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Protein Conformation and Dynamics Research

 

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Publications

  • Pfefferkorn, C.M., Lee, J.C.* (2009) "Tryptophan probes at the α-synuclein and phospholipid interface: insights into surface coverage and binding equilibrium," J. Am. Chem. Soc., submitted.
  • Urie, K.G., Angulo, R., Lee, J.C., Kozak, J.J., Gray, H.B., Winkler, J.R. (2009) "Synchronous vs. asynchronous chain motion in α-synuclein contact dynamics," J. Phys. Chem. B 113, 522-530.
  • Grabenauer, M., Bernstein, S.L., Lee, J.C., Wyttenbach, T., Dupuis, N.F., Gray, H.B., Winkler, J.R., Bowers, M.T. (2008) "Spermine binding to Parkinson’s protein and its disease-related A30P and A53T mutants," J. Phys. Chem. B 112, 11147-11154.
  • Lee, J.C.,* Gray, H.B., Winkler, J.R. (2008) "Copper(II) binding to α-synuclein, the Parkinson’s protein," J. Am. Chem. Soc. 130, 6898-6899.
  • Kimura, T.; Lee, J.C., Gray, H.B., Winkler, J.R. (2007) "Site-specific collapse dynamics guide the formation of the cytochrome c’ four helix bundle," Proc. Natl. Acad. Sci. USA 104, 117-122.
  • Finke, J.M., Jennings, P.A., Lee, J.C., Onuchic, J.N., Winkler, J.R. (2007) "Equilibrium unfolding of poly-(glutamic acid)20 helix," Biopolymers 86, 193-211.
  • Lee, J.C., Lai, B.T., Kozak, J., Gray, H.B., Winkler, J.R. (2007) "α-Synuclein tertiary contact formation dynamics," J. Phys. Chem. B 111, 2107-2112.
  • Winkler, G.R., Harkins, S.B., Lee, J.C.,* Gray, H.B. (2006) "α-Synuclein structures probed by 5-fluorotryptophan fluorescence and 19F NMR spectroscopy," J. Phys. Chem. B 110, 7058-7061.
  • Lee, J.C.,* Gray, H.B., Winkler, J.R. (2005) "Tertiary contact formation in α-synuclein probed by electron transfer," J. Am. Chem. Soc. 127, 16388-16389.
  • Lee, J.C.,* Hummel, P.A., Gray, H.B., Langen, R., Winkler, J.R. (2004) "α-Synuclein structures from fluorescence energy transfer kinetics: Implications for the role of the protein in Parkinson’s disease," Proc. Natl. Acad. Sci. USA 101, 16466-16471.
  • Bernstein, S.L., Liu, D., Wyttenbach, T., Bowers, M.T., Lee, J.C., Gray, H.B., Winkler, J.R. (2004) "α-Synuclein: Stable compact and extended monomeric structures and pH dependence of dimer formation," J. Am. Soc. Mass. 15, 1435-1443.
  • Chang, I.-J, Lee, J.C., Winkler, J.R., Gray, H.B. (2003) "The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c," Proc. Natl. Acad. Sci. USA 100, 3838-3840.
  • McGuirl, M. A., Lee, J. C., Lyubovitsky, J., Thanyakoop, C., Richards, J. H., Winkler, J. R., Gray, H. B. (2003) "Cloning, heterologous expression, and characterization of recombinant Rhodopseudomonas palustris class II cytochromes c," Biochim. Biophys. Acta 1619, 23-28.
  • Lee, J.C., Engman, K.C.,Tezcan, F.A., Gray, H.B., Winkler, J.R. (2002) "Structural features of cytochrome c' folding intermediates revealed by fluorescence-energy transfer kinetics," Proc. Natl. Acad. Sci. USA 99, 14778-14782.
  • Lee, J.C., Chang, I.-J., Gray, H.B., Winkler, J.R. (2002) "The cytochrome c folding landscape revealed by electron-transfer kinetics," J. Mol. Biol. 320, 159-164.
  • Lee, J.C., Gray, H.B., Winkler, J.R. (2001) "Cytochrome c' folding triggered by electron transfer: fast and slow formation of four-helix bundles," Proc. Natl. Acad. Sci. USA. 98, 7760-7764. Wittung-Stafshede, P.,
  • Lee, J.C., Winkler, J.R., Gray, H.B. (1999) "Cytochrome b562 folding triggered by electron transfer: approaching the speed limit for formation of a four-helix bundle protein," Proc. Natl. Acad. Sci. USA. 96, 6587-6590.
  • Banin, U., Lee, J.C., Guzelian, A.A., Kadavanich, A.V., Alivisatos, A.P. (1997) "Exchange Interaction in InAs nanocrystal quantum dots," Superlatt-M. 22, 559-567.
*corresponding author

 

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