Urinary Exosome Protein Database. LKEM, DIR, NHLBI, NIH

BLAST your amino acid sequence against the Urinary Exosome Protein Database

Sort database by:

Mechanism of exosome formation and excretion Urinary Exosome Protein Database This database of urinary exosome proteins is based on published and unpublished protein mass spectrometry data from the NHLBI Laboratory of Kidney and Electrolyte Metabolism. All data are from urinary exosomes isolated from healthy human volunteers. The figure on the right illustrates the mechanism of exosome formation and excretion.

In the first step of the process, apical membrane proteins undergo endocytosis. In the second step, the endosome is targeted to the multivesicular body (MVB). The signal that marks plasma membrane proteins for incorporation into MVB is mono-ubiquitination. In the third step, the endosome fuses with the MVB. Consequently, the apical plasma membrane proteins are segregated in the MVB outer membranes and internalized by membrane invagination. Finally, the outer membrane of the MVB fuses with the apical plasma membrane releasing its internal vesicles, called 'exosomes', in the urinary space. Exosomes contain both membrane and cytosolic proteins.

This current database contains protein identification of human urinary exosomes using two different mass spectrometer analyzers. The LCQ mass analyzer was used for technique # 1 and the LTQ mass analyzer was used for technique # 2.

References:

Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA. Large-scale Proteomics and Phosphoproteomics of Human Urinary Exosomes. J Am Soc Nephrol. in press

Current Database Size: 1160 proteins (Download Data).

The Urinary Exosome Protein Database was created by Patricia A. Gonzales, Guozhong Ma, Trairak Pisitkun, Brian Ruttenberg and Mark A. Knepper.

Protein Name	Gene Name	Peptide #	Acc No	GO Component	GO Process	GO Function	Tech
alpha 1B- glycoprotein	A1BG	1	NP_570602	extracellular region	not classified	not classified	2
alpha- 2- macroglobulin- like 1	A2ML1	1	NP_653271	not classified	not classified	endopeptidase inhibitor activity	2
aminoadipate- semialdehyde dehydrogenase- phosphopantetheinyl transferase	AASDHPPT	1	NP_056238	not classified	fatty acid biosynthesis	magnesium ion binding phosphopantetheinyltransferase activity transferase activity	2
ATP- binding cassette sub- family B member 1	ABCB1	23	NP_000918	cell surface integral to membrane membrane membrane fraction	response to drug transport	ATP binding ATPase activity hydrolase activity nucleotide binding transporter activity xenobiotic- transporting ATPase activity	1, 2
ATP- binding cassette, sub- family B (MDR/TAP), member 11	ABCB11	1	NP_003733	integral to plasma membrane membrane membrane fraction	transport	ATP binding ATPase activity bile acid- exporting ATPase activity nucleotide binding sodium- exporting ATPase activity, phosphorylative mechanism transporter activity	2
ATP- binding cassette, sub- family B, member 6	ABCB6	1	NP_005680	ATP- binding cassette (ABC) transporter complex integral to membrane membrane mitochondrial envelope mitochondrion	iron ion homeostasis transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding	2
ATP- binding cassette, sub- family C, member 11 isoform a	ABCC11	1	NP_149163	integral to membrane membrane	transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding	2
ATP- binding cassette, sub- family C, member 9 isoform SUR2A- delta- 14	ABCC9	1	NP_064694	integral to membrane membrane	potassium ion transport transport	ATP binding ATPase activity ATPase activity, coupled to transmembrane movement of substances nucleotide binding receptor activity sulfonylurea receptor activity transporter activity	2
abhydrolase domain containing 14B	ABHD14B	6	NP_116139	nucleus	not classified	not classified	1, 2
abl- interactor 1 isoform d	ABI1	2	NP_001012770	cytoskeleton cytosol endoplasmic reticulum nucleus soluble fraction	negative regulation of cell proliferation transmembrane receptor protein tyrosine kinase signaling pathway	cytoskeletal protein binding	2
acetyl- Coenzyme A acetyltransferase 1 precursor	ACAT1	1	NP_000010	mitochondrion	not classified	acetyl- CoA C- acetyltransferase activity acyltransferase activity transferase activity	2
angiotensin I converting enzyme isoform 1 precursor	ACE	23	NP_000780	integral to membrane membrane membrane fraction plasma membrane soluble fraction	blood pressure regulation metabolism proteolysis	carboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding	1, 2
angiotensin I converting enzyme isoform 2 precursor	ACE	12	NP_690043	integral to membrane membrane membrane fraction plasma membrane soluble fraction	blood pressure regulation metabolism proteolysis	carboxypeptidase activity chloride ion binding hydrolase activity, acting on glycosyl bonds metal ion binding peptidyl- dipeptidase A activity zinc ion binding	2
angiotensin I converting enzyme 2 precursor	ACE2	8	NP_068576	extracellular region integral to membrane membrane	entry of virus into host cell proteolysis	carboxypeptidase activity chloride ion binding metal ion binding peptidyl- dipeptidase A activity protein binding viral receptor activity zinc ion binding	2
ATP citrate lyase isoform 2	ACLY	1	NP_942127	citrate lyase complex	ATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolism	ATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity	2
ATP citrate lyase isoform 1	ACLY	1	NP_001087	citrate lyase complex	ATP catabolism citrate metabolism coenzyme A metabolism lipid biosynthesis metabolism	ATP binding ATP citrate synthase activity catalytic activity magnesium ion binding nucleotide binding transferase activity	1
aconitase 1	ACO1	6	NP_002188	cytoplasm	metabolism tricarboxylic acid cycle	4 iron, 4 sulfur cluster binding aconitate hydratase activity iron ion binding lyase activity metal ion binding RNA binding	2
thioesterase, adipose associated isoform BFIT2	ACOT11	1	NP_671517	cytoplasm	fatty acid metabolism intracellular signaling cascade response to temperature stimulus	acyl- CoA thioesterase activity hydrolase activity serine esterase activity	2
acyl- CoA thioesterase 7 isoform hBACHd	ACOT7	1	NP_863656	cytoplasm mitochondrion	lipid metabolism	acyl- CoA binding hydrolase activity palmitoyl- CoA hydrolase activity serine esterase activity	2
acid phosphatase 1 isoform b	ACP1	1	NP_009030	cytoplasm soluble fraction	protein amino acid dephosphorylation	acid phosphatase activity hydrolase activity non- membrane spanning protein tyrosine phosphatase activity protein tyrosine phosphatase activity	2
lysosomal acid phosphatase 2 precursor	ACP2	7	NP_001601	integral to membrane lysosomal membrane lysosome	not classified	acid phosphatase activity hydrolase activity	1, 2
prostatic acid phosphatase precursor	ACPP	8	NP_001090	extracellular region	regulation of progression through cell cycle	acid phosphatase activity hydrolase activity protein tyrosine phosphatase activity	1, 2
acyl- CoA synthetase long- chain family member 4 isoform 2	ACSL4	1	NP_075266	integral to membrane membrane peroxisome	fatty acid metabolism learning and/or memory lipid metabolism metabolism	ligase activity long- chain- fatty- acid- CoA ligase activity magnesium ion binding	2
acyl- CoA synthetase medium- chain family member 1	ACSM1	1	NP_443188	mitochondrial matrix	benzoate metabolism butyrate metabolism energy derivation by oxidation of organic compounds fatty acid oxidation metabolism	acyl- CoA ligase activity butyrate- CoA ligase activity catalytic activity	2
actinin, alpha 1	ACTN1	1	NP_001093	cytoskeleton focal adhesion pseudopodium	focal adhesion formation negative regulation of cell motility regulation of apoptosis	actin binding calcium ion binding integrin binding protein binding vinculin binding	2
ARP1 actin- related protein 1 homolog A, centractin alpha	ACTR1A	1	NP_005727	actin filament cytoplasm cytoskeleton	not classified	ATP binding nucleotide binding protein binding structural constituent of cytoskeleton	2
actin- related protein 2 isoform a	ACTR2	1	NP_001005386	cytoskeleton	not classified	protein binding structural molecule activity	2
ARP3 actin- related protein 3 homolog	ACTR3	6	NP_005712	Arp2/3 protein complex	cell motility	ATP binding nucleotide binding protein binding structural molecule activity	2
aminoacylase 1	ACY1	15	NP_000657	cytoplasm cytosol	amino acid metabolism proteolysis	aminoacylase activity hydrolase activity metallopeptidase activity protein dimerization activity zinc ion binding	1, 2
aspartoacylase (aminocyclase) 3	ACY3	1	NP_542389	not classified	metabolism	aspartoacylase activity hydrolase activity, acting on ester bonds	2
brain adenylate cyclase 1	ADCY1	1	NP_066939	integral to membrane membrane	cAMP biosynthesis intracellular signaling cascade	calcium- and calmodulin- responsive adenylate cyclase activity calmodulin binding magnesium ion binding	2
class III alcohol dehydrogenase 5 chi subunit	ADH5	1	NP_000662	not classified	ethanol oxidation	alcohol dehydrogenase activity electron carrier activity fatty acid binding formaldehyde dehydrogenase (glutathione) activity metal ion binding S- (hydroxymethyl)glutathione dehydrogenase activity zinc ion binding	2
class V alcohol dehydrogenase 6	ADH6	1	NP_000663	not classified	ethanol oxidation	alcohol dehydrogenase activity electron carrier activity metal ion binding oxidoreductase activity zinc ion binding	2
transcription factor ELYS	AHCTF1	1	NP_056261	nucleus	development transcription	DNA binding	2
S- adenosylhomocysteine hydrolase	AHCY	10	NP_000678	cytoplasm	one- carbon compound metabolism	adenosylhomocysteinase activity hydrolase activity	2
AHNAK nucleoprotein isoform 1	AHNAK	1	NP_001611	nucleus	nervous system development	protein binding	2
AHA1, activator of heat shock 90kDa protein ATPase homolog 1	AHSA1	1	NP_036243	cytoplasm endoplasmic reticulum	protein folding response to stress	ATPase stimulator activity chaperone activator activity chaperone binding	2
alpha- 2- HS- glycoprotein (Fetuin- A)	AHSG	1	NP_001613	extracellular region extracellular space	acute- phase response negative regulation of bone mineralization negative regulation of insulin receptor signaling pathway pinocytosis positive regulation of phagocytosis regulation of inflammatory response skeletal development	cysteine protease inhibitor activity kinase inhibitor activity	2
adenylate kinase 1	AK1	4	NP_000467	cytoplasm cytosol	ATP metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism	adenylate kinase activity ATP binding kinase activity nucleotide binding transferase activity	2
aldo- keto reductase family 1, member A1	AKR1A1	7	NP_006057	not classified	aldehyde metabolism glucose metabolism	alcohol dehydrogenase (NADP+) activity aldehyde reductase activity electron carrier activity oxidoreductase activity protein binding	2
aldo- keto reductase family 1, member B1	AKR1B1	3	NP_001619	extracellular space	carbohydrate metabolism	aldehyde reductase activity electron carrier activity oxidoreductase activity	1, 2
aldo- keto reductase family 7, member A2	AKR7A2	2	NP_003680	not classified	aldehyde metabolism carbohydrate metabolism	aldehyde reductase activity electron carrier activity	2
aldo- keto reductase family 7, member A3	AKR7A3	2	NP_036199	cytosol	aldehyde metabolism	aldo- keto reductase activity electron carrier activity	2
delta- aminolevulinic acid dehydratase isoform a	ALAD	1	NP_001003945	not classified	heme biosynthesis	lyase activity metal ion binding porphobilinogen synthase activity zinc ion binding	2
albumin precursor	ALB	36	NP_000468	extracellular region extracellular space protein complex	body fluid osmoregulation cellular response to starvation hemolysis of host red blood cells maintenance of mitochondrion localization negative regulation of apoptosis negative regulation of non- apoptotic programmed cell death transport water homeostasis	antioxidant activity carrier activity copper ion binding DNA binding drug binding fatty acid binding metal ion binding oxygen binding protein binding pyridoxal phosphate binding toxin binding water binding	1, 2
activated leukocyte cell adhesion molecule	ALCAM	1	NP_001618	integral to plasma membrane membrane membrane fraction	antimicrobial humoral response (sensu Vertebrata) cell adhesion signal transduction	receptor binding	2
aldehyde dehydrogenase 1A1	ALDH1A1	10	NP_000680	cytoplasm	aldehyde metabolism metabolism	aldehyde dehydrogenase (NAD) activity androgen binding oxidoreductase activity Ras GTPase activator activity retinal dehydrogenase activity	2
aldehyde dehydrogenase 1 family, member L1	ALDH1L1	9	NP_036322	cytoplasm	10- formyltetrahydrofolate catabolism biosynthesis one- carbon compound metabolism protein biosynthesis	cofactor binding formyltetrahydrofolate dehydrogenase activity hydroxymethyl- , formyl- and related transferase activity methyltransferase activity oxidoreductase activity	2
mitochondrial aldehyde dehydrogenase 2 precursor	ALDH2	1	NP_000681	mitochondrion	alcohol metabolism carbohydrate metabolism metabolism	aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity electron carrier activity	2
aldehyde dehydrogenase 3B1 isoform a	ALDH3B1	1	NP_000685	not classified	alcohol metabolism aldehyde metabolism lipid metabolism metabolism	3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity	2
aldehyde dehydrogenase 3B1 isoform b	ALDH3B1	1	NP_001025181	not classified	alcohol metabolism aldehyde metabolism lipid metabolism metabolism	3- chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity	2
aldehyde dehydrogenase 8A1 isoform 1	ALDH8A1	1	NP_072090	intracellular	cell surface extracellular matrix (sensu Metazoa) membrane	oxidoreductase activity retinal dehydrogenase activity	2
aldehyde dehydrogenase 9A1	ALDH9A1	5	NP_000687	cytoplasm	aldehyde metabolism electron transport hormone metabolism metabolism neurotransmitter biosynthesis	4- trimethylammoniobutyraldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity aminobutyraldehyde dehydrogenase activity oxidoreductase activity	2
aldolase A	ALDOA	7	NP_908930	not classified	fructose metabolism glycolysis metabolism striated muscle contraction	fructose- bisphosphate aldolase activity lyase activity	2
fructose- bisphosphate aldolase C	ALDOC	1	NP_005156	not classified	fructose metabolism glycolsis metabolism	fructose- bisphosphate aldolase activity lyase activity	2
anaplastic lymphoma kinase Ki- 1	ALK	1	NP_004295	integral to plasma membrane membrane	brain development nervous system development protein amino acid N- linked glycosylation protein amino acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway	ATP binding nucleotide binding receptor activity receptor signaling protein tyrosine kinase activity transferase activity transmembrane receptor protein tyrosine kinase activity	2
arachidonate 12- lipoxygenase	ALOX12	1	NP_000688	cytosol sarcolemma	anti- apoptosis arachidonic acid metabolism cell motility electron transport fatty acid oxidation leukotriene biosynthesis negative regulation of cell volume oxygen and reactive oxygen species metabolism positive regulation of cell adhesion positive regula	arachidonate 12- lipoxygenase activity hepoxilin- epoxide hydrolase activity iron ion binding lipoxygenase activity metal ion binding oxidoreductase activity potassium channel inhibitor activity	2
tissue non- specific alkaline phosphatase precursor	ALPL	3	NP_000469	integral to membrane membrane	metabolism ossification	alkaline phosphatase activity GPI anchor binding hydrolase activity magnesium ion binding zinc ion binding	2
alpha- 1- microglobulin/bikunin precursor	AMBP	4	NP_001624	extracellular region plasma membrane	anti- inflammatory response cell adhesion heme catabolism negative regulation of immune response negative regulation of JNK cascade pregnancy protein- chromophore linkage transport	calcium channel inhibitor activity calcium oxalate binding heme binding IgA binding plasmin inhibitor activity protein homodimerization activity transporter activity trypsin inhibitor activity	1, 2
amnionless protein precursor	AMN	1	NP_112205	integral to membrane membrane	development	not classified	2
angiopoietin- like 2 precursor	ANGPTL2	1	NP_036230	extracellular space	development	receptor binding	2
ankyrin repeat and FYVE domain containing 1 isoform 1	ANKFY1	2	NP_057460	endosome membrane membrane	endocytosis	metal ion binding protein binding zinc ion binding	2
ankyrin repeat and FYVE domain containing 1 isoform 2	ANKFY1	2	NP_065791	endosome membrane membrane	endocytosis	metal ion binding protein binding zinc ion binding	2
membrane alanine aminopeptidase precursor	ANPEP	69	NP_001141	ER- Golgi intermediate compartment integral to plasma membrane	angiogenesis cell differentiation proteolysis	aminopeptidase activity membrane alanyl aminopeptidase activity metal ion binding metallopeptidase activity receptor activity zinc ion binding	1, 2
annexin I	ANXA1	19	NP_000691	cornified envelope cytoplasm	anti- apoptosis cell motility cell surface receptor linked signal transduction inflammatory response keratinocyte differentiation lipid metabolism peptide cross- linking	calcium ion binding calcium- dependent phospholipid binding phospholipase A2 inhibitor activity phospholipase inhibitor activity protein binding, bridging receptor binding structural molecule activity	2
annexin A11	ANXA11	31	NP_665875	cytoplasm nuclear envelope nucleoplasm nucleus	immune response	calcium ion binding calcium- dependent phospholipid binding protein binding	2
annexin A13 isoform b	ANXA13	1	NP_001003954	plasma membrane	cell differentiation	calcium ion binding calcium- dependent phospholipid binding	2
annexin A2 isoform 2	ANXA2	29	NP_001002857	plasma membrane soluble fraction	skeletal development	calcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity	2
annexin A2 isoform 1	ANXA2	20	NP_001002858	plasma membrane soluble fraction	skeletal development	calcium ion binding calcium- dependent phospholipid binding cytoskeletal protein binding phospholipase inhibitor activity	2
annexin A3	ANXA3	8	NP_005130	cytoplasm	signal transduction	calcium ion binding calcium- dependent phospholipid binding diphosphoinositol- polyphosphate diphosphatase activity phospholipase A2 inhibitor activity	1, 2
annexin IV	ANXA4	24	NP_001144	cytoplasm	anti- apoptosis negative regulation of coagulation signal transduction	calcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity	1, 2
annexin 5	ANXA5	24	NP_001145	cytoplasm intracellular	anti- apoptosis blood coagulation negative regulation of coagulation signal transduction	calcium ion binding calcium- dependent phospholipid binding phospholipase inhibitor activity protein binding	1, 2
annexin VI isoform 1	ANXA6	27	NP_001146	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding protein binding	1, 2
annexin VI isoform 2	ANXA6	20	NP_004024	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding protein binding	2
annexin VII isoform 2	ANXA7	13	NP_004025	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity	2
annexin VII isoform 1	ANXA7	2	NP_001147	not classified	not classified	calcium ion binding calcium- dependent phospholipid binding voltage- gated calcium channel activity	1
aldehyde oxidase 1	AOX1	1	NP_001150	not classified	electron transport inflammatory response oxygen and reactive oxygen species metabolism	2 iron, 2 sulfur cluster binding aldehyde oxidase activity electron carrier activity iron ion binding metal ion binding molybdenum ion binding oxidoreductase activity xanthine dehydrogenase activity	2
adaptor- related protein complex 1, mu 1 subunit	AP1M1	1	NP_115882	clathrin vesicle coat coated pit	intracellular protein transport	protein binding	2
adaptor- related protein complex 2, mu 1 subunit isoform a	AP2M1	1	NP_004059	clathrin vesicle coat coated pit	intracellular protein transport transport	lipid binding protein binding transporter activity	2
adaptor- related protein complex 4, mu 1 subunit	AP4M1	1	NP_004713	clathrin vesicle coat coated pit coated vesicle membrane Golgi trans cisterna membrane coat adaptor complex	intracellular protein transport transport vesicle- mediated transport	transporter activity	2
apoptotic peptidase activating factor 1 isoform b	APAF1	1	NP_001151	cytosol intracellular	caspase activation via cytochrome c nervous system development regulation of apoptosis	ATP binding caspase activator activity nucleotide binding protein binding	2
serum amyloid P component precursor	APCS	5	NP_001630	extracellular region extracellular space	acute- phase response chaperone- mediated protein complex assembly protein folding	calcium ion binding sugar binding unfolded protein binding	1, 2
apolipoprotein A- I preproprotein	APOA1	6	NP_000030	extracellular region extracellular space	cholesterol metabolism cholesterol transport circulation lipid metabolism lipid transport lipoprotein metabolism steroid metabolism	high- density lipoprotein binding lipid binding lipid transporter activity protein binding	2
apolipoprotein A- II preproprotein	APOA2	1	NP_001634	extracellular region	glucose metabolism lipid transport negative regulation of lipid catabolism negative regulation of lipoprotein metabolism neutrophil activation positive regulation of interleukin- 8 biosynthesis regulation of cytokine production response to glucose stimulus	lipid binding lipid transporter activity protein heterodimerization activity protein homodimerization activity	2
apolipoprotein A- IV precursor	APOA4	2	NP_000473	chylomicron extracellular region	circulation lipid metabolism lipid transport lipoprotein metabolism	lipid binding lipid transporter activity	2
apolipoprotein D precursor	APOD	7	NP_001638	extracellular region extracellular space	lipid metabolism transport	high- density lipoprotein binding lipid binding lipid transporter activity protein binding	1, 2
apolipoprotein E precursor	APOE	6	NP_000032	chylomicron cytoplasm extracellular region	cholesterol homeostasis circulation cytoskeleton organization and biogenesis induction of apoptosis intracellular transport learning and/or memory lipid transport lipoprotein metabolism protein tetramerization regulation of axon extension regulation of ne	antioxidant activity apolipoprotein E receptor binding beta- amyloid binding heparin binding lipid transporter activity phospholipid binding tau protein binding	2
adaptor protein containing pH domain, PTB domain and leucine zipper motif	APPL	1	NP_036228	cytoplasm endosome membrane membrane nucleus NuRD complex	cell cycle cell proliferation signal transduction	protein binding	2
adenine phosphoribosyltransferase isoform a	APRT	3	NP_000476	cytoplasm	adenine salvage nucleoside metabolism purine ribonucleoside salvage	adenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups	1, 2
adenine phosphoribosyltransferase isoform b	APRT	3	NP_001025189	cytoplasm	adenine salvage nucleoside metabolism purine ribonucleoside salvage	adenine phosphoribosyltransferase activity AMP binding transferase activity, transferring glycosyl groups	2
aquaporin 1	AQP1	3	NP_932766	integral to membrane integral to plasma membrane membrane outer membrane	excretion transport water transport	porin activity transporter activity water transporter activity	1, 2
aquaporin 2	AQP2	7	NP_000477	apical plasma membrane integral to membrane plasma membrane	excretion transport water transport	transporter activity water channel activity	1, 2
ADP- ribosylation factor 1	ARF1	6	NP_001649	intracellular plasma membrane	ER to Golgi vesicle- mediated transport transport rRNA processing small GTPase mediated signal transduction	GTP binding GTPase activity nucleotide binding protein binding receptor signaling protein activity	1
ADP- ribosylation factor interacting protein 1 isoform 2	ARFIP1	1	NP_055262	cytosol Golgi membrane	intracellular protein transport regulation of protein secretion	not classified	1
Rho GTPase activating protein 1	ARHGAP1	1	NP_004299	intracellular	cytoskeleton organization and biogenesis Rho protein signal transduction signal transduction	GTP binding protein binding Rho GTPase activator activity SH3/SH2 adaptor activity	2
Rho GDP dissociation inhibitor (GDI) alpha	ARHGDIA	1	NP_004300	cytoplasm cytoskeleton	anti- apoptosis cell motility negative regulation of cell adhesion Rho protein signal transduction	GTPase activator activity protein binding Rho GDP- dissociation inhibitor activity	2
Rho GDP dissociation inhibitor (GDI) beta	ARHGDIB	1	NP_001166	cytoplasm cytoplasmic membrane- bound vesicle cytoskeleton	actin cytoskeleton organization and biogenesis cell motility development immune response negative regulation of cell adhesion Rho protein signal transduction	GTPase activator activity Rho GDP- dissociation inhibitor activity	2
Rho guanine nucleotide exchange factor (GEF) 12	ARHGEF12	1	NP_056128	intracellular	regulation of Rho protein signal transduction	GTPase activator activity protein binding Rho guanyl- nucleotide exchange factor activity	2
ADP- ribosylation factor related protein 2	ARL15	1	NP_061960	not classified	not classified	GTP binding	2
ADP- ribosylation factor- like 3	ARL3	2	NP_004302	intracellular	G- protein coupled receptor protein signaling pathway rRNA processing small GTPase mediated signal transduction	GTP binding nucleotide binding signal transducer activity	1, 2
ADP- ribosylation factor- like 6	ARL6	3	NP_115522	cytoplasm intracellular membrane	rRNA processing small GTPase mediated signal transduction	GTP binding nucleotide binding protein binding	2
ADP- ribosylation factor- like 10B	ARL8A	1	NP_620150	cytoplasm intracellular membrane midbody spindle midzone	chromosome segregation rRNA processing small GTPase mediated signal transduction	alpha- tubulin binding beta- tubulin binding GTP binding GTPase activity nucleotide binding	2
ADP- ribosylation factor- like 10C	ARL8B	1	NP_060654	cytoplasm intracellular membrane midbody spindle midzone	chromosome segregation rRNA processing small GTPase mediated signal transduction	alpha- tubulin binding beta- tubulin binding GDP binding GTP binding GTPase activity nucleotide binding	2
armadillo repeat containing 3	ARMC3	1	NP_775104	not classified	not classified	binding	2
armadillo repeat containing 9	ARMC9	1	NP_079415	not classified	not classified	binding	2
actin related protein 2/3 complex subunit 1A	ARPC1A	1	NP_006400	not classified	not classified	not classified	2
actin related protein 2/3 complex subunit 2	ARPC2	5	NP_005722	Arp2/3 protein complex cytoskeleton	cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 3	ARPC3	2	NP_005710	Arp2/3 protein complex	cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 4 isoform a	ARPC4	2	NP_005709	Arp2/3 protein complex cytoskeleton	actin filament polymerization actin nucleation	actin filament binding protein binding, bridging structural constituent of cytoskeleton	1, 2
actin related protein 2/3 complex subunit 4 isoform b	ARPC4	2	NP_001020130	Arp2/3 protein complex cytoskeleton	actin filament polymerization actin nucleation	actin filament binding protein binding, bridging structural constituent of cytoskeleton	2
actin related protein 2/3 complex subunit 5	ARPC5	1	NP_005708	Arp2/3 protein complex cytoplasm cytoskeleton	actin cytoskeleton organization and biogenesis cell motility regulation of actin filament polymerization	structural constituent of cytoskeleton	2
actin related protein 2/3 complex, subunit 5- like	ARPC5L	1	NP_112240	cytoskeleton	regulation of actin filament polymerization	not classified	2
arrestin domain containing 1	ARRDC1	5	NP_689498	not classified	not classified	not classified	1, 2
arylsulfatase E precursor	ARSE	1	NP_000038	not classified	metabolism skeletal development	arylsulfatase activity calcium ion binding hydrolase activity	2
arylsulfatase F precursor	ARSF	12	NP_004033	not classified	metabolism	arylsulfatase activity calcium ion binding hydrolase activity	2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 preproprotein isoform a	ASAH1	7	NP_808592	lysosome	carboxylic acid metabolism ceramide metabolism fatty acid metabolism	ceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	1, 2
N- acylsphingosine amidohydrolase (acid ceramidase) 1 isoform b	ASAH1	9	NP_004306	lysosome	carboxylic acid metabolism ceramide metabolism fatty acid metabolism	ceramidase activity hydrolase activity transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	2
argininosuccinate lyase isoform 3	ASL	1	NP_001020117	cytoplasm	amino acid biosynthesis arginine biosynthesis arginine catabolism urea cycle	argininosuccinate lyase activity catalytic activity lyase activity	2
arsA arsenite transporter, ATP- binding, homolog 1	ASNA1	1	NP_004308	cytoplasm membrane nucleolus soluble fraction	anion transport response to arsenic transport	arsenite transporter activity arsenite- transporting ATPase activity ATP binding hydrolase activity nucleotide binding transporter activity	2
argininosuccinate synthetase 1	ASS1	20	NP_000041	cytoplasm	amino acid biosynthesis arginine biosynthesis urea cycle	argininosuccinate synthase activity ATP binding ligase activity nucleotide binding protein binding	1, 2
two AAA domain containing protein	ATAD2	1	NP_054828	not classified	not classified	ATP binding nucleoside- triphosphatase activity nucleotide binding	2
5- aminoimidazole- 4- carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	ATIC	1	NP_004035	not classified	nucleobase, nucleoside, nucleotide and nucleic acid metabolism	hydrolase activity IMP cyclohydrolase activity phosphoribosylaminoimidazolecarboxamide formyltransferase activity transferase activity	2
Na+/K+ - ATPase beta 1 subunit isoform b	ATP1B1	1	NP_001001787	integral to membrane membrane sodium:potassium- exchanging ATPase complex	ion transport potassium ion transport sodium ion transport	potassium ion binding sodium ion binding sodium:potassium- exchanging ATPase activity	2
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precursor	ATP5A1	3	NP_001001937	membrane fraction mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement ofsubstances meta	2
ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit precursor	ATP5B	4	NP_001677	mitochondrion proton- transporting ATP synthase complex (sensu Eukaryota) proton- transporting ATP synthase complex, catalytic core F(1) proton- transporting ATP synthase, catalytic core (sensu Eukaryota)	ATP synthesis coupled proton transport generation of precursor metabolites and energy ion transport proton transport	ATP binding hydrogen- exporting ATPase activity, phosphorylative mechanism hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleoside- triphos	2
ATPase, H+ transporting, lysosomal accessory protein 1 precursor	ATP6AP1	1	NP_001174	membrane proton- transportin two- sector ATPase complex vacuole	ATP synthesis coupled proton transport ion transport proton transport	ATP binding hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding nucleotide binding transporter activity	2
ATPase, H+ transporting, lysosomal accessory protein 2	ATP6AP2	1	NP_005756	integral to membrane membrane	not classified	receptor activity	2
ATPase, H+ transporting, lysosomal V0 subunit a isoform 1	ATP6V0A1	1	NP_005168	integral to membrane membrane	ion transport proton transport	hydrogen ion transporter activity	2
ATPase, H+ transporting, lysosomal V0 subunit a4	ATP6V0A4	1	NP_065683	hydrogen- translocating V- type ATPase complex integral to membrane membrane	ion transport proton transport regulation of pH	hydrogen ion transporter activity	2
ATPase, H+ transporting, lysosomal, V0 subunit c	ATP6V0C	1	NP_001685	membrane proton- transporting two- sector ATPase complex vacuole	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotation mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal, V0 subunit d1	ATP6V0D1	1	NP_004682	hydrogen- translocating V- type ATPase complex proton- transporting two- sector ATPase complex	ATP synthesis coupled proton transport ion transport proton transport	hydrogen- transporting ATP synthase activity, rotational mechanism hydrogen- transporting ATPase activity, rotational mechanism hydrolase activity metal ion binding	2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D2	ATP6V0D2	2	NP_689778