To see "High
Resolution Profiles of Histone Methylations in the Human Genome",
use this recent data set
[Cell 2007 (129) 823-837]
The genome-wide distributions of K9/K14 di-acetylated histone H3 (H3Ac2),
K4 trimethylated histone H3 (H3K4me3), and K27 trimethylated histone
H3 (H3K27me3) in resting and activated human T lymphocytes
were mapped by Genome-wide MApping
Technique (GMAT), a combination of chromatin
immunoprecipitation and SAGE technique. The level of the histone
modification at a genetic locus is positively correlated with the
detection frequency of a 21-bp sequence tag identified by the GMAT
analysis. The detection frequency (y-axis) is plotted against the
chromosome coordinate (x-axis). The bottom panel represents a gene
map generated by the UCSC genome Browser.
References:
- Proc. Natl. Acad. Sci USA 2006 (103) 15782-15787
- Genes & Dev. 2005 (19) 542-552
- Nat. Biotechnol. 2004 (22) 1013-1016
Tips for using this browser
If you know the position of a gene on a chromosome, choose the
chromosome number from the pull-down box on the left side and enter
the genomic position in the blank box in the middle. The size of
query should not exceed 200,000 bp because of the limitation
of server resources. Examples of valid queries are as following:
- A specific position (e.g., 15000)
- A range (e.g., 62000-70000 or 62,000-70,000)
If you do not know the position of your gene,
please find the information from
the UCSC Genome Browser.
The GMAT analysis are based on the July 2003 human reference sequence
(UCSC hg16/NCBI build 34).
System requirements:
Adobe SVG viewer 3.0 or above is required to view and print
high quality GMAT figures. If you cannot see the figures properly,
please download SVG viewer plug-in from
Adobe website.
We recommend using Internet Explorer 5.x, Mozilla Firefox 1.5
and Netscape 4.7 for PC, Internet Explorer 5.x and Netscape 7.x
for Mac computers.
If you have any questions, please
contact Keji Zhao
at zhaok@nhlbi.nih.gov |