase activity, transferrin glycosyl groups	2
grancalcin, EF- hand calcium binding protein	GCA	1	NP_036330	cytoplasm plasma membrane	membrane fusion	calcium ion binding	2
mannosyl- oligosaccharide glucosidase	GCS1	1	NP_006293	endoplasmic reticulum integral to membrane membrane membrane fraction	metabolism oligosaccharide metabolism protein amino acid N- linked glycosylation	mannosyl- oligosaccharide glucosidase activity not classified	2
growth differentiation factor 2	GDF2	1	NP_057288	extracellular region extracellular space	growth	cytokine activity growth factor activity	2
GDP dissociation inhibitor 2	GDI2	17	NP_001485	cell surface cytoplasm	protein transport regulation of GTPase activity signal transduction	GTPase activator activity Rab GDP- dissociation inhibitor activity	2
glycerophosphodiester phosphodiesterase domain containing 3	GDPD3	1	NP_077283	not classified	glycerol metabolism	glycerophosphodiester phosphodiesterase activity	2
gemin4	GEMIN4	1	NP_056536	cytoplasm nucleolus nucleus small nuclear ribonucleoprotein complex spliceosome complex	nuclear mRNA splicing, via spliceosome rRNA processing	protein binding	2
GDNF family receptor alpha 1 isoform b preproprotein	GFRA1	1	NP_665736	extrinsic to membrane membrane	cell surface receptor linked signal transduction	glial cell line- derived neurotrophic factor receptor activity GPI anchor binding receptor activity receptor binding	2
gamma- glutamyl hydrolase precursor	GGH	5	NP_003869	lysosome	glutamine metabolism	exopeptidase activity gamma- glutamyl hydrolase activity hydrolase activit	2
growth hormone inducible transmembrane protein	GHITM	1	NP_055209	integral to membrane membrane mitochondrion	not classified	protein binding	2
regulator of G- protein signalling 19 interacting protein 1 isoform 1	GIPC1	1	NP_974197	cytosol membrane membrane fraction soluble fraction	G- protein coupled receptor protein signaling pathway	protein binding receptor binding	2
regulator of G- protein signalling 19 interacting protein 1 isoform 2	GIPC1	1	NP_974196	cytosol membrane membrane fraction soluble fraction	G- protein coupled receptor protein signaling pathway	receptor binding ATP binding	2
PDZ domain protein GIPC2	GIPC2	1	NP_060125	not classified	not classified	protein binding	2
glycerol kinase isoform a	GK	1	NP_976325	cytoplasm mitrochondrial outer membrane	carbohydrate metabolism glycerol- 3- phosphate metabolism	glycerol kinase activity nucleotide binding transferase activity ATP binding	2
glycerol kinase 2	GK2	1	NP_149991	cytoplasm mitrochondrial outer membrane	carbohydrate metabolism glycerol- 3- phosphate metabolism	glycerol kinase activity nucleotide binding transferase activity GTP binding	2
galactosidase, beta 1 isoform a	GLB1	16	NP_000395	beta- galactosidase complex lysosome	carbohydrate metabolism metabolism	beta- galactosidase activity cation binding hydrolase activity, acting on glycosyl bonds	1, 2
golgi apparatus protein 1	GLG1	2	NP_036333	Golgi membrane integral to membrane membrane	not classified	fibroblast growth factor binding receptor binding	1, 2
glyoxalase I	GLO1	1	NP_006699	cytoplasm	anti- apoptosis carbohydrate metabolism	lactoylglutathione lyase activity lyase activity metal ion binding zinc ion binding	2
glutamine synthetase	GLUL	2	NP_001028216	not classified	glutamine biosynthesis nitrogen compound metabolism regulation of neurotransmitter levels	glutamate- ammonia ligase activity ligase activity	2
GM2 ganglioside activator precursor	GM2A	2	NP_000396	lysosome	glycolipid catabolism glycosphingolipid metabolism lipid metabolism sphingolipid catabolism	sphingolipid activator protein activity	2
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	GNA11	7	NP_002058	cytoplasm plasma membrane	G- protein coupled receptor protein signaling pathway protein amino acid ADP- ribosylation signal transduction	GTP binding GTPase activity nucleotide binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	GNAI1	8	NP_002060	plasma membrane	G- protein coupled receptor protein signaling pathway signal transduction	GTP binding nucleotide binding protein binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	GNAI2	8	NP_002061	not classified	G- protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity response to nutrient signal transduction	GTP binding GTPase activity nucleotide binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	GNAI3	8	NP_006487	not classified	G- protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity signal transduction transport	GTP binding GTPase activity nucleotide binding signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), q polypeptide	GNAQ	10	NP_002063	cytoplasm heterotrimeric G- protein complex plasma membrane	blood coagulation G- protein coupled receptor protein signaling pathway phospholipase C activation protein amino acid ADP- ribosylation signal transduction	GTP binding GTPase activity nucleotide binding signal transducer activity	2
guanine nucleotide- binding protein, beta- 1 subunit	GNB1	2	NP_002065	not classified	signal transduction	signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), beta polypeptide 2- like 1	GNB2L1	1	NP_006089	cytoplasm	protein kinase C activation signal transduction	protein kinase C binding receptor binding	2
G- protein gamma- 12 subunit	GNG12	5	NP_061329	heterotrimeric G- protein complex membrane	G- protein coupled receptor protein signaling pathway signal transduction	signal transducer activity	1, 2
guanine nucleotide binding protein (G protein), gamma 5	GNG5	1	NP_005265	heterotrimeric G- protein complex membrane	G- protein coupled receptor protein signaling pathway signal transduction	signal transducer activity	2
guanine nucleotide binding protein (G protein), gamma 7	GNG7	1	NP_443079	heterotrimeric G- protein complex membrane	regulation of G- protein coupled receptor protein signaling pathway signal transduction	signal transducer activity	1, 2
glucosamine- 6- phosphate deaminase 1	GNPDA1	1	NP_005462	not classified	carbohydrate metabolism fertilization (sensu Metazoa) generation of precursor metabolites and energy glucosamine catabolism N- acetylglucosamine metabolism	glucosamine- 6- phosphate deaminase activity hydrolase activity	2
golgi autoantigen, golgin subfamily a, 7	GOLGA7	1	NP_001002296	membrane	not classified	not classified	2
aspartate aminotransferase 1	GOT1	9	NP_002070	cytosol	amino acid metabolism aspartate catabolism biosynthesis	aspartate transaminase activity	2
glycerol- 3- phosphate dehydrogenase 1 (soluble)	GPD1	11	NP_005267	cytoplasm glycerol- 3- phosphate dehydrogenase complex	carbohydrate metabolism glycerol- 3- phosphate catabolism	glycerol- 3- phosphate dehydrogenase (NAD+) activity NAD binding	2
glucose phosphate isomerase	GPI	9	NP_000166	extracellular space	carbohydrate metabolism gluconeogenesis glycolysis hemostasis humoral immune response nervous system development	cytokine activity glucose- 6- phosphate isomerase activity growth factor activity isomerase activity	1, 2
glycoprotein M6A isoform 2	GPM6A	1	NP_963885	cell surface integral to plasma membrane membrane	not classified	glutathione peroxidase activity	2
G protein- coupled receptor 155 isoform 10	GPR155	1	NP_689742	integral to membrane membrane	intracellular signaling cascade	not classified	2
G protein- coupled receptor 98 precursor	GPR98	1	NP_115495	integral to membrane membrane	cell- cell adhesion nervous system development neuropeptide signaling pathway response to stimulus sensory perception of sound signal transduction visual perception	calcium ion binding G- protein coupled receptor activity receptor activity	2
G protein- coupled receptor, family C, group 5, member A	GPRC5A	1	NP_003970	integral to plasma membrane membrane	G- protein coupled receptor protein signaling pathway signal transduction	metabotropic glutamate, GABA- B- like receptor activity receptor activity	1, 2
G protein- coupled receptor, family C, group 5, member B precursor	GPRC5B	7	NP_057319	integral to membrane membrane	G- protein coupled receptor protein signaling pathway signal transduction visual perception	metabotropic glutamate, GABA- B- like receptor activity receptor activity sevenless binding	1, 2
G protein- coupled receptor family C, group 5, member C isoform b	GPRC5C	11	NP_061123	integral to plasma membrane membrane	G- protein coupled receptor protein signaling pathway signal transduction	metabotropic glutamate, GABA- B- like receptor activity protein binding receptor activity	2
glutamic- pyruvate transaminase (alanine aminotransferase)	GPT	1	NP_005300	cytoplasm soluble fraction	biosynthesis gluconeogenesis nitrogen compound metabolism	1- aminocyclopropane- 1- carboxylate synthase activity alanine transaminase activity	2
glutathione peroxidase 4 isoform A precursor	GPX4	3	NP_002076	mitochondrion	development electron transport phospholipid metabolism response to oxidative stress	glutathione peroxidase activity oxidoreductase activity phospholipid- hydroperoxide glutathione peroxidase activity selenium binding	2
glutathione peroxidase 4 isoform C precursor	GPX4	4	NP_001034937	mitochondrion	development electron transport phospholipid metabolism response to oxidative stress	oxidoreductase activity phospholipid- hydroperoxide glutathione peroxidase activity selenium binding epidermal growth factor receptor binding	2
growth factor receptor- bound protein 2 isoform 1	GRB2	3	NP_002077	cytosol	cell- cell signaling epidermal growth factor receptor signaling pathway insulin receptor signaling pathway intracellular signaling cascade Ras protein signal transduction	epidermal growth factor receptor binding insulin receptor substrate binding SH3/SH2 adaptor activity	2
growth factor receptor- bound protein 2 isoform 2	GRB2	2	NP_987102	cytosol	cell- cell signaling epidermal growth factor receptor signaling pathway insulin receptor signaling pathway intracellular signaling cascade Ras protein signal transduction	insulin receptor substrate binding SH3/SH2 adaptor activity glycerate dehydrogenase activity	2
glyoxylate reductase/hydroxypyruvate reductase	GRHPR	1	NP_036335	cytoplasm	electron transport excretion L- serine biosynthesis metabolism	glyoxylate reductase (NADP) activity hydrohypyruvate reductase activity NAD binding oxidoreductase activity oxidoreductase activity, acting on the CH- OH group of donors, NAD or NADP as acceptor protein binding glutathione transferase activity	2
glutamate receptor, ionotropic, delta 1	GRID1	1	NP_060021	integral to membrane membrane periplasmic space (sensu Proteobacteria) postsynaptic membrane	ion transport	glutamate- gated ion channel activity ion channel activity ionotropic glutamate receptor activity receptor activity transporter activity	2
gelsolin isoform b	GSN	10	NP_937895	actin cytoskeleton cytosol extracellular region	actin filament polymerization actin filament severing barbed- end actin filament capping	actin binding calcium ion binding protein binding	2
glutathione reductase	GSR	1	NP_000628	cytoplasm mitochondrion	electron transport glutathione metabolism	disulfide oxidoreductase activity FAD binding glutathione- disulfide reductase activity	2
glutathione synthetase	GSS	1	NP_000169	not classified	amino acid metabolism glutathione biosynthesis nervous system development response to oxidative stress	ATP binding glutathioone synthase activity ligase activity nucleotide binding	2
glutathione S- transferase A1	GSTA1	1	NP_665683	cytoplasm	glutathione metabolism metabolism	glutathione transferase activity transferase activity	1, 2
glutathione S- transferase, C- terminal domain containing isoform 1	GSTCD	1	NP_001026890	not classified	not classified	methyltransferase activity transferase activity	2
glutathione S- transferase M2	GSTM2	1	NP_000839	not classified	metabolism	glutathione transferase activity transferase activity	2
glutathione- S- transferase omega 1	GSTO1	1	NP_004823	cytoplasm	metabolism	glutathione transferase activity monodehydroascorbate reductase (NADH) activity transferase activity	2
glutathione S- transferase omega 2	GSTO2	1	NP_899062	cytoplasm	metabolism	glutathione transferase activity transferase activity	2
glutathione transferase	GSTP1	9	NP_000843	cytoplasm	anti- apoptosis central nervous system development metabolism	glutathione transferase activity transferase activity	1, 2
GTP- binding protein PTD004 isoform 1	GTPBP9	2	NP_037473	cytoplasm intracellular	not classified	GTP binding nucleotide binding	2
glucuronidase, beta	GUSB	5	NP_000172	lysosome	carbohydrate metabolism glycosaminoglycan catabolism metabolism	beta- glucuronidase activity cation binding	1, 2
oocyte- specific histone H1	H1FOO	1	NP_722575	nucleosome nucleus	nucleosome assembly	DNA binding	2
beta globin	HBB	2	NP_000509	hemoglobin complex	nitric oxide transport oxygen transport positive regulation of nitric oxide biosynthesis transport	heme binding hemoglobin binding iron ion binding metal ion binding oxygen binding oxygen transporter activity selenium binding	2
HBS1- like	HBS1L	1	NP_006611	not classified	protein biosynthesis signal transduction	GTP binding nucleotide binding translation elongation factor activity	2
haloacid dehalogenase- like hydrolase domain containing 2	HDHD2	1	NP_115500	not classified	metabolism	metal ion binding	2
heme binding protein 1	HEBP1	6	NP_057071	not classified	not classified	not classified	1, 2
heme binding protein 2	HEBP2	1	NP_055135	not classified	not classified	not classified	2
homogentisate 1, 2- dioxygenase	HGD	2	NP_000178	not classified	L- phenylalanine catabolism tyrosine catabolism	homogentisate 1, 2- dioxygenase activity iron ion binding metal ion binding oxidoreductase activity	2
hepatocyte growth factor- regulated tyrosine kinase substrate	HGS	1	NP_004703	endosome membrane	intracellular protein transport negative regulation of cell proliferation signal transduction	zinc ion binding hydrolase activity	2
histidine triad nucleotide binding protein 1	HINT1	1	NP_005331	cytoskeleton nucleus	signal transduction	protein kinase C binding zinc ion binding nucleic acid binding	2
histone H2A	HIST2H2AB	1	NP_778235	chromosome nucleosome nucleus	chromosome organization and biogenesis (sensu Eukaryota) nucleosome assembly	DNA binding	2
histone 2, H2bf	HIST2H2BF	4	NP_001019770	chromosome nucleosome nucleus	chromosome organization and biogenesis (sensu Eukaryota) nucleosome assembly	DNA binding	2
histone H4	HIST4H4	2	NP_778224	chromosome nucleosome nucleus	establishment and/or maitenance of chromatin architecture nucleosome assembly phosphoinositide- mediated signaling	DNA binding	1
major histocompatibility complex, class I, B	HLA- B	1	NP_005505	integral to membrane integral to plasma membrane membrane membrane fraction MHC class I protein complex	antigen processing and presentation antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I	MHC class I receptor activity	2
major histocompatibility complex, class II, DR alpha precursor	HLA- DRA	1	NP_061984	integral to plasma membrane lysosome membrane plasma membrane	antigen processing and presentation of exogenous antigen antigen processing and presentation of exogenous peptide antigen via MHC class II immune response	MHC class II receptor activity	2
histamine N- methyltransferase isoform 1	HNMT	1	NP_008826	not classified	respiratory gaseous exchange	histamine N- methyltransferase activity methyltransferase activity transferase activity	2
heterogeneous nuclear ribonucleoprotein L isoform b	HNRNPL	1	NP_001005335	heterogeneous nuclear ribonucleoprotein complex nucleoplasm nucleus	mRNA processing	nucleotide binding RNA binding ATP binding	2
haptoglobin	HP	2	NP_005134	extracellular region	defense response iron ion homeostasis proteolysis	hemoglobin binding serine- type endopeptidase activity	2
4- hydroxyphenylpyruvate dioxygenase	HPD	1	NP_002141	not classified	aromatic amino acid family metabolism L- phenylalanine catabolism tyrosine catabolism	4- hydroxyphenylpyruvate dioxygenase activity iron ion binding metal ion binding oxidoreductase activity	2
hydroxyprostaglandin dehydrogenase 15- (NAD)	HPGD	6	NP_000851	cytosol	fatty acid metabolism lipid metabolism lipoxygenase pathway metabolism negative regulation of progression through cell cycle parturition pregnancy prostaglandin metabolism transforming growth factor beta receptor signaling pathway	15- hydroxyprostaglandin dehydrogenase (NAD+) activity NAD binding oxidoreductase activity prostaglandin E receptor activity protein homodimerization activity	1, 2
hemopexin	HPX	1	NP_000604	extracellular region extracellular space	heme transport iron ion homeostasis transport	binding heme transporter activity iron ion binding metal ion binding	2
v- Ha- ras Harvey rat sarcoma viral oncogene homolog isofrom 1	HRAS	2	NP_005334	cytoplasm intracellular membrane plasma membrane	cell motility cell surface receptor linked signal transduction chemotaxis organ morphogenesis regulation of progression through cell cycle small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein C- terminus binding	1
histidine- rich glycoprotein precursor	HRG	2	NP_000403	extracellular region	not classified	cysteine protease inhibitor activity heparin binding	2
heat- responsive protein 12	HRSP12	2	NP_005827	cytoplasm nucleus	regulation of translational termination	endonuclease activity hydrolase activity	1, 2
heat shock protein 90Bf	HSP90AB6P	1	NP_001014441	not classified	protein folding response to unfolded protein	unfolded protein binding	2
heat shock 70kDa protein 12A	HSPA12A	1	NP_079291	not classified	not classified	ATP binding nucleotide binding	2
heat shock 70kDa protein 1B	HSPA1B	4	NP_005337	cytoplasm endoplasmic reticulum mitochondrion nucleus	anti- apoptosis mRNA catabolism protein folding response to unfolded protein	ATP binding nucleotide binding unfolded protein binding	1
heat shock 70kDa protein 2	HSPA2	16	NP_068814	cell surface	male meiosis protein folding response to unfolded protein spermatid development	ATP binding nucleotide binding unfolded protein binding	2
heat shock 70kDa protein 5	HSPA5	1	NP_005338	caspase complex cell surface endoplasmic reticulum endoplasmic reticulum lumen ER- Golgi intermediate compartment integral to endoplasmic reticulum membrane nucleus perinuclear region	anti- apoptosis negative regulation of caspase activity	ATP binding calcium ion binding caspase inhibitor activity nucleotide binding protein binding, bridging unfolded protein binding	1, 2
heat shock 70kDa protein 8 isoform 1	HSPA8	19	NP_006588	cell surface intracellular nucleus	protein folding response to unfolded protein	ATP binding ATPase activity, coupled nucleotide binding protein binding	1, 2
heat shock 27kDa protein 1	HSPB1	8	NP_001531	cell surface cytoplasm cytoskeleton	anti- apoptosis cell motility protein folding regulation of translational initiation response to unfolded protein	protein binding	2
chaperonin	HSPD1	1	NP_955472	cytoplasm mitochondrion	cellular protein metabolism protein folding protein import into mitochondrial matrix regulation of apoptosis response to unfolded protein	ATP binding chaperone binding nucleotide binding protein binding unfolded protein binding	1, 2
heparan sulfate proteoglycan 2	HSPG2	18	NP_005520	basement membrane extracellular space	cell adhesion	not classified	2
HECT, UBA and WWE domain containing 1	HUWE1	1	NP_113584	cytoplasm intracellular nucleus	histone ubiquitination mRNA transport protein polyubiquitination ubiquitin cycle	binding DNA binding ligase activity protein binding ubiquitin- protein ligase activity	2
intercellular adhesion molecule 1 precursor	ICAM1	1	NP_000192	integral to plasma membrane plasma membrane	cell- cell adhesion	transmembrane receptor activity insulin- like growth factor receptor activity	2
isocitrate dehydrogenase 1 (NADP+), soluble	IDH1	14	NP_005887	cytoplasm cytosol peroxisome	carbohydrate metabolism glyoxylate cycle isocitrate metabolism main pathways of carbohydrate metabolism metabolism tricarboxylic acid cycle	isocitrate dehydrogenase (NADP+) activity oxidoreductase activity oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor	1, 2
insulin- like growth factor 2 receptor precursor	IGF2R	1	NP_000867	endosome integral to plasma membrane lysosome membrane trans- Golgi network transport vesicle	receptor mediated endocytosis signal transduction transport	receptor activity transporter activity metal iion binding	2
insulin- like growth factor binding protein, acid labile subunit	IGFALS	6	NP_004961	extracellular region extracellular space soluble fraction	cell adhesion signal transduction	insulin- like growth factor binding protein binding transferase activity	2
zinc finger protein, subfamily 1A, 5	IKZF5	1	NP_071911	intracellular nucleus	not classified	nucleic acid binding zinc ion binding interleukin- 1 receptor antagonist activity	2
interleukin 1 receptor antagonist isoform 1 precursor	IL1RN	2	NP_776214	extracellular region extracellular space intracellular	inflammatory response	interleukin- 1 receptor antagonist activity	2
interleukin 1 receptor antagonist isoform 4	IL1RN	1	NP_776215	extracellular region extracellular space intracellular	inflammatory response	calcium ion binding	2
InaD- like protein	INADL	7	NP_795352	membrane tight junction	not classified	protein binding	2
IQ motif containing G	IQCG	1	NP_115639	not classified	not classified	not classified	2
IQ motif containing GTPase activating protein 1	IQGAP1	20	NP_003861	actin filament intracellular membrane	negative regulation of Ras protein signal transduction regulation of small GTPase mediated signal transduction signal transduction	calmodulin binding GTPase inhibitor activity Ras GTPase activator activity	2
IQ motif containing GTPase activating protein 2	IQGAP2	5	NP_006624	actin cytoskeleton intracellular	regulation of small GTPase mediated signal transduction signal transduction	actin binding calmodulin binding GTPase inhibitor activity Ras GTPase activator activity	2
interferon regulatory factor 6	IRF6	1	NP_006138	nucleus	regulation of transcription, DNA- dependent transcription	transcription factor activity	2
integrin, alpha 1 precursor	ITGA1	1	NP_852478	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pathway	calcium ion binding collagen binding magnesium ion binding receptor activity	2
integrin alpha 3 isoform a precursor	ITGA3	1	NP_002195	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pathway	calcium ion binding protein binding receptor activity	2
integrin alpha 3 isoform b, precursor	ITGA3	1	NP_005492	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pahtwya	protein binding receptor activity protein binding	2
integrin alpha- V precursor	ITGAV	1	NP_002201	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pathway	calcium ion binding protein binding receptor activity	2
integrin beta 1 isoform 1A precursor	ITGB1	1	NP_002202	endoplasmic reticulum integral to membrane integrin complex membrane ruffle	cell adhesion cell migration cell- matrix adhesion cellular defense response development homophilic cell adhesion integrin- mediated signaling pathway	identical protein binding protein binding protein heterodimerization activity receptor activity	2
integrin beta 4 binding protein isoform a	ITGB4BP	1	NP_852133	nucleus	integrin- mediated signaling pathway mature ribosome assembly protein biosynthesis	protein binding ribosome binding translation initiation factor activity	2
integrin, beta 8 precursor	ITGB8	1	NP_002205	integral to membrane integrin complex membrane	cell adhesion cell- matrix adhesion integrin- mediated signaling pahtwya	receptor activity not classified	2
inter- alpha (globulin) inhibitor H4	ITIH4	2	NP_002209	extracellular region	acute- phase response hyaluronan metabolism	serine- type endopeptidase inhibitor activity	2
intelectin	ITLN1	4	NP_060095	membrane	not classified	GPI anchor binding sugar binding	2
integral membrane protein 2B	ITM2B	5	NP_068839	integral to plasma membrane membrane membrane fraction	nervous system development sensory perception of sound	not classified	1, 2
integral membrane protein 2C isoform 1	ITM2C	1	NP_112188	Golgi apparatus integral to membrane membrane	not classified	not classified	2
integral membrane protein 2C isoform 2	ITM2C	1	NP_001012534	Golgi apparatus integral to membrane membrane	not classified endocytosis regulation of Rho protein signal transduction	calcium ion binding	2
intersectin 2 isoform 1	ITSN2	1	NP_006268	intracellular	endocytosis regulation of Rho protein signal transduction	protein binding Rho guanyl- nucleotide exchange factor activity SH3/SH2 adaptor activity cytoskeletal protein binding	2
junction plakoglobin	JUP	9	NP_068831	cytoplasm cytoskeleton membrane fraction soluble fraction	cell adhesion	cytoskeletal protein binding structural molecule activity	2
kalirin, RhoGEF kinase isoform 3	KALRN	1	NP_008995	actin cytoskeleton intracellular	intracellular signaling cascade nervous system development protein amino acid phosphorylation regulation of Rho protein signal transduction signal transduction vesicle- mediated transport	ATP binding nucleotide binding protein binding protein serine/threonine kinase activity Rho guanyl- nucleotide exchange factor activity transferase activity	2
potassium voltage- gated channel, subfamily G, member 2	KCNG2	1	NP_036415	integral to membrane membrane voltage- gated potassium channel complex	ion transport potassium ion transport regulation of heart contraction	delayed rectifier potassium channel activity potassium ion binding protein binding	2
ketohexokinase isoform a	KHK	2	NP_000212	cytoplasm	carbohydrate metabolism	ketohexokinase activity kinase activity transferase activity	2
ketohexokinase isoform b	KHK	1	NP_006479	cytoplasm	carbohydrate metabolism	ketohexokinase activity kinase activity transferase activity	2
putative MAPK activating protein PM28	KIAA0174	19	NP_055576	ER- Golgi intermediate compartment	not classified	protein binding	1, 2
PREDICTED: similar to Protein KIAA0841 isoform 1	KIAA0841	1	XP_049237	not classified	not classified	not classified	2
hypothetical protein LOC57471 isoform a	KIAA1189	1	NP_001009959	cytoplasm membrane	not classified	not classified	2
hypothetical protein LOC57653	KIAA1529	1	NP_065944	not classified	not classified	not classified	2
PREDICTED: similar to c11.1 CG12132- PA isoform 11	KIAA1833	2	XP_946410	not classified	not classified	ATP binding	2
kinesin family member 12	KIF12	16	NP_612433	microtubule microtubule associated complex	microtubule- based movement	ATP binding microtubule motor activity nucleotide binding	2
kinesin family member 3A	KIF3A	1	NP_008985	microtubule microtubule associated complex	microtubule- based movement organelle organization and biogenesis	ATP binding microtubule motor activity nucleotide binding	2
kinesin family member 3B	KIF3B	1	NP_004789	microtubule microtubule associated complex plus- end kinesin complex	anterograde axon cargo transport determination of left/right symmetry microtubule- based movement	nucleotide binding plus- end- directed microtubule motor activity ATP binding	2
kinesin family member 9 isoform 3	KIF9	1	NP_878906	microtubule microtubule associated complex	microtubule- based movement	microtubule motor activity nucleotide binding ATP binding	2
kinesin family member C3	KIFC3	1	NP_005541	kinesin complex microtubule microtubule associated complex	microtubule- based movement visual perception	microtubule motor activity nucleotide binding beta- glucuronidase activity	2
klotho	KL	1	NP_004786	integral to membrane membrane	aging carbohydrate metabolism metabolism positive regulation of bone mineralization	cation binding glucosidase activity hormone activity vitamin D binding IgE binding	2
kallikrein 1 preproprotein	KLK1	1	NP_002248	not classified	proteolysis	peptidase activity tissue kallikrein activity	2
kininogen 1	KNG1	17	NP_000884	extracellular region	blood coagulation diuresis inflammatory response natriuresis negative regulation of blood coagulation negative regulation of cell adhesion positive regulation of apoptosis smooth muscle contraction vasodilation	cysteine protease inhibitor activity heparin binding receptor binding zinc ion binding	1, 2
karyopherin beta 1	KPNB1	2	NP_002256	cytoplasm nuclear pore nucleus	NLS- bearing substrate import into nucleus protein import into nucleus, docking protein import into nucleus, translocation protein transport	nuclear localization sequence binding protein binding protein transporter activity zinc ion binding	2
laminin alpha 5	LAMA5	1	NP_005551	basal lamina extracellular matrix (sensu Metazoa) integral to membrane laminin- 1 membrane	cell adhesion regulation of cell adhesion regulation of cell migration regulation of embryonic development	protein binding receptor binding structural molecule activity	2
laminin, gamma 1 precursor	LAMC1	1	NP_002284	basement membrane laminin- 1	cell adhesion endoderm development positive regulation of epithelial cell proliferation protein complex assembly	extracellular matrix structural constituent protein binding	2
lysosomal- associated membrane protein 1	LAMP1	3	NP_005552	integral to plasma membrane late endosome lysosome membrane membrane fraction	not classified	not classified	1, 2
lysosomal- associated membrane protein 2 precursor	LAMP2	4	NP_054701	integral to membrane late endosome lysosomal membrane membrane membrane fraction platelet dense granule membrane	not classified	not classified	2
leucine aminopeptidase 3	LAP3	1	NP_056991	cytoplasm intracellular	protein metabolism proteolysis	leucyl aminopeptidase activity magnesium ion binding manganese ion binding peptidase activity prolyl aminopeptidase activity zinc ion binding	2
lipopolysaccharide- binding protein precursor	LBP	2	NP_004130	extracellular region extracellular space integral to membrane membrane	acute- phase response cellular defense response defense response to bacterium lipid transport	lipid binding	2
lipocalin 2	LCN2	2	NP_005555	cytoplasm soluble fraction	transport	binding transporter activity	2
L- plastin	LCP1	1	NP_002289	cytoplasm cytosol	not classified	actin binding calcium ion binding protein binding	2
lactate dehydrogenase A	LDHA	6	NP_005557	cytoplasm cytosol	anaerobic glycolysis tricarboxylic acid cycle intermediate metabolism	L- lactate dehydrogenase activity oxidoreductase activity protein binding	1, 2
lactate dehydrogenase B	LDHB	14	NP_002291	cytoplasm	anaerobic glycolysis tricarboxylic acid cycle intermediate metabolism	L- lactate dehydrogenase activity oxidoreductase activity	1, 2
leucine proline- enriched proteoglycan (leprecan) 1	LEPRE1	1	NP_071751	endoplasmic reticulum	protein metabolism	binding iron ion binding L- ascorbic acid binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, each of oxygen into both donors oxidoreductase activity, actin	2
galectin 3	LGALS3	1	NP_002297	cytoplasm extracellular region nucleus plasma membrane	not classified	sugar binding not classified	2
galectin 3 binding protein	LGALS3BP	26	NP_005558	extracellular matrix (sensu Metazoa) extracellular space membrane	cell adhesion cellular defense response signal transduction	protein binding scavenger receptor activity	1, 2
lectin, mannose- binding 2	LMAN2	10	NP_006807	endoplasmic reticulum ER- Golgi intermediate compartment integral to membrane membrane	protein transport	calcium ion binding sugar binding	1, 2
hypothetical protein LOC124220	LOC124220	4	NP_660295	not classified	not classified	not classified	2
PREDICTED: similar to peptidylprolyl isomerase A isoform 1	LOC128192	1	XP_060887	not classified	not classified	not classified	2
PREDICTED: similar to peptidylprolyl isomerase A isoform 1	LOC131691	1	XP_946711	not classified	not classified	not classified	2
hypothetical protein LOC146909	LOC146909	1	NP_001073912	not classified	not classified	not classified	2
hypothetical protein LOC283537	LOC283537	1	NP_861450	not classified	not classified	not classified	2
PREDICTED: hypothetical protein	LOC284422	1	XP_209196	not classified	not classified	not classified	2
similar to F- box only protein 2	LOC342897	2	NP_001001414	not classified	protein catabolism	protein binding receptor activity	2
PREDICTED: similar to fibrillarin	LOC345630	2	XP_946024	not classified	not classified	not classified	2
PREDICTED: similar to ubiquitin and ribosomal protein S27a precursor	LOC388720	1	XP_371330	not classified	not classified	not classified	2
peptidylprolyl isomerase A	LOC388817	5	NP_001008741	not classified	protein folding	not classified	2
PREDICTED: hypothetical protein	LOC388849	1	XP_948564	not classified	not classified	not classified	2
PREDICTED: similar to peptidylprolyl isomerase A isoform 1	LOC390299	1	XP_945177	not classified	not classified	not classified	2
PREDICTED: hypothetical protein isoform 4	LOC440335	1	XP_950835	not classified	not classified	not classified	2
PREDICTED: hypothetical protein LOC643008 isoform 2	LOC643008	1	XP_951274	not classified	not classified	not classified	2
hypothetical protein LOC643751	LOC643751	1	NP_001083064	not classified	not classified	not classified	2
hypothetical protein LOC643752	LOC643752	1	NP_001083173	not classified	not classified	not classified	2
PREDICTED: similar to cytoplasmic beta- actin	LOC646821	1	XP_942241	not classified	not classified	not classified	2
PREDICTED: similar to actin- related protein 2	LOC649125	1	XP_943300	not classified	not classified	not classified	2
PREDICTED: similar to immunoglobulin iota chain preproprotein	LOC651536	1	XP_945805	not classified	not classified	transferase activity	2
PREDICTED: similar to Programmed cell death 6- interacting protein (ALG- 2- interacting protein X) (ALG- 2- interacting protein 1) (E2F1- inducible protein) (Eig2)	LOC654259	6	XP_290660	not classified	not classified	not classified	2
exonuclease NEF- sp	LOC81691	1	NP_112203	intracellular nucleolus	not classified	exonuclease activity nucleic acid binding nucleotide binding	2
low density lipoprotein- related protein 2	LRP2	84	NP_004516	coated pit integral to membrane lysosome membrane	lipid metabolism protein amino acid glycosylation receptor mediated endocytosis	calcium ion binding protein binding receptor activity	1, 2
leucine rich repeat containing 15	LRRC15	1	NP_570843	integral to membrane membrane	not classified	transferase activity	2
leucine rich repeat containing 57	LRRC57	1	NP_694992	not classified	not classified	protein binding	2
leucine- rich repeat kinase 2	LRRK2	4	NP_940980	not classified	protein amino acid phosphorylation small GTPase mediated signal transduction	ATP binding binding GTP binding GTPase activator activity nucleotide binding protein serine/threonine kinase activity transferase activity	2
leukotriene A4 hydrolase	LTA4H	6	NP_000886	not classified	inflammatory response leukotriene biosynthesis proteolysis	epoxide hydrolase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity peptidase activity zinc ion binding	2
NADP- dependent leukotriene B4 12- hydroxydehydrogenase	LTB4DH	5	NP_036344	cytoplasm	leukotriene metabolism	15- oxoprostaglandin 13- oxidase activity alcohol dehydrogenase activity oxidoreductase activity zinc ion binding	1, 2
lysophospholipase II	LYPLA2	1	NP_009191	not classified	fatty acid metabolism lipid metabolism	hydrolase activity	2
lysozyme precursor	LYZ	1	NP_000230	extracellular region	cell wall catabolism cytolysis defense response to bacterium metabolism	hydrolase activity, acting on glycosyl bonds lysozyme activity	2
membrane- associated guanylate kinase- related 3 isoform 1	MAGI3	2	NP_066016	membrane	apoptosis intracellular signaling cascade	guanylate kinase activity kinase activity protein binding	2
MAL2 proteolipid protein	MAL2	1	NP_443118	integral to membrane membrane	not classified	ferric iron binding	2
mannosidase, alpha, class 1A, member 1	MAN1A1	15	NP_005898	endoplasmic reticulum ER- Golgi intermediate compartment integral to membrane membrane membrane fraction	metabolism protein amino acid glycosylation	calcium ion binding hydrolase activity, acting on glycosyl bonds mannosidase activity mannosyl- oligosaccharide 1, 2- alpha- mannosidase activity	1, 2
mannosidase, alpha, class 2A, member 1	MAN2A1	1	NP_002363	Golgi apparatus integral to membrane membrane membrane fraction	cell motility carbohydrate metabolism glycoprotein biosynthesis mannose metabolism metabolism	alpha- mannosidase activity hydrolase activity, acting on glycosyl bonds mannosyl- oligosaccharide 1, 3- 1, 6- alpha- mannosidase activity	2
mitogen- activated protein kinase kinase 1 interacting protein 1	MAP2K1IP1	1	NP_068805	membrane	not classified	not classified	2
myristoylated alanine- rich protein kinase C substrate	MARCKS	4	NP_002347	actin cytoskeleton plasma membrane	cell motility	actin filament binding calmodulin binding	2
mannan- binding lectin serine protease 2 isoform 1 precursor	MASP2	12	NP_006601	extracellular region	antimicrobial humoral response (sensu Vertebrata) complement activation, classical pathway innate immune response proteolysis	calcium ion binding serine- type endopeptidase activity	1, 2
methyl- CpG binding domain protein 5	MBD5	1	NP_060798	nucleus	not classified	DNA binding	2
cytosolic malate dehydrogenase	MDH1	5	NP_005908	cytosol	glycolysis malate metabolism tricarboxylic acid cycle	L- lactate dehydrogenase activity L- malate dehydrogenase activity malic enzyme activity oxidoreductase activity	1, 2
mitochondrial malate dehydrogenase precursor	MDH2	1	NP_005909	mitochondrial matrix mitochondrion	glycolysis malate metabolism tricarboxylic acid cycle	L- lactate dehydrogenase activity L- malate dehydrogenase activity oxidoreductase activity	2
EGF- like- domain, multiple 4	MEGF8	2	NP_001401	integral to membrane membrane	development	calcium ion binding receptor activity structural molecule activity	2
milk fat globule- EGF factor 8 protein	MFGE8	2	NP_005919	lipid particle	cell adhesion fertilization (sensu Metazoa)	protein binding	2
melanoma- associated antigen p97 isoform 1, precursor	MFI2	2	NP_005920	extracellular region integral to plasma membrane membrane	ion transport iron ion homeostasis iron ion transport	ferric iron binding GPI anchor binding metal ion binding zinc ion binding	2
melanoma- associated antigen p97 isoform 2, precursor	MFI2	1	NP_201573	extracellular region integral to plasma membrane membrane	ion transport iron ion homeostasis iron ion transport	GPI anchor binding metal ion binding zinc ion binding cytokine activity	2
hypothetical protein LOC146556	MGC45438	1	NP_689672	not classified	not classified	not classified	2
hypothetical protein LOC375791	MGC59937	1	NP_945352	not classified	not classified	not classified	2
mahogunin, ring finger 1	MGRN1	1	NP_056061	not classified	ubiquitin cycle	ligase activity metal ion binding protein binding zinc ion binding	2
midline 2 isoform 2	MID2	1	NP_438112	intracellular microtubule microtubule associated complex	not classified	metal ion binding protein binding zinc ion binding	2
macrophage migration inhibitory factor (glycosylation- inhibiting factor)	MIF	1	NP_002406	extracellular region extracellular space	cell proliferation cell surface receptor linked signal transduction inflammatory response negative regulation of apoptosis prostaglandin biosynthesis regulation of macrophage activation	isomerase activity phenylpyruvate tautomerase activity protein binding ATP binding	2
macrophage migration inhibitory factor (glycosylation- inhibiting factor)	MIF	1	NP_002406	extracellular region extracellular space	cell proliferation cell surface receptor linked signal transduction inflammatory response negative regulation of apoptosis prostaglanding biosynthesis regulation of macrophase activation	cytokine activity isomerase activity phenylpyruvate tautomerase activity protein binding	1
misshapen/NIK- related kinase isoform 4	MINK1	2	NP_001020108	not classified	development JNK cascade protein amino acid phosphorylation protein kinase cascade response to stress	nucleotide binding protein serine/threonine kinase activity small GTPase regulator activity transferase activity metal ion binding	2
MIT, microtubule interacting and transport, domain containing 1	MITD1	9	NP_620153	not classified	not classified	not classified	1, 2
myeloid/lymphoid or mixed- lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	MLLT3	1	NP_004520	nucleus	regulation of transcription, DNA- dependent transcription	not classified	2
myeloid/lymphoid or mixed- lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 isoform 3	MLLT4	1	NP_005927	intercellular junction myosin	cell adhesion cell- cell signaling signal transduction	motor activity protein binding protein C- terminus binding	2
membrane metallo- endopeptidase	MME	48	NP_009219	integral to plasma membrane plasma membrane	cell- cell signaling proteolysis	metal ion binding metallopeptidase activity neprilysin activity zinc ion binding	1, 2
matrix metalloproteinase 24 preproprotein	MMP24	1	NP_006681	extracellular matrix (sensu Metazoa) integral to plasma membrane membrane	peptidoglycan metabolism proteolysis	calcium ion binding enzyme activator activity metalloendopeptidase activity zinc ion binding	2
matrix metalloproteinase 25 preproprotein	MMP25	1	NP_073209	cell surface extracellular matrix (sensu Metazoa) membrane	inflammatory response peptidoglycan metabolism proteolysis	calcium ion binding GPI anchor binding metalloendopeptidase activity zinc ion binding	2
multimerin 2	MMRN2	1	NP_079032	extracellular matrix (sensu Metazoa)	not classified	not classified	1, 2
myeloid cell nuclear differentiation antigen	MNDA	1	NP_002423	nucleus	cellular defense response regulaion of transcription, DNA- dependent transcription	3- mercaptopyruvate sulfurtransferase activity	2
Mob4B protein	MOBK1B	1	NP_060691	not classified	not classified	metal ion binding zinc ion binding	1
myeloperoxidase	MPO	7	NP_000241	lysosome	anti- apoptosis defense response hydrogen peroxide catabolism response to oxidative stress	calcium ion binding chromatin binding iron ion binding oxidoreductase activity peroxidase activity	2
membrane protein, palmitoylated 5	MPP5	1	NP_071919	cytoplasm membrane tight junction	not classified	protein binding	2
3- mercaptopyruvate sulfurtransferase	MPST	3	NP_001013454	mitochondrial matrix	cyanate catabolism response to toxin sulfate transport	3- mercaptopyruvate sulfurtransferase activity thiosulfate sulfurtransferase activity transferase activityy	2
moesin	MSN	27	NP_002435	cytoplasm cytoskeleton plasma membrane	cell motility	cytoskeletal protein binding receptor binding structural constituent of cytoskeleton	1, 2
methionine sulfoxide reductase A	MSRA	1	NP_036463	not classified	methionine metabolism protein metabolism protein modification response to oxidative stress	oxidoreductase activity protein- methionine- S- oxide reductase activity	2
5'- methylthioadenosine phosphorylase	MTAP	1	NP_002442	not classified	nucleobase, nucleoside, nucleotide and nucleic acid metabolism	S- methyl- 5- thioadenosine phosphorylase activity transferase activity, transferring pentosyl groups actin binding	2
methylenetetrahydrofolate dehydrogenase 1	MTHFD1	4	NP_005947	mitochondrion	amino acid biosynthesis folic acid and derivative biosynthesis histidine biosynthesis methionine biosynthesis one- carbon compound metabolism purine nucleotide biosynthesis	ATP binding formate- tetrahydrofolate ligase activity hydrolase activity ligase activity methenyltetrahydrofolate cyclohydrolase activity methylenetetrahydrofolate dehydrogenase (NADP+) activity nucleotide binding oxidoreductase activity	2
mucin 1 isoform 3 precursor	MUC1	7	NP_001018017	cytoskeleton extracellular region integral to membrane integral to plasma membrane membrane	not classified	actin binding hormone activity	2
mucin 1 isoform 7 precursor	MUC1	2	NP_001037857	cytoskeleton extracellular region integral to membrane integral to plasma membrane membrane	not classified	hormone activity extracellular matrix structural constituent	2
MUC1 mucin isoform 1 precursor	MUC1	6	NP_002447	cytoskeleton extracellular region integral to membrane integral to plasma membrane membrane	not classified	actin binding hormone activity	1
mu- protocadherin isoform 2	MUCDHL	1	NP_060187	integral to membrane membrane	calcium- dependent cell- cell adhesion cell adhesion homophilic cell adhesion	calcium ion binding protein binding	2
melanoma associated antigen (mutated) 1- like 1	MUM1L1	2	NP_689636	not classified	not classified	not classified	2
mucin and cadherin- like isoform 3	MUPCDH	1	NP_112554	integral to membrane membrane	calcium- dependent cell- cell cell adhesion homophilic cell adhesion	protein binding actin binding	2
major vault protein	MVP	6	NP_005106	cytoplasm nucleus ribonucleoprotein complex	response to drug	not classified	2
adlican	MXRA5	1	NP_056234	not classified	protein amino acid phosphorylation	ATP binding transferase activity vascular endothelial growth factor receptor activity	2
matrix- remodelling associated 8	MXRA8	7	NP_115724	not classified	not classified	not classified	1, 2
myosin, heavy polypeptide 13, skeletal muscle	MYH13	1	NP_003793	muscle myosin myosin striated muscle thick filament	striated muscle contraction	actin binding ATP binding calmodulin binding microfilament motor activity nucleotide binding	2
myosin, heavy chain 14 isoform 2	MYH14	8	NP_079005	myosin	regulation of cell shape sensory perception of sound	actin binding ATP binding calmodulin binding motor activity nucleotide binding	2
myosin, heavy chain 14 isoform 1	MYH14	1	NP_001070654	myosin	regulation of cell shape sensory perception of sound	ATP binding calmodulin binding motor activity nucleotide binding ATP binding	2
myosin, heavy chain 3, skeletal muscle, embryonic	MYH3	1	NP_002461	myosin striated muscle thick filament	actin filament- based movement muscle development striated muscle contraction	actin binding ATP binding ATPase activity, coupled calmodulin binding microfilament motor activity nucleotide binding	2
myosin, heavy polypeptide 9, non- muscle	MYH9	19	NP_002464	myosin	regulation of cell shape sensory perception of sound	actin binding ATP binding calmodulin binding motor activity nucleotide binding	1, 2
myosin XV	MYO15A	1	NP_057323	cytoskeleton myosin	sensory perception of sound	actin binding ATP binding calmodulin binding motor activity nucleotide binding structural molecule activity	2
myosin IB	MYO1B	2	NP_036355	myosin	not classified	actin binding ATP binding calmodulin binding motor activity nucleotide binding	2
myosin IC	MYO1C	33	NP_203693	myosin unconventional myosin	not classified	actin binding ATP binding calmodulin binding motor activity nucleotide binding	2
myosin ID	MYO1D	16	NP_056009	myosin	not classified	actin binding ATP binding calmodulin binding motor activity nucleotide binding	2
Myosin VB	MYO5B	1	NP_001073936	myosin	not classified	actin binding ATP binding calmodulin binding motor activity nucleotide binding	2
myosin VI	MYO6	7	NP_004990	unconventional myosin	actin filament- based movement sensory perception of sound striated muscle contraction	actin binding ATP binding ATPase activity, coupled calmodulin binding microfilament motor activity motor activity nucleotide binding structural constituent of muscle	2
N- Acetylglucosamine kinase	NAGK	1	NP_060037	not classified	N- acetylglucosamine metabolism N- acetylmannosamine metabolism	kinase activity N- acetylglucosamine kinase activity nucleotide binding protein binding transferase activity N- acetyltransferase activity	2
alpha- N- acetylglucosaminidase precursor	NAGLU	21	NP_000254	lysosome	glycosaminoglycan metabolism metabolism nervous system development	alpha- N- acetylglucosaminidase activity hydrolase activity, acting on glycosyl bonds	1, 2
N- ethylmaleimide- sensitive factor attachment protein, alpha	NAPA	1	NP_003818	endoplasmic reticulum Golgi apparatus	ER to Golgi vesicle- mediated transport intra- Golgi vesicle- mediated transport intracellular protein transport membrane fusion	binding intracellular transporter activity protein binding	2
N- acyl- phosphatidylethanolamine- hydrolyzing phospholipase D	NAPE- PLD	1	NP_945341	not classified	not classified	hydrolase activity	2
N- ethylmaleimide- sensitive factor attachment protein, gamma	NAPG	1	NP_003817	endoplasmic reticulum Golgi apparatus membrane fraction mitochondrion	ER to Golgi vesicle- mediated transport intra- Golgi vesicle- mediated transport intracellular protein transport membrane fusion protein complex assembly protein stabilization	intracellular transporter activity protein binding	2
nicotinate phosphoribosyltransferase domain containing 1	NAPRT1	2	NP_660202	not classified	pyridine nucleotide biosynthesis	nicotinate phosphoribosyltransferase activity transferase activity, transferring glycosyl groups	2
napsin A preproprotein	NAPSA	8	NP_004842	not classified	proteolysis	pepsin A activity peptidase activity	1, 2
NMDA receptor regulated 1- like protein isoform 1	NARG1L	1	NP_078837	cytoplasm nucleus transcription factor complex	N- terminal protein amino acid acetylation positive regulation of transcription, DNA- dependent	acetyltransferase activity protein binding ribosome binding	2
asparaginyl- tRNA synthetase	NARS	1	NP_004530	cytoplasm soluble fraction	asparaginyl- tRNA aminoacylation aspartyl- tRNA aminoacylation DNA replication protein biosynthesis	asparagine- tRNA ligase activity aspartate- tRNA ligase activity ATP binding DNA- directed DNA polymerase activity ligase activity nucleic acid binding nucleotide binding protein binding transferase activity	2
N- acetyltransferase 13	NAT13	1	NP_079422	cytoplasm	N- terminal protein amino acid acetylation	protein binding transferase activity protein binding	2
NCK- associated protein 1 isoform 1	NCKAP1	7	NP_038464	integral to membrane membrane	apoptosis central nervous system development	protein binding	2
NCK- associated protein 1 isoform 2	NCKAP1	6	NP_995314	integral to membrane membrane	apoptosis central nervous system development	calcium ion binding	2
nicastrin precursor	NCSTN	2	NP_056146	endoplasmic reticulum Golgi apparatus integral to plasma membrane membrane	amyloid precursor protein catabolism membrane protein ectodomain proteolysis Notch receptor processing positive regulation of enzyme activity protein processing	protein binding	2
N- myc downstream regulated gene 1	NDRG1	2	NP_006087	nucleus	cell differentiation response to metal ion	not classified	2
N- myc downstream- regulated gene 3 isoform b	NDRG3	1	NP_071922	cytoplasm	cell differentiation negative regulation of cell growth spermatogenesis	not classified	2
nebulin	NEB	2	NP_004534	actin cytoskeleton striated muscle thin filament Z disc	regulation of actin filament length somatic muscle development	actin binding protein binding structural constituent of muscle	2
nebulette sarcomeric isoform	NEBL	1	NP_006384	actin cytoskeleton	regulation of actin filament length	actin binding structural constituent of muscle zinc ion binding	2
nidogen 1 precursor	NID1	1	NP_002499	basement membrane membrane	cell adhesion cell- matrix adhesion	extracellular matrix structural constituent protein binding hedgehog receptor activity	2
delangin isoform B	NIPBL	1	NP_056199	nucleus	cell cycle	binding	2
nitrilase family, member 2	NIT2	1	NP_064587	not classified	nitrogen compound metabolism	hydrolase activity, acting on carbon- nitrogen (but not peptide) bonds	2
NK6 transcription factor related, locus 1	NKX6- 1	1	NP_006159	nucleus	development organ morphogenesis regulation of transcription, DNA- dependent	sequence- specific DNA binding transcription factor activity	2
non- POU domain containing, octamer- binding	NONO	1	NP_031389	nucleus	DNA recombination DNA repair nuclear mRNA splicing, via spliceosome regulation of transcription, DNA- dependent RNA splicing transcription	DNA binding nucleotide binding protein binding RNA binding	1
NADPH oxidase 3	NOX3	1	NP_056533	integral to membrane membrane	electron transport	FAD binding iron ion binding oxidoreductase activity	2
purine nucleoside phosphorylase	NP	7	NP_000261	not classified	DNA modification nucleobase, nucleoside, nucleotide and nucleic acid metabolism	purine- nucleoside phosphorylase activity	2
Niemann- Pick disease, type C1 precursor	NPC1	1	NP_000262	endoplasmic reticulum integral to membrane lysosome membrane nuclear envelope perinuclear region	bile acid metabolism cholesterol homeostasis cholesterol transport lysosomal transport	intracellular transporter activity sterol transporter activity sequence- specific DNA binding	2
aminopeptidase puromycin sensitive	NPEPPS	4	NP_006301	cytosol nucleus	proteolysis	aminopeptidase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity zinc ion binding	2
nephrin	NPHS1	1	NP_004637	cell adhesion excretion	cell adhesion excretion	protein binding	2
podocin	NPHS2	6	NP_055440	integral to plasma membrane membrane	excretion	protein binding	1, 2
nucleophosmin 1 isoform 1	NPM1	1	NP_002511	centrosome cytoplasm nucleolus nucleus	activation of NF- kappaB transcription factor anti- apoptosis cell aging centrosome cycle intracellular protein transport negative regulation of cell proliferation nucleocytoplasmic transport response to stress ribosome assembly signal transduction	NF- kappaB binding protein heterodimerization activity protein homodimeriation activity RNA binding Tat protein binding unfolded protein binding	1
NAD(P)H dehydrogenase, quinone 2	NQO2	1	NP_000895	not classified	electron transport	electron carrier activity metal ion binding NAD(P)H dehydrogenase (quinone) activity NADPH dehydrogenase (quinone) activity zinc ion binding	2
nuclear respiratory factor 1	NRF1	1	NP_001035199	nucleus	generation of precursor metabolites and energy regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA- dependent transcription	transcription factor activity ADP reductase activity	2
5', 3'- nucleotidase, cytosolic	NT5C	2	NP_055410	cytoplasm nucleus	dephosphorylation nucleotide metabolism pyrimidine deoxyribonucleotide catabolism	hydrolase activity magnesium ion binding nucleotidase activity pyrimidine nucleotide binding	2
5' nucleotidase, ecto	NT5E	1	NP_002517	membrane membrane fraction	DNA metabolism nucleotide catabolism	5'- nucleotidase activity GPI anchor binding hydrolase activity, acting on ester bonds metal ion binding nucleotide binding zinc ion binding	2
nudix- type motif 5	NUDT5	2	NP_054861	intracellular	D- ribose catabolism nucleotide metabolism ribonucleoside diphosphate catabolism	ADP- ribose diphosphatase activity ADP- sugar diphosphatase activity hydrolase activity magnesium ion binding protien binding olfactory receptor activity	2
nuclear transport factor 2	NUTF2	1	NP_005787	intracellular	protein transport	protein binding	1
olfactomedin 4 precursor	OLFM4	19	NP_006409	membrane	not classified	latrotoxin receptor activity	1, 2
olfactory receptor, family 11, subfamily L, member 1	OR11L1	1	NP_001001959	integral to membrane membrane	G- protein coupled receptor protein signaling pathway response to stimulus sensory perception of smell signal transduction	receptor activity cysteine- type peptidase activity	2
oxysterol- binding protein- like 1A isoform A	OSBPL1A	1	NP_060500	intracellular	cholesterol metabolism lipid transport steroid metabolism vesicle- mediated transport	phospholipid binding	2
otubain 1	OTUB1	2	NP_060140	not classified	immune response ubiquitin cycle	protein binding	2
oxidative- stress responsive 1	OXSR1	2	NP_005100	not classified	protein amino acid phosphorylation protein kinase cascade response to oxidative stress	ATP binding magnesium ion binding nucleotide binding protein binding protein serine/threonine kinase activity transferase activity	2
purinergic receptor P2X4	P2RX4	2	NP_002551	integral to membrane integral to plasma membrane membrane	ion transport signal transduction	ATP binding ATP- gated cation channel activity ion channel activity receptor activity	1, 2
prolyl 4- hydroxylase, beta subunit	P4HB	1	NP_000909	cell surface endoplasmic reticulum ER- Golgi intermediate compartment extracellular region membrane	peptidyl- proline hydroxylation to 4- hydroxy- L- proline protein folding	electron carrier activity isomerase activity procollagen- proline 4- dioxygenase activity protein disulfide isomerase activity protein disulfide oxidoreductase activity	1
protein kinase C and casein kinase substrate in neurons 2	PACSIN2	4	NP_009160	cytoplasm	actin cytoskeleton organization and biogenesis endocytosis intracellular protein transport	transporter activity	2
protein kinase C and casein kinase substrate in neurons 3	PACSIN3	4	NP_057307	cytoplasm	endocytosis negative regulation of endocytosis	cytoskeletal protein binding enzyme binding	1, 2
peptidyl arginine deiminase, type II	PADI2	1	NP_031391	not classified	protein modification	calcium ion binding hydrolase activity protein- arginine deiminase activity	2
platelet- activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD)	PAFAH1B1	1	NP_000421	astral microtubule cell cortex cytoskeleton kinetochore microtubule microtubule associated complex nuclear envelope	cell cycle cell differentiation cell division cell motility establishment of mitotic spindle orientation lipid catabolism microtubule- based process mitosis nervous system development signal transduction transport	dynein binding	2
platelet- activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa	PAFAH1B2	1	NP_002563	not classified	lipid catabolism	1- alkyl- 2- acetylglycerophosphocholine esterase activity hydrolase activity, acting on ester bonds	2
PAR- 6 beta	PARD6B	1	NP_115910	plasma membrane tight junction	axonogenesis cell cycle cell division establishment and/or maintenance of cell polarity intercellular junction assembly regulation of cell migration	not classified	2
DJ- 1 protein	PARK7	1	NP_009193	cytoplasm nucleus	protein folding Ras protein signal transduction	catalytic activity	2
poly (ADP- ribose) polymerase family, member 4	PARP4	1	NP_006428	intracellular nucleus ribonucleoprotein complex	cell death DNA repair inflammatory response protein amino acid ADP- ribosylation response to drug transport	DNA binding enzyme binding NAD+ ADP- ribosyltransferase activity transferase activity, transferring glycosyl groups	2
MAWD binding protein isoform a	PBLD	4	NP_071412	not classified	biosynthesis	catalytic activity isomerase activity	2
MAWD binding protein isoform b	PBLD	1	NP_001028255	not classified	biosynthesis	isomerase activity calcium ion binding	2
pterin- 4 alpha- carbinolamine dehydratase precursor	PCBD1	1	NP_000272	not classified	tetrahydrobiopterin biosynthesis	4- alpha- hydroxytetrahydrobiopterin dehydratase activity identical protein binding lyase activity	2
poly(rC) binding protein 1	PCBP1	1	NP_006187	cytoplasm nucleus ribonucleoprotein complex	mRNA metabolism	DNA binding protein binding RNA binding single- stranded DNA binding	2
cytosolic phosphoenolpyruvate carboxykinase 1	PCK1	4	NP_002582	cytosol	gluconeogenesis	GTP binding lyase activity nucleotide binding phosphoenolpyruvate carboxykinase (GTP) activity	2
protocadherin LKC precursor	PCLKC	1	NP_060145	integral to membrane membrane	cell adhesion homophilic cell adhesion negative regulation of cell growth	protein binding not classified	2
prenylcysteine oxidase 1	PCYOX1	4	NP_057381	lysosome	prenylated protein catabolism prenylcysteine metabolism	lyase activity oxidoreductase activity prenylcysteine oxidase activity	2
programmed cell death 10	PDCD10	2	NP_009148	not classified	apoptosis	not classified	2
programmed cell death 2 isoform 1	PDCD2	1	NP_002589	cytoplasm nucleus	apoptosis	DNA binding metal ion binding protein binding zinc ion binding	2
programmed cell death 6	PDCD6	11	NP_037364	not classified	apoptosis induction of apoptosis by extracellular signals	calcium ion binding	1, 2
programmed cell death 6 interacting protein	PDCD6IP	42	NP_037506	cytosol	apoptosis protein transport	signal transducer activity	1, 2
Parkinson disease 7 domain containing 1	PDDC1	1	NP_872418	not classified	not classified	not classified	2
phosphodiesterase 8A isoform 2	PDE8A	1	NP_775656	not classified	cyclic nucleotide metabolism regulation of transcription, DNA- dependent two- component signal transduction system (phosphorelay)	hydrolase activity magensium ion binding manganese ion binding two- component response regulator activity 6- phosphofructokinase activity	2
pyridoxal kinase	PDXK	1	NP_003672	not classified	not classified	ATP binding metal ion binding nucleotide binding pyridoxal kinase activity transferase activity zinc ion binding	2
PDZ domain containing 1	PDZK1	16	NP_002605	not classified	drug transport	PDZ domain binding protein C- terminus binding	2
PDZK1 interacting protein 1	PDZK1IP1	4	NP_005755	extracellular region integral to membrane membrane	not classified	not classified	1, 2
prostatic binding protein	PEBP1	8	NP_002558	not classified	not classified	ATP binding lipid binding nucleotide binding phosphatidylethanolamine binding serine- type endopeptidase inhibitor activity	1, 2
penta- EF hand domain containing 1	PEF1	5	NP_036524	membrane	not classified	calcium ion binding protein binding	1, 2
Xaa- Pro dipeptidase	PEPD	1	NP_000276	not classified	amino acid metabolism collagen catabolism proteolysis	manganese ion binding metal ion binding metallocarboxypeptidase D activity X- Pro dipeptidase activity	2
phosphonoformate immuno- associated protein 5	PFAAP5	1	NP_055702	not classified	not classified	not classified	2
liver phosphofructokinase isoform b	PFKL	11	NP_002617	6- phosphofructokinase complex cytoplasm	fructose 6- phosphate metabolism glycolysis regulation of glycolysis	6- phosphofructokinase activity ATP binding kinase activity magnesium ion binding nucleotide binding transferase activity	2
liver phosphofructokinase isoform a	PFKL	6	NP_001002021	6- phosphofructokinase complex cytoplasm	fructose 6- phosphate metabolism glycolysis regulation of glycolysis	ATP binding kinase activity magnesium ion binding nucleotide binding trnasferase activity hydrolase activity	2
profilin 1	PFN1	5	NP_005013	actin cytoskeleton	actin cytoskeleton organization and biogenesis cytoskeleton organization and biogenesis	actin monomer binding	1, 2
profilin 2 isoform a	PFN2	1	NP_444252	actin cytoskeleton	actin cytoskeleton organization and biogenesis cytoskeleton organization and biogenesis regulation of actin polymerization and/or depolymerization	actin binding phosphatidylinositol- 4, 5- bisphosphate binding protein binding	1, 2
phosphogluconate dehydrogenase	PGD	6	NP_002622	not classified	electron transport pentose- phosphate shunt, oxidative branch	NADP binding oxidoreductase activity phosphogluconate dehydrogenase (decarboxylating) activity protein binding	2
6- phosphogluconolactonase	PGLS	4	NP_036220	not classified	carbohydrate metabolism pentose- phosphate shunt	6- phosphogluconolactonase activity hydrolase activity	1, 2
peptidoglycan recognition protein 1	PGLYRP1	1	NP_005082	extracellular region	defense response to Gram- positive bacterium detection of bacterium innate immune response peptidoglycan catabolism	bacterial binding N- acetylmuramoyl- L- alanine amidase activity peptidoglycan receptor activity protein binding	2
phosphoglucomutase 1	PGM1	2	NP_002624	cytoplasm	carbohydrate metabolism gluconeogenesis glucose metabolism glycolysis	intramolecular transferase activity, phosphotransferases isomerase activity magnesium ion binding phosphoglucomutase activity	2
PHD finger protein 15	PHF15	1	NP_056103	not classified	regulation of transcription, DNA- dependent	metal ion binding protein binding zinc ion binding	2
phosphoglycerate dehydrogenase	PHGDH	2	NP_006614	extracellular region	amino acid biosynthesis brain development L- serine biosynthesis metabolism transport	electron carrier activity NAD binding oxidoreductase activity oxidoreductase activity, acting on the CH- OH group of donors, NAD or NADP as acceptor phosphoglycerate dehydrogenase activity transporter activity	2
phosphohistidine phosphatase 1	PHPT1	2	NP_054891	cytoplasm cytosol	dephosphorylation	phosphohistidine phosphatase activity phosphoprotein phosphatase activity kinase activity	2
polymeric immunoglobulin receptor	PIGR	17	NP_002635	integral to plasma membrane membrane	protein secretion	protein transporter activity	1, 2
phosphoinositide- 3- kinase, class 2, alpha polypeptide	PIK3C2A	1	NP_002636	nucleus phosphoinositide 3- kinase complex	intracellular signaling cascade phosphatidylinositol biosynthesis	inositol or phosphatidylinositol kinase activity phosphatidylinositol 3- kinase activity phosphatidylinositol- 4- phosphate 3- kinase activity phosphoinositide binding protein binding transferase activity	2
phosphoinositide- 3- kinase, class 2, beta polypeptide	PIK3C2B	1	NP_002637	cytosol microsome nucleus phosphoinositide 3- kinase complex plasma membrane	intracellular signaling cascade	inositol or phosphatidylinositol kinase activity kinase activity phosphatidylinositol 3- kinase activity phosphatidylinositol- 4- phosphate 3- kinase activity phosphoinositide binding phosphotransferase activity, alcohol group as acceptor protein binding tran	1
prolactin- induced protein	PIP	2	NP_002643	extracellular region	not classified	actin binding	2
phosphatidylinositol- 5- phosphate 4- kinase, type II, gamma	PIP4K2C	1	NP_079055	not classified	not classified	kinase activity magnesium ion binding	2
polycystin 1 isoform 1 precursor	PKD1	1	NP_001009944	extracellular matrix (sensu Metazoa) integral to membrane integral to plasma membrane membrane	calcium- independent cell- matrix adhesion homophilic cell adhesion morphogenesis neuropeptide signaling pathway	sugar binding transferase activity	1, 2
polycystin 1- like 3	PKD1L3	1	NP_853514	integral to membrane membrane	cation transport neuropeptide signaling pathway	calcium ion binding cation channel activity	2
polycystin 2	PKD2	1	NP_000288	actin cytoskeleton basal body integral to membrane membrane plasma membrane	cation transport cell- matrix adhesion organ morphogenesis	calcium ion binding cytoskeletal protein binding ion channel activity protein C- terminus binding voltage- gated chloride channel activity voltage- gated sodium channel activity	2
polyductin isoform 2	PKHD1	6	NP_733842	anchored to external side of plasma membrane apical plasma membrane basal body integral to membrane membrane	cell- cell adhesion homeostasis negative regulation of cell motility	protein binding receptor activity	2
pyruvate kinase, liver and RBC isoform 1	PKLR	1	NP_000289	not classified	glycolysis	magnesium ion binding pyruvate kinase activity	2
pyruvate kinase, liver and RBC isoform 2	PKLR	1	NP_870986	not classified	glycolysis	pyruvate kinase activity magnesium ion binding	2
pyruvate kinase 3 isoform 2	PKM2	17	NP_872270	cytoplasm cytosol	glycolysis	magnesium ion binding protein binding pyruvate kinase activity transferase activity	2
phospholipase C, delta 1	PLCD1	8	NP_006216	not classified	intracellular signaling cascade lipid catabolism lipid metabolism phospholipid metabolism	calcium ion binding hydrolase activity phosphoinositide phospholipase C activity signal transducer activity	2
phospholipase D3 isoform 1	PLD3	1	NP_001026866	membrane	metabolism	catalytic activity	2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	PLEKHA1	1	NP_001001974	membrane nucleus	not classified	phospholipid binding	2
pleckstrin homology domain containing, family A member 7	PLEKHA7	1	NP_778228	not classified	not classified	not classified	2
lysyl hydroxylase precursor	PLOD1	1	NP_000293	endoplasmic reticulum membrane	electron transport epidermis development hydroxylysine biosynthesis protein metabolism protein modification	iron ion binding L- ascorbic acid binding metal ion binding oxidoreductase activity procollagen- lysine 5- dioxygenase activity protein homodimerization activity	2
procollagen- lysine, 2- oxoglutarate 5- dioxygenase 3 precursor	PLOD3	1	NP_001075	endoplasmic reticulum membrane	protein metabolism protein modification	iron ion binding L- ascorbic acid binding metal ion binding oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen procollagen- lysine 5- dioxygenase activity prot	2
plastin 1	PLS1	1	NP_002661	actin cytoskeleton brush border	not classified	actin filament binding calcium ion binding structural constituent of cytoskeleton	2
phospholipid scramblase 1	PLSCR1	2	NP_066928	integral to membrane plasma membrane	phospholipid scrambling platelet activation response to virus	calcium ion binding phospholipid scramblase activity protein binding	1, 2
phosphomevalonate kinase	PMVK	1	NP_006547	cytoplasm peroxisome	cholesterol biosynthesis lipid metabolism protein amino acid phosphorylation	phosphomevalonate kinase activity transferase activity	2
podocalyxin- like precursor isoform 2	PODXL	8	NP_005388	integral to plasma membrane membrane	not classified	not classified	2
phosphatidic acid phosphatase type 2A isoform 2	PPAP2A	2	NP_795714	integral to plasma membrane membrane fraction plasma membrane	androgen receptor signaling pathway germ cell migration negative regulation of cell proliferation phospholipid dephosphorylation protein kinase C activation regulation of lipid metabolism	hydrolase activity phosphatidate phosphatase activity	2
PTPRF interacting protein alpha 2	PPFIA2	1	NP_003616	cytoplasm	cell- matrix adhesion	protein binding	2
peptidylprolyl isomerase A	PPIA	5	NP_066953	not classified	protein folding regulation of viral genome replication	isomerase activity peptide binding peptidyl- prolyl cis- trans isomerase activity unfolded protein binding virion binding	2
peptidylprolyl isomerase B precursor	PPIB	1	NP_000933	ndoplasmic reticulum endoplasmic reticulum lumen	protein folding	isomerase activity peptide binding peptidyl- prolyl cis- trans isomerase activity unfolded protein binding	2
periplakin	PPL	18	NP_002696	cytoskeleton	keratinization	protein binding structural constituent of cytoskeleton	2
protein phosphatase 1, regulatory subunit 7	PPP1R7	1	NP_002703	cytoplasm nucleus	not classified	transferase activity oxidoreductase activity	2
prolylcarboxypeptidase isoform 2 preproprotein	PRCP	1	NP_955450	lysosome	proteolysis	serine- type peptidase activity serine- type Pro- X carboxypeptidase activity	2
peroxiredoxin 5 precursor, isoform a	PRDX5	2	NP_036226	mitochondrion peroxisome	inflammatory response response to oxidative stress	oxidoreductase activity peroxiredoxin activity	2
peroxiredoxin 5 precursor, isoform c	PRDX5	2	NP_857635	mitochondrion perosixome	inflammatory response response to oxidative stress	oxidoreductase activity peroxiredoxin activity	2
peroxiredoxin 5 precursor, isoform b	PRDX5	1	NP_857634	mitochondrion peroxisome	regulation of apoptosis response to oxidative stress	peroxiredoxin activity ATP binding	2
peroxiredoxin 6	PRDX6	7	NP_004896	cytosol lysosome	lipid catabolism phospholipid catabolism response to oxidative stress	hydrolase activity oxidoreductase activity peroxiredoxin activity phospholipase A2 activity	1, 2
cAMP- dependent protein kinase, regulatory subunit alpha 2	PRKAR2A	1	NP_004148	cAMP- dependent protein kinase complex cytoplasm membrane fraction plasma membrane	intracellular signaling cascade protein amino acid phosphorylation signal transduction	cAMP binding cAMP- dependent protein kinase regulator activity kinase activity nucleotide binding	2
protein kinase C, alpha	PRKCA	1	NP_002728	membrane fraction	cell surface receptor linked signal transduction induction of apoptosis by extracellular signals intracellular signaling cascade protein amino acid phosphorylation regulation of progression through cell cycle	ATP binding calcium ion binding diacylglycerol binding nucleotide binding protein binding protein kinase C activity transferase activity zinc ion binding	2
protein kinase C, delta	PRKCD	1	NP_006245	cytoplasm membrane nucleus	intracellular signaling cascade protein amino acid phosphorylation protein stabilization	ATP binding diacylglycerol binding diacylglycerol- activated phospholipid- dependent protein kinase C activity enzyme activator activity enzyme binding metal ion binding nucleotide binding protein C- terminus binding protein serine/threonine kinase activity	2
protein kinase C, eta	PRKCH	1	NP_006246	not classified	intracellular signaling cascade protein amino acid phosphorylation	ATP binding diacylglycerol binding metal ion binding nucleotide binding protein kinase C activity transferase activity zinc ion binding	2
protein kinase C, iota	PRKCI	1	NP_002731	cytosol nucleus polarisome	cytoskeleton organization and biogenesis establishment and/or maintenance of epithelial cell polarity intercellular junction assembly and maintenance intracellular signaling cascade membrane organization and biogenesis protein amino acid phosphorylation p	ATP binding atypical protein kinase C activity diacylglycerol binding metal ion binding nucleotide binding phospholipid binding protein binding protein serine/threonine kinase activity transferase activity zinc ion binding	2
protein kinase C, zeta isoform 1	PRKCZ	1	NP_002735	cytoplasm membrane fraction plasma membrane	anti- apoptosis intracellular signaling cascade protein amino acid phosphorylation	ATP binding atypical protein kinase C activity diacylglycerol binding metal ion binding nucleotide binding protein binding protein serine/threonine kinase activity transferase activity zinc ion binding	2
protein kinase C, zeta isoform 2	PRKCZ	1	NP_001028754	cytoplasm membrane fraction plasma membrane	anti- apoptosis intracellular signaling cascade protein amino acid phosphorylation	atypical protein kinase C activity diacylglycerol binding metal ion binding nucleotide binding protein binding protien serine/threonine kinase activity transferase activity zinc ion binding copper ion binding	2
PRKR interacting protein 1 (IL11 inducible)	PRKRIP1	1	NP_078929	not classified	not classified	not classified	2
prion protein preproprotein	PRNP	1	NP_898902	cytoplasm endoplasmic reticulum extrinsic to membrane Golgi apparatus lipid raft plasma membrane	copper ion homeostasis metabolism response to oxidative stress	copper ion binding GPI anchor binding microtubule binding	2
prominin 1	PROM1	23	NP_006008	integral to plasma membrane membrane	response to stimulus visual perception	not classified	1, 2
prominin 2	PROM2	18	NP_653308	integral to membrane	not classified	not classified	2
protein Z, vitamin K- dependent plasma glycoprotein	PROZ	4	NP_003882	extracellular region extracellular space	blood coagulation proteolysis	calcium ion binding protein binding serine- type endopeptidase activity	2
prostasin preproprotein	PRSS8	4	NP_002764	extracellular region extracellular space integral to membrane plasma membrane	proteolysis	serine- type endopeptidase activity	2
proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)	PRTN3	1	NP_002768	not classified	collagen catabolism positive regulation of cell proliferation proteolysis	protein binding serine- type endopeptidase activity	2
prosaposin isoform a preproprotein	PSAP	3	NP_002769	extracellular space integral to membrane lysosome	glycosphingolipid metabolism lipid metabolism lipid transport lysosome organization and biogenesis sphingolipid metabolism	alpha- galactosidase activity beta- galactosidase activity cerebroside- sulfatase activity enzyme activator activity galactosylceramidase activity glucosylceramidase activity lipid binding sphingomyelin phosphodiesterase activity	1, 2
prosaposin isoform c preproprotein	PSAP	1	NP_001035931	extracellular space integral to membrane lysosome	glycosphingolipid metabolism lipid metabolism lipid transport lysosome organization and biogenesis sphingolipid metabolism	beta- galactosidase activity cerebroside- sulfatase activity enzyme activator activity galactosylceramidase activity glucosylceramidase activity lipid binding sphingomyelin phosphodiesterase activity phosphoserine transaminase activity	2
phosphoserine aminotransferase isoform 1	PSAT1	2	NP_478059	not classified	amino acid biosynthesis L- serine biosynthesis metabolism pyridoxine biosynthesis	transferase activity RNA binding	2
prostate stem cell antigen preproprotein	PSCA	1	NP_005663	plasma membrane	not classified	GPI anchor binding	1, 2
proteasome alpha 1 subunit isoform 1	PSMA1	2	NP_683877	cytosol nucleus polysome proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	threonine endopeptidase activity	2
proteasome alpha 2 subunit	PSMA2	2	NP_002778	cytosol proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	threonine endopeptidase activity	2
proteasome alpha 3 subunit isoform 2	PSMA3	1	NP_687033	cytoplasm cytosol nucleus proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	protein binding threonine endopeptidase activity	2
proteasome alpha 4 subunit	PSMA4	1	NP_002780	cytosol proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	threonine endopeptidase activity	2
proteasome alpha 5 subunit	PSMA5	2	NP_002781	cytosol proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	hydrolase activity, acting on ester bonds	2
proteasome beta 1 subunit	PSMB1	1	NP_002784	cytosol proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	protein binding threonine endopeptidase activity	2
proteasome beta 2 subunit	PSMB2	1	NP_002785	cytosol nucleus proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	peptidase activity threonine endopeptidase activity	2
proteasome beta 3 subunit	PSMB3	4	NP_002786	cytosol nucleus proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	threonine endopeptidase activity	1, 2
proteasome beta 5 subunit	PSMB5	3	NP_002788	cytosol proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	protein binding threonine endopeptidase activity	2
proteasome beta 6 subunit	PSMB6	1	NP_002789	cytosol proteasome core complex (sensu Eukaryota)	ubiquitin- dependent protein catabolism	threonine endopeptidase activity	2
proteasome 26S ATPase subunit 5	PSMC5	1	NP_002796	cytoplasm cytosol nucleus proteasome complex (sensu Eukaryota)	negative regulation of programmed cell death positive regulation of gene- specific transcription proteasomal ubiquitin- dependent protein catabolism protein catabolism	ATP binding ATPase activity hydrolase activity nucleotide binding thyrotropin- releasing hormone receptor binding transcription factor binding	2
proteasome 26S ATPase subunit 6	PSMC6	1	NP_002797	cytoplasm cytosol nucleus proteasome complex (sensu Eukaryota)	protein catabolism ubiquitin- dependent protein catabolism	ATP binding ATPase activity hydrolase activity nucleic acid binding nucleotide binding protein binding, bridging	2
proteasome 26S non- ATPase subunit 12	PSMD12	1	NP_002807	cytosol proteasome regulatory particle (sensu Eukaryota)	not classified	not classified	2
proteasome 26S non- ATPase subunit 3	PSMD3	1	NP_002800	cytosol proteasome complex (sensu Eukaryota) protein complex	not classified	binding	2
proteasome activator subunit 2	PSME2	1	NP_002809	cytosol proteasome activator complex proteasome complex (sensu Eukaryota)	immune response	proteasome activator activity	2
polypyrimidine tract- binding protein 1 isoform a	PTBP1	1	NP_002810	heterogeneous nuclear ribonucleoprotein complex nucleolus nucleoplasm nucleus	nuclear mRNA splicing, via spliceosome RNA splicing	nucleic acid binding nucleotide binding poly- pyrimidine tract binding protein binding RNA binding	1
phosphotriesterase related	PTER	2	NP_109589	not classified	catabolism	hydrolase activity, acting on ester bonds metal ion binding zinc ion binding	2
protein tyrosine phosphatase type IVA, member 2 isoform 2	PTP4A2	1	NP_536317	membrane	protein amino acid dephosphorylation	prenylated protein tyrosine phosphatase activity hydrolase activity	2
protein tyrosine phosphatase, non- receptor type 13 isoform 4	PTPN13	9	NP_542416	cytoplasm cytoskeleton	protein amino acid dephosphorylation	hydrolase activity non- membrane spanning protein tyrosine phosphatase activity protein binding structural molecule activity	2
protein tyrosine phosphatase, non- receptor type 23	PTPN23	4	NP_056281	not classified	protein amino acid dephosphorylation	hydrolase activity protein tyrosine phosphatase activity	2
protein tyrosine phosphatase, non- receptor type 6 isoform 3	PTPN6	1	NP_536859	cytoskeleton membrane	apoptosis G- protein coupled receptor protein signaling pathway intracellular signaling cascade negative regulation of cell proliferation protein amino acid dephosphorylation	hydrolase activity protein binding protein tyrosine phosphatase activity	2
protein tyrosine phosphatase, receptor type, J precursor	PTPRJ	1	NP_002834	integral to plasma membrane membrane	cell- cell signaling protein amino acid dephosphorylation transmembrane receptor protein tyrosine kinase signaling pathway	hydrolase activity transmembrane receptor protein tyrosine phosphatase activity	1, 2
receptor- type protein tyrosine phosphatase O isoform d precursor	PTPRO	2	NP_109595	integral to membrane integral to plasma membrane membrane	protein amino acid dephosphorylation	hydrolase activity protein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity	2
receptor- type protein tyrosine phosphatase O isoform c precursor	PTPRO	2	NP_109596	integral to membrane integral to plasma membrane membrane	protein amino acid dephosphorylation	protein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity not classified	2
pituitary tumor- transforming gene 1 protein- interacting protein precursor	PTTG1IP	1	NP_004330	cytoplasm integral to membrane membrane nucleus	development protein import into nucleus	GTP binding	2
quinoid dihydropteridine reductase	QDPR	1	NP_000311	cytoplasm	amino acid metabolism dihydrobiopterin metabolism L- phenylalanine catabolism metabolism tetrahydrobioprotein biosynthesis	6, 7- dihydropteridine reductase activity electron carrier activity	2
ras- related GTP- binding protein RAB10	RAB10	10	NP_057215	membrane	protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	1, 2
RAB13, member RAS oncogene family	RAB13	2	NP_002861	intracellular tight junction	cell adhesion protein transport regulation of transcription, DNA- dependent small GTPase mediated signal transduction vesicle- mediated transport	ATP binding GTP binding GTPase activity nucleotide binding transcription factor binding	1, 2
GTPase Rab14	RAB14	6	NP_057406	cytosol early endosome Golgi stack intracellular late endosome lysosome membrane fraction nuclear envelope- endoplasmic reticulum network perinuclear region plasma membrane rough endoplasmic reticulum trans- Golgi network transport vesicle	Golgi to endosome transport intracellular transport neurotransmitter secretion protein transport small GTPase mediated signal transduction vesicle- mediated transport	GTP binding GTPase activity nucleotide binding	1, 2
RAB15, member RAS onocogene family	RAB15	1	NP_941959	membrane	protein transport small GTPase mediated signal transduction	nucleotide binding GTP binding	2
RAB17, member RAS oncogene family	RAB17	1	NP_071894	intracellular membrane	protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	2
GTP- binding protein RAB19B	RAB19B	1	NP_001008749	not classified	small GTPase mediated signal transduction	GTP binding nucleotide binding	2
RAB2, member RAS oncogene family	RAB2	6	NP_002856	endoplasmic reticulum	ER to Golgi vesicle- mediated transport protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	1, 2
RAB21, member RAS oncogene family	RAB21	2	NP_055814	endosome	protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	1, 2
RAS- related protein RAB- 22A	RAB22A	6	NP_065724	early endosome plasma membrane	endocytosis endosome organization and biogenesis protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein binding	2
RAB25	RAB25	1	NP_065120	membrane	protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	2
Ras- related protein Rab- 27A	RAB27A	1	NP_004571	not classified	protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding	2
RAB33B, member RAS oncogene family	RAB33B	1	NP_112586	Golgi apparatus	protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	1
RAB39	RAB34	1	NP_114140	membrane	protein transport small GTPase mediated signal transduction	nucleotide binding GTP binding	2
RAB35, member RAS oncogene family	RAB35	4	NP_006852	membrane	protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding	1, 2
RAB3B, member RAS oncogene family	RAB3B	2	NP_002858	membrane	protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding	1, 2
RAB3D, member RAS oncogene family	RAB3D	1	NP_004274	membrane	exocytosis hemocyte development (sensu Arthropoda) protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein binding	1, 2
RAB3 GTPase- activating protein	RAB3GAP1	1	NP_036365	soluble fraction	regulation of GTPase activity	Rab GTPase binding GTP binding	2
RAB43 protein	RAB43	1	NP_940892	exosome (RNase complex) membrane	intracellular protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	2
RAB5B, member RAS oncogene family	RAB5B	5	NP_002859	endosome intracellular	protein transport small GTPase mediated signal transduction	GTP binding GTP- dependent protein binding nucleotide binding	1, 2
RAB5C, member RAS oncogene family isoform a	RAB5C	5	NP_958842	not classified	protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding	2
RAB7, member RAS oncogene family	RAB7	9	NP_004628	late endosome lysosome	endocytosis protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding	1, 2
RAB7, member RAS oncogene family- like 1	RAB7L1	4	NP_003920	membrane	protein transport small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein binding	2
mel transforming oncogene	RAB8A	5	NP_005361	membrane	protein transport small GTPase mediated signal transduction	GTP binding nucleotide binding	1, 2
RAB8B, member RAS oncogene family	RAB8B	2	NP_057614	intracellular membrane	protein transport regulation of transcription, DNA- dependent small GTPase mediated signal transduction	ATP binding GTP binding GTPase activity nucleotide binding transcription factor binding	1, 2
ras- related C3 botulinum toxin substrate 1 isoform Rac1	RAC1	6	NP_008839	intracellular	actin filament polymerization lamellipodium biogenesis negative regulation of receptor mediated endocytosis positive regulation of Rho protein signal transduction ruffle organization and biogenesis small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein binding	1
ras related v- ral simian leukemia viral oncogene homolog A	RALA	2	NP_005393	intracellular membrane	chemotaxis signal transduction small GTPase mediated signal transduction	GTP binding nucleotide binding protein binding	2
ras- related nuclear protein	RAN	2	NP_006316	chromatin cytoplasm exosome (RNase complex) nuclear pore nucleus	androgen receptor signaling pathway DNA metabolism intracellular protein transport mitosis mitotic spindle organization and biogenesis positive regulation of transcription, DNA- dependent protein export from nucleus regulation of progression through cell c	androgen receptor binding chromatin binding GTP binding GTPase activity nucleotide binding protein binding transcription coactivator activity	2
RAP1B, member of RAS oncogene family	RAP1B	5	NP_056461	intracellular membrane	small GTPase mediated signal transduction	GTP binding nucleotide binding	1
RAP1, GTP- GDP dissociation stimulator 1	RAP1GDS1	1	NP_066982	not classified	not classified	binding GTPase activator activity	2
RAP2B, member of RAS oncogene family	RAP2B	1	NP_002877	intracellular membrane	small GTPase mediated signal transduction	GTP binding nucleotide binding	2
RAP2C, member of RAS oncogene family	RAP2C	1	NP_067006	intracellular membrane	small GTPase mediated signal transduction	nucleotide binding intracellular transporter activity	2
RAP guanine- nucleotide- exchange factor 3	RAPGEF3	2	NP_006096	cAMP- dependent protein kinase complex intracellular membrane fraction	cell proliferation protein amino acid phosphorylation regulation of small GTPase mediated signal transduction	cAMP binding cAMP- dependent protein kinase regulator activity guanyl- nucleotide exchange factor activity nucleotide binding	2
arginyl- tRNA synthetase	RARS	1	NP_002878	cytoplasm soluble fraction	arginyl- tRNA aminoacylation protein biosynthesis	arginine- tRNA ligase activity ATP binding ligase activity nucleotide binding	2
retinoblastoma- like 2 (p130)	RBL2	1	NP_005602	nucleus	cell cycle negative regulation of progression through cell cycle regulation of lipid kinase activity regulation of transcription, DNA- dependent transcription	DNA binding protein binding	2
RNA binding motif protein 3 isoform a	RBM3	1	NP_006734	not classified	RNA processing	nucleic acid binding nucleotide binding RNA binding	1
retinol- binding protein 4, plasma precursor	RBP4	2	NP_006735	extracellular region extracellular space	response to stimulus transport visual perception	binding retinal binding retinol binding transporter activity	2
retinol binding protein 5, cellular	RBP5	1	NP_113679	cytoplams	transport	intracellular transporter activity lipid binding retinal binding retinol binding	1, 2
radixin	RDX	16	NP_002897	actin cytoskeleton cytoplasm plasma membrane	barbed- end actin filament capping cytoskeletal anchoring	actin binding binding structural molecule activity	1, 2
renin binding protein	RENBP	1	NP_002901	intracellular	blood pressure regulation mannose metabolism	endopeptidase inhibitor activity isomerase activity mannose- 6- phosphate isomerase activity N- acylglucosamine 2- epimerase activity	2
replication factor C large subunit	RFC1	1	NP_002904	DNA replication factor C complex intracellular nucleus	DNA- dependent DNA replication regulation of transcription, DNA- dependent telomere maintenance via telomerase transcription	DNA binding enzyme activator activity metal ion binding nucleoside- triphosphatase activity nucleotide binding protein binding zinc ion binding methyltransferase activity	2
RNA (guanine- 9- ) methyltransferase domain containing 2	RG9MTD2	1	NP_689505	not classified	tRNA processing	RNA binding tranferase activity tRNA methyltransferasea activity GTP binding	2
Rhesus blood group, C glycoprotein	RHCG	5	NP_057405	apical plasma membrane integral to plasma membrane plasma membrane	amine transport ammonium transport cell ion homeostasis epithelial cell differentiation homeostasis	ammonium transporter activity	1, 2
Ras homolog enriched in brain	RHEB	1	NP_005605	intracellular membrane	signal transduction small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding	2
ras homolog gene family, member A	RHOA	4	NP_001655	cytoskeleton intracellular membrane	actin cytoskeleton organization and biogenesis positive regulation of I- kappaB kinase/NF- kappaB cascade positive regulation of NF- kappaB import into nucleus Rho protein signal transduction small GTPase mediated signal transduction	GTP binding GTPase activity magnesium ion binding nucleotide binding protein binding signal transducer activity	1, 2
ras homolog gene family, member B	RHOB	1	NP_004031	endosome membrane intracellular nucleus plasma membrane	angiogenesis cell adhesion cell cycle cell differentiation endosome to lysosome transport negative regulation of progression through cell cycle positive regulation of angiogenesis protein transport small GTPase mediated signal transduction transformed cel	GTP binding nucleotide binding protein binding	2
ras homolog gene family, member C precursor	RHOC	1	NP_786886	intracellular membrane	positive regulation of I- kappaB kinase/NF- kappaB cascade small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding signal transducer activity	2
ras homolog gene family, member F	RHOF	1	NP_061907	cytoskeleton intracellular membrane	actin filament organization small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding	2
ras homolog gene family, member G	RHOG	5	NP_001656	intracellular membrane	positive regulation of cell proliferation regulation of progression through cell cycle Rho protein signal transduction	GTP binding GTPase activity nucleotide binding protein binding	1, 2
ribonuclease, RNase A family, 2 (liver, eosinophil- derived neurotoxin)	RNASE2	1	NP_002925	extracellular region	chemotaxis RNA catabolism	endonuclease activity hydrolase activity nucleic acid binding pancreatic ribonuclease activity ribonuclease activity	1
ring finger protein 11	RNF11	1	NP_055187	ubiquitin ligase complex	protein ubiquitination during ubiquitin- dependent protein catabolism	DNA binding metal ion binding protein binding zinc ion binding	1, 2
ring finger protein 213	RNF213	1	NP_065965	not classified	not classified	protein binding zinc ion binding protein binding	2
ribonuclease/angiogenin inhibitor	RNH1	4	NP_976318	not classified	mRNA catabolism regulation of angiogenesis	protein binding ribonuclease inhibitor activity transferase activity	2
arginyl aminopeptidase (aminopeptidase B)	RNPEP	4	NP_064601	extracellular region Golgi apparatus plasma membrane	protein processing proteolysis	aminopeptidase B activity epoxide hydrolase activity membrane alanyl aminopeptidase activity metal ion binding zinc ion binding	2
roundabout, axon guidance receptor, homolog 2	ROBO2	1	NP_002933	cell surface integral to membrane membrane	brain development cell adhesion cell differentiation chemotaxis homophilic cell adhesion positive regulation of axonogenesis ureteric bud development	axon guidance receptor activity identical protein binding	2
XRP2 protein	RP2	3	NP_008846	not classified	beta- tubulin folding CTP biosynthesis GTP biosynthesis response to stimulus UTP biosynthesis visual perception	ATP binding nucleoside diphosphate kinase activity unfolded protein binding	2
ribosomal protein S11	RPS11	1	NP_001006	cytosolic small ribosomal subunit (sensu Eukaryota) intracellular ribosome	protein biosynthesis	rRNA binding structural constituent of ribosome	2
ribosomal protein S18	RPS18	2	NP_072045	cytosolic small ribosomal subunit (sensu Eukaryota) intracellular	protein biosynthesis	rRNA binding structural constituent of ribosome	2
related RAS viral (r- ras) oncogene homolog	RRAS	4	NP_006261	intracellular	Ras protein signal transduction	GTP binding GTPase activity nucleotide binding	2
related RAS viral (r- ras) oncogene homolog 2	RRAS2	4	NP_036382	intracellular membrane	small GTPase mediated signal transduction	GTP binding nucleotide binding protein binding	1, 2
ras responsive element binding protein 1 isoform 1	RREB1	1	NP_001003699	cytoplasm intracellular nuclear body nucleus	development Ras protein signal transduction regulation of transcription, DNA- dependent transcription transcription from RNA polymerase II promoter	DNA binding metal ion binding nucleic acid binding transcriptional activator activity zinc ion binding	2
RUN and SH3 domain containing 2	RUSC2	1	NP_055621	not classified	not classified	not classified	2
skeletal muscle ryanodine receptor isoform 1	RYR1	1	NP_000531	integral to plasma membrane membrane smooth endoplasmic reticulum	calcium ion homeostasis calcium ion transport ion transport muscle contraction	calcium ion binding calcium- release channel activity ion channel activity receptor activity ryanodine- sensitive calcium- release channel activity	2
S100 calcium binding protein A10	S100A10	1	NP_002957	not classified	not classified	calcium ion binding	2
S100 calcium binding protein A14	S100A14	2	NP_065723	not classified	not classified	calcium ion binding	2
S100 calcium binding protein A16	S100A16	1	NP_525127	not classified	not classified	calcium ion binding	1, 2
S100 calcium- binding protein A4	S100A4	1	NP_002952	not classified	not classified	calcium ion binding	2
S100 calcium- binding protein A6	S100A6	2	NP_055439	cytoplasm nuclear envelope nucleus ruffle	axonogenesis cell cycle cell proliferation cell- cell signaling positive regulation of fibroblast proliferation regulation of progression through cell cycle signal transduction	calcium ion binding calcium- dependent protein binding growth factor activity protein homodimerization activity S100 beta binding	1, 2
S100 calcium- binding protein A8	S100A8	6	NP_002955	extracellular space	inflammatory response	calcium ion binding	2
S100 calcium- binding protein A9	S100A9	7	NP_002956	extracellular space	cell- cell signaling inflammatory response	calcium ion binding signal transducer activity	2
S100 calcium binding protein P	S100P	1	NP_005971	cytoplasm nucleus	endothelial cell migration	calcium ion binding calcium- dependent protein binding magnesium ion binding	1, 2
sorting and assembly machinery component 50 homolog	SAMM50	1	NP_056195	integral to membrane membrane mitochondrion outer membrane	not classified	not classified	1, 2
spermidine/spermine N1- acetyltransferase 2	SAT2	1	NP_597998	not classified	not classified	diamine N- acetyltransferase activity N- acetyltransferase activity transferase activity metal ion binding	2
scavenger receptor class B, member 2	SCARB2	9	NP_005497	integral to plasma membrane lysosomal membrane membrane membrane fraction	cell adhesion	receptor activity	2
sciellin isoform b	SCEL	2	NP_659001	cornified envelope cytoplasm	embryonic development epidermis development keratinocyte differentiation	protein binding zinc ion binding sodium ion binding	2
scinderin	SCIN	3	NP_149119	cell cortex cytoplasm cytoskeleton	actin filament severing actin nucleation barbed- end actin filament capping calcium ion- dependent exocytosis negative regulation of cell proliferation positive regulation of apoptosis positive regulation of megakaryocyte differentiation positive regulation	actin filament binding calcium ion binding phosphatidylinositol binding phosphatidylinositol- 4, 5- bisphosphate binding phosphatidylserine binding	2
sodium channel, voltage- gated, type X, alpha	SCN10A	1	NP_006505	membrane membrane fraction voltage- gated sodium channel complex	ion transport sensory perception sodium ion transport synaptic transmission	sodium ion binding voltage- gated calcium channel activity voltage- gated sodium channel activity	2
sodium channel, voltage- gated, type XI, alpha	SCN11A	1	NP_054858	membrane membrane fraction voltage- gated sodium channel complex	ion transport response to drug sodium ion transport synaptic transmission	voltage- gated sodium channel activity dipeptidase activity	2
serine carboxypeptidase 1 precursor protein	SCPEP1	1	NP_067639	not classified	proteolysis	peptidase activity serine carboxypeptidase activity	2
secernin 2	SCRN2	1	NP_612364	not classified	proteolysis	cytoskeletal protein binding	2
syndecan 1 precursor	SDC1	1	NP_002988	integral to plasma membrane membrane	not classified	cytoskeletal protein binding	2
syntenin isoform 3	SDCBP	11	NP_001007070	adherens junction cytoskeleton endoplasmic reticulum interleukin- 5 receptor complex membrane nucleus	actin cytoskeleton organization and biogenesis intracellular signaling cascade metabolism protein targeting to membrane substrate- bound cell migration, cell extension synaptic transmission	cytoskeletal adaptor activity interleukin- 5 receptor binding neurexin binding oxidoreductase activity protein binding protein heterodimerization activity syndecan binding	2
syntenin isoform 1	SDCBP	16	NP_005616	adherens junction cytoskeleton endoplasmic reticulum interleukin- 5 receptor complex membrane nucleus	actin cytoskeleton organization and biogenesis intracellular signaling cascade metabolism protein targeting to membrane substrate- bound cell migration, cell extension synaptic transmission	interleukin- 5 receptor binding neurexin binding oxidoreductase activity protein binding protein heterodimerization activity syndecan binding cytoskeletal adaptor activity not classified	2
syndecan binding protein 2 isoform a	SDCBP2	1	NP_536737	cytoplasm plasma membrane	intracellular signaling cascade intracellular transport nervous system development	protein C- terminus binding protein heterodimerization activity protein homodimerization activity	2
SEC13 protein	SEC13L1	1	NP_899195	not classified	intracellular protein transport	not classified	2
SEC31- like 1 isoform 1	SEC31L1	1	NP_055748	COPII vesicle coat	ER to Golgi vesicle- mediated transport	not classified	1
secreted and transmembrane 1 precursor	SECTM1	2	NP_002995	extracellular space Golgi apparatus integral to membrane membrane	immune response mesoderm development	cytokine activity signal transducer activity	2
selenium binding protein 1	SELENBP1	5	NP_003935	not classified	not classified	selenium binding	2
tumor differentially expressed 2- like	SERINC2	1	NP_849196	membrane	phosphatidylserine metabolism positive regulation of transferase activity	not classified	2
developmentally regulated protein TPO1	SERINC5	1	NP_840060	membrane	phosphatidylserine metabolism positive regulation of transferase activity	protein binding	2
serine (or cysteine) proteinase inhibitor, clade A (alpha- 1 antiproteinase, antitrypsin), member 1	SERPINA1	4	NP_001002236	extracellular region extracellular space	acute- phase response	protein binding serine- type endopeptidase inhibitor activity	2
serpin peptidase inhibitor, clade A, member 3 precursor	SERPINA3	3	NP_001076	extracellular region intracellular	acute- phase response inflammatory response regulation of lipid metabolism	chymotrypsin inhibitor activity DNA binding protein binding	1, 2
serine (or cysteine) proteinase inhibitor, clade A (alpha- 1 antiproteinase, antitrypsin), member 4	SERPINA4	2	NP_006206	not classified	not classified	protein binding serine- type endopeptidase inhibitor activity	2
serine (or cysteine) proteinase inhibitor, clade A (alpha- 1 antiproteinase, antitrypsin), member 5	SERPINA5	12	NP_000615	extracellular region membrane protein complex	fusion of sperm to egg plasma membrane spermatogenesis	acrosin binding heparin binding serine- type endopeptidase inhibitor activity	1, 2
serine (or cysteine) proteinase inhibitor, clade A, member 7	SERPINA7	1	NP_000345	extracellular region extracellular space	not classified	binding serine- type endopeptidase inhibitor activity	2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1	SERPINB1	7	NP_109591	cytoplasm	not classified	serine- type endopeptidase inhibitor activity	2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13	SERPINB13	1	NP_036529	not classified	regulation of proteolysis response to UV	serine- type endopeptidase inhibitor activity	2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3	SERPINB3	3	NP_008850	not classified	not classified	serine- type endopeptidase inhibitor activity	2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6	SERPINB6	2	NP_004559	cytosol	not classified	protein binding serine- type endopeptidase inhibitor activity	2
serine (or cysteine) proteinase inhibitor, clade F (alpha- 2 antiplasmin, pigment epithelium derived factor), member 1	SERPINF1	2	NP_002606	extracellular region	cell proliferation development negative regulation of angiogenesis positive regulation of neurogenesis	serine- type endopeptidase inhibitor activity	2
complement component 1 inhibitor precursor	SERPING1	7	NP_000053	extracellular region	blood coagulation circulation complement activiation, classical pathway innate immune response	serine- type endopeptidase inhibitor activity	2
stratifin	SFN	4	NP_006133	cytoplasm extracellular space	cell proliferation negative regulation of protein kinase activity regulation of progression through cell cycle signal transduction	protein domain specific binding	1, 2
SFT2 domain containing 2	SFT2D2	1	NP_955376	integral to membrane membrane	protein transport	SH3/SH2 adaptor activity	2
SH3 domain binding glutamic acid- rich protein like	SH3BGRL	1	NP_003013	nucleus	not classified	glycine hydroxymethyltransferase activity	2
SH3 domain binding glutamic acid- rich protein like 3	SH3BGRL3	1	NP_112576	nucleus	not classified	not classified	2
SH3- domain binding protein 4	SH3BP4	1	NP_055336	nucleus	cell cycle endocytosis	signal transducer activity	2
serine hydroxymethyltransferase 1 (soluble) isoform 2	SHMT1	8	NP_683718	cytosol	glycine metabolism L- serine catabolism L- serine metabolism one- carbon compound metabolism	glycine hydroxymethyltransferase activity transferase activity	2
serine hydroxymethyltransferase 2 (mitochondrial)	SHMT2	1	NP_005403	mitochondrion	glycine metabolism L- serine metabolism one- carbon compound metabolism	transferase activity hydrolase activity	2
apical protein of Xenopus- like	SHROOM2	1	NP_001640	not classified	not classified	amiloride- sensitive sodium channel activity protein binding	2
cytosolic sialic acid 9- O- acetylesterase homolog	SIAE	1	NP_733746	lysosome	not classified	serine esterase activity sialate O- acetylesterase activity not classified	2
signal- regulatory protein alpha precursor	SIRPA	1	NP_001035112	integral to membrane plasma membrane	cell adhesion	sodium ion binding	2
sodium potassium chloride cotransporter 2	SLC12A1	25	NP_000329	integral to membrane membrane membrane fraction plasma membrane	chloride transport ion transport potassium ion transport sodium ion transport	potassium ion binding sodium ion binding sodium:potassium:chloride symporter activity symporter activity transporter activity	1, 2
solute carrier family 12 (sodium/chloride transporters), member 3	SLC12A3	28	NP_000330	integral to plasma membrane membrane membrane fraction	chloride transport ion transport sodium ion transport	sodium ion binding sodium:chloride symporter activity symporter activity transporter activity	1, 2
solute carrier family 12 (potassium/chloride transporters), member 9	SLC12A9	1	NP_064631	integral to membrane membrane	transport	cation:chloride symporter activity protein binding	2
solute carrier family 13 (sodium- dependent dicarboxylate transporter), member 2	SLC13A2	5	NP_003975	integral to plasma membrane membrane membrane fraction	ion transport sodium ion transport	low affinity sodium:dicarboxylate symporter activity sodium ion binding symporter activity transporter activity	2
solute carrier family 13 member 3 isoform a	SLC13A3	2	NP_073740	integral to membrane membrane	ion transport	sodium ion binding symporter activity transporter activity	2
solute carrier family 13 member 3 isoform b	SLC13A3	1	NP_001011554	integral to membrane membrane	ion transport sodium ion trasnport	symporter activity tranporter activity oligopeptide transporter activity	2
solute carrier family 15 (H+/peptide transporter), member 2	SLC15A2	1	NP_066568	integral to plasma membrane membrane	drug transport oligopeptide transport protein transport	peptide:hydrogen symporter activity protein binding symporter activity transporter activity organic cation transporter activity	2
solute carrier family 1, member 1	SLC1A1	3	NP_004161	integral to plasma membrane membrane membrane fraction	dicarboxylic acid transport glutamate transport synaptic transmission transport	L- glutamate transporter activity sodium:dicarboxylate symporter activity symporter activity	1, 2
solute carrier family 22 member 11	SLC22A11	2	NP_060954	integral to plasma membrane membrane	ion transport	sodium- independent organic anion transporter activity transporter activity	2
urate anion exchanger 1 isoform a	SLC22A12	1	NP_653186	apical plasma membrane brush border membrane integral to membrane plasma membrane	cell homeostasis transport urate transport	PDZ domain binding protein binding transporter activity urate transporter activity	2
organic cation transporter like 3	SLC22A13	1	NP_004247	integral to plasma membrane membrane membrane fraction	transport	transporter activity ATP binding	2
solute carrier family 22 member 2 isoform a	SLC22A2	2	NP_003049	integral to membrane integral to plasma membrane membrane membrane fraction	fluid secretion ion transport organic cation transport sodium ion transport transport	ATP binding ion transporter activity nucleotide binding organic cation transporter activity sodium ion binding symporter activity transporter activity	2
solute carrier family 22 member 5	SLC22A5	1	NP_003051	integral to membrane membrane	carnitine transport ion transport sodium ion transport transport	carnitine transporter activity ion transporter activity nucleotide binding sodium ion binding symporter activity transporter activity ATP binding	2
solute carrier family 22 member 6 isoform a	SLC22A6	1	NP_004781	integral to membrane integral to plasma membrane membrane membrane fraction	alpha- ketoglutarate transport ion transport organic anion transport sodium ion transport	ATP binding ion transporter activity nucleotide binding organic anion transporter activity sodium ion binding symporter activity	2
solute carrier family 22 member 6 isoform d	SLC22A6	1	NP_695010	integral to membrane integral to plasma membrane membrane membrane fraction	alpha- ketoglutarate transport ion transport organic anion transport sodium ion tranport	ion transporter activity nucleotide binding organic anion transporter activity sodium ion binding symporter activity nucleobase transporter activity	2
solute carrier family 22 member 8	SLC22A8	1	NP_004245	integral to membrane integral to plasma membrane membrane membrane fraction	ion transport organic anion transport sodium ion transport transport	nucleotide binding organic anion transporter activity sodium ion binding symporter activity transporter activity	2
solute carrier family 23 (nucleobase transporters), member 1 isoform b	SLC23A1	6	NP_689898	integral to plasma membrane membrane membrane fraction	ion transport nucleobase transport nucleobase, nucleoside, nucleotide and nucleic acid metabolism sodium ion transport	nucleobase transporter activity sodium ion binding symporter activity transporter activity	2
solute carrier family 23 (nucleobase transporters), member 1 isoform a	SLC23A1	4	NP_005838	integral to plasma membrane membrane membrane fraction	ion transport nucleobase transport nucleobase, nucleoside, nucleotide and nucleic acid metabolism sodium ion transport	sodium ion binding symporter activity transporter activity binding	2
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	SLC25A1	1	NP_005975	integral to membrane membrane mitochondrial inner membrane mitochondrion	mitochondrial citrate transport transport	citrate transporter activity transporter activity adenine transporter activity	2
solute carrier family 25 member 3 isoform b precursor	SLC25A3	1	NP_998776	integral to plasma membrane membrane mitochondrial inner membrane mitochondrion	generation of precursor metabolites and energy transport	binding phosphate carrier activity symporter activity	2
solute carrier family 26, member 11	SLC26A11	1	NP_775897	integral to membrane	transport	transporter activity	2
pendrin	SLC26A4	2	NP_000432	integral to membrane membrane	sensory perception of sound sulfate transport transport	chloride ion binding chloride transporter activity iodide transporter activity sulfate porter activity transporter activity	2
solute carrier family 27 (fatty acid transporter), member 2	SLC27A2	1	NP_003636	endoplasmic reticulum integral to membrane membrane peroxisomal matrix peroxisome	lipid metabolism metabolism very- long- chain fatty acid metabolism	catalytic activity ligase activity long- chain- fatty- acid- CoA ligase activity nucleotide binding	2
solute carrier family 2 (facilitated glucose/fructose transporter), member 5	SLC2A5	12	NP_003030	integral to membrane membrane plasma membrane	carbohydrate metabolism carbohydrate transport fructose transport glucose transport	fructose transporter activity glucose transporter activity sugar porter activity transporter activity	1, 2
solute carrier family 36 (proton/amino acid symporter), member 2	SLC36A2	7	NP_861441	not classified	not classified	not classified	2
solute carrier family 39 (metal ion transporter), member 5	SLC39A5	1	NP_775867	integral to membrane membrane	ion transport metal ion transport zinc ion transport	zinc ion binding calcium:sodium antiporter activity	2
solute carrier family 3, member 1	SLC3A1	14	NP_000332	integral to plasma membrane membrane membrane fraction	amino acid metabolism basic amino acid transport carbohydrate metabolism L- cystine transport transport	catalytic activity cation binding L- cystine transporter activity	2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform a	SLC3A2	10	NP_001012679	cell surface integral to membrane membrane	amino acid transport calcium ion transport carbohydrate metabolism cell growth tryptophan transport	calcium:sodium antiporter activity catalytic activity cation binding protein binding	2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 isoform c	SLC3A2	3	NP_002385	cell surface integral to membrane membrane	amino acid transport calcium ion transport carbohydrate metabolism cell growth tryptophan transport	catalytic activity cation binding protein binding not classified	2
CDW92 antigen	SLC44A1	1	NP_536856	integral to membrane membrane	transport	transporter activity	2
CTL2 protein	SLC44A2	18	NP_065161	integral to membrane membrane	positive regulation of I- kappaB kinase/NF- kappaB cascade transport	signal transducer activity	1, 2
NG22 protein isoform 1	SLC44A4	6	NP_079533	integral to membrane membrane	not classified	not classified	1, 2
solute carrier family 4, anion exchanger, member 1	SLC4A1	2	NP_000333	cortical cytoskeleton integral to plasma membrane membrane	anion transport cell ion homeostasis	anion transporter activity inorganic anion exchanger activity protein binding	2
solute carrier family 4, sodium bicarbonate cotransporter, member 4	SLC4A4	2	NP_003750	integral to membrane membrane	anion transport sodium ion transport	inorganic anion exchanger activity sodium ion binding symporter activity	2
solute carrier family 5 (sodium/glucose cotransporter), member 1	SLC5A1	2	NP_000334	integral to plasma membrane membrane	glucose transport ion transport sodium ion transport	glucose:sodium symporter activity sodium ion binding sugar porter activity symporter activity transporter activity	2
solute carrier family 5 (sodium/glucose cotransporter), member 10 isoform 1	SLC5A10	2	NP_689564	integral to membrane membrane	ion transport sodium ion transport	transporter activity	2
solute carrier family 5 (sodium/glucose cotransporter), member 10 isoform 2	SLC5A10	1	NP_001035915	integral to membrane membrane	ion transport sodium ion trasnport	transporter activity	2
solute carrier family 5 (sodium/glucose cotransporter), member 12 isoform 2	SLC5A12	2	NP_848593	integral to membrane membrane	ion transport sodium ion transport transport	transporter activity	2
solute carrier family 5 (sodium/glucose cotransporter), member 2	SLC5A2	4	NP_003032	integral to membrane membrane	carbohydrate metabolism ion transport sodium ion transport	low- affinity glucose:sodium symporter activity sodium ion binding sugar porter activity symporter activity transporter activity	2
solute carrier family 5 (iodide transporter), member 8	SLC5A8	1	NP_666018	integral to membrane membrane	ion transport sodium ion transport	transporter activity	2
solute carrier family 5 (sodium/glucose cotransporter), member 9	SLC5A9	1	NP_001011547	integral to membrane membrane	ion transport sodium ion trasnport	protein binding	2
solute carrier family 6 (neurotransmitter transporter, GABA), member 13	SLC6A13	1	NP_057699	integral to plasma membrane membrane	neurotransmitter transport	gamma- aminobutyric acid:sodium symporter activity neurotransmitter:sodium symporter activity symporter activity	2
solute carrier family 6, member 19	SLC6A19	4	NP_001003841	integral to plasma membrane membrane	amino acid transport neurotransmitter transport	amino acid transporter activity neurotransmitter:sodium symporter activity symporter activity	2
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3	SLC9A3	2	NP_004165	integral to membrane membrane	ion transport regulation of pH sodium ion transport	antiporter activity sodium ion binding sodium:hydrogen antiporter activity solute:hydrogen antiporter activity	2
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1	SLC9A3R1	4	NP_004243	actin cytoskeleton	protein complex assembly Wnt receptor signaling pathway	beta- 2 adrenergic receptor binding protein binding sodium:hydrogen antiporter regulator activity	1, 2
solute carrier family 9 isoform 3 regulator 2	SLC9A3R2	1	NP_004776	nucleus plasma membrane	intracellular signaling cascade protein complex assembly	ATP binding	2
solute carrier organic anion transporter family, member 4C1	SLCO4C1	2	NP_851322	integral to membrane membrane	transport	transporter activity	2
slit homolog 2	SLIT2	1	NP_004778	extracellular region extracellular space integral to membrane	cell differentiation chemotaxis G- protein coupled receptor protein signaling pathway glial cell migration induction of negative chemotaxis mesoderm migration motor axon guidance nervous system development neuron recognition positive regulation of axonogen	calcium ion binding follicle- stimulating hormone receptor activity receptor binding transferase activity	2
serine/threonine kinase 2	SLK	9	NP_055535	not classified	apoptosis nucleotide- excision repair protein amino acid phosphorylation	ATP binding DNA binding nuclease activity nucleotide binding protein serine/threonine kinase activity transferase activity	2
structural maintenance of chromosomes 2- like 1	SMC2	1	NP_001036016	chromosome condensin complex cytoplasm nuclear chrosome nucleus	cell cycle cell division chromosome organization and biogenesis mitosis mitotic chromosome condensation	nucleotide binding protein binding protein heterodimerization activity protein binding	2
smoothened	SMO	1	NP_005622	integral to membrane membrane membrane fraction	development G- protein coupled receptor protein signaling pathway	G- protein coupled receptor activity non- G- protein coupled 7TM receptor activity protein binding receptor activity	2
acid sphingomyelinase- like phosphodiesterase 3B isoform 1	SMPDL3B	1	NP_055289	not classified	metabolism	hydrolase activity, acting on glycosyl bonds	1, 2
Smad ubiquitination regulatory factor 1 isoform 2	SMURF1	1	NP_851994	intracellular	cell differentiation ectoderm development negative regulation of BMP signaling pathway protein ubiquitination during ubiquitin- dependent protein catabolism ubiquitin cycle	ligase activity ubiquitin- protein ligase activity	2
sorting nexin associated golgi protein 1	SNAG1	4	NP_443102	not classified	intracellular signaling cascade protein transport	phosphoinositide binding protein binding	1, 2
synaptosomal- associated protein 23 isoform SNAP23B	SNAP23	1	NP_570710	plasma membrane synapse synaptosome	membrane fusion post- Golgi- vesicle- mediated transport protein transport vesicle targeting	t- SNARE activity phosphoionsitide binding	2
synuclein, gamma (breast cancer- specific protein 1)	SNCG	9	NP_003078	cytoplasm	not classified	not classified	1, 2
EAP30 subunit of ELL complex	SNF8	1	NP_009172	nucleus	protein transport regulation of transcription, DNA- dependent transcription	not classified	2
small nuclear ribonucleoprotein D1 polypeptide 16kDa	SNRPD1	1	NP_008869	nucleus ribonucleoprotein complex	nuclear mRNA splicing, via spliceosome	protein binding	1
sorting nexin 12	SNX12	1	NP_037478	not classified	intracellular signaling cascade protein transport	protein binding phosphoinositide binding	2
sorting nexin 3	SNX3	1	NP_003786	not classified	endocytosis intracellular signaling cascade protein transport	phosphoinositide binding protein binding	2
sorting nexin 9	SNX9	2	NP_057308	not classified	intracellular signaling cascade protein localization protein transport	protein binding SH3/SH2 adaptor activity lipid transporter activity	2
superoxide dismutase 1, soluble	SOD1	2	NP_000445	cytoplasm	nervous system development response to oxidative stress superoxide metabolism	antioxidant activity copper ion binding copper, zinc superoxide dismutase activity metal ion binding oxidoreductase activity zinc ion binding	1, 2
sorbitol dehydrogenase	SORD	3	NP_003095	not classified	sorbitol metabolism visual perception	L- iditol 2- dehydrogenase activity metal ion binding oxidoreductase activity zinc ion binding	2
sortilin- related receptor containing LDLR class A repeats preproprotein	SORL1	1	NP_003096	integral to plasma membrane membrane	cholesterol metabolism intracellular protein transport lipid metabolism lipid transport receptor mediated endocytosis steroid metabolism	protein transporter activity transmembrane receptor activity not classified	2
sperm associated antigen 9 isoform 1	SPAG9	2	NP_003962	not classified	not classified	not classified	2
spastin isoform 2	SPAST	3	NP_955468	nucleus	not classified	ATP binding nucleoside- triphosphatase activity nucleotide binding	2
spen homolog, transcriptional regulator	SPEN	2	NP_055816	nucleus	Notch signaling pathway regulation of transcription, DNA- dependent	DNA binding nucleic acid binding nucleotide binding RNA binding	2
spondin 2, extracellular matrix protein	SPON2	1	NP_036577	extracellular matrix (sensu Metazoa) extraellular space	axon guidance cell adhesion development immune response	actin binding	2
sepiapterin reductase (7, 8- dihydrobiopterin:NADP+ oxidoreductase)	SPR	1	NP_003115	not classified	electron transport metabolism nitric oxide biosynthesis tetrahydrobiopterin biosynthesis	aldo- keto reductase activity NADP binding oxidoreductase activity sepiapterin reductase activity	2
small proline- rich protein 3	SPRR3	5	NP_005407	cornified envelope	epidermis development keratinization keratinocyte differentiation wound healing	protein binding structural molecule activity	2
spectrin, beta, non- erythrocytic 1 isoform 1	SPTBN1	1	NP_003119	cytoskeleton membrane spectrin	barbed- end actin filament capping	actin binding calmodulin binding structural constituent of cytoskeleton	2
spectrin, beta, non- erythrocytic 1 isoform 2	SPTBN1	1	NP_842565	cytoskeleton membrane spectrin	barbed- end actin filament capping	calmodulin binding structural constituent of cytoskeleton calcium channel regulator activity	2
sequestosome 1	SQSTM1	1	NP_003891	cytosol nucleus	apoptosis cell differentiation endosome transport immune response intracellular signaling cascade positive regulation of transcription from RNA polymerase II promoter protein localization regulation of I- kappaB kinase/NF- kappaB cascade response to stress	metal ion binding protein binding protein kinase binding SH2 domain binding ubiquitin binding zinc ion binding	2
proto- oncogene tyrosine- protein kinase SRC	SRC	1	NP_005408	integral to membrane membrane	protein amino acid phosphorylation protein kinase cascade signal complex formation	ATP binding nucleotide binding protein binding protein- tyrosine kinase activity SH2 domain binding SH3/SH2 adaptor activity transferase activity	2
sorcin isoform a	SRI	4	NP_003121	cytoplasm	heart development intracellular sequestering of iron ion muscle development regulation of action potential regulation of heart contraction regulation of striated muscle contraction signal transduction transport	calcium channel regulator activity calcium ion binding receptor binding	1, 2
sorcin isoform b	SRI	3	NP_944490	cytoplasm	heart development intracellular sequestering of iron ion muscle development regulation of action potential regulation of heart contraction regulation of striated muscle contraction signal transduction transport	calcium ion binding receptor binding binding	2
heat shock 70kD protein binding protein	ST13	2	NP_003923	cytoplasm	protein folding	protein binding, bridging metal ion binding	2
STAM binding protein	STAMBP	2	NP_998787	membrane nucleus	JAK- STAT cascade positive regulation of cell proliferation ubiquitin cycle	metallopeptidase activity protein binding ubiquitin thiolesterase activity zinc ion binding not classified	2
serine/threonine protein kinase 11	STK11	1	NP_000446	not classified	protein amino acid phosphorylation	ATP binding nucleotide binding protein binding protein serine/threonine kinase activity transferase activity	2
serine/threonine kinase 24 (STE20 homolog, yeast) isoform b	STK24	5	NP_001027467	not classified	protein amino acid phosphorylation signal transduction	ATP binding kinase activity nucleotide binding protein serine/threonine kinase activity protein- tyrosine kinase activity transferase activity	2
stomatin isoform a	STOM	13	NP_004090	cytoskeleton integral to plasma membrane membrane	not classified	not classified	1, 2
syntaxin 3A	STX3	2	NP_004168	integral to membrane membrane	intracellular protein transport neurotransmitter transport	protein transporter activity	2
syntaxin binding protein 1 isoform b	STXBP1	1	NP_001027392	not classified	protein transport vesicle docking during exocytosis vesicle- mediated transport	calcium ion binding	2
syntaxin binding protein 2	STXBP2	10	NP_008880	not classified	intracellular protein transport vesicle docking during exocytosis vesicle- mediated transport	syntaxin- 2 binding syntaxin- 3 binding	2
syntaxin binding protein 4	STXBP4	1	NP_848604	not classified	not classified	protein binding ATP binding	2
succinate- CoA ligase, ADP- forming, beta subunit	SUCLA2	1	NP_003841	mitochondrion	metabolism succinyl- CoA metabolism succinyl- CoA pathway tricarboxylic acid cycle	ligase activity succinate- CoA ligase (ADP- forming) activity G- protein coupled receptor activity, unknown ligand	2
succinate receptor 1	SUCNR1	1	NP_149039	integral to membrane membrane	G- protein coupled receptor protein signaling pathway signal transduction	purinergic nucleotide receptor activity, G- protein coupled receptor activity rhodopsin- like receptor activity not classified	2
sushi domain containing 2	SUSD2	5	NP_062547	not classified	not classified	not classified	2
synaptophysin- like 1 isoform b	SYPL1	1	NP_874384	integral to plasma membrane membrane synaptic vesicle	synaptic transmission transport	transporter activity	2
tumor- associated calcium signal transducer 1 precursor	TACSTD1	1	NP_002345	integral to membrane plasma membrane	not classified	ATP binding	2
transgelin 2	TAGLN2	4	NP_003555	nuclear membrane plasma membrane	muscle development	not classified	2
TAO kinase 1	TAOK1	1	NP_065842	not classified	protein amino acid phosphorylation	ATP binding nucleotide binding protein serine/threonine kinase activity transferase activity	2
Tax1 (human T- cell leukemia virus type I) binding protein 3	TAX1BP3	1	NP_055419	cytoplasm integral to membrane membrane nucleus	intracellular signaling cascade ion transport negative regulation of Wnt receptor signaling pathway Rho protein signal transduction Wnt receptor signaling pathway	ATP binding ion channel activity protein binding receptor activity	2
TBC1 domain family, member 10A	TBC1D10A	4	NP_114143	microvillus	not classified	PDZ domain binding protein binding	2
TBC1 domain family, member 21	TBC1D21	1	NP_699187	not classified	not classified	GTPase activator activity	2
T- complex protein 1 isoform a	TCP1	1	NP_110379	cytosol	protein folding tubulin folding	ATP binding nucleotide binding unfolded protein binding	2
T- complex protein 1 isoform b	TCP1	2	NP_001008897	cytosol	protein folding tubulin folding	nucleotide binding unfolded protein binding structural molecule activity	2
tectorin alpha precursor	TECTA	1	NP_005413	extracellular matrix (sensu Metazoa) extracellular space membrane	cell- matrix adhesion sensory perception of sound	extracellular matrix structural constituent GPI anchor binding	2
tektin 3	TEKT3	1	NP_114104	microtubule	microtubule cytoskeleton organization and biogenesis	glycosaminoglycan binding	2
transferrin	TF	12	NP_001054	endocytic vesicle extracellular region	ion transport iron ion homeostasis iron ion transport	ferric iron binding metal ion binding	1, 2
transforming growth factor, beta receptor III	TGFBR3	1	NP_003234	integral to membrane membrane	development signal transduction transforming growth factor beta receptor signaling pathway	receptor activity acyltransferase activity	2
transglutaminase 2 isoform b	TGM2	1	NP_945189	cytosol extracellular matrix (sensu Metazoa) membrane	G- protein coupled receptor protein signaling pathway peptide cross- linking positive regulation of cell adhesion	calcium ion binding GTP binding protein- glutamine gamma- glutamyltransferase activity transferase activity nucleotide binding	2
transglutaminase 4 (prostate)	TGM4	5	NP_003232	not classified	peptide cross- linking protein amino acid polyamination	acyltransferase activity calcium ion binding protein- glutamine gamma- glutamyltransferase activity transferase activity	2
thrombospondin 1 precursor	THBS1	9	NP_003237	extracellular region	blood coagulation cell adhesion cell motility development nervous system development	calcium ion binding endopeptidase inhibitor activity heparin binding protein binding signal transducer activity structural molecule activity	1, 2
THO complex 4	THOC4	1	NP_005773	nucleus spliceosome complex	mRNA export from nucleus nuclear mRNA splicing, via spliceosome protein folding transport	protein binding RNA binding not classified	2
Thy- 1 cell surface antigen	THY1	3	NP_006279	cytosol endoplasmic reticulum external side of plasma membrane growth cone integral to plasma membrane lipid raft plasma membrane	angiogenesis cell- cell adhesion cytoskeleton organization and biogenesis focal adhesion formation mast cell activation negative regulation of apoptosis negative regulation of axonogenesis negative regulation of cell migration negative regulation of fibrob	GPI anchor binding integrin binding protein binding Rho GTPase activator activity	1, 2
T- cell lymphoma invasion and metastasis 2 isoform b	TIAM2	1	NP_001010927	intracellular	intracellular signaling cascade regulation of Rho protein signal transduction	protein binding receptor signaling protein activity Rho guanyl- nucleotide exchange factor activity	2
transketolase	TKT	1	NP_001055	not classified	not classified	calcium ion binding transferase activity transketolase activity	2
talin 1	TLN1	4	NP_006280	cytoskeleton cytosol focal adhesion intercellular junction ruffle	cell motility cytoskeletal anchoring intercellular junction assembly	actin binding binding LIM domain binding protein binding structural constituent of cytoskeleton vinculin binding	2
transmembrane 7 superfamily member 3	TM7SF3	3	NP_057635	integral to membrane membrane	not classified	not classified	1, 2
transmembrane BAX inhibitor motif containing 1	TMBIM1	1	NP_071435	integral to membrane membrane	not classified	not classified	1, 2
transmembrane protein 12	TMEM12	1	NP_689524	integral to membrane	not classified	not classified	2
transmembrane protein 16F	TMEM16F	6	NP_001020527	integral to membrane membrane	not classified	not classified	2
transmembrane protein 2	TMEM2	1	NP_037522	integral to membrane	not classified	not classified	2
transmembrane protein 27	TMEM27	2	NP_065716	integral to membrane membrane	not classified	not classified	2
transmembrane protein 38A	TMEM38A	1	NP_076979	integral to membrane	not classified	serine- type endopeptidase inhibitor activity	2
thymic dendritic cell- derived factor 1	TMEM59	1	NP_004863	integral to membrane	not classified	peptidase activity	2
transmembrane protein 63A	TMEM63A	2	NP_055513	integral to membrane membrane	not classified	nucleotide binding	2
transmembrane protease, serine 11D	TMPRSS11D	1	NP_004253	extracellular region integral to plasma membrane membrane	proteolysis respiratory gaseous exchange	serine- type endopeptidase activity not classified	2
transmembrane protease, serine 2	TMPRSS2	2	NP_005647	integral to plasma membrane membrane	proteolysis	scavenger receptor activity serine- type endopeptidase activity	1, 2
toll interacting protein	TOLLIP	1	NP_061882	cytoplasm interleukin- 1 receptor complex interleukin- 18 receptor complex	cell- cell signaling inflammatory response intracellular signaling cascade leukocyte activation phosphorylation	protein binding signal transducer activity Toll binding	2
target of myb1	TOM1	1	NP_005479	cytosol early endosome endosome intracellular lysosome membrane	endocytosis endosome transport intracellular protein transport	protein binding	2
target of myb1- like 2 isoform 2	TOM1L2	1	NP_653279	intracellular	intracellular protein transport	not classified	2
target of myb1- like 2 isoform 1	TOM1L2	1	NP_001028723	intracellular	intracellular protein transport	protein binding	2
triosephosphate isomerase 1	TPI1	7	NP_000356	not classified	fatty acid biosynthesis gluconeogenesis glycolysis metabolism pentose- phosphate shunt	isomerase activity triose- phosphate isomerase activity	1, 2
tripeptidyl- peptidase I preproprotein	TPP1	8	NP_000382	lysosome	lipid metabolism nervous system development proteolysis	peptidase activity serine- type endopeptidase activity tripeptidyl- peptidase I activity	1, 2
trehalase	TREH	4	NP_009111	anchored to plasma membrane plasma membrane	metabolism trehalose catabolism trehalose metabolism	alpha, alpha- trehalase activity GPI anchor binding hydrolase activity, acting on glycosyl bonds	2
thyroid hormone receptor interactor 10	TRIP10	1	NP_004231	cytoplasm	actin cytoskeleton organization and biogenesis signal transduction	alpha- actinin binding	2
tumor susceptibility gene 101	TSG101	17	NP_006283	membrane	protein transport regulation of cell growth ubiquitin cycle	DNA binding protein binding transcription corepressor activity ubiquitin- protein ligase activity	1, 2
tetraspan 1	TSPAN1	1	NP_005718	integral to membrane membrane	cell adhesion cell motility cell proliferation	not classified	1, 2
transmembrane 4 superfamily member 8 isoform 2	TSPAN3	1	NP_944492	integral to membrane membrane	cell motility cell proliferation	not classified	2
transmembrane 4 superfamily member 6	TSPAN6	1	NP_003261	integral to membrane membrane	cell motility positive regulation of I- kappaB kinase/NF- kappaB cascade	signal transducer activity	2
translocator protein (18kDa) isoform PBR	TSPO	1	NP_000705	integral to membrane membrane mitochondrial outer membrane mitochondrion	protein targeting to mitochondrion signal transduction	benzodiazepine receptor activity receptor activity	2
tissue specific transplantation antigen P35B	TSTA3	1	NP_003304	cytoplasm	de novo' GDP- L- fucose biosynthesis cellular metabolism leukocyte adhesion nucleotide- sugar metabolism protein amino acid glycosylation	coenzyme binding electron carrier activity GDP- 4- dehydro- D- rhamnose reductase activity GDP- L- fucose synthase activity isomerase activity	2
tetratricopeptide repeat domain 18	TTC18	1	NP_660153	not classified	not classified	binding	2
titin isoform novex- 1	TTN	4	NP_597676	condensed nuclear chromosome integral to membrane membrane myofibril nucleus Z disc	carbohydrate metabolism mitosis muscle contraction myofibril assembly protein amino acid autophosphorylation protein amino acid phosphorylation response to oxidative stress	alpha- actinin binding ATP binding calmodulin binding identical protein binding myosin binding nucleotide binding peroxidase activity protein serine/threonine kinase activity protein- tyrosine kinase activity structural constituent of cell wall transferase	2
titin isoform N2- A	TTN	1	NP_596869	condensed nuclear chromosome integral to membrane membrane myofibril nucleus Z disc	carbohydrate metabolism mitosis muscle contraction myofibril assembly protein amino acid autophosphorylation protein amino acid phosphorylation response to oxidative stress	ATP binding calmoduling binding identical protein binding myosin binding nucleotide binding peroxidase activity protein serine/threoninen kinase activity protein- tyrosine kinase activity structural constituent of cell wall transferase activity GTP binding	2
tweety 3	TTYH3	1	NP_079526	not classified	not classified	not classified	1, 2
tubulin, alpha 3	TUBA3	15	NP_006000	microtubule protein complex	microtubule- based movement protein polymerization	GTP binding GTPase activity nucleotide binding structural molecule activity	2
tubulin, beta 2	TUBB2A	7	NP_001060	cytoplasm cytoskeleton microtubule protein complex	microtubule- based movement protein polymerization	GTP binding GTPase activity nucleotide binding structural constituent of cytoskeleton	1, 2
tubulin, beta 6	TUBB6	1	NP_115914	cytoplasm microtubule protein complex	microtubule- based movement protein polymerization	GTPase activity nucleotide binding structural molecule activity GTP binding	2
tubulin, beta 8	TUBB8	1	NP_817124	cytoplasm microtubule protein complex	microtubule- based movement protein polymerization	GTPase activity nucleotide binding structural molecule activity GTP binding not classified	2
thioredoxin	TXN	2	NP_003320	not classified	cell motility cell proliferation cell- cell signaling electron transport signal transduction transport	electron carrier activity protein binding protein disulfide oxidoreductase activity thiol- disulfide exchange intermediate activity	2
thioredoxin domain containing 8	TXNDC8	1	NP_001003936	not classified	cell differentiation spermatogenesis	electron carrier activity protein disulfide oxidoreductase activity	2
thioredoxin- like 5	TXNL5	2	NP_116120	not classified	not classified	electron carrier activity protein disulfide oxidoreductase activity	2
uveal autoantigen with coiled- coil domains and ankyrin repeats isoform 1	UACA	1	NP_060473	cytoskeleton extracelluar region nucleus	viral life cycle	ATP binding	2
ubiquitin- activating enzyme E1	UBA1	4	NP_695012	not classified	DNA replication ubiquitin cycle	catalytic activity ligase activity nucleotide binding protein binding ubiquitin activating enzyme activity ligase activity	2
ubiquitin associated domain containing 1	UBADC1	1	NP_057256	not classified	not classified	not classified	2
ubiquitin- activating enzyme E1	UBE1	2	NP_003325	not classified	DNA replication ubiquitin cycle	ATP binding catalytic activity ligase activity nucleotide binding protein binding ubiquitin activating enzyme activity	2
ubiquitin- conjugating enzyme E2G 1	UBE2G1	1	NP_003333	not classified	ubiquitin cycle	ubiquitin- protein ligase activity not classified	2
ubiquitin- like 3	UBL3	2	NP_009037	intracellular membrane	protein modification	L- lactate dehydrogenase activity	2
UBX domain containing 1	UBXD1	1	NP_079517	not classified	not classified	not classified	2
ubiquitin- conjugating enzyme E2- like isoform b	UEVLD	11	NP_060784	not classified	glycolysis protein transport tricarboxylic acid cycle intermediate metabolism ubiquitin cycle	L- lactate dehydrogenase activity oxidoreductase activity ubiquitin- protein ligase activity	1, 2
ubiquitin- conjugating enzyme E2- like isoform a	UEVLD	4	NP_001035787	not classified	glycolysis protein transport tricarboxylic acid cycle intermediate metabolism ubiquitn cycle	oxidoreductase activity ubiquitin- protein ligase activity not classified	2
ubiquitin- fold modifier conjugating enzyme 1	UFC1	1	NP_057490	not classified	ubiquitin cycle	kinase activity	2
UDP- glucose pyrophosphorylase 2 isoform a	UGP2	2	NP_006750	not classified	metabolism UDP- glucose metabolism	kinase activity nucleotidyltransferase activity transferase activity UTP:glucose- 1- phosphate uridylyltransferase activity	2
UDP- glucose pyrophosphorylase 2 isoform b	UGP2	3	NP_001001521	not classified	metabolism UDP- glucose metabolism	nucleotidyltransferase activity transferase activity UTP: glucose- 1- phosphate uridylyltransfease activity ATP binding	2
unc- 51- like kinase 3	ULK3	4	NP_056333	not classified	protein amino acid phosphorylation	ATP binding nucleotide binding protein serine/threonine kinase activity protein- tyrosine kinase activity transferase activity	1, 2
uromodulin precursor	UMOD	35	NP_003352	extracellular space extrinsic to membrane membrane	cellular defense response negative regulation of cell proliferation	calcium ion binding GPI anchor binding	1, 2
beta- ureidopropionase	UPB1	1	NP_057411	not classified	nitrogen compound metabolism	hydrolase activity, acting on carbon- nitrogen (but not peptide) bonds metal ion binding zinc ion binding protein binding	2
uroplakin 1A	UPK1A	5	NP_008931	endoplasmic reticulum integral to membrane plasma membrane	endocytosis epithelial cell differentiation protein oligomerization signal transduction	monosaccharide binding protein binding protein homodimerization activity	1, 2
uroplakin 1B	UPK1B	1	NP_008883	integral to membrane membrane	epithelial cell differentiation physiological process	structural molecule activity	2
uroplakin 2	UPK2	4	NP_006751	endoplasmic reticulum integral to endoplasmic reticulum membrane integral to plasma membrane membrane	development epithelial cell differentiation membrane organization and biogenesis	not classified	1, 2
uroplakin 3A precursor	UPK3A	1	NP_008884	endoplasmic reticulum integral to membrane membrane membrane fraction	epithelial cell differentiation	not classified	2
utrophin	UTRN	1	NP_009055	cytoskeleton membrane fraction plasma membrane	muscle contraction muscle development	actin binding calcium ion binding protein binding structural molecule activity zinc ion binding	2
vesicle- associated membrane protein 3 (cellubrevin)	VAMP3	1	NP_004772	integral to membrane membrane synapse synaptosome	membrane fusion protein complex assembly vesicle docking during exocytosis	protein binding	1
vesicle- associated membrane protein 7	VAMP7	1	NP_005629	endoplasmic reticulum integral to membrane membrane	protein transport vesicle docking during exocytosis vesicle- mediated transport	actin binding	2
vesicle- associated membrane protein 8	VAMP8	1	NP_003752	early endosome integral to membrane membrane membrane fraction synaptic vesicle	protein complex assembly vesicle docking during exocytosis vesicle- mediated transport	not classified	2
slit- like 2	VASN	1	NP_612449	integral to membrane membrane	not classified	transferase activity	2
vasodilator- stimulated phosphoprotein	VASP	1	NP_003361	actin cytoskeleton	cell motility	actin binding	2
vesicle amine transport protein 1	VAT1	7	NP_006364	integral to membrane nucleus synaptic vesicle	cell growth	DNA binding oxidoreductase activity zinc ion binding	2
vinculin isoform VCL	VCL	4	NP_003364	actin cytoskeleton adherens junction cell- matrix junction costamere focal adhesion intercellular junction protein complex	apical junction assembly cell adhesion cell motility lamellipodium biogenesis negative regulation of cell migration	actin binding alpha- catenin binding oxidoreductase activity structural molecule activity	2
vinculin isoform meta- VCL	VCL	3	NP_054706	actin cytoskeleton adherens junction cell- matrix junction constamere focal adhesion intercellular junction protein complex	apical junction assembly cell adhesion cell motility lamellipodium biogenesis negative regulation of cell migration	alpha- catenin binding oxidoreductase activity structural molecule activity not classified	2
valosin- containing protein	VCP	2	NP_009057	cytosol endoplasmic reticulum microsome nucleus	caspase activation double- strand break repair ER- associated protein catabolism establishment of protein localization protein ubiquitination regulation of apoptosis retrograde protein transport, ER to cytosol transport unfolded protein response	ATP binding ATPase activity hydrolase activity lipid binding nucleotide binding protein binding	2
voltage- dependent anion channel 1	VDAC1	6	NP_003365	integral to membrane membrane mitochondrial outer membrane mitochondrion outer membrane	anion transport apoptotic program	apoptogenic cytochrome c release channel activity voltage- gated anion channel porin activity voltage- gated ion- selective channel activity	2
voltage- dependent anion channel 3	VDAC3	1	NP_005653	integral to plasma membrane membrane mitochondrial outer membrane mitochondrion outer membrane	adenine transport anion transport	voltage- gated anion channel porin activity voltage- gated ion- selective channel activity	2
villin 1	VIL1	2	NP_009058	cytoskeleton F- actin capping protein complex	actin filament bundle formation actin filament severing barbed- end actin filament capping cytoskeleton organization and biogenesis protein complex assembly	actin binding calcium ion binding	2
secretory protein LOC284013	VMO1	4	NP_872372	not classified	not classified	not classified	2
vacuolar protein sorting 13C protein isoform 1B	VPS13C	1	NP_060550	not classified	protein localization	not classified	2
vacuolar protein sorting 13D isoform 1	VPS13D	1	NP_056193	not classified	protein localization	not classified	2
vacuolar protein sorting 24 isoform 1	VPS24	1	NP_057163	membrane	protein transport	not classified	2
vacuolar protein sorting 24 isoform 2	VPS24	1	NP_001005753	membrane	protein transport	protein binding	2
vacuolar protein sorting 25	VPS25	6	NP_115729	nucleus	protein transport regulation of transcription, DNA- dependent transcription	not classified	2
vacuolar protein sorting 28 isoform 1	VPS28	7	NP_057292	cytosol endosome	protein transport	protein binding	1, 2
vacuolar protein sorting 28 isoform 2	VPS28	2	NP_898880	cytosol endosome	protein transport	protease binding	2
vacuolar protein sorting 35	VPS35	3	NP_060676	cytosol endosome membrane	protein transport retrograde transport, endosome to Golgi	protein binding	2
vacuolar protein sorting 36	VPS36	5	NP_057159	nucleus	protein transport regulation of transcription, DNA- dependent transcription	lipid binding	2
vacuolar protein sorting 37B	VPS37B	5	NP_078943	not classified	not classified	not classified	2
vacuolar protein sorting 37C	VPS37C	1	NP_060436	not classified	not classified	not classified	2
vacuolar protein sorting 37D	VPS37D	5	NP_001071089	not classified	not classified	not classified	2
vacuolar protein sorting factor 4B	VPS4B	15	NP_004860	endosome membrane vacuole	endosome transport membrane fusion peroxisome organization and biogenesis regulation of transcription, DNA- dependent	ATP binding ATPase activity, coupled nucleotide binding protein binding	1, 2
von Willebrand factor preproprotein	VWF	1	NP_000543	extracellular matrix (sensu Metazoa) extracellular region	cell adhesion platelet activation response to wounding	protein binding actin binding	2
Wiskott- Aldrich syndrome gene- like protein	WASL	1	NP_003932	actin cytoskeleton nucleus	actin polymerization and/or depolymerization cell motility protein complex assembly regulation of transcription, DNA- dependent transcription	actin binding small GTPase regulator activity	2
eukaryotic translation initiation factor 4H isoform 1	WBSCR1	1	NP_071496	eukaryotic translation initiation factor 4F complex	protein biosynthesis regulation of translational initiation	nucleic acid binding nucleotide binding RNA binding translation initiation factor activity	1
WD repeat- containing protein 1 isoform 1	WDR1	10	NP_059830	cytoskeleton	sensory perception of sound	actin binding protein binding	2
WD repeat- containing protein 1 isoform 2	WDR1	4	NP_005103	cytoskeleton	sensory perception of sound	protein binding metal ion binding	2
widely- interspaced zinc finger motifs	WIZ	1	NP_067064	intracellular nucleus	not classified	nucleic acid binding zinc ion binding metal ion binding	2
wingless- type MMTV integration site family, member 5B precursor	WNT5B	2	NP_116031	extracellular region	development frizzled- 2 signaling pathway	signal transducer activity	2
X- prolyl aminopeptidase 2, membrane- bound	XPNPEP2	33	NP_003390	membrane	proteolysis	GPI anchor binding manganese ion binding metal ion binding metalloexopeptidase activity X- Pro aminopeptidase activity	1, 2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, epsilon polypeptide	YWHAE	4	NP_006752	not classified	not classified	enzyme binding protein domain specific binding	1, 2
tyrosine 3- monooxygenase/tryptophan 5- monooxygenase activation protein, gamma polypeptide	YWHAG	2	NP_036611	cytoplasm	cytoskeleton organization and biogenesis negative regulation of apoptosis negative regulation of protein kinase activity regulation of mitosis regulation of neuron differentiation regulation of signal transduction regulation of synaptic plasticity	actin binding insulin- like growth factor receptor binding protein domain specific binding protein homodimerization activity protein kinase C binding protein kinase C inhibitor activity	1, 2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, eta polypeptide	YWHAH	1	NP_003396	cytoplasm	cytoskeleton organization and biogenesis glucocorticoid catabolism glucocorticoid receptor signaling pathway intracellular protein transport negative regulation of apoptosis negative regulation of dendrite morphogenesis negative regulation of protein kina	actin binding glucocorticoid receptor binding insulin- like growth factor receptor binding protein domain specific binding protein kinase C inhibitor activity transcriptional activator activity	2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, theta polypeptide	YWHAQ	1	NP_006817	not classified	exocytosis regulation of progression through cell cycle	protein domain specific binding protein kinase C inhibitor activity	1, 2
tyrosine 3/tryptophan 5 - monooxygenase activation protein, zeta polypeptide	YWHAZ	8	NP_003397	not classified	not classified	protein domain specific binding transcription factor binding	1, 2
zinc finger, CCHC domain containing 11 isoform a	ZCCHC11	1	NP_001009881	not classified	not classified	metal ion binding nucleic acid binding nucleotidyltransferase activity zinc ion binding	2
zinc finger, DHHC domain containing 1	ZDHHC1	1	NP_037436	integral to membrane membrane	not classified	acyltransferase activity DNA binding metal ion binding protein binding transferase activity zinc ion binding	2
zinc metalloproteinase STE24	ZMPSTE24	1	NP_005848	endoplasmic reticulum integral to membrane membrane	proteolysis	metalloendopeptidase activity metalloexopeptidase activity zinc ion binding DNA binding	2
zinc finger protein 114	ZNF114	1	NP_705836	intracellular nucleus	regulation of transcription, DNA- dependent	metal ion binding nucleic acid binding zinc ion binding	2
zinc finger protein 486	ZNF486	1	NP_443084	intracellular nucleus	regulation of transcription, DNA- dependent transcription	metal ion binding zinc ion binding	2