AADDx – a model for differential diagnosis of aplastic anemia in adulthood
Prediction models:
Choose a model
Machine Learning model
Logistic Regression model
Clinical and laboratory data at diagnosis:
Age
Sex
Male
Female
Red Blood Cell Count [x10^3/mL]:
Hemoglobin Level [dL/g]:
MCV:
Platelet Count [x10^3/mL]:
Neutrophil Count [x10^3/mL]:
Red Cell Distribution Width (RDW):
Lymphocytes Count [x10^3/mL]:
Monocytes Count [x10^3/mL]:
Eosinophil Count [x10^3/mL]:
Basophil Count [x10^3/mL]:
Reticulocytes Count [x10^3/mL]
Telomere Length measurement by Flow-FISH or Southern Blot
Not Availible
< 1st Percentile
< 10th Percentile
Normal
Bone Marrow Cellularity
Hypocellular BM for age
Normal
Hypercellular BM for age
Dysplasia or increased blasts
Criteria for myelodysplastic syndromes (WHO 2016)
With increased number of blasts (>5%)
None
DC mucocutaneous clinical triad
At least two of three manifestations of the clinical mucocutaneous triad (dystrophic nails, skin hyper- or hypo-pigmentation, and oral leukoplakia)
None
Isolated mucocutaneous or skin findings
Skin hyper or hypo pigmentation
Leukoplakia
Nail dystrophy
Cafe au lait spots
Petechiae
Skin infections
Skin rash or lesions
Ichthyosis
Mouth ulcers & macules
Nevi
Wart
None
Physical anomalies
Short stature
Thumb and arm anomalies
Failure to thrive
Microcephaly
Clinodactyly
Polydactyly
Syndactyly
Fanconi facies
Dysmorphic features
Palate high arch
Skeletal anomalies
Renal anomalies
Gonadal anomalies
Esophageal/Uretheral stenosis
Lacrimal duct stenosis
None
Multiorgan disease
Fatty liver/NASH
Cirrhosis or portal hypertension
Other Liver disease
pulmonary fibrosis
Clubbing
Other Pulmonary disease
pancreatic insufficiency
Other GI dysfunction
cerebellar ataxia
growth and development delay
Other Neurological findings
Hip necrosis
Ear infections or hearing loss
septo-optic dysplasia
Congenital cataracts
Others features
None
History of longstanding cytopenia or macrocytosis
At birth
Since childhood
For more than 5 years
None
History of longstanding bleeding or recurrent infections
recurrent bleeding during childhood
recurrent bleeding for more than 5 years
recurrent infections during childhood
recurrent infections for more than 5 years
None
Immunodeficiency
Common variable immunodeficiency
Hypogammaglobulinemia
B and NK cell lymphopenia
T-cell lymphopenia
None
Immediate family members with similar phenotypes
Parent with hematologic/physical findings for IBMFS
Siblings with hematologic/physical findings for IBMFS
Offsprings with hematologic/physical findings for IBMFS
None
Extended family members with similar phenotype
Any relative with findings for IBMFS
None
Early hair greying
Proband <30 years old and patchy grey hair
Proband <30 years old and full grey hair
None
Predict
Prediction Results
Model Results
Flowchart