Clinical Cardiology Section
Richard Cannon, MD, Principal Investigator
Dr. Richard Cannon is involved in the study of the regulation of coronary blood flow in health and in cardiac diseases including CAD and cardiomyopathies. Currently, collaborative efforts with investigators in the NIH Critical Care Medicine Department and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) include the study of the coronary blood flow effect of nitric oxide bound to hemoglobin, enriched by nitric oxide inhalation, with preferential delivery expected to vascular regions deficient in local nitric oxide synthesis, i.e., the coronary circulation of patients with coronary artery disease. Additional novel approaches to enhance coronary blood flow to ischemic myocardium are planned in collaboration with investigators in the Hematology Branch of NHLBI, including cytokine mobilization of stem cells from bone marrow, with the potential of cardiac arteriogenesis in patients with coronary artery disease.
Robert J Lederman, MD, Principal Investigator
Cardiovascular Intervention Program
Dr. Lederman, MD, is applying real-time MRI imaging to guide novel
mechanical and biological therapeutic cardiovascular interventions.
He collaborates closely with the NHLBI Medical Imaging Section to develop custom
hardware and software solutions for interventional MRI. A combined
X-ray/MRI interventional suite has been installed for clinical
and animal experiments. These tools are being applied toward investigation
of stem cell and angiogenic therapies for patients with acute and
chronic ischemic myocardial and peripheral artery disease.
MRI-guided injection of stem cells into the heart
Sequence of real-time MRI-guided cardiac injections
Angiogram of a kidney after a catheter is placed in the renal artery using real-time MRI guidance
Dr. Vandana Sachdev
Dr. Sachdev's main areas of interest are: 1) Use of ultrasound and microbubbles to enhance gene transfection, 2) Using Doppler tissue imaging to assess diastolic function, 3) Evaluation of pulmonary hypertension in the sickle cell population and 4) Use of resting and stress echocardiography to evaluate various interventions for CAD.
Projects for the near future include: 1) Use of intracardiac echo to evaluate hypertrophic cardiomyopathy, 2) Real-time three-dimensional echocardiography and 3) Myocardial contrast echo for assessment of perfusion.