Hematology Branch (HB)
Neal S Young, MD, Principal Investigator
Welcome to the Hematology Branch. The Branch is an intramural research
program within the National Heart, Lung, and Blood Institute in
Bethesda Maryland. The Chief of the Branch is Neal Young, MD.
Research activities are directed to the investigation of hematologic
disease. Activities range from basic biology to applied clinical
research and the treatment of patients in experimental protocols.
For these purposes, advanced techniques are utilized from molecular
biology, cellular biology, immunology, and virology. Individual,
investigator-led units focus on bone marrow failure and its mechanism,
especially immune suppression of hematopoiesis and the interaction
of viruses with hematopoietic cells; bone marrow transplantation,
both autologous and allogeneic, with emphases on stem cell isolation
and mechanisms of graft-versus-host and graft-versus-leukemia effects;
gene therapy, with protocols for gene marking the clinical treatment
of Fanconi's anemia; and the use of primate models for gene therapy.
Viruses of interest include B19 parvovirus; adeno-associated virus,
especially as a vector for gene therapy; retroviruses, including
the human immunodeficiency virus; and herpesviruses. Extensive facilities
are available for pre-clinical trials in non-human primates and
for human gene therapy. The research is focused on the pathogenesis
of disease at the molecular and cellular level and the use of laboratory
insights to develop novel strategies for treatment.
Information on the clinical research studies being conducted by
the Hematology Branch is available. This information, as well as
information on other NHLBI clinical studies is also available in
the category, Health Related Information, under Studies