| Urinary Exosome Protein Database |
| This database of urinary exosome proteins is based on published
protein mass spectrometry data from the NHLBI Laboratory of Kidney and
Electrolyte Metabolism. All data are from urinary exosomes isolated from
healthy human volunteers. Figure on the right illustrates mechanism of
exosome formation and excretion. In the first step of the process, apical
membrane proteins undergo endocytosis. Second, the endosome is targeted to
the multivesicular body (MVB). The signal that marks plasma membrane proteins
for incorporation into MVB is mono-ubiquitination. In the third step, the
endosome fuses with the MVB. Consequently, the apical plasma membrane
proteins are segregated in the MVB outer membranes and internalized by
membrane invagination. Finally, the outer membrane of the MVB fuses with the
apical plasma membrane releasing its internal vesicles, called ‘exosomes’, in
the urinary space. Exosomes contain both membrane and cytosolic proteins. |
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| Reference:
Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of
exosomes in human urine. Proc Natl Acad Sci U S A. 2004 Sep
7;101(36):13368-73. |
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| Current Database Size: 304 proteins (Download Urinary Exosome Protein Database in
CSV file format). |
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The Urinary Exosome
Protein Database was created by Trairak Pisitkun and Mark A. Knepper.
Contact us with questions or comments. |
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| Protein
Name |
|
Accession Number |
|
Gene Name |
Number of Unique Peptide |
|
Number of Total Spectra |
|
Mw (Da) |
|
pI |
|
Subcellular Localization |
| ADP-ribosylation
factor 1 |
|
NP_001649 |
|
ARF1 |
6 |
|
27 |
|
20697 |
|
6.31 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| ADP-ribosylation
factor 3 |
|
NP_001650 |
|
ARF3 |
6 |
|
27 |
|
20601 |
|
6.84 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| ADP-ribosylation factor 4 |
|
NP_001651 |
|
ARF4 |
1 |
|
4 |
|
20511 |
|
6.60 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| ADP-ribosylation
factor 5 |
|
NP_001653 |
|
ARF5 |
1 |
|
3 |
|
20530 |
|
6.30 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| ADP-ribosylation factor 6 |
|
NP_001654 |
|
ARF6 |
4 |
|
11 |
|
20082 |
|
9.04 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| ADP-ribosylation
factor-like 3 |
|
NP_004302 |
|
ARL3 |
1 |
|
1 |
|
20456 |
|
6.74 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Alix;
Programmed cell death 6 interacting protein |
|
NP_037506 |
|
PDCD6IP |
12 |
|
69 |
|
96023 |
|
6.13 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Annexin
5 |
|
NP_001145 |
|
ANXA5 |
7 |
|
15 |
|
35937 |
|
4.94 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Annexin
A11 |
|
NP_001148 |
|
ANXA11 |
13 |
|
113 |
|
54390 |
|
7.53 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Annexin
A2 |
|
NP_001002858 |
|
ANXA2 |
6 |
|
40 |
|
38604 |
|
7.57 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Annexin
A3 |
|
NP_005130 |
|
ANXA3 |
2 |
|
2 |
|
36375 |
|
5.63 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Annexin
IV |
|
NP_001144 |
|
ANXA4 |
7 |
|
23 |
|
36085 |
|
5.84 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Annexin
VI |
|
NP_001146 |
|
ANXA6 |
1 |
|
1 |
|
75904 |
|
5.51 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Annexin
VII |
|
NP_001147 |
|
ANXA7 |
2 |
|
8 |
|
50316 |
|
6.25 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Arfaptin
1 |
|
NP_055262 |
|
ARFIP1 |
1 |
|
1 |
|
38599 |
|
6.10 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Calpain
7 |
|
NP_055111 |
|
CAPN7 |
3 |
|
4 |
|
92652 |
|
7.55 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Cell
division cycle 42 isoform 1 |
|
NP_001782 |
|
CDC42 |
4 |
|
13 |
|
21259 |
|
6.16 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Chloride
intracellular channel 4 |
|
NP_039234 |
|
CLIC4 |
1 |
|
2 |
|
28772 |
|
5.45 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Chromatin
modifying protein 1B |
|
NP_065145 |
|
CHMP1B |
2 |
|
4 |
|
22109 |
|
7.81 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Chromatin
modifying protein 2A |
|
NP_055268 |
|
CHMP2A |
1 |
|
16 |
|
25104 |
|
5.88 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Chromatin
modifying protein 2B |
|
NP_054762 |
|
CHMP2B |
3 |
|
10 |
|
23907 |
|
8.81 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Chromatin
modifying protein 4B |
|
NP_789782 |
|
CHMP4B |
2 |
|
3 |
|
24950 |
|
4.76 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Chromatin
modifying protein 5 |
|
NP_057494 |
|
CHMP5 |
3 |
|
24 |
|
24571 |
|
4.68 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Copine III |
|
NP_003900 |
|
CPNE3 |
5 |
|
13 |
|
60131 |
|
5.60 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Copine
V |
|
NP_065990 |
|
CPNE5 |
2 |
|
5 |
|
65734 |
|
5.65 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Copine VIII |
|
NP_705898 |
|
CPNE8 |
2 |
|
5 |
|
63108 |
|
5.66 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| EH-domain
containing 1 |
|
NP_006786 |
|
EHD1 |
2 |
|
4 |
|
60627 |
|
6.35 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| EH-domain containing 3 |
|
NP_055415 |
|
EHD3 |
2 |
|
4 |
|
60887 |
|
6.12 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| EH-domain
containing 4 |
|
NP_644670 |
|
EHD4 |
4 |
|
7 |
|
61175 |
|
6.33 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Hypothetical
protein LOC129531 |
|
NP_620153 |
|
LOC129531 |
3 |
|
8 |
|
29314 |
|
8.12 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Hypothetical
protein LOC148362 |
|
NP_653296 |
|
C1orf58 |
10 |
|
82 |
|
46464 |
|
7.55 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| N-ethylmaleimide-sensitive
factor attachment protein, alpha |
|
NP_003818 |
|
NAPA |
1 |
|
1 |
|
33247 |
|
5.23 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Penta-EF
hand domain containing 1 |
|
NP_036524 |
|
PEF1 |
2 |
|
5 |
|
30381 |
|
6.10 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Phosphoinositide-3-kinase,
class 2, beta polypeptide |
|
NP_002637 |
|
PIK3C2B |
1 |
|
1 |
|
184826 |
|
6.87 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Programmed
cell death 6 |
|
NP_037364 |
|
PDCD6 |
6 |
|
23 |
|
21868 |
|
5.16 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Protein
kinase C and casein kinase substrate in neurons 3 |
|
NP_057307 |
|
PACSIN3 |
1 |
|
1 |
|
48487 |
|
5.83 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB1A |
|
NP_004152 |
|
RAB1A |
2 |
|
11 |
|
22678 |
|
5.93 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB1B |
|
NP_112243 |
|
RAB1B |
2 |
|
11 |
|
22171 |
|
5.55 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB2 |
|
NP_002856 |
|
RAB2 |
4 |
|
4 |
|
23546 |
|
6.08 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB3A
or RAB3C or RAB4A or RAB4B or RAB9B or RAB30 or RAB37 or RAB39B |
|
|
|
RAB3A, RAB3C, RAB4A, RAB4B,
RAB9B, RAB30, RAB37, RAB39B |
1 |
|
18 |
|
|
|
|
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB3B |
|
NP_002858 |
|
RAB3B |
1 |
|
2 |
|
24758 |
|
4.85 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB3D |
|
NP_004274 |
|
RAB3D |
1 |
|
1 |
|
24267 |
|
4.76 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB5A |
|
NP_004153 |
|
RAB5A |
3 |
|
6 |
|
23659 |
|
8.32 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB5B |
|
NP_002859 |
|
RAB5B |
6 |
|
13 |
|
23707 |
|
8.29 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB5C |
|
NP_004574 |
|
RAB5C |
5 |
|
30 |
|
23568 |
|
8.87 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB6A
or RAB6B or RAB27A or RAB34 or RAB39 |
|
|
|
RAB6A, RAB6B, RAB27A, RAB34,
RAB39 |
1 |
|
18 |
|
|
|
|
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB7 |
|
NP_004628 |
|
RAB7 |
5 |
|
14 |
|
23490 |
|
6.39 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB8 |
|
NP_005361 |
|
RAB8A |
4 |
|
10 |
|
23668 |
|
9.15 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB8B |
|
NP_057614 |
|
RAB8B |
1 |
|
1 |
|
23584 |
|
9.15 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB10 |
|
NP_057215 |
|
RAB10 |
2 |
|
4 |
|
22469 |
|
8.80 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB
11A |
|
NP_004654 |
|
RAB11A |
4 |
|
5 |
|
24394 |
|
6.12 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB11B |
|
NP_004209 |
|
RAB11B |
4 |
|
5 |
|
24574 |
|
5.86 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB13 |
|
NP_002861 |
|
RAB13 |
1 |
|
1 |
|
22774 |
|
9.27 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB14 |
|
NP_057406 |
|
RAB14 |
2 |
|
7 |
|
23897 |
|
5.85 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB21 |
|
NP_055814 |
|
RAB21 |
2 |
|
2 |
|
24348 |
|
8.11 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB27B |
|
NP_004154 |
|
RAB27B |
1 |
|
3 |
|
24608 |
|
5.35 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB33B |
|
NP_112586 |
|
RAB33B |
1 |
|
18 |
|
25718 |
|
6.70 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAB35 |
|
NP_006852 |
|
RAB35 |
2 |
|
10 |
|
23025 |
|
8.53 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| RAP1B |
|
NP_056461 |
|
RAP1B |
5 |
|
13 |
|
20825 |
|
5.65 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Ras homolog gene family, member
A |
|
NP_001655 |
|
RHOA |
4 |
|
8 |
|
21768 |
|
5.83 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Ras
homolog gene family, member G |
|
NP_001656 |
|
RHOG |
1 |
|
2 |
|
21339 |
|
8.41 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Ras-related
C3 botulinum toxin substrate 1 |
|
NP_008839 |
|
RAC1 |
6 |
|
15 |
|
21450 |
|
8.77 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Related
RAS viral (r-ras) oncogene homolog 2 |
|
NP_036382 |
|
RRAS2 |
2 |
|
10 |
|
23400 |
|
5.74 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Ring finger protein 11 |
|
NP_055187 |
|
RNF11 |
1 |
|
28 |
|
17444 |
|
4.64 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| S100
calcium binding protein A11 (calgizzarin) |
|
NP_005611 |
|
S100A11 |
4 |
|
9 |
|
11740 |
|
6.56 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| S100
calcium-binding protein A6 |
|
NP_055439 |
|
S100A6 |
2 |
|
5 |
|
10180 |
|
5.32 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| SEC31-like
1 isoform 1 |
|
NP_055748 |
|
SEC31L1 |
1 |
|
1 |
|
133015 |
|
6.43 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Sorcin |
|
NP_003121 |
|
SRI |
1 |
|
4 |
|
21676 |
|
5.32 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Sorting
nexin associated golgi protein 1 |
|
NP_443102 |
|
SNAG1 |
1 |
|
5 |
|
68880 |
|
5.43 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Tumor susceptibility gene 101 |
|
NP_006283 |
|
TSG101 |
7 |
|
13 |
|
43944 |
|
6.06 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Ubiquitin |
|
NP_066289 |
|
UBC |
4 |
|
85 |
|
8565 |
|
6.56 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Ubiquitin-conjugating enzyme
E2-like |
|
NP_060784 |
|
UEV3 |
4 |
|
8 |
|
42268 |
|
5.94 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Ubiquitin-conjugating
enzyme E2N |
|
NP_003339 |
|
UBE2N |
1 |
|
2 |
|
17138 |
|
6.13 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Vacuolar
protein sorting 28 isoform 1 |
|
NP_057292 |
|
VPS28 |
6 |
|
24 |
|
25425 |
|
5.37 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Vacuolar
protein sorting factor 4A |
|
NP_037377 |
|
VPS4A |
7 |
|
52 |
|
48898 |
|
7.64 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Vacuolar
protein sorting factor 4B |
|
NP_004860 |
|
VPS4B |
7 |
|
52 |
|
49302 |
|
6.75 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| Vesicle-associated
membrane protein 3 (cellubrevin) |
|
NP_004772 |
|
VAMP3 |
1 |
|
1 |
|
11309 |
|
8.89 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| v-Ha-ras
Harvey rat sarcoma viral oncogene homolog |
|
NP_005334 |
|
HRAS |
2 |
|
7 |
|
21298 |
|
5.16 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| v-ral
simian leukemia viral oncogene homolog B |
|
NP_002872 |
|
RALB |
2 |
|
4 |
|
23409 |
|
6.24 |
|
CYTOPLASM (ENDOSOMAL
TRAFFICKING) |
| 6-phosphogluconolactonase |
|
NP_036220 |
|
PGLS |
1 |
|
1 |
|
27547 |
|
