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Structural Biophysics Section

Nico Tjandra, PhD, Principal Investigator

The main interest of the Structural Biophysics Section is to develop new techniques in NMR to efficiently study structure and dynamics of biomolecules. We are focused on discovering the underlying basic physical principle that defines some parameters that we observe with solution NMR. The intent is to develop a protocol to apply this knowledge into structure determination. In most of these parameters that we measure there are always some dynamic components. One aspects of our research is to try to separate the structural from the dynamic components of the NMR parameters. The detail dynamic information that we obtain together with the solution structure of the biomolecules completes the full picture of the molecules in their physiological environment.

In addition we also utilize other biophysical techniques such as light scattering and imaging to gain additional structural and cellular information on the molecules of interest. Our goal is to understand the basic mechanism of protein interactions that govern various cellular processes.

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