Congenital Heart Disease Section, LDB, Division of Intramural Research, NHLBI, NIH

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Congenital Heart Disease Section

The major research objective of the laboratory is to elucidate the complex etiology of congenital heart disease. Towards this goal, the laboratory specializes in the use of non-invasive ultrasound and MRI techniques and other imaging modalities to study cardiovascular development and function in genetically engineered and chemically mutagenized mouse models. In parallel with our work on mouse models, we are developing a human cardiovascular developmental atlas to study human congenital heart malformations. We also have a very active research program focused on elucidating the cell and molecular biology of cell signaling pathways that regulate heart outflow tract morphogenesis and coronary artery development.

Connexin Regulation of Cell Motility Neural Crest Cell Migration Primordial Germ Cell Migration	Mouse ENU Mutagenesis LDB Mouse ENU Mutagenesis Program
Connexin Protein Interactions and Cell Signaling Connexin 45 Distribution Gap Junction Cell Signaling	Protocols Genotyping Automations

Image	Description
	MRI of Fetal Mouse Heart.
	Ultrasound of Fetal Mouse Heart.
	EFIC Reconstruction of E16.5 Mouse Embryo.

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National Heart, Lung, and Blood Institute