Laboratory of Biophysical Chemistry (LBC)
James Ferretti, MD, Chief
This laboratory investigates the physical and chemical properties
of molecules with a view to relate their structures to biochemical
functions. Specialties are high field nuclear magnetic resonance,
mass spectrometry, x-ray crystallography, scanning tunneling/force
field microscopy, chromatography, and laboratory computer applications.
These techniques are increasingly applied to the study of proteins
and other macromolecular species such as oligosaccharides and glycolipids.
Structural studies of smaller molecules such as cofactors, colchinoids,
adducts of heme and anesthesia metabolites, cyclic peptides, and
signaling substances are also being conducted. A special concern
is the identification and development of new analytical techniques
and integration with problems of current interest within NHLBI and
NIH. Extensive collaborations are carried out with chemists, physicists,
clinicians, biologists and computer specialists.