Department of Health and Human ServicesNational Institutes of HealthNational Heart Lung and Blood Institute
IMCD Proteome Database
NHLBI Division of Intramural ResearchLaboratory of Kidney and Electrolyte Metabolism
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This database of renal inner medullary collecting duct (IMCD) proteins is based on published protein mass spectrometry data from the NHLBI Laboratory of Kidney and Electrolyte Metabolism. All data are from IMCD cells freshly isolated from the renal medullas of rats or mice.

The technical approach used in each experiment, including the measures that were taken to ensure the validity of the identifications, can be viewed by clicking here.

Use the menu bar above to sort the database by the protein name, gene name, accession number, theoretical pI, or theoretical molecular weight.

Current Database Size: 2338 proteins.

The IMCD Proteome Database was created by Dmitry Tchapyjnikov, Brian Ruttenberg, Vinitha Jacob, Guozhong Ma, Trairak Pisitkun, and Mark A. Knepper.

Contact us with questions or comments.

Protein NameGeneAcc NOTheoretical pITheoretical M.W.Tech
aminoadipate aminotransferase Aadat NP_058889.18.0847784.1510
PREDICTED: similar to alanyl- tRNA synthetase Aars XP_214690.35.41106790.376
PREDICTED: similar to ATP- binding cassette transporter sub- family A member 9 Abca9 XP_221101.47.48185196.716
ATP- binding cassette, sub- family B (MDR/TAP), member 11 Abcb11 NP_113948.17.1146258.4710
ATP- binding cassette, sub- family B (MDR/TAP), member 4 Abcb4 NP_036822.19.11140655.274
ATP- binding cassette, sub- family C (CFTR/MRP), member 4 Abcc4 NP_596902.18.34148864.868, 10
PREDICTED: similar to ATP- binding cassette sub- family F member 1 (ATP- binding cassette 50) Abcf1 XP_0010561516.2795251.98
abhydrolase domain containing 14b Abhd14b NP_001007665.15.6522617.936
PREDICTED: similar to v- abl Abelson murine leukemia viral oncogene 2 (arg, Abelson- related gene) isoform 2 Abl2 XP_0010681488.6125988.478
actin- binding LIM protein 1 Ablim1 NP_001037859.18.3348700.738
Ms1 Abra NP_787038.18.5542870.0210
acetyl- Coenzyme A acyltransferase 2 (mitochondrial 3- oxoacyl- Coenzyme A thiolase) Acaa2 NP_569117.18.0941870.926, 10
acetyl- coenzyme A carboxylase alpha Acaca NP_071529.15.97265193.5110
acetyl- Coenzyme A carboxylase beta Acacb NP_446374.15.84276099.856
PREDICTED: similar to very- long- chain acyl- CoA dehydrogenase VLCAD homolog isoform 1 Acad9 XP_001061665.17.9969926.476
acetyl- Coenzyme A dehydrogenase, long- chain Acadl NP_036951.17.6347872.856, 10
acetyl- coenzyme A dehydrogenase, medium chain Acadm NP_058682.18.6346555.376, 10
acetyl- Coenzyme A dehydrogenase, short chain Acads NP_071957.18.4744967.6410
acyl- Coenzyme A dehydrogenase, short/branched chain Acadsb NP_037216.18.2747823.966, 10
acyl- Coenzyme A dehydrogenase, very long chain Acadvl NP_037023.19.0170749.286, 10
acetyl- coenzyme A acetyltransferase 1 Acat1 NP_058771.18.9244709.026, 10
acyl- Coenzyme A binding domain containing 3 Acbd3 NP_878263.14.9960479.166, 10
PREDICTED: similar to Apoptotic chromatin condensation inducer in the nucleus (Acinus) Acin1 XP_2401785.68151038.48
ATP citrate lyase Acly NP_058683.16.96120635.946, 8, 10
aconitase 1 Aco1 NP_059017.16.7298127.526
aconitase 2, mitochondrial Aco2 NP_077374.27.8785433.446, 7, 10
acid phosphatase 2, lysosomal Acp2 NP_058684.16.1648319.6110
acyl- CoA synthetase long- chain family member 1 Acsl1 NP_036952.16.678178.686, 10
actin, beta Actb NP_1124065.2941736.731, 2
actin- like 6A Actl6a NP_001034122.15.3947420.946
actinin, alpha 1 Actn1 NP_112267.15.23102960.336, 10
alpha actinin 4 Actn4 NP_113863.25.27104915.024, 6, 10
PREDICTED: similar to Alpha- centractin (Centractin) (Centrosome- associated actin homolog) (Actin- RPV) (ARP1) Actr1a XP_238177.48.2754544.896
ARP2 actin- related protein 2 homolog Actr2 NP_001009268.16.2944733.763, 6, 10
ARP3 actin- related protein 3 homolog Actr3 NP_112330.15.6147357.153, 4, 6, 10
PREDICTED: similar to ARP5 actin- related protein 5 homolog Actr5 XP_342564.35.1168376.366
PREDICTED: hypothetical protein Acy1l2 XP_232864.45.3946684.0110
PREDICTED: similar to ADAM 10 precursor (A disintegrin and metalloproteinase domain 10) (Mammalian desintegrin- metalloprotease) (Kuzbanian protein homolog) Adam10 XP_001054737.18.0384087.166, 10
a disintegrin and metalloprotease domain 17 Adam17 NP_064702.15.5493017.066, 10
PREDICTED: similar to a disintegrin- like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 Adamts12 XP_226837.37.8178494.616
adenylate cyclase 6 Adcy6 NP_0369538.49130506.352
adenylate cyclase 8 Adcy8 NP_058838.16.49139822.7910
adducin 1 (alpha) Add1 NP_058686.25.8180355.268
adiponectin, C1Q and collagen domain containing Adipoq NP_653345.15.4226409.6710
adenosine kinase Adk NP_037027.25.8440132.666
PREDICTED: similar to Poly Adprtl1 XP_341327.35.851849936
adrenergic receptor, alpha 2a Adra2a NP_036871.29.748939.610
adhesion regulating molecule 1 Adrm1 NP_113896.14.9642114.288
PREDICTED: similar to adenylosuccinate synthetase, non muscle Adss XP_222946.25.9850085.186
glycosyltransferase Aer61 Aer61 NP_001009502.16.0661523.910
afadin Af6 NP_037349.15.82207677.768, 10
PREDICTED: similar to ALL1 fused gene from 5q31 Aff4 XP_001073824.19.38126673.3210
PREDICTED: similar to AFG3(ATPase family gene 3)- like 1 Afg3l1 XP_341715.28.7487274.8110
aspartylglucosaminidase Aga NP_001026811.16.7537167.356
agrin Agrn NP_786930.15.83206560.584, 5, 10
alanine- glyoxylate aminotransferase Agxt NP_085914.18.3743399.296
PREDICTED: similar to transcription factor ELYS Ahctf1 XP_341162.36.16247882.88
S- adenosylhomocysteine hydrolase Ahcy NP_058897.16.0747538.021, 4, 6
PREDICTED: similar to AHNAK nucleoprotein isoform 1 isoform 4 Ahnak XP_001078113.16.42252504.596, 8, 10
alpha- 2- HS- glycoprotein Ahsg NP_0370306.338003.418
adenylate kinase 1 Ak1 NP_077325.27.6621583.766
adenylate kinase 3 Ak3 NP_037350.18.8925438.346, 10
PREDICTED: similar to A kinase (PRKA) anchor protein 10 Akap10 XP_001077273.16.273774.1310
A kinase anchor protein 12 isoform beta Akap12 NP_001028825.14.371730646
PREDICTED: similar to A- kinase anchor protein 13 isoform 1 Akap13 XP_001063231.15.24303778.846
A kinase (PRKA) anchor protein (yotiao) 9 Akap9 NP_001032170.15.83128489.856
aldo- keto reductase family 1, member A1 Akr1a1 NP_112262.16.8436505.884, 6
aldehyde reductase 1 Akr1b4 NP_036630.16.2635797.281, 2, 3, 4, 5, 6, 9, 10
aldo- keto reductase family 1, member B8 Akr1b8 NP_775159.17.0836190.86
aldo- keto reductase family 7, member A2 (aflatoxin aldehyde reductase) Akr7a2 NP_599234.16.2737597.576
aldo- keto reductase family 7, member A3 (aflatoxin aldehyde reductase) Akr7a3 NP_037347.16.836747.076
aminolevulinate, delta- , dehydratase Alad NP_037031.16.3236031.596
albumin Alb NP_599153.16.0968718.742, 3, 4, 5, 6, 10
activated leukocyte cell adhesion molecule Alcam NP_113941.15.7765021.956, 10
aldehyde dehydrogenase family 1, member A1 Aldh1a1 NP_071852.27.9454458.666
aldehyde dehydrogenase family 1, subfamily A3 Aldh1a3 NP_695212.16.1956171.434, 6, 10
aldehyde dehydrogenase family 3, subfamily A2 Aldh3a2 NP_113919.17.5654081.615, 6, 10
PREDICTED: similar to Succinate semialdehyde dehydrogenase (NAD(+)- dependent succinic semialdehyde dehydrogenase) Aldh5a1 XP_214478.4 8.3556145.392
aldehyde dehydrogenase family 6, subfamily A1 Aldh6a1 NP_112319.28.4457747.566
PREDICTED: similar to aldehyde dehydrogenase family 7, member A1 Aldh7a1 XP_214535.37.9958748.666
aldehyde dehydrogenase family 9, subfamily A1 Aldh9a1 NP_071609.26.3154050.114, 6, 10
aldolase A Aldoa NP_036627.18.339351.941, 4, 6
PREDICTED: similar to Alpha- 1, 3- mannosyltransferase ALG2 (GDP- Man:Man(1)GlcNAc(2)- PP- dolichol mannosyltransferase) Alg2 XP_232987.38.247318.885, 10
arachidonate 15- lipoxygenase, second type Alox15b NP_695213.15.8676145.336
alkaline phosphatase, tissue- nonspecific Alpl NP_037191.16.5257714.4510
alpha 1 microglobulin/bikunin Ambp NP_037033.15.7738851.0110
adenosine monophosphate deaminase 3 Ampd3 NP_113732.16.8692200.396
aminomethyltransferase Amt NP_001014026.19.154406410
ankyrin 3, epithelial isoform 2 Ank3 NP_0010291567.94284442.648
acidic (leucine- rich) nuclear phosphoprotein 32 family, member A Anp32a NP_037035.13.9928564.594, 6
acidic nuclear phosphoprotein 32 family, member B Anp32b NP_571986.13.8731060.636
acidic (leucine- rich) nuclear phosphoprotein 32 family, member E Anp32e NP_001013218.13.829418.336
kidney aminopeptidase M Anpep NP_112274.15.3109448.525, 6, 10
annexin A1 Anxa1 NP_037036.16.9738829.474, 5, 6, 10
annexin A11 Anxa11 NP_001011918.17.5354160.465, 6
PREDICTED: similar to annexin A13 Anxa13 XP_001068572.15.5736837.856
annexin A2 Anxa2 NP_063970.17.5538678.241, 2, 4, 5, 6, 7, 9, 10
annexin A3 Anxa3 NP_036955.16.0436322.196
annexin A4 Anxa4 NP_077069.35.4335893.761, 4, 5, 6, 10
annexin A5 Anxa5 NP_037264.14.9235744.512, 5, 6
annexin A6 Anxa6 NP_077070.25.3975756.176, 10
annexin A7 Anxa7 NP_569100.25.9150019.296, 10
adaptor protein complex AP- 1, beta 1 subunit Ap1b1 NP_058973.15104588.576
PREDICTED: similar to AP- 1 complex subunit gamma- 1 (Adapter- related protein complex 1 gamma- 1 subunit) (Gamma- adaptin) (Adaptor protein complex AP- 1 gamma- 1 subunit) (Golgi adaptor HA1/AP1 adaptin subunit gamma- 1) (Clathrin assembly protein complex 1 gammAp1g1 XP_001075367.16.3691350.476, 10
adaptor- related protein complex AP- 1, mu subunit 1 Ap1m1 NP_001037704.16.8248556.8710
PREDICTED: similar to AP- 1 complex subunit sigma- 2 (Adapter- related protein complex 1 sigma- 1B subunit) (Sigma- adaptin 1B) (Adaptor protein complex AP- 1 sigma- 1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma- 1B subunit) (Clathrin assembly protein complex Ap1s2 XP_217618.45.418929.096
PREDICTED: similar to AP- 2 complex subunit alpha- 1 (Adapter- related protein complex 2 alpha- 1 subunit) (Alpha- adaptin A) (Adaptor protein complex AP- 2 alpha- 1 subunit) (Clathrin assembly protein complex 2 alpha- A large chain) (100 kDa coated vesicle proteAp2a1 XP_218624.36.63107666.065, 6
adaptor protein complex AP- 2, alpha 2 subunit Ap2a2 NP_112270.16.51104044.585, 6, 10
adaptor- related protein complex 2, beta 1 subunit Ap2b1 NP_542150.15.19105691.85, 6, 10
adaptor- related protein complex 2, mu 1 subunit Ap2m1 NP_446289.19.5749654.685, 6
adaptor- related protein complex 2, sigma 1 subunit Ap2s1 NP_075241.25.8217017.76
PREDICTED: similar to AP- 3 complex subunit beta- 1 (Adapter- related protein complex 3 beta- 1 subunit) (Beta3A- adaptin) (Adaptor protein complex AP- 3 beta- 1 subunit) (Clathrin assembly protein complex 3 beta- 1 large chain) Ap3b1 XP_001067082.16.53137740.2610
adenomatosis polyposis coli Apc NP_0366317.05310532.678
n- acylaminoacyl- peptide hydrolase Apeh NP_036632.15.4681383.786
PREDICTED: similar to apoptosis inhibitor 5 Api5 XP_342471.36.9959019.626, 8
PREDICTED: similar to apolipoprotein A- I binding protein Apoa1bp XP_001068886.16.4430890.686
apolipoprotein E Apoe NP_620183.15.5336037.825, 10
PREDICTED: similar to androgen- induced prostate proliferative shutoff associated protein AS3 isoform 2 Aprin XP_0010565638.94164462.388
adenine phosphoribosyl transferase (predicted) Aprt NP_001013079.16.1719545.754, 6
adaptor protein with pleckstrin homology and src homology 2 domains Aps NP_446121.15.9566707.6710
apical protein of Xenopus- like Apxl NP_001041358.16.32157989.0710
aquaporin 1 Aqp1 NP_036910.17.728856.565, 6, 10
aquaporin 2 Aqp2 NP_037041.26.4428930.635, 6, 8, 10
aquaporin 4 Aqp4 NP_036957.16.6534480.156, 8, 10
acidic ribosomal phosphoprotein P0 Arbp NP_071797.15.9134215.473, 4, 5, 6, 8, 10
archain Arcn1 NP_001007663.15.8957199.386, 10
ADP- ribosylation factor 4 Arf4 NP_077065.16.5920396.636
ADP- ribosylation factor 5 Arf5 NP_077063.16.320529.665, 10
ADP- ribosylation factor 6 Arf6 NP_077066.19.0420082.165, 6
ADP- ribosylation factor guanine nucleotide- exchange factor 2 (brefeldin A- inhibited) Arfgef2 NP_851597.26.08201974.096, 8
ADP- ribosylation factor interacting protein 1 Arfip1 NP_0685316.3340779.128
arginase 2 Arg2 NP_062041.16.2438640.142, 6
PREDICTED: similar to Rho GTPase activating protein 1 Arhgap1 XP_230284.46.0650622.896
PREDICTED: similar to Rho- GTPase- activating protein 12 isoform 1 Arhgap12 XP_001055788.18.1992580.396
Rho GTPase activating protein 20 Arhgap20 NP_998794.16.21127667.8810
PREDICTED: similar to Rho GTPase activating protein 21 Arhgap21 XP_2256288.51230603.818
PREDICTED: similar to Rho- GTPase- activating protein 26 (Oligophrenin- 1- like protein) (GTPase regulator associated with focal adhesion kinase) Arhgap26 XP_001066829.16.53103332.516
Rho GTPase activating protein 27 Arhgap27 NP_9420545.5497179.818
Rho GTPase activating protein 5 Arhgap5 NP_001041334.16.31142757.776
Rho GDP dissociation inhibitor (GDI) alpha Arhgdia NP_001007006.15.1223407.414, 6
Rho, GDP dissociation inhibitor (GDI) beta Arhgdib NP_001009600.14.9822883.956
Rho guanine nucleotide exchange factor (GEF) 12 Arhgef12 NP_001013264.15.39172670.768
rac/cdc42 guanine nucleotide exchange factor 6 arhgef6 NP_0010055655.6287013.28
PREDICTED: similar to AT rich interactive domain 1A isoform a Arid1a XP_0010657946.19206825.898
ADP- ribosylation factor- like 1 Arl1 NP_071780.15.6320411.576
ADP- ribosylation factor- like 6 interacting protein 5 Arl6ip5 NP_076462.19.6221548.66
PREDICTED: similar to arginine- rich, mutated in early stage tumors Armet XP_001072112.18.5420387.765
actin related protein 2/3 complex, subunit 1A Arpc1a NP_112408.18.4641599.2810
actin related protein 2/3 complex, subunit 1B Arpc1b NP_062162.18.6941056.846, 10
PREDICTED: similar to actin related protein 2/3 complex subunit 2 Arpc2 XP_001056906.16.8434347.056
PREDICTED: similar to actin related protein 2/3 complex, subunit 4 Arpc4 XP_001078712.19.4228671.114, 5, 6
actin related protein 2/3 complex, subunit 5 Arpc5 NP_001020888.15.4716320.425, 6, 10
arrestin, beta 1 Arrb1 NP_037042.15.947019.596, 8
arylsulfatase E Arse NP_001041350.17.165675.410
type 1 tumor necrosis factor receptor shedding aminopeptidase regulator Arts1 NP_110463.15.96100729.586
N- acylsphingosine amidohydrolase 1 Asah1 NP_445859.28.5444443.196
PREDICTED: similar to Ankyrin repeat and SOCS box protein 1 (ASB- 1) Asb1 XP_237397.47.9837098.486
PREDICTED: similar to activating signal cointegrator 1 complex subunit 3 isoform a Ascc3 XP_001062104.16.45250529.666
PREDICTED: similar to absent, small, or homeotic discs 1 Ash1l XP_001074246.19.42331558.546
argininosuccinate lyase Asl NP_067588.25.8851390.776
ATPase family, AAA domain containing 1 Atad1 NP_001030174.16.4340717.0110
5- aminoimidazole- 4- carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Atic NP_112276.26.6964208.424, 6
ATX1 (antioxidant protein 1) homolog 1 Atox1 NP_445811.16.77292.446
ATPase, H+/K+ transporting, nongastric, alpha polypeptide Atp12a NP_598201.16.16114974.8610
ATPase, Na+/K+ transporting, alpha 1 polypeptide Atp1a1 NP_036636.15.3113054.274, 5, 6, 10
ATPase, Na+/K+ transporting, alpha 2 polypeptide Atp1a2 NP_036637.15.39112217.326
Na+/K+ - ATPase alpha 4 subunit Atp1a4 NP_074039.15.55114004.886
ATPase, Na+/K+ transporting, beta 1 polypeptide Atp1b1 NP_037245.28.8335201.594, 5, 6, 10
Na+/K+ - ATPase beta 3 subunit Atp1b3 NP_037045.18.0831829.686, 10
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Atp2a1 NP_478120.15.13109409.486
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Atp2a2 NP_058986.15.23114767.975, 6, 10
plasma membrane calcium ATPase 1 Atp2b1 NP_445763.15.85129510.1510
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 Atp5a1 NP_075581.19.2259753.633, 6, 9, 10
ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit Atp5b NP_599191.15.1856353.552, 5, 6, 7, 9, 10
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit Atp5c1 NP_446277.19.0632996.033, 6, 10
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit precursor Atp5d NP_620806.15.1617595.076
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 Atp5f1 NP_599192.19.3928868.86, 9, 10
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d Atp5h NP_062256.16.1618763.443, 4, 6
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 Atp5j NP_446054.19.4312494.426
mitochondrial ATP synthase, O subunit Atp5o NP_620238.110.0323397.553, 4, 5, 6, 10
ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 Atp6v0a1 NP_113792.26.196255.665, 6
ATPase, H+ transporting, V0 subunit D isoform 1 Atp6v0d1 NP_001011927.14.8940301.085, 10
PREDICTED: similar to ATPase, H+ transporting, V1 subunit B, isoform 1 Atp6v1b1 XP_001073086.15.2456850.676, 10
vacuolar H+ATPase B2 Atp6v1b2 NP_476561.15.5756550.86
ATPase, H+ transporting, V1 subunit C, isoform 1 Atp6v1c1 NP_001011992.17.0243900.566
vacuolar H+ ATPase C2 Atp6v1c2 NP_001014221.16.3148243.2510
ATPase, H+ transporting, V1 subunit D Atp6v1d NP_955418.19.4428308.926
vacuolar H+ ATPase E1 Atp6v1e1 NP_942040.18.4426128.415, 6
PREDICTED: similar to ATPase, H+ transporting, V1 subunit G, isoform 3 Atp6v1g3 XP_213980.39.2313772.88, 10
vacuolar ATPase subunit H Atp6v1h NP_001013951.16.2550859.56
ATPase, Cu++ transporting, alpha polypeptide Atp7a NP_4346906.18162092.888
PREDICTED: similar to ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Atp8a1 XP_001070245.16.25131814.235, 6
autogenous vein graft remodeling associated protein 1 Avgr1 NP_001034677.19.8547188.786